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Conserved domains on  [gi|767962008|ref|XP_011537754|]
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zinc finger CCHC domain-containing protein 24 isoform X1 [Homo sapiens]

Protein Classification

zf-3CxxC_2 domain-containing protein( domain architecture ID 12182554)

zf-3CxxC_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-3CxxC_2 pfam17180
Zinc-binding domain;
94-160 2.37e-36

Zinc-binding domain;


:

Pssm-ID: 407306  Cd Length: 74  Bit Score: 120.59  E-value: 2.37e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767962008   94 KRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDV------SDQSKEHPQHLCEKC 160
Cdd:pfam17180   2 KRLFGKFTCTKCAREWSSGNSWANMGQECKKCKIPVYPWVQRPLLKKEDYDEdlmrggSIGDRAHETHLCEKC 74
COG5222 super family cl34947
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
33-87 4.86e-07

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5222:

Pssm-ID: 227547 [Multi-domain]  Cd Length: 427  Bit Score: 48.20  E-value: 4.86e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767962008  33 DGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCP-QARPKGEGL 87
Cdd:COG5222  148 DKMSSATPIYKPNQHRIGAQKHNKPPPPGYVCYRCGQKGHWIQNCPtNQDPNFDGK 203
 
Name Accession Description Interval E-value
zf-3CxxC_2 pfam17180
Zinc-binding domain;
94-160 2.37e-36

Zinc-binding domain;


Pssm-ID: 407306  Cd Length: 74  Bit Score: 120.59  E-value: 2.37e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767962008   94 KRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDV------SDQSKEHPQHLCEKC 160
Cdd:pfam17180   2 KRLFGKFTCTKCAREWSSGNSWANMGQECKKCKIPVYPWVQRPLLKKEDYDEdlmrggSIGDRAHETHLCEKC 74
COG5222 COG5222
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
33-87 4.86e-07

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227547 [Multi-domain]  Cd Length: 427  Bit Score: 48.20  E-value: 4.86e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767962008  33 DGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCP-QARPKGEGL 87
Cdd:COG5222  148 DKMSSATPIYKPNQHRIGAQKHNKPPPPGYVCYRCGQKGHWIQNCPtNQDPNFDGK 203
zf-CCHC_2 pfam13696
Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of ...
 59-79 6.86e-07

Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.


Pssm-ID: 463959 [Multi-domain]  Cd Length: 21  Bit Score: 43.66  E-value: 6.86e-07
                          10        20
                  ....*....|....*....|.
gi 767962008   59 PPNYLCHLCFNKGHYIKDCPQ 79
Cdd:pfam13696   1 PPGYVCHICGKKGHYIQDCPT 21
 
Name Accession Description Interval E-value
zf-3CxxC_2 pfam17180
Zinc-binding domain;
94-160 2.37e-36

Zinc-binding domain;


Pssm-ID: 407306  Cd Length: 74  Bit Score: 120.59  E-value: 2.37e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767962008   94 KRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDV------SDQSKEHPQHLCEKC 160
Cdd:pfam17180   2 KRLFGKFTCTKCAREWSSGNSWANMGQECKKCKIPVYPWVQRPLLKKEDYDEdlmrggSIGDRAHETHLCEKC 74
COG5222 COG5222
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
33-87 4.86e-07

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227547 [Multi-domain]  Cd Length: 427  Bit Score: 48.20  E-value: 4.86e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767962008  33 DGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCP-QARPKGEGL 87
Cdd:COG5222  148 DKMSSATPIYKPNQHRIGAQKHNKPPPPGYVCYRCGQKGHWIQNCPtNQDPNFDGK 203
zf-CCHC_2 pfam13696
Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of ...
 59-79 6.86e-07

Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.


Pssm-ID: 463959 [Multi-domain]  Cd Length: 21  Bit Score: 43.66  E-value: 6.86e-07
                          10        20
                  ....*....|....*....|.
gi 767962008   59 PPNYLCHLCFNKGHYIKDCPQ 79
Cdd:pfam13696   1 PPGYVCHICGKKGHYIQDCPT 21
zf-3CxxC pfam13695
Zinc-binding domain; This is a family with several pairs of CxxC motifs possibly representing ...
 95-161 3.93e-05

Zinc-binding domain; This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.


Pssm-ID: 463958  Cd Length: 96  Bit Score: 40.48  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767962008   95 RCFGEYKCPKCKRKWMSGNSWA--------------NM---GQECIKCHINVYPH-------------KQRPLEKPDGLD 144
Cdd:pfam13695   1 KVYGRFRCSSCSRKWTSAKVWItirmyldppgngtyNArvyGQRCKKCKRLERPEldeeevervlyrlKKKIEKPCYGEK 80

                          90
                  ....*....|....*..
gi 767962008  145 VsdqSKEHPQHLCEKCK 161
Cdd:pfam13695  81 T---TGPHERDLCEGCK 94
UPF0515 pfam15135
Uncharacterized protein UPF0515; This family of proteins is functionally uncharacterized. This ...
 98-160 2.58e-03

Uncharacterized protein UPF0515; This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. There are two conserved sequence motifs: PLT and HSC.


Pssm-ID: 464521  Cd Length: 271  Bit Score: 37.09  E-value: 2.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767962008   98 GEYKCPKCKRKWmsgNSWANMG--QECIKCHINVYPHKQRPLEKPDGldvsdQSKEHpQHLC--EKC 160
Cdd:pfam15135 152 AEFHCPKCKRTF---RGFGQMEvsSPCYGCGNPVLPSRILPPRRSQG-----PRSRN-QHSCfaEDC 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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