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Conserved domains on  [gi|767981086|ref|XP_011535287|]
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aarF domain-containing protein kinase 1 isoform X3 [Homo sapiens]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 16-142 4.47e-76

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd13969:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 253  Bit Score: 232.76  E-value: 4.47e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  16 RSDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGT 95
Cdd:cd13969  127 RPDVYVPKVYWDLSSKRVLTMEFIDGIKIDDVEALKKLGIDPKEVARLLSEAFAEMIFVHGFVHCDPHPGNLLVRKNPGP 206

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767981086  96 GKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLG 142
Cdd:cd13969  207 GKPQIVLLDHGLYRELDEEFRLNYCRLWKALILGDEKKIKKYSKALG 253
 
Name Accession Description Interval E-value
ADCK1-like cd13969
aarF domain containing kinase 1 and similar proteins; This subfamily is composed of ...
 16-142 4.47e-76

aarF domain containing kinase 1 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 1 (ADCK1). Eukaryotes contain at least three ABC1-like proteins: in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamilies 14 and 15 (ABC1K14-15) belong to the same group of ABC1 kinases as human ADCK1. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270871 [Multi-domain]  Cd Length: 253  Bit Score: 232.76  E-value: 4.47e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  16 RSDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGT 95
Cdd:cd13969  127 RPDVYVPKVYWDLSSKRVLTMEFIDGIKIDDVEALKKLGIDPKEVARLLSEAFAEMIFVHGFVHCDPHPGNLLVRKNPGP 206

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767981086  96 GKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLG 142
Cdd:cd13969  207 GKPQIVLLDHGLYRELDEEFRLNYCRLWKALILGDEKKIKKYSKALG 253
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
 17-138 1.86e-54

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 177.04  E-value: 1.86e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086   17 SDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPgtg 96
Cdd:pfam03109 129 PDVYVPKVYWELTTERVLTMEYVDGIKIDDLDALSEAGIDRKEIARRLVELFLEQIFRDGFFHADPHPGNILVRKDG--- 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767981086   97 kaEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYS 138
Cdd:pfam03109 206 --RIVLLDFGLMGRLDEKFRRLYAELLLALVNRDYKRVAEML 245
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
 18-142 3.49e-26

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 107.21  E-value: 3.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  18 DVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKhpgTGK 97
Cdd:COG0661  221 DVYVPKVYWELSTRRVLTMEWIDGIKISDLEALDAAGIDRKRLAERLVRAFLRQVFRDGFFHADPHPGNIFVLP---DGR 297

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767981086  98 aeIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLG 142
Cdd:COG0661  298 --LVLLDFGMVGRLDPETREGLAELLLALLNRDYDRVAEALLELG 340
UbiB TIGR01982
2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the ...
 17-143 2.45e-17

2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the first hydroxylation step in the ubiquinone biosynthetic pathway in bacteria. It is believed that the reaction is 2-polyprenylphenol -> 6-hydroxy-2-polyprenylphenol. This model finds hits primarily in the proteobacteria. The gene is also known as AarF in certain species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273909  Cd Length: 437  Bit Score: 81.57  E-value: 2.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086   17 SDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPgtg 96
Cdd:TIGR01982 218 PGVYVPEVYWDRTSERVLTMEWIDGIPLSDIAALDEAGLDRKALAENLARSFLNQVLRDGFFHADLHPGNIFVLKDG--- 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767981086   97 kaEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGA 143
Cdd:TIGR01982 295 --KIIALDFGIVGRLSEEDRRYLAEILYGFLNRDYRRVAEVHFDAGY 339
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
 17-114 1.35e-10

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 61.46  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  17 SDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTG 96
Cdd:PRK04750 221 DMLYVPEVYWDYCSETVMVMERMYGIPVSDVAALRAAGTDMKLLAERGVEVFFTQVFRDGFFHADMHPGNIFVSYDPPEN 300

