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Conserved domains on  [gi|767963002|ref|XP_011538149|]
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exosome complex component CSL4 isoform X1 [Homo sapiens]

Protein Classification

ECR1_N and S1_CSL4 domain-containing protein( domain architecture ID 10146546)

ECR1_N and S1_CSL4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
S1_CSL4 cd05791
S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide ...
 27-119 1.40e-55

S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in eukarytes and archaea. Its functions include the removal of incorrectly processed RNA and the maintenance of proper levels of mRNA, rRNA and a number of small RNA species. In S. cerevisiae, the exosome includes nine core components, six of which are homologous to bacterial RNase PH. These form a hexameric ring structure. The other three subunits (RrP4, Rrp40, and Csl4) contain an S1 RNA binding domain and are part of the "S1 pore structure".


:

Pssm-ID: 240217  Cd Length: 92  Bit Score: 169.35  E-value: 1.40e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  27 QLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSn 106
Cdd:cd05791    1 LVLPKVGSIVIARVTRINPRFAKVDILCVGGRPLKESFRGVIRKEDIRATEKDKVEMYKCFRPGDIVRAKVISLGDASS- 79

                         90
                 ....*....|...
gi 767963002 107 YLLTTAENELGVV 119
Cdd:cd05791   80 YYLSTAENELGVV 92
 
Name Accession Description Interval E-value
S1_CSL4 cd05791
S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide ...
 27-119 1.40e-55

S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in eukarytes and archaea. Its functions include the removal of incorrectly processed RNA and the maintenance of proper levels of mRNA, rRNA and a number of small RNA species. In S. cerevisiae, the exosome includes nine core components, six of which are homologous to bacterial RNase PH. These form a hexameric ring structure. The other three subunits (RrP4, Rrp40, and Csl4) contain an S1 RNA binding domain and are part of the "S1 pore structure".


Pssm-ID: 240217  Cd Length: 92  Bit Score: 169.35  E-value: 1.40e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  27 QLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSn 106
Cdd:cd05791    1 LVLPKVGSIVIARVTRINPRFAKVDILCVGGRPLKESFRGVIRKEDIRATEKDKVEMYKCFRPGDIVRAKVISLGDASS- 79

                         90
                 ....*....|...
gi 767963002 107 YLLTTAENELGVV 119
Cdd:cd05791   80 YYLSTAENELGVV 92
Csl4 COG1096
Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains [Intracellular ...
 17-151 2.05e-16

Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440713 [Multi-domain]  Cd Length: 191  Bit Score: 72.24  E-value: 2.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  17 VVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSM--PLKNSFRGTIRKEDVRATEKDKveIYKSFRPGDIVL 94
Cdd:COG1096   50 VISVKPKKKPPPVPKKGDIVIGEVVDVRESMALVKIYAIEGNerELPSSFSGIIHISQVSDSYVKD--LSDEFRVGDIVR 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767963002  95 AKVISLGdaqSNYLLTTAENELGVVVAH-SESGIQMVPISwCEMQCPKTHTKEFRKVA 151
Cdd:COG1096  128 AKVISTL---PPIQLSIKEPDLGVIKAKcSKCGSPLVKDG-DKLKCPNCGNVEKRKLS 181
EXOSC1 pfam10447
Exosome component EXOSC1/CSL4; This family of proteins are components of the exosome 3'->5' ...
 29-100 6.67e-13

Exosome component EXOSC1/CSL4; This family of proteins are components of the exosome 3'->5' exoribonuclease complex. The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions.


Pssm-ID: 402191  Cd Length: 112  Bit Score: 61.36  E-value: 6.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002   29 LPDVGAIVTCKVSSINSRFAKVHIL--------------------YVGSMP--------------------LKNSFRGTI 68
Cdd:pfam10447   1 LPKEGDVVLARVTRLSQQQANVEILsvegennvlgdsgvgsngegAVASIPagggldilfsvstvasqssdLGETFKGII 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767963002   69 RKEDVRATEKDKVEIYKSFRPGDIVLAKVISL 100
Cdd:pfam10447  81 RSQDVRATERDRVKVIEMFRPGDIVRAQVISL 112
PRK09521 PRK09521
exosome complex RNA-binding protein Csl4; Provisional
 18-151 4.61e-10

