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Conserved domains on  [gi|767961672|ref|XP_011537611|]
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A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 238-352 1.66e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 110.36  E-value: 1.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672  238 TVKGTLGKAsKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNqVTGSFILNPKGK-EATSRTFTAMGLEWEDAV-EDA 315
Cdd:pfam05986   1 TVSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767961672  316 KESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 352
Cdd:pfam05986  79 LEELHAPGPTQEDLEIQVLRQYGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 2-64 2.97e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 79.31  E-value: 2.97e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767961672    2 DEQCRFDFGSGYQTCLAFrTFEPCKQLWCSHPDNPYfCKTKKGPPLDGTECAPGKWCFKGHCI 64
Cdd:pfam17771   8 DEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 78-130 1.76e-14

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 68.00  E-value: 1.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767961672    78 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 130
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 374-429 3.75e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 3.75e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767961672  374 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPkPIRRRCNQHPC 429
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 495-544 1.49e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 1.49e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767961672  495 WRLGAWSQCSATCGEGIQQRQVVCR------TNANSLghCEGD-RPDTVQVCSLPAC 544
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsIVPDSE--CSAQkKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 132-236 1.04e-07

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 50.86  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672  132 TYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAqkCELICQSADTGDVVFMNQVVHDGTRCSYRDP----- 199
Cdd:pfam19236   1 TQLEFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgt 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767961672  200 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHC 236
Cdd:pfam19236  79 LSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 434-491 1.69e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 1.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767961672  434 WVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkVMPAKACAGD-RPEARRPCLRVPC 491
Cdd:pfam19030   1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGS---IVPDSECSAQkKPPETQSCNLKPC 55
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 632-746 3.93e-04

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672 632 TSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQ-HPFAPETPIPGASWSISPTTPGGL 710
Cdd:PRK07764 600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPkHVAVPDASDGGDGWPAKAGGAAPA 679

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767961672 711 PWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT 746
Cdd:PRK07764 680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 238-352 1.66e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 110.36  E-value: 1.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672  238 TVKGTLGKAsKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNqVTGSFILNPKGK-EATSRTFTAMGLEWEDAV-EDA 315
Cdd:pfam05986   1 TVSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767961672  316 KESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 352
Cdd:pfam05986  79 LEELHAPGPTQEDLEIQVLRQYGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 2-64 2.97e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 79.31  E-value: 2.97e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767961672    2 DEQCRFDFGSGYQTCLAFrTFEPCKQLWCSHPDNPYfCKTKKGPPLDGTECAPGKWCFKGHCI 64
Cdd:pfam17771   8 DEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 78-130 1.76e-14

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 68.00  E-value: 1.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767961672    78 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 130
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 374-429 3.75e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 3.75e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767961672  374 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPkPIRRRCNQHPC 429
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 495-544 1.49e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 1.49e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767961672  495 WRLGAWSQCSATCGEGIQQRQVVCR------TNANSLghCEGD-RPDTVQVCSLPAC 544
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsIVPDSE--CSAQkKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 132-236 1.04e-07

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 50.86  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672  132 TYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAqkCELICQSADTGDVVFMNQVVHDGTRCSYRDP----- 199
Cdd:pfam19236   1 TQLEFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgt 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767961672  200 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHC 236
Cdd:pfam19236  79 LSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 434-491 1.69e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 1.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767961672  434 WVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkVMPAKACAGD-RPEARRPCLRVPC 491
Cdd:pfam19030   1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGS---IVPDSECSAQkKPPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
79-129 6.20e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.64  E-value: 6.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767961672   79 SSWTKFGSCSRSCGGGVRSRSRSCNNPSPayGGRLCLGPMFEYQVCNSEEC 129
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 498-544 1.31e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.04  E-value: 1.31e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767961672   498 GAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTvQVCSLPAC 544
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGggPCTGEDVET-RACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 433-492 3.06e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 3.06e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672   433 VWVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkvmPAKACAGDRPEaRRPCLRVPCP 492
Cdd:smart00209   1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQN-----GGGPCTGEDVE-TRACNEQPCP 53
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 632-746 3.93e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672 632 TSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQ-HPFAPETPIPGASWSISPTTPGGL 710
Cdd:PRK07764 600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPkHVAVPDASDGGDGWPAKAGGAAPA 679

