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Conserved domains on  [gi|767963323|ref|XP_011538278|]
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transmembrane 9 superfamily member 3 isoform X1 [Homo sapiens]

Protein Classification

transmembrane 9 family protein( domain architecture ID 10503172)

transmembrane 9 (TM9) family protein similar to human TM9 member 1 (hMP70) that plays a role in autophagy, and to Dictyostelium discoideum phagocytic receptors that are involved in adhesion and phagocytosis

Gene Ontology:  GO:0016020
PubMed:  12857872
TCDB:  8.A.68

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EMP70 pfam02990
Endomembrane protein 70;
75-545 0e+00

Endomembrane protein 70;


:

Pssm-ID: 460774  Cd Length: 512  Bit Score: 593.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323   75 TYKYFSL-PFCVGSKKSISHyhETLGEALQGVELEFSGLDIKFKDDVMPATYCEIDLDKEKRDAFVYAIKNHYWYQMYID 153
Cdd:pfam02990   1 PYDYYDLlPFCPPEDGIKKE--ESLGEILFGDRIYNSPYELKFGKDETCKVLCTKTLTKEDVKFLKELIKNGYRVNWIID 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  154 DLPIW----------GIVGEADENGEDYYLWTYKKLEIGFN------GNRIVDVNLT-----------SEGKVKLVPNTK 206
Cdd:pfam02990  79 NLPVAttfysagfplGFVGSEDTDDNKYYLNNHLDFVIRYHkvsgdeGYRIVGFEVYpksvkhedacpKNPLEVEDEDTT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  207 IQMSYSVKWKKSD-VKFEDRFDKYLDpsFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSkeeEMDDMDRD 285
Cdd:pfam02990 159 IPFTYSVYWRESDdVPWATRWDKYLH--VPDPKIHWFSIINSLVIVLFLSGIVAMILLRTLRKDIARYN---ELDDEEEE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  286 LGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLY-TERGSMLSTAIFVYAATSPVNGYFGGSL 364
Cdd:pfam02990 234 DQEESGWKLVHGDVFRPPSHPMLLSVLVGSGVQLLFMALGTILFALLGFLSpSNRGSLLTAMIVLYVLTGFVAGYVSARL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  365 YARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIPFGTMVAVCCICFFVILPLNLVGTILGRNlSGQPNF 444
Cdd:pfam02990 314 YKTFGGENWKRNILLTALLFPGLVFIIFFILNLFLWAKGSSGAIPFGTLLALLLLWFLISVPLSLIGSYFGFK-KPAIEH 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  445 PCRVNAVPRPIPEKKWFMEPAVIVCLGGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFL 524
Cdd:pfam02990 393 PVRTNQIPRQIPPQPWYLKPLPSMLLGGILPFGAIFIELYFIFTSLWLNKIYYMFGFLFLVFIILIITTAEVTILLTYFQ 472
                         490       500
                  ....*....|....*....|.
gi 767963323  525 LNAEDYRWQWTSFLSAASTAI 545
Cdd:pfam02990 473 LCAEDYRWWWRSFLTGGSTAL 493
 
Name Accession Description Interval E-value
EMP70 pfam02990
Endomembrane protein 70;
75-545 0e+00

Endomembrane protein 70;