exosome complex RNA-binding protein Csl4; Provisional


Pssm-ID: 236547 [Multi-domain]  Cd Length: 189  Bit Score: 55.37  E-value: 4.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  18 VSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYV--GSMPLKNSFRGTIRKEDVRatEKDKVEIYKSFRPGDIVLA 95
Cdd:PRK09521  50 ISVIPFKKTPPLLKKGDIVYGRVVDVKEQRALVRIVSIegSERELATSKLAYIHISQVS--DGYVESLTDAFKIGDIVRA 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767963002  96 KVISLGDaqsNYLLTTAENELGVVVAH-SESGIQMVPISWCEMQCPKTHTKEFRKVA 151
Cdd:PRK09521 128 KVISYTD---PLQLSTKGKDLGVIYAMcSRCRTPLVKKGENELKCPNCGNIETRKLS 181
S1 smart00316
Ribosomal protein S1-like RNA-binding domain;
32-111 8.98e-05

Ribosomal protein S1-like RNA-binding domain;


Pssm-ID: 197648 [Multi-domain]  Cd Length: 72  Bit Score: 38.74  E-value: 8.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002    32 VGAIVTCKVSSINSRFAKVHILyvgsmplkNSFRGTIRKEDVraTEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTT 111
Cdd:smart00316   2 VGDVVEGTVTEITPGGAFVDLG--------NGVEGLIPISEL--SDKRVKDPEEVLKVGDEVKVKVLSVDEEKGRIILSL 71
 
Name Accession Description Interval E-value
S1_CSL4 cd05791
S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide ...
 27-119 1.40e-55

S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in eukarytes and archaea. Its functions include the removal of incorrectly processed RNA and the maintenance of proper levels of mRNA, rRNA and a number of small RNA species. In S. cerevisiae, the exosome includes nine core components, six of which are homologous to bacterial RNase PH. These form a hexameric ring structure. The other three subunits (RrP4, Rrp40, and Csl4) contain an S1 RNA binding domain and are part of the "S1 pore structure".


Pssm-ID: 240217  Cd Length: 92  Bit Score: 169.35  E-value: 1.40e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  27 QLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSn 106
Cdd:cd05791    1 LVLPKVGSIVIARVTRINPRFAKVDILCVGGRPLKESFRGVIRKEDIRATEKDKVEMYKCFRPGDIVRAKVISLGDASS- 79

                         90
                 ....*....|...
gi 767963002 107 YLLTTAENELGVV 119
Cdd:cd05791   80 YYLSTAENELGVV 92
S1_Rrp4_like cd04454
S1_Rrp4_like: Rrp4-like, S1-like RNA-binding domain. S1-like RNA-binding domains are found in ...
 27-119 3.54e-32

S1_Rrp4_like: Rrp4-like, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein, and Rrp40 and Csl4 proteins, also represented in this group, are subunits of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in eukarytes and archaea. Its functions include the removal of incorrectly processed RNA and the maintenance of proper levels of mRNA, rRNA and a number of small RNA species. In Saccharomyces cerevisiae, the exosome includes nine core components, six of which are homologous to bacterial RNase PH. These form a hexameric ring structure. The other three subunits (RrP4, Rrp40, and Csl4) contain an S1 RNA binding domain and are part of the "S1 pore structure".


Pssm-ID: 239901 [Multi-domain]  Cd Length: 82  Bit Score: 109.95  E-value: 3.54e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  27 QLLPDVGAIVTCKVSSINSRFAKVHILYvgsmplknsfRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAqSN 106
Cdd:cd04454    1 RYLPDVGDIVIGIVTEVNSRFWKVDILS----------RGTARLEDSSATEKDKKEIRKSLQPGDLILAKVISLGDD-MN 69

                         90
                 ....*....|...
gi 767963002 107 YLLTTAENELGVV 119
Cdd:cd04454   70 VLLTTADNELGVI 82
Csl4 COG1096
Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains [Intracellular ...
 17-151 2.05e-16

Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440713 [Multi-domain]  Cd Length: 191  Bit Score: 72.24  E-value: 2.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  17 VVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSM--PLKNSFRGTIRKEDVRATEKDKveIYKSFRPGDIVL 94
Cdd:COG1096   50 VISVKPKKKPPPVPKKGDIVIGEVVDVRESMALVKIYAIEGNerELPSSFSGIIHISQVSDSYVKD--LSDEFRVGDIVR 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767963002  95 AKVISLGdaqSNYLLTTAENELGVVVAH-SESGIQMVPISwCEMQCPKTHTKEFRKVA 151
Cdd:COG1096  128 AKVISTL---PPIQLSIKEPDLGVIKAKcSKCGSPLVKDG-DKLKCPNCGNVEKRKLS 181
EXOSC1 pfam10447
Exosome component EXOSC1/CSL4; This family of proteins are components of the exosome 3'->5' ...
 29-100 6.67e-13

Exosome component EXOSC1/CSL4; This family of proteins are components of the exosome 3'->5' exoribonuclease complex. The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions.


