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Conserved domains on  [gi|767979673|ref|XP_011534714|]
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adenylosuccinate synthetase isozyme 1 isoform X1 [Homo sapiens]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
108-498 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 658.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqqeA 187
Cdd:pfam00709  31 GGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIEELEERGI-DVPDRLFISDRAHLilp-yhkA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  188 VDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL---EIDIEGQLKR 264
Cdd:pfam00709 109 LDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  265 LKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 344
Cdd:pfam00709 185 LLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  345 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 424
Cdd:pfam00709 264 YTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYE 343

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767979673  425 LNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:pfam00709 344 LDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
108-498 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 658.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqqeA 187
Cdd:pfam00709  31 GGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIEELEERGI-DVPDRLFISDRAHLilp-yhkA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  188 VDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL---EIDIEGQLKR 264
Cdd:pfam00709 109 LDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  265 LKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 344
Cdd:pfam00709 185 LLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  345 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 424
Cdd:pfam00709 264 YTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYE 343

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767979673  425 LNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:pfam00709 344 LDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 108-498 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 592.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQEa 187
Cdd:smart00788  33 GGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKEIEELEAKGV-DVKDRLFISDRAHLILPYHIA- 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   188 VDglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLK 263
Cdd:smart00788 111 LD-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVLREKLEELLDYKNFLLKKLygaePVDVEEILE 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   264 RLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVK 343
Cdd:smart00788 183 ELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVK 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   344 AYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSY 423
Cdd:smart00788 262 AYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRINGITGLALTKLDVLDGLDEIKVCVAY 341

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767979673   424 KLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:smart00788 342 KLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 108-498 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 560.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlKDWEKRLIISDRAHLGDSGQQeA 187
Cdd:PTZ00350  46 GGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQ-A 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKG 267
Cdd:PTZ00350 124 IDGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 268 FAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTT 347
Cdd:PTZ00350 202 YAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYPYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTT 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 348 RVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNG 427
Cdd:PTZ00350 281 RVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKG 360

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767979673 428 K--RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:PTZ00350 361 TglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 108-500 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 547.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQeA 187
Cdd:COG0104   33 GGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEEIDGLEARGV-DVRSRLRISERAHLILPYHR-A 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLK 263
Cdd:COG0104  111 LDKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLygaePLDFEELLE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 264 RLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVV 342
Cdd:COG0104  187 EYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVV 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 343 KAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVS 422
Cdd:COG0104  265 KAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVA 344

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767979673 423 YKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 500
Cdd:COG0104  345 YELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIEELLGVPISIVSVGPDREQTIVR 422
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 108-498 4.01e-156

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 446.56  E-value: 4.01e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQEa 187
Cdd:cd03108   34 GGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFEEIEELEKKGI-DVKGRLLISDRAHLVFPYHQE- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfdefssrfknlahqhqsmfptleidiegqlkrlkg 267
Cdd:cd03108  112 LDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD--------------------------------------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 268 faerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTT 347
Cdd:cd03108  150 ------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYVTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTT 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 348 RVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDIldvlgevkvgvsyklng 427
Cdd:cd03108  223 RVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRINGLTELALTKLDV----------------- 285

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767979673 428 kripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:cd03108  286 -----------------------------------------NAQKYIERIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 108-500 3.44e-154

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 445.84  E-value: 3.44e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKkGLKDWEKRLIISDRAHLGDSGQQEa 187
Cdd:TIGR00184  31 GGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEMEYLEK-RGISVRDRLFVSYRCHLILPYHKK- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  188 vdgLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKR 264
Cdd:TIGR00184 109 ---LDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAEKAKNILEYLNEQLVKYYKDEGVDYEKKLDE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  265 LKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 344
Cdd:TIGR00184 186 YMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYVTSSNTTAGGVATGVGIGPTKVDEVIGVFKA 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  345 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 424
Cdd:TIGR00184 265 YTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGATQLALTKLDVLDGIDEIKVCVAYR 344

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767979673  425 LNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 500
Cdd:TIGR00184 345 MKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEELTGVPVTIISTGPEREQTIDL 420
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
108-399 2.08e-19

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 88.58  E-value: 2.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqq 185
Cdd:NF038379  34 AGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVLREEIEELEDAGH-DVGKRLLIHEQATV------ 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 186 eaVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsdfdefssrfknlahqhqsmfPTLEIDIEGQLKRL 265
Cdd:NF038379 107 --IELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN-----------------------------PSTLGDAEGDFGEG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 266 KGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNI--GDVYGVVK 343
Cdd:NF038379 156 AVRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYPYCTSRDCTPADFLADAGIPLPNVdaFKVVGTAR 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767979673 344 AYTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKRRCGWLDLMILRYAHMVNG 399
Cdd:NF038379 236 TYPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVRRVGTFSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
108-498 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 658.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqqeA 187
Cdd:pfam00709  31 GGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIEELEERGI-DVPDRLFISDRAHLilp-yhkA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  188 VDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL---EIDIEGQLKR 264
Cdd:pfam00709 109 LDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  265 LKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 344
Cdd:pfam00709 185 LLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  345 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 424
Cdd:pfam00709 264 YTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYE 343

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767979673  425 LNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:pfam00709 344 LDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 108-498 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 592.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQEa 187
Cdd:smart00788  33 GGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKEIEELEAKGV-DVKDRLFISDRAHLILPYHIA- 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   188 VDglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLK 263
Cdd:smart00788 111 LD-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVLREKLEELLDYKNFLLKKLygaePVDVEEILE 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   264 RLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVK 343
Cdd:smart00788 183 ELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVK 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673   344 AYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSY 423
Cdd:smart00788 262 AYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRINGITGLALTKLDVLDGLDEIKVCVAY 341

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767979673   424 KLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:smart00788 342 KLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 108-498 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 560.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlKDWEKRLIISDRAHLGDSGQQeA 187
Cdd:PTZ00350  46 GGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQ-A 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKG 267
Cdd:PTZ00350 124 IDGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 268 FAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTT 347
Cdd:PTZ00350 202 YAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYPYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTT 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 348 RVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNG 427
Cdd:PTZ00350 281 RVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKG 360

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767979673 428 K--RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:PTZ00350 361 TglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 108-500 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 547.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQeA 187
Cdd:COG0104   33 GGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEEIDGLEARGV-DVRSRLRISERAHLILPYHR-A 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLK 263
Cdd:COG0104  111 LDKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLygaePLDFEELLE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 264 RLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVV 342
Cdd:COG0104  187 EYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVV 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 343 KAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVS 422
Cdd:COG0104  265 KAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVA 344

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767979673 423 YKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 500
Cdd:COG0104  345 YELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIEELLGVPISIVSVGPDREQTIVR 422
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 108-500 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 536.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqqeA 187
Cdd:PRK01117  35 GGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLKEIDELEARGV-DVRERLRISERAHLilp-yhrA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEVQRqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQH----QSMFPTLEIDIEGQL 262
Cdd:PRK01117 113 LDKAREKAR----GKKkIGTTGRGIGPAYEDKVARRGIRVGDLL-DPETFAEKLEENLEYKnfllTKYYGAEAVDFEEIL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 263 KRLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGV 341
Cdd:PRK01117 188 DEYLEYAERLKPYVTDTSLLLNDALKaG--KRVLFEGAQGTLLDIDHGTYPFVTSSNTTAGGAATGSGVGPTKIDYVLGI 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 342 VKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGV 421
Cdd:PRK01117 266 AKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVRVNGLTGLALTKLDVLDGLEEIKICV 345

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767979673 422 SYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 500
Cdd:PRK01117 346 AYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKRIEELTGVPISIISTGPDRDQTIIL 424
PLN02513 PLN02513
adenylosuccinate synthase
 108-498 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 518.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVV-VDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQE 186
Cdd:PLN02513  36 GGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGLFEEIDGLESNGV-SCEGRLLVSDRAHLLFDFHQE 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 187 aVDGLQEVQRqaqEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEID---IEGQLK 263
Cdd:PLN02513 115 -VDGLREAEL---AGSKIGTTKRGIGPAYSSKATRNGLRVGDLR-HMDTFAEKLRELLADAAARFEGFEYDasmVEEEVE 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 264 RLKGFAERIRPMVRDGVYFMYEAlHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVK 343
Cdd:PLN02513 190 AYKKFAERLEPFITDTVHYLNEA-IQAGKKILVEGAQATMLDIDFGTYPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVK 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 344 AYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSY 423
Cdd:PLN02513 269 AYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAY 348