                         90
                 ....*....|....*...
gi 767981086  97 KAEIVlLDHGLYQMLTEE 114
Cdd:PRK04750 301 PRYIA-LDFGIVGSLNKE 317
 
Name Accession Description Interval E-value
ADCK1-like cd13969
aarF domain containing kinase 1 and similar proteins; This subfamily is composed of ...
 16-142 4.47e-76

aarF domain containing kinase 1 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 1 (ADCK1). Eukaryotes contain at least three ABC1-like proteins: in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamilies 14 and 15 (ABC1K14-15) belong to the same group of ABC1 kinases as human ADCK1. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270871 [Multi-domain]  Cd Length: 253  Bit Score: 232.76  E-value: 4.47e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  16 RSDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGT 95
Cdd:cd13969  127 RPDVYVPKVYWDLSSKRVLTMEFIDGIKIDDVEALKKLGIDPKEVARLLSEAFAEMIFVHGFVHCDPHPGNLLVRKNPGP 206

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767981086  96 GKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLG 142
Cdd:cd13969  207 GKPQIVLLDHGLYRELDEEFRLNYCRLWKALILGDEKKIKKYSKALG 253
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
 17-138 1.86e-54

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 177.04  E-value: 1.86e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086   17 SDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPgtg 96
Cdd:pfam03109 129 PDVYVPKVYWELTTERVLTMEYVDGIKIDDLDALSEAGIDRKEIARRLVELFLEQIFRDGFFHADPHPGNILVRKDG--- 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767981086   97 kaEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYS 138
Cdd:pfam03109 206 --RIVLLDFGLMGRLDEKFRRLYAELLLALVNRDYKRVAEML 245
ABC1_ADCK3-like cd05121
Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and ...
 17-127 3.26e-31

Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins; This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270691 [Multi-domain]  Cd Length: 247  Bit Score: 116.83  E-value: 3.26e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  17 SDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHpgtG 96
Cdd:cd05121  131 PDVYVPKVYPELSTRRVLVMEYIDGVKLTDLEALRAAGIDRKELARRLVDAYLKQIFEDGFFHADPHPGNILVLPD---G 207

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767981086  97 KaeIVLLDHGLYQMLTEEFRLNYCHLWQSLI 127
Cdd:cd05121  208 R--IALLDFGMVGRLDPETREALADLLLALV 236
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
 18-142 3.49e-26

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 107.21  E-value: 3.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  18 DVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKhpgTGK 97
Cdd:COG0661  221 DVYVPKVYWELSTRRVLTMEWIDGIKISDLEALDAAGIDRKRLAERLVRAFLRQVFRDGFFHADPHPGNIFVLP---DGR 297

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767981086  98 aeIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLG 142
Cdd:COG0661  298 --LVLLDFGMVGRLDPETREGLAELLLALLNRDYDRVAEALLELG 340
ABC1_ADCK3 cd13970
Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This ...
 18-142 2.33e-23

Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270872 [Multi-domain]  Cd Length: 251  Bit Score: 96.04  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  18 DVEVPRIHWDLSTERVLLMEFVDG---GQVNDRDYMERNKIdvneiSRHLGKMYSEMIFVNGFVHCDPHPGNVLVRkhPG 94
Cdd:cd13970  133 RFVVPEVIPELSTKRVLTTEFVDGvplDEAADLSQEERNRI-----GELLLRLCLRELFEFGFMQTDPNPGNFLYD--PE 205

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767981086  95 TGKaeIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLG 142
Cdd:cd13970  206 DGR--LGLLDFGAVREYPPEFVDGYRRLVRAALEGDREALLEASVELG 251
UbiB TIGR01982
2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the ...
 17-143 2.45e-17

