second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767980974  325 ATVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 767980974  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767980974  325 ATVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 767980974  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974    143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                            90
                    ....*....|
gi 767980974    221 VQLSEEFGTP 230
Cdd:smart00225   74 LELADYLQIP 83

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767980974   413 YGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKR 478
Cdd:pfam07707   11 YGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERR 77

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974   269 CLDEELKAHKAVISARSPFFRNLLQrriRTGEEITDRTLrtptrIILDESiipkkYATV--ILHCMYTDVVDlsvlhcsp 346
Cdd:pfam00651   17 VGDKEFRAHKAVLAACSPYFKALFS---GQESESSVSEI-----TLDDVS-----PEDFeaLLEFMYTGKLI-------- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767980974   347 svgslsevqalvagkpnmtRAEEAMELYHIALFLEFNMLAQGCEDIIAESI 397
Cdd:pfam00651   76 -------------------SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284     1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767980974  325 ATVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDI 392
Cdd:cd18284    78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                          90
                  ....*....|..
gi 767980974  220 LVQLSEEFGTPN 231
Cdd:cd18283    81 LIQLSEEFGTPN 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974   137 EYKYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPE--YGAEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrf 214
Cdd:pfam00651    7 QGELC-DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLD----DVSPEDFEALLEFMYTGKLISEE--- 78

                           90       100
                   ....*....|....*....|.
gi 767980974   215 qNVDILVQLSEEFGTPNSLDV 235
Cdd:pfam00651   79 -NVDDLLAAADKLQIPSLVDK 98

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974    143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                            90
                    ....*....|
gi 767980974    221 VQLSEEFGTP 230
Cdd:smart00225   74 LELADYLQIP 83

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974    410 SHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKRIaDREPNLLS 488
Cdd:smart00875    8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRR-EHLPELLE 86

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  136 YEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYTGEFGMEDsrfQ 215
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNL--KEVTLEDVEPEIFETVLKYMYTGQVTLSE---E 75

                          90
                  ....*....|....*
gi 767980974  216 NVDILVQLSEEFGTP 230
Cdd:cd18314    76 NVLDLLMLASKYQVP 90

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  397 ISLDTLIAILKWSShPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQL 475
Cdd:cd18480     1 LDLSNCLQLLSFAE-SYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNvPDEEAVLKAVLRWTKHDL 79

                  ...
gi 767980974  476 MKR 478
Cdd:cd18480    80 EAR 82

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767980974   413 YGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQ-ASEQDILKYLIKWGEHQLMKR 478
Cdd:pfam07707   11 YGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERR 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSS--SPEYGAEIIMDintaGIDMPMFSALLHYLYTG 205
Cdd:cd18269    14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSdlEESKKKEVVLE----DVDPDVMGMILKYLYTS 89

                          90       100
                  ....*....|....*....|....*
gi 767980974  206 EFGMEDsrfQNVDILVQLSEEFGTP 230
Cdd:cd18269    90 EIDLND---QNVQDIFALASRFQIP 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV-- 217
Cdd:cd18245    14 LC-DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIvq 92

                  ....*
gi 767980974  218 --DIL 220
Cdd:cd18245    93 aaDLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSS--SPEYGAEIIMDintaGIDMPMFSALLHYLYTG 205
Cdd:cd18341    14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSeeSEEKKKEVVLD----NVDPNIMDMILKYLYSA 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 767980974  206 EFGMEDSrfqNVDILVQLSEEFGTPNSLDV 235
Cdd:cd18341    90 EIDLNDG---NVQDIFALASRFQIPSVFTV 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  139 KYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDIntAGIDMPMFSALLHYLYTGEFgmeDSRFQNVD 218
Cdd:cd18240    16 KLC-DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKI--PGVSPEMMELIIEYAYTRTV---PITAENVE 89

                  ....*....
gi 767980974  219 ILVQLSEEF 227
Cdd:cd18240    90 ELLPAADQF 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTA-----------GIDMPMFSALLHYLYTGEFG 208
Cdd:cd18195    18 FC-DVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGAtqspervlelpGVKAGVFSDVLNFIYSSRVA 96