Pssm-ID: 460774  Cd Length: 512  Bit Score: 593.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323   75 TYKYFSL-PFCVGSKKSISHyhETLGEALQGVELEFSGLDIKFKDDVMPATYCEIDLDKEKRDAFVYAIKNHYWYQMYID 153
Cdd:pfam02990   1 PYDYYDLlPFCPPEDGIKKE--ESLGEILFGDRIYNSPYELKFGKDETCKVLCTKTLTKEDVKFLKELIKNGYRVNWIID 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  154 DLPIW----------GIVGEADENGEDYYLWTYKKLEIGFN------GNRIVDVNLT-----------SEGKVKLVPNTK 206
Cdd:pfam02990  79 NLPVAttfysagfplGFVGSEDTDDNKYYLNNHLDFVIRYHkvsgdeGYRIVGFEVYpksvkhedacpKNPLEVEDEDTT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  207 IQMSYSVKWKKSD-VKFEDRFDKYLDpsFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSkeeEMDDMDRD 285
Cdd:pfam02990 159 IPFTYSVYWRESDdVPWATRWDKYLH--VPDPKIHWFSIINSLVIVLFLSGIVAMILLRTLRKDIARYN---ELDDEEEE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  286 LGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLY-TERGSMLSTAIFVYAATSPVNGYFGGSL 364
Cdd:pfam02990 234 DQEESGWKLVHGDVFRPPSHPMLLSVLVGSGVQLLFMALGTILFALLGFLSpSNRGSLLTAMIVLYVLTGFVAGYVSARL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  365 YARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIPFGTMVAVCCICFFVILPLNLVGTILGRNlSGQPNF 444
Cdd:pfam02990 314 YKTFGGENWKRNILLTALLFPGLVFIIFFILNLFLWAKGSSGAIPFGTLLALLLLWFLISVPLSLIGSYFGFK-KPAIEH 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  445 PCRVNAVPRPIPEKKWFMEPAVIVCLGGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFL 524
Cdd:pfam02990 393 PVRTNQIPRQIPPQPWYLKPLPSMLLGGILPFGAIFIELYFIFTSLWLNKIYYMFGFLFLVFIILIITTAEVTILLTYFQ 472
                         490       500
                  ....*....|....*....|.
gi 767963323  525 LNAEDYRWQWTSFLSAASTAI 545
Cdd:pfam02990 473 LCAEDYRWWWRSFLTGGSTAL 493
 
Name Accession Description Interval E-value
EMP70 pfam02990
Endomembrane protein 70;
75-545 0e+00

Endomembrane protein 70;


Pssm-ID: 460774  Cd Length: 512  Bit Score: 593.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323   75 TYKYFSL-PFCVGSKKSISHyhETLGEALQGVELEFSGLDIKFKDDVMPATYCEIDLDKEKRDAFVYAIKNHYWYQMYID 153
Cdd:pfam02990   1 PYDYYDLlPFCPPEDGIKKE--ESLGEILFGDRIYNSPYELKFGKDETCKVLCTKTLTKEDVKFLKELIKNGYRVNWIID 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  154 DLPIW----------GIVGEADENGEDYYLWTYKKLEIGFN------GNRIVDVNLT-----------SEGKVKLVPNTK 206
Cdd:pfam02990  79 NLPVAttfysagfplGFVGSEDTDDNKYYLNNHLDFVIRYHkvsgdeGYRIVGFEVYpksvkhedacpKNPLEVEDEDTT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  207 IQMSYSVKWKKSD-VKFEDRFDKYLDpsFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSkeeEMDDMDRD 285
Cdd:pfam02990 159 IPFTYSVYWRESDdVPWATRWDKYLH--VPDPKIHWFSIINSLVIVLFLSGIVAMILLRTLRKDIARYN---ELDDEEEE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  286 LGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLY-TERGSMLSTAIFVYAATSPVNGYFGGSL 364
Cdd:pfam02990 234 DQEESGWKLVHGDVFRPPSHPMLLSVLVGSGVQLLFMALGTILFALLGFLSpSNRGSLLTAMIVLYVLTGFVAGYVSARL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  365 YARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIPFGTMVAVCCICFFVILPLNLVGTILGRNlSGQPNF 444
Cdd:pfam02990 314 YKTFGGENWKRNILLTALLFPGLVFIIFFILNLFLWAKGSSGAIPFGTLLALLLLWFLISVPLSLIGSYFGFK-KPAIEH 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963323  445 PCRVNAVPRPIPEKKWFMEPAVIVCLGGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFL 524
Cdd:pfam02990 393 PVRTNQIPRQIPPQPWYLKPLPSMLLGGILPFGAIFIELYFIFTSLWLNKIYYMFGFLFLVFIILIITTAEVTILLTYFQ 472
                         490       500
                  ....*....|....*....|.
gi 767963323  525 LNAEDYRWQWTSFLSAASTAI 545
Cdd:pfam02990 473 LCAEDYRWWWRSFLTGGSTAL 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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