2-polyprenylphenol 6-hydroxylase; This model represents the enzyme (UbiB) which catalyzes the first hydroxylation step in the ubiquinone biosynthetic pathway in bacteria. It is believed that the reaction is 2-polyprenylphenol -> 6-hydroxy-2-polyprenylphenol. This model finds hits primarily in the proteobacteria. The gene is also known as AarF in certain species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273909  Cd Length: 437  Bit Score: 81.57  E-value: 2.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086   17 SDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPgtg 96
Cdd:TIGR01982 218 PGVYVPEVYWDRTSERVLTMEWIDGIPLSDIAALDEAGLDRKALAENLARSFLNQVLRDGFFHADLHPGNIFVLKDG--- 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767981086   97 kaEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGA 143
Cdd:TIGR01982 295 --KIIALDFGIVGRLSEEDRRYLAEILYGFLNRDYRRVAEVHFDAGY 339
UbiB cd13972
Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ...
 21-136 3.34e-16

Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ADCK3 (aarF domain containing kinase 3). It is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is required in the first monooxygenase step in Q biosynthesis. Mutant strains with disrupted ubiB genes lack Q and accumulate octaprenylphenol, a Q biosynthetic intermediate.


Pssm-ID: 270874 [Multi-domain]  Cd Length: 247  Bit Score: 76.09  E-value: 3.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  21 VPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGtgkaeI 100
Cdd:cd13972  135 VPEVYWELTSKNVLTMEWIDGIPISDIEALDAAGIDRKALAERLVEIFFRQVFRDGFFHADMHPGNIFVDPNGR-----I 209

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767981086 101 VLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKE 136
Cdd:cd13972  210 IAVDFGIMGRLDKKDRRYLAEILYGFLTRDYRRVAE 245
ADCK2-like cd13971
aarF domain containing kinase 2 and similar proteins; This subfamily is composed of ...
 16-127 2.61e-12

aarF domain containing kinase 2 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 2 (ADCK2). Eukaryotes contain at least three ABC1-like proteins; in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamily 10 (ABC1K10) belong to the same group of ABC1 kinases as human ADCK2. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270873 [Multi-domain]  Cd Length: 298  Bit Score: 65.71  E-value: 2.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  16 RSDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNkidvNEISRHLGKM----YSEMIFVNGFVHCDPHPGNVLVRK 91
Cdd:cd13971  137 RKDVSFPKPLYPLVTEEVLVETFEEGVPISRTVLAHGG----EPLKRKLARIgldaFLKMLFVDNFVHGDLHPGNILVRF 212

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767981086  92 HPGTGKA------------EIVLLDHGLYQMLTEEFRLNYCHLWQSLI 127
Cdd:cd13971  213 NDSNRPSllvsldargsppRLVFLDAGLVTELSPQDRRNFIDLFKAVA 260
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
 17-114 1.35e-10

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 61.46  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  17 SDVEVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTG 96
Cdd:PRK04750 221 DMLYVPEVYWDYCSETVMVMERMYGIPVSDVAALRAAGTDMKLLAERGVEVFFTQVFRDGFFHADMHPGNIFVSYDPPEN 300

                         90
                 ....*....|....*...
gi 767981086  97 KAEIVlLDHGLYQMLTEE 114
Cdd:PRK04750 301 PRYIA-LDFGIVGSLNKE 317
PRK09605 PRK09605
bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;
31-107 1.59e-06

bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;


Pssm-ID: 236586 [Multi-domain]  Cd Length: 535  Bit Score: 49.12  E-value: 1.59e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767981086  31 ERVLLMEFVDGGQVndRDYMERNKIDVNEISRHLGKMYSemifvNGFVHCDPHPGNVLVRkhpgtgKAEIVLLDHGL 107
Cdd:PRK09605 410 EKTIVMEYIGGKDL--KDVLEGNPELVRKVGEIVAKLHK-----AGIVHGDLTTSNFIVR------DDRLYLIDFGL 473
Bud32 COG3642
tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and ...
 16-109 2.17e-06

tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]; tRNA A-37 threonylcarbamoyl transferase component Bud32 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442859 [Multi-domain]  Cd Length: 159  Bit Score: 46.88  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  16 RSDVEVPRIHwDLSTER-VLLMEFVDGGQVndRDYMERNKID---VNEISRHLGKMYSemifvNGFVHCDPHPGNVLVRK 91
Cdd:COG3642   15 EAGVPVPKVL-DVDPDDaDLVMEYIEGETL--ADLLEEGELPpelLRELGRLLARLHR-----AGIVHGDLTTSNILVDD 86

