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Conserved domains on  [gi|767981585|ref|XP_011535486|]
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iron-sulfur cluster transfer protein NUBPL isoform X10 [Homo sapiens]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 1-128 4.00e-73

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam10609:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 246  Bit Score: 218.09  E-value: 4.00e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585    1 MPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLA 80
Cdd:pfam10609 119 LPPGTGDEQLTLAQLLPLTGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFGKGGGEKLA 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767981585   81 QTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVV 128
Cdd:pfam10609 199 EELGVPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-128 4.00e-73

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 218.09  E-value: 4.00e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585    1 MPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLA 80
Cdd:pfam10609 119 LPPGTGDEQLTLAQLLPLTGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFGKGGGEKLA 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767981585   81 QTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVV 128
Cdd:pfam10609 199 EELGVPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
1-131 1.32e-59

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 187.94  E-value: 1.32e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585   1 MPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLA 80
Cdd:PRK11670 223 MPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIFGTGGAEKLA 302

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767981585  81 QTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRL 131
Cdd:PRK11670 303 EKYHTQLLGQMPLHISLREDLDRGTPTVVSRPESEFTAIYRQLADRVAAQL 353
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 1-99 6.11e-51

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 160.74  E-value: 6.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585   1 MPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLA 80
Cdd:cd02037  115 LPPGTGDEHLSLVQLIPIDGAVVVTTPQEVSLIDVRKAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIFGKGGGEKLA 194

                         90
                 ....*....|....*....
gi 767981585  81 QTLGLEVLGDIPLHLNIRE 99
Cdd:cd02037  195 EELGVPFLGKIPLDPELAK 213
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 1-72 4.51e-14

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 66.75  E-value: 4.51e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767981585   1 MPPGTGDVQLSVSQNIpITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSvfqcpkCKHKTHIFG 72
Cdd:COG0489  209 TPPGLGVADATLLASL-VDGVLLVVRPGKTALDDVRKALEMLEKAGVPVLGVVLNMV------CPKGERYYG 273
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-128 4.00e-73

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 218.09  E-value: 4.00e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585    1 MPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLA 80
Cdd:pfam10609 119 LPPGTGDEQLTLAQLLPLTGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFGKGGGEKLA 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767981585   81 QTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVV 128
Cdd:pfam10609 199 EELGVPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
1-131 1.32e-59

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 187.94  E-value: 1.32e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585   1 MPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLA 80
Cdd:PRK11670 223 MPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIFGTGGAEKLA 302

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767981585  81 QTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRL 131
Cdd:PRK11670 303 EKYHTQLLGQMPLHISLREDLDRGTPTVVSRPESEFTAIYRQLADRVAAQL 353
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 1-99 6.11e-51

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 160.74  E-value: 6.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585   1 MPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARKLA 80
Cdd:cd02037  115 LPPGTGDEHLSLVQLIPIDGAVVVTTPQEVSLIDVRKAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIFGKGGGEKLA 194

                         90
                 ....*....|....*....
gi 767981585  81 QTLGLEVLGDIPLHLNIRE 99
Cdd:cd02037  195 EELGVPFLGKIPLDPELAK 213
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 1-72 4.51e-14

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 66.75  E-value: 4.51e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767981585   1 MPPGTGDVQLSVSQNIpITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSvfqcpkCKHKTHIFG 72
Cdd:COG0489  209 TPPGLGVADATLLASL-VDGVLLVVRPGKTALDDVRKALEMLEKAGVPVLGVVLNMV------CPKGERYYG 273
FlhG COG0455
MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell ...
 22-134 8.16e-09

MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440223 [Multi-domain]  Cd Length: 230  Bit Score: 51.81  E-value: 8.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981585  22 VIVSTPQDIALMDAHKGAEMFRRVH-VPVLGLVQNMSvfqcpkckhKTHIFGADGARKLAQTLG------LEVLGDIPLH 94
Cdd:COG0455  120 VVVTTPEPTSITDAYALLKLLRRRLgVRRAGVVVNRV---------RSEAEARDVFERLEQVAErflgvrLRVLGVIPED 190

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767981585  95 LNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSP 134
Cdd:COG0455  191 PAVREAVRRGRPLVLAAPDSPAARAIRELAARLAGWPVPE 230
MinD cd02036
septum site-determining protein MinD; Septum site-determining protein MinD is part of the ...
 81-131 2.62e-05

septum site-determining protein MinD; Septum site-determining protein MinD is part of the operon MinCDE that determines the site of the formation of a septum at mid-cell, an important part of bacterial cell division. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal role, selecting the mid-cell over other sites through the activation and regulation of MinC and MinE. MinD is a membrane-associated ATPase, related to nitrogenase iron protein.


Pssm-ID: 349756 [Multi-domain]  Cd Length: 236  Bit Score: 42.19  E-value: 2.62e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767981585  81 QTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAvevvRRL 131
Cdd:cd02036  190 EILGIPLLGVIPEDPEVIVATNRGEPLVLYKPNSLAAKAFENIA----RRL 236
ParA COG1192
ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein ...
 76-131 8.16e-05

ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440805 [Multi-domain]  Cd Length: 253  Bit Score: 40.61  E-value: 8.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767981585  76 ARKLAQTLGLEVLG-DIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRL 131
Cdd:COG1192  196 LEELREEFGDKVLDtVIPRSVALAEAPSAGKPVFEYDPKSKGAKAYRALAEELLERL 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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