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767979673 424 KL-NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:PLN02513 349 KTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAYVERIEELVGVPVHYIGVGPGRDALI 424
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 108-498 4.01e-156

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 446.56  E-value: 4.01e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQEa 187
Cdd:cd03108   34 GGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFEEIEELEKKGI-DVKGRLLISDRAHLVFPYHQE- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfdefssrfknlahqhqsmfptleidiegqlkrlkg 267
Cdd:cd03108  112 LDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD--------------------------------------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 268 faerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTT 347
Cdd:cd03108  150 ------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYVTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTT 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 348 RVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDIldvlgevkvgvsyklng 427
Cdd:cd03108  223 RVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRINGLTELALTKLDV----------------- 285

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767979673 428 kripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:cd03108  286 -----------------------------------------NAQKYIERIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 108-500 3.44e-154

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 445.84  E-value: 3.44e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKkGLKDWEKRLIISDRAHLGDSGQQEa 187
Cdd:TIGR00184  31 GGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEMEYLEK-RGISVRDRLFVSYRCHLILPYHKK- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  188 vdgLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKR 264
Cdd:TIGR00184 109 ---LDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAEKAKNILEYLNEQLVKYYKDEGVDYEKKLDE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  265 LKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 344
Cdd:TIGR00184 186 YMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYVTSSNTTAGGVATGVGIGPTKVDEVIGVFKA 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673  345 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 424
Cdd:TIGR00184 265 YTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGATQLALTKLDVLDGIDEIKVCVAYR 344

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767979673  425 LNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 500
Cdd:TIGR00184 345 MKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEELTGVPVTIISTGPEREQTIDL 420
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 107-500 2.28e-104

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 318.43  E-value: 2.28e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKrLIISDRAHLGDSGQQE 186
Cdd:PRK13787  34 QGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEECDRLQKEGFPVKDK-LLLSDACHLLFPYHSQ 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 187 aVDGLQEVQrQAQEGKnIGTTKKGIGPTYSSKAARTGLRICDLLSDfdEFSSRFKNLAH-------QHQSMFPTLEIDIE 259
Cdd:PRK13787 113 -IDSARETT-SSQEHK-IGTTKKGIGICYADKMMRTGLRVGDLLDK--SYKRRLKHLVDeknreldKLYGMPPVSYNDIN 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 260 gqlKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVY 339
Cdd:PRK13787 188 ---DGLKFFLSKVGKNIINTAYYLDTELK-KGKRVLLEGAQGTGLDVDFGTYPYVTSSNPTTGGALIGTGISFQHLKHVI 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 340 GVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKV 419
Cdd:PRK13787 264 GITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHSVRINGITSIALTKIDILSDYDTIPV 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 420 GVSYKLNGKRIPYFPAnqEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQ 499
Cdd:PRK13787 344 AVGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYISALEKWIGVKINLVSTGPDRKDTII 421


                 .
gi 767979673 500 L 500
Cdd:PRK13787 422 G 422
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 108-500 6.21e-99

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 303.95  E-value: 6.21e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlKDWEKRLIISDRAHLGDSGQQEa 187
Cdd:PRK13783  34 GGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELEELKEKF-PDYSGRIFISELAHVVLPVHKE- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 188 VDGLQEVQRqaqeGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDfDEFSSRFKNLAHQHQSMFpTLEIDIEGQLKRLKG 267
Cdd:PRK13783 112 LDEIIESVR----KNAIGTTKRGIGPAYADKVMRVGVRLADLFDE-EKLREFLEKILSLYKKLY-GIEFDVEKMMEDLLT 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 268 FAERIRPMVRDGVYfMYEALHGppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQnIGDVYGVVKAYTT 347
Cdd:PRK13783 186 FYEKIKDLVVSPVE-IKRILEE--KSVLFEGTQGVLLDLDVGTYPYVTSSNCSTTGVSAGMGFPVK-VDEVIGVFKAYTT 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 348 RVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNG 427
Cdd:PRK13783 262 RVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEVSGVDSLVMTKADVLNGFEKIKVCVRYEIGG 341