                         90
                 ....*....|....*...
gi 767981086  92 HpgtgkaEIVLLDHGLYQ 109
Cdd:COG3642   87 G------GVYLIDFGLAR 98
APH_ChoK_like cd05120
Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ...
 16-92 3.49e-04

Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270690 [Multi-domain]  Cd Length: 158  Bit Score: 40.36  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  16 RSDVEVPRIH--WDLSTERVLLMEFVDGgQVNDRDYMERNKIDVNEISRHLGKMYSEM--IFVNGFVHCDPHPGNVLVRK 91
Cdd:cd05120   49 KLSLPVPKVYgfGESDGWEYLLMERIEG-ETLSEVWPRLSEEEKEKIADQLAEILAALhrIDSSVLTHGDLHPGNILVKP 127


                 .
gi 767981086  92 H 92
Cdd:cd05120  128 D 128
PRK14879 PRK14879
Kae1-associated kinase Bud32;
16-107 4.49e-04

Kae1-associated kinase Bud32;


Pssm-ID: 237847 [Multi-domain]  Cd Length: 211  Bit Score: 40.66  E-value: 4.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  16 RSDVEVPRIHW-DLStERVLLMEFVDGgqVNDRDYMERNKIDVNEISRHLG----KMYSemifvNGFVHCDPHPGNVLVR 90
Cdd:PRK14879  58 KAGVNVPAVYFvDPE-NFIIVMEYIEG--EPLKDLINSNGMEELELSREIGrlvgKLHS-----AGIIHGDLTTSNMILS 129

                         90
                 ....*....|....*..
gi 767981086  91 khpgtgKAEIVLLDHGL 107
Cdd:PRK14879 130 ------GGKIYLIDFGL 140
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
 18-113 5.50e-04

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 40.77  E-value: 5.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  18 DVEVPRI-----HWDLSTERVLLMEFVDGGQVND-----RDYMERNKID-VNEISRHLGKMYSEMIfvngfVHCDPHPGN 86
Cdd:cd14095   54 RVKHPNIvqlieEYDTDTELYLVMELVKGGDLFDaitssTKFTERDASRmVTDLAQALKYLHSLSI-----VHRDIKPEN 128

                         90       100
                 ....*....|....*....|....*..
gi 767981086  87 VLVRKHpGTGKAEIVLLDHGLYQMLTE 113
Cdd:cd14095  129 LLVVEH-EDGSKSLKLADFGLATEVKE 154
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
 34-107 1.99e-03

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 38.88  E-value: 1.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767981086  34 LLMEFVDGGQVndRDYMER-NKIDVNEISRHLGKMYSEMIFV--NGFVHCDPHPGNVLVRKHPGTGKAEivLLDHGL 107
Cdd:cd14012   81 LLTEYAPGGSL--SELLDSvGSVPLDTARRWTLQLLEALEYLhrNGVVHKSLHAGNVLLDRDAGTGIVK--LTDYSL 153
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
 26-116 2.73e-03

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 38.76  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981086  26 WDLSTERVLLMEFVDGGQVNDRDYMERNK-IDVNEISRHLGKMYSEMIFV--NGFVHCDPHPGNVLVRKHPGTGKAEIVl 102
Cdd:cd14197   78 YETASEMILVLEYAAGGEIFNQCVADREEaFKEKDVKRLMKQILEGVSFLhnNNVVHLDLKPQNILLTSESPLGDIKIV- 156

                         90
                 ....*....|....*.
gi 767981086 103 lDHGLYQML--TEEFR 116
Cdd:cd14197  157 -DFGLSRILknSEELR 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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