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Conserved domains on  [gi|767980972|ref|XP_011535240|]
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rho guanine nucleotide exchange factor 40 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpJ super family cl15454
HrpJ-like domain; This family represents a conserved region approximately 200 residues long ...
 760-889 7.55e-03

HrpJ-like domain; This family represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered to plant cells. This family also includes the InvE invasion protein from Salmonella. This protein is involved in host parasite interactions and mutations in the InvE gene render Salmonella typhimurium non-invasive. InvE S. typhimurium mutants fail to elicit a rapid Ca2+ increase in cultured cells, an important event in the infection procedure and internalization of S. typhimurium into epithelial cells. This family includes bacterial SepL and SsaL proteins. SepL plays an essential role in the infection process of enterohemorrhagic Escherichia coli and is thought to be responsible for the secretion of EspA, EspD, and EspB. SsaL of Salmonella typhimurium is thought to be a component of the type III secretion system.


The actual alignment was detected with superfamily member pfam07201:

Pssm-ID: 417714  Cd Length: 165  Bit Score: 38.10  E-value: 7.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980972  760 QEVDEAIHQLVRLSnLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAM----PGDTLSALQETELRFRAFSAEVQERL 835
Cdd:pfam07201  23 RSRSEKLEELSDLL-ERVLDLEAEEKLRELRQLLGSGQSSLPDLLALLESlfgdPSDQFLALRALLRQARPLSAALLELL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767980972  836 AQAREALALEENATsqkvldifeqrleqVESGLHRALRLQRFFQQALPSPYQLR 889
Cdd:pfam07201 102 EQALEELEQEDGRE--------------IRAGINIALAAALFSKVDPLSLQALR 141
 
Name Accession Description Interval E-value
HrpJ pfam07201
HrpJ-like domain; This family represents a conserved region approximately 200 residues long ...
 760-889 7.55e-03

HrpJ-like domain; This family represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered to plant cells. This family also includes the InvE invasion protein from Salmonella. This protein is involved in host parasite interactions and mutations in the InvE gene render Salmonella typhimurium non-invasive. InvE S. typhimurium mutants fail to elicit a rapid Ca2+ increase in cultured cells, an important event in the infection procedure and internalization of S. typhimurium into epithelial cells. This family includes bacterial SepL and SsaL proteins. SepL plays an essential role in the infection process of enterohemorrhagic Escherichia coli and is thought to be responsible for the secretion of EspA, EspD, and EspB. SsaL of Salmonella typhimurium is thought to be a component of the type III secretion system.


Pssm-ID: 399881  Cd Length: 165  Bit Score: 38.10  E-value: 7.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980972  760 QEVDEAIHQLVRLSnLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAM----PGDTLSALQETELRFRAFSAEVQERL 835
Cdd:pfam07201  23 RSRSEKLEELSDLL-ERVLDLEAEEKLRELRQLLGSGQSSLPDLLALLESlfgdPSDQFLALRALLRQARPLSAALLELL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767980972  836 AQAREALALEENATsqkvldifeqrleqVESGLHRALRLQRFFQQALPSPYQLR 889
Cdd:pfam07201 102 EQALEELEQEDGRE--------------IRAGINIALAAALFSKVDPLSLQALR 141
 
Name Accession Description Interval E-value
HrpJ pfam07201
HrpJ-like domain; This family represents a conserved region approximately 200 residues long ...
 760-889 7.55e-03

HrpJ-like domain; This family represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered to plant cells. This family also includes the InvE invasion protein from Salmonella. This protein is involved in host parasite interactions and mutations in the InvE gene render Salmonella typhimurium non-invasive. InvE S. typhimurium mutants fail to elicit a rapid Ca2+ increase in cultured cells, an important event in the infection procedure and internalization of S. typhimurium into epithelial cells. This family includes bacterial SepL and SsaL proteins. SepL plays an essential role in the infection process of enterohemorrhagic Escherichia coli and is thought to be responsible for the secretion of EspA, EspD, and EspB. SsaL of Salmonella typhimurium is thought to be a component of the type III secretion system.


Pssm-ID: 399881  Cd Length: 165  Bit Score: 38.10  E-value: 7.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980972  760 QEVDEAIHQLVRLSnLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAM----PGDTLSALQETELRFRAFSAEVQERL 835
Cdd:pfam07201  23 RSRSEKLEELSDLL-ERVLDLEAEEKLRELRQLLGSGQSSLPDLLALLESlfgdPSDQFLALRALLRQARPLSAALLELL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767980972  836 AQAREALALEENATsqkvldifeqrleqVESGLHRALRLQRFFQQALPSPYQLR 889
Cdd:pfam07201 102 EQALEELEQEDGRE--------------IRAGINIALAAALFSKVDPLSLQALR 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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