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767979673 428 KRIPYfPANQEMLQKVEVEYETLPGWKadTTGARRWEDlppqaqnYIRFVENHVGVAVKWVGVGKSRESMIQL 500
Cdd:PRK13783 342 KEVRD-PSSLRDLEKAEPVYEEFDGWK--SLEDKNFLK-------FVDFIERETGRKIAYISTGPKIEEIVEV 404
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 107-499 1.09e-96

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 298.64  E-value: 1.09e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVsFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLGDSGQQE 186
Cdd:PRK13786  33 QGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEIDMLEKHGVKVDAEKLGIDAKTSIIMPYHIE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 187 aVDGLQEVQRQAQegknIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEIDI-----EGQ 261
Cdd:PRK13786 112 -LDGLRESARTEK----IGTTKRGIGFAYIDKIARDEVRMSDLV-DKERLMRRLEELAPQKEKEIKELGGDPsivrdEAL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 262 LKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGV 341
Cdd:PRK13786 186 IDKYLELGRQLAPYITDVSYEINKALD-EGKSVLAEGAQGTHLDVIHGTQKFVTSSSTIAGSACANLGVGPTRVDNVLGI 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 342 VKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGV 421
Cdd:PRK13786 265 VKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLNGYTEIALTKLDVLTGLDPIKICV 344

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767979673 422 SYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQ 499
Cdd:PRK13786 345 GYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERLEELMGVPIKYISVGPGREQTFK 422
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 107-495 5.21e-92

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 285.93  E-value: 5.21e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkdwEKRLIISDRAHLGDSgQQE 186
Cdd:PRK13788  34 QGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEERENLRAGGL---NPKLLISERAHLVLP-HHK 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 187 AVDGlqevqrqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLSD--FDEFSSRFknLAHQHQSMFPTLEIDIEGQLK 263
Cdd:PRK13788 110 YVDG----------RKNfVGTTGRGIGPAYSDRARRVGIRFGDLLDEavLRERVERL--LEAKPNSTREAGWDTVEKALA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 264 RLKGFAERIRPMVRDGVYFMYEAL-HGppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVV 342
Cdd:PRK13788 178 DLAPMREILLPFIADTGSLLREAIrEG--KRVLFEGAQATLLDLNYGTYPYVTSSHPTVGGILVGAGVNHKAINKVYGVA 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 343 KAYTTRVGIGAFPTEQINEIGGLLQTRG----HEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVK 418
Cdd:PRK13788 256 KAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLKYACEVNGFDGLVLTKLDVLSGLEKVK 335

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767979673 419 VGVSYKLNGKripyfpanqemlqkveVEYETLPGWkADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRE 495
Cdd:PRK13788 336 VCVEYDDDGQ----------------PVYKELPGW-GDLDGVKSREALPKEAQAYLELIEETTGVPVVMFSTSPRRE 395
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 107-500 4.31e-87

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 275.10  E-value: 4.31e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKaVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRliISDRAHLgDSGQQE 186
Cdd:PRK13785  33 QGGDNAGHTVVHGGEEYKLSLVPSGAVRGK-IGVLGNGCVVNPETLFDEIDALRERGL-DPDVR--VAERAHV-ILPYHR 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 187 AVDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----------EI 256
Cdd:PRK13785 108 VLDGIEE-EAKSDSDLEVGTTGRGIGPTYEDKAGRRGVRVGDLL-DPDVLRDRLEYVVPQKRALAEDVygldasetpeAF 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 257 DIEGQLKRLKGFAERIRP--MVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQN 334
Cdd:PRK13785 186 DVDALFEEYREYGERLAEedMTVNAGDFLAERIDDG-DNVMLEGAQGTSIDIDHGNYPYVTSSNPTAGGAATGTGLGPTV 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 335 IGD--VYGVVKAYTTRVGIGAFPTE---------------QINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMV 397
Cdd:PRK13785 265 VGQgeVVGIVKAYLSRVGSGPLPTElggvegdtpdeggrpDEEELATYIREEGGEYGTVTGRPRRVGWLDMPMLRHAARA 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 398 NGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKA---DTTGARRWEDLPPQAQNYI 474
Cdd:PRK13785 345 SGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNFRSFDGWPEvdwAAVAEEGYDALPENARTYL 424