Pssm-ID: 402191  Cd Length: 112  Bit Score: 61.36  E-value: 6.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002   29 LPDVGAIVTCKVSSINSRFAKVHIL--------------------YVGSMP--------------------LKNSFRGTI 68
Cdd:pfam10447   1 LPKEGDVVLARVTRLSQQQANVEILsvegennvlgdsgvgsngegAVASIPagggldilfsvstvasqssdLGETFKGII 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767963002   69 RKEDVRATEKDKVEIYKSFRPGDIVLAKVISL 100
Cdd:pfam10447  81 RSQDVRATERDRVKVIEMFRPGDIVRAQVISL 112
PRK09521 PRK09521
exosome complex RNA-binding protein Csl4; Provisional
 18-151 4.61e-10

exosome complex RNA-binding protein Csl4; Provisional


Pssm-ID: 236547 [Multi-domain]  Cd Length: 189  Bit Score: 55.37  E-value: 4.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  18 VSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYV--GSMPLKNSFRGTIRKEDVRatEKDKVEIYKSFRPGDIVLA 95
Cdd:PRK09521  50 ISVIPFKKTPPLLKKGDIVYGRVVDVKEQRALVRIVSIegSERELATSKLAYIHISQVS--DGYVESLTDAFKIGDIVRA 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767963002  96 KVISLGDaqsNYLLTTAENELGVVVAH-SESGIQMVPISWCEMQCPKTHTKEFRKVA 151
Cdd:PRK09521 128 KVISYTD---PLQLSTKGKDLGVIYAMcSRCRTPLVKKGENELKCPNCGNIETRKLS 181
S1 smart00316
Ribosomal protein S1-like RNA-binding domain;
32-111 8.98e-05

Ribosomal protein S1-like RNA-binding domain;


Pssm-ID: 197648 [Multi-domain]  Cd Length: 72  Bit Score: 38.74  E-value: 8.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002    32 VGAIVTCKVSSINSRFAKVHILyvgsmplkNSFRGTIRKEDVraTEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTT 111
Cdd:smart00316   2 VGDVVEGTVTEITPGGAFVDLG--------NGVEGLIPISEL--SDKRVKDPEEVLKVGDEVKVKVLSVDEEKGRIILSL 71
rpsA PRK06299
30S ribosomal protein S1; Reviewed
 27-99 1.58e-03

30S ribosomal protein S1; Reviewed


Pssm-ID: 235775 [Multi-domain]  Cd Length: 565  Bit Score: 37.84  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963002  27 QLLPD----------VGAIVTCKVSSINSRFAKVHilyvgsmpLKNSFRGTIRKEDVratEKDKVE-IYKSFRPGDIVLA 95
Cdd:PRK06299 445 QLEEDpfeefakkhkKGSIVTGTVTEVKDKGAFVE--------LEDGVEGLIRASEL---SRDRVEdATEVLKVGDEVEA 513


                 ....
gi 767963002  96 KVIS 99
Cdd:PRK06299 514 KVIN 517
S1_RPS1_repeat_ec6 cd05691
S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ...
 33-100 5.50e-03

S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of 4-6 tandem S1 domains. In some bacteria, the tandem S1 array is located C-terminal to a 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HMBPP reductase) domain. While RPS1 is found primarily in bacteria, proteins with tandem RPS1-like domains have been identified in plants and humans, however these lack the N-terminal HMBPP reductase domain. This CD includes S1 repeat 6 (ec6) of the Escherichia coli RPS1. Autoantibodies to double-stranded DNA from patients with systemic lupus erythematosus cross-react with the human RPS1 homolog.


Pssm-ID: 240196 [Multi-domain]  Cd Length: 73  Bit Score: 34.17  E-value: 5.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767963002  33 GAIVTCKVSSINSRFAKVHilyvgsmpLKNSFRGTIRKEDVratEKDKVE-IYKSFRPGDIVLAKVISL 100
Cdd:cd05691    1 GSIVTGKVTEVDAKGATVK--------LGDGVEGFLRAAEL---SRDRVEdATERFKVGDEVEAKITNV 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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