                  ....*
gi 767980974  209 MEDSR 213
Cdd:cd18195    97 LPGSA 101

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  128 LQKDMADLYEYKYCTDV--DLIFQ---ETcFPVHRAILAARCPFFKTLLSSSPEYGAEIIMD--INTAGIDMPMFSALLH 200
Cdd:cd18301     1 FQEDFKKLLDEADEGDNihDVVFQvggKT-FPAHKFILASRSDYFRKLFLSSLLTSEDAVGCdvVHIEKVPPEIFEQLLQ 79

                  ....*
gi 767980974  201 YLYTG 205
Cdd:cd18301    80 FIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767980974  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSS-SPEYGAEIIMDINTAGIdmpmFSALLHYLYTGE 206
Cdd:cd18315     2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSE----LKALLDFIYTGE 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYTGEF 207
Cdd:cd18340    14 LQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKK--REIVLEDVDPDVMGKILHYIYTSEI 91

                          90       100
                  ....*....|....*....|....*...
gi 767980974  208 GMEDsrfQNVDILVQLSEEFGTPNSLDV 235
Cdd:cd18340    92 EITE---QNVQDIFAAANMFQIPSIFTV 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  125 ARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYT 204
Cdd:cd18270    10 AVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ--THVHLRNVDAATLQIIITYAYT 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767980974  205 GEFGMEDSR---------FQNVDILVQLSEEF 227
Cdd:cd18270    88 GNLAINDSTveqlyetacFLQVEDVLQRCREY 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  123 PEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYL 202
Cdd:cd18279     1 PECR-LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND--VDPEVFKEMMRFI 77

                  ...
gi 767980974  203 YTG 205
Cdd:cd18279    78 YTG 80

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767980974  398 SLDTLIAILKWSSHpYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQS 453
Cdd:cd14733     1 DPENCLGILELADL-YNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  141 CTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA-EIIMDINTAGIDMPMFSALLHYLYTGEFGMEDsrfQNVDI 219
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATdELSITIDCDYLSPETVEQLLDYFYTGKIVISE---KNVED 77

                          90
                  ....*....|....*
gi 767980974  220 LVQLSEEFGTPNSLD 234
Cdd:cd18307    78 LLKGAKYFNIPRLKD 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  127 TLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYLYTGE 206
Cdd:cd18344     9 MLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHD--LDPQVFKEMMGFIYTGK 86

                          90
                  ....*....|....
gi 767980974  207 FGMEDSRFQNVDIL 220
Cdd:cd18344    87 APHLHSHSMACDVL 100

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767980974  422 ALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQA-SEQDILKYLIKWGEHQLMKRIAD 481
Cdd:cd18516    25 ARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVeKEEDVFEAVMKWVGKDQEERTKA 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSS-PEYGAEIimdINTAGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:cd18265    24 TDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHlKESRQAV---VEIQKVSAAAMEVLLDYMYGGGLRIQE---DNVESV 97

                          90
                  ....*....|
gi 767980974  221 VQLSEEFGTP 230
Cdd:cd18265    98 LEASDLLQVS 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  124 EARTLQKDMADLyeykyctDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG-AEIIMDINTAGidmpMFSALLHYL 202
Cdd:cd18231     6 EQRLFQPDLCDV-------DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQrVELSLEALTSQ----GLQQILNFI 74

                          90
                  ....*....|....*
gi 767980974  203 YTGEFGMEDSRFQNV 217
Cdd:cd18231    75 YTSKLLVNSCNVQDV 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980974  130 KDMADLYEYkycTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSpeygaeiIMDINTAGI---DMPM--FSALLHYLYT 204
Cdd:cd18276    13 NRMKELAEL---TDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCG-------LMECSQREVvlhDITAesVSIILNYMYS 82

                          90       100
                  ....*....|....*....|....*.
gi 767980974  205 GEFGMEDSRFQNVDI---LVQLSEEF 227
Cdd:cd18276    83 SDLHLTNSNVQGVATaafFLQMEDIF 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767980974  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINtaGIDMPMFSALLHYLYTGE 206
Cdd:cd18253    19 TDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN--GILAEAMDCFLQYVYTGK 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767980974  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAgidmpMFSALLHYLYTGEFGMEDS 212
Cdd:cd18289    29 YC-DVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPA-----CFQQILSFCYTGKLTMAAS 95