                        410       420
                 ....*....|....*....|....*.
gi 767979673 475 RFVENHVGVAVKWVGVGKSRESMIQL 500
Cdd:PRK13785 425 EYVSDELDTPIYAVGVGPGREETVVL 450
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 107-498 5.59e-75

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 242.62  E-value: 5.59e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLGDSGQQe 186
Cdd:PRK13784  34 QGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEITRLQAKGIAISAENLFVSESCTIITSYHK- 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 187 avdgLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMF--------PTLEIDI 258
Cdd:PRK13784 113 ----LLDAVRESNTSEKIGTTGKGIGPAYEDKVSRKGIKFKHLF-DKDLLRSRLAISLAEKETLFrdlykveyPTLEQEF 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 259 EgqlkRLKGFAERIRPMVRDGVYFMYEALhGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDV 338
Cdd:PRK13784 188 D----KLFALGQKLKQYAADTFSIIDQAI-AAGKNVVYEGAQGVLLDVDYGTYPFVTSSNTSVAGVYSGATTAGHGLDHV 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 339 YGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVK 418
Cdd:PRK13784 263 IGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSAKCSNLTSIALTKVDVLSDMDTLK 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 419 VGVSYKLNGKRIpYFPANQEMLQKVEVEYETLPGWKADTTGARrwEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:PRK13784 343 VCIGYKYEGKEI-YCAYPGIDLYKVEPILVEMEPFSIDETVTK--DNMPAALKTYLKTIENHVGIPISSLAYGPSREQIL 419
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 107-500 2.46e-49

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 172.37  E-value: 2.46e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 107 RGGN--NAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlkdwekRLIISDRAHLgdsgq 184
Cdd:PRK04293  34 RGGVgpNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLLKEVEELNVGG------RVFVDYRCGI----- 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 185 qeavdgLQEVQRQAQEG-----KNIGTTKKGIGPTYSSKAARTGlricDLLSDFDEfssrfknlahqhqsmfptleidie 259
Cdd:PRK04293 103 ------IEEKHVEEDRSdehlsKKIGSTGTGCGPANADRVLRRL----KLAKDVEE------------------------ 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 260 gqlkrlkgfaerIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVY 339
Cdd:PRK04293 149 ------------LEKYLTDVPEEVNEALDRG-ENVLIEGTQGFGLSLYYGTYPYVTSKDTTASGIASDVGVGPTKVDEVI 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 340 GVVKAYTTRVGIGAFPTEQINEIGgllQTRG-HEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDvlgevk 418
Cdd:PRK04293 216 VVFKSYPTRVGEGPFPTELSLEEA---EKLGlVEYGTVTGRRRRVGPFDFELARRAARINGATQIAITKLDKLD------ 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 419 vgvsyklngkripyfpanqemlqkveveyetlpgwkADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 498
Cdd:PRK04293 287 ------------------------------------KEAYGVTEYDKLPPEAKKFIEEIEEELGVPVTLISTGPELEDTI 330


                 ..
gi 767979673 499 QL 500
Cdd:PRK04293 331 DL 332
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
108-399 2.08e-19

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 88.58  E-value: 2.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 108 GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqq 185
Cdd:NF038379  34 AGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVLREEIEELEDAGH-DVGKRLLIHEQATV------ 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 186 eaVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsdfdefssrfknlahqhqsmfPTLEIDIEGQLKRL 265
Cdd:NF038379 107 --IELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN-----------------------------PSTLGDAEGDFGEG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979673 266 KGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNI--GDVYGVVK 343
Cdd:NF038379 156 AVRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYPYCTSRDCTPADFLADAGIPLPNVdaFKVVGTAR 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767979673 344 AYTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKRRCGWLDLMILRYAHMVNG 399
Cdd:NF038379 236 TYPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVRRVGTFSAEQVREAVQANG 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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