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767961672 711 PWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT 746
Cdd:PRK07764 680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 238-352 1.66e-28

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 110.36  E-value: 1.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672  238 TVKGTLGKAsKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNqVTGSFILNPKGK-EATSRTFTAMGLEWEDAV-EDA 315
Cdd:pfam05986   1 TVSGSFTEG-RAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKN-VQGKYILNGKGSiSLNPTYPSLLGTVLEYRRsLPA 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767961672  316 KESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 352
Cdd:pfam05986  79 LEELHAPGPTQEDLEIQVLRQYGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 2-64 2.97e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 79.31  E-value: 2.97e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767961672    2 DEQCRFDFGSGYQTCLAFrTFEPCKQLWCSHPDNPYfCKTKKGPPLDGTECAPGKWCFKGHCI 64
Cdd:pfam17771   8 DEQCRLIFGPGSTFCPNG-DEDVCSKLWCSNPGGST-CTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 78-130 1.76e-14

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 68.00  E-value: 1.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767961672    78 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 130
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 374-429 3.75e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 3.75e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767961672  374 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPkPIRRRCNQHPC 429
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 495-544 1.49e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.30  E-value: 1.49e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767961672  495 WRLGAWSQCSATCGEGIQQRQVVCR------TNANSLghCEGD-RPDTVQVCSLPAC 544
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgggsIVPDSE--CSAQkKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 132-236 1.04e-07

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 50.86  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672  132 TYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAqkCELICQSADTGDVVFMNQVVHDGTRCSYRDP----- 199
Cdd:pfam19236   1 TQLEFMSQQCARTDGQPLRSSpggaSFYHWgaaVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgt 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767961672  200 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHC 236
Cdd:pfam19236  79 LSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 434-491 1.69e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 1.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767961672  434 WVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkVMPAKACAGD-RPEARRPCLRVPC 491
Cdd:pfam19030   1 WVAGPWGECSVTCGG-GVQTRLVQCVQKGGGS---IVPDSECSAQkKPPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
79-129 6.20e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.64  E-value: 6.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767961672   79 SSWTKFGSCSRSCGGGVRSRSRSCNNPSPayGGRLCLGPMFEYQVCNSEEC 129
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 498-544 1.31e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.04  E-value: 1.31e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767961672   498 GAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTvQVCSLPAC 544
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGggPCTGEDVET-RACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 79-129 1.78e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 1.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767961672   79 SSWTKFGSCSRSCGGGVRSRSRSCNNPsPAYGGRLClGPMFEYQVCNSEEC 129
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
498-544 2.60e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 44.72  E-value: 2.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767961672  498 GAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTvQVCSLPAC 544
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIET-QACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 433-492 3.06e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 3.06e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672   433 VWVTEEWGACSRSCGKlGVQTRGIQCLLPLSNGthkvmPAKACAGDRPEaRRPCLRVPCP 492
Cdd:smart00209   1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQN-----GGGPCTGEDVE-TRACNEQPCP 53
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 632-746 3.93e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672 632 TSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQ-HPFAPETPIPGASWSISPTTPGGL 710
Cdd:PRK07764 600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPkHVAVPDASDGGDGWPAKAGGAAPA 679

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767961672 711 PWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT 746
Cdd:PRK07764 680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715
PHA03247 PHA03247
large tegument protein UL36; Provisional
 640-746 7.32e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 7.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961672  640 PGSPLPGPQDPA---------DAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASwSISPTTPGGl 710
Cdd:PHA03247 2676 ASSPPQRPRRRAarptvgsltSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-PAGPATPGG- 2753

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767961672  711 pwgwtqtPTPVPEDKGQPGedlrhPGTSLPAASPVT 746
Cdd:PHA03247 2754 -------PARPARPPTTAG-----PPAPAPPAAPAA 2777
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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