NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767978261|ref|XP_011533612|]
View 

zinc finger MYM-type protein 5 isoform X3 [Homo sapiens]

Protein Classification

zinc finger and BTB domain-containing protein( domain architecture ID 10534321)

zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Drosophila melanogaster fruitless (fru), which plays a key role in the formation of neural circuits underlying Drosophila male courtship behavior

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 220-260 2.65e-08

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 49.68  E-value: 2.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767978261  220 LIMNCCEHCGEYMPSKSTGNnILVIGGQQKRFCCQSCINEY 260
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
408-483 1.23e-07

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 49.41  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767978261   408 YYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKL 483
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
 
Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 220-260 2.65e-08

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 49.68  E-value: 2.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767978261  220 LIMNCCEHCGEYMPSKSTGNnILVIGGQQKRFCCQSCINEY 260
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
408-483 1.23e-07

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 49.41  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767978261   408 YYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKL 483
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
TRASH smart00746
metallochaperone-like domain;
225-264 4.15e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.52  E-value: 4.15e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767978261   225 CEHCGEYMPSKSTGNNiLVIGGQQKRFCCQSCINEYKQMM 264
Cdd:smart00746   1 CSFCGKDIYNPGTGIM-VVNDGKVYYFCSSKCLSKFKKKR 39
 
Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 220-260 2.65e-08

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 49.68  E-value: 2.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767978261  220 LIMNCCEHCGEYMPSKSTGNnILVIGGQQKRFCCQSCINEY 260
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
408-483 1.23e-07

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 49.41  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767978261   408 YYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLF---GEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKL 483
Cdd:smart00597   1 KPRRFQKSWFHQFPDWLEYSVEKDAAFCKYCYLFrpgRDGGSDLFVTEGFCSWKKERIRLKQHEVSKRHRNARLCVNLM 79
TRASH smart00746
metallochaperone-like domain;
225-264 4.15e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.52  E-value: 4.15e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767978261   225 CEHCGEYMPSKSTGNNiLVIGGQQKRFCCQSCINEYKQMM 264
Cdd:smart00746   1 CSFCGKDIYNPGTGIM-VVNDGKVYYFCSSKCLSKFKKKR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH