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Conserved domains on  [gi|767977458|ref|XP_011533299|]
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fibronectin type-III domain-containing protein 3A isoform X2 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
402-791 5.21e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 5.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  402 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 476
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  477 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 556
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  557 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 634
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  635 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 712
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  713 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 791
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
747-1006 3.41e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 3.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  747 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 823
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  824 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 896
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  897 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 973
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767977458  974 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1006
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 307-398 2.21e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  307 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 385
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 767977458  386 GTSGFSEEVLYYT 398
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 203-302 2.25e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  203 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 281
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 767977458  282 KVQAEYNSIKGTPSEAEIFTT 302
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
402-791 5.21e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 5.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  402 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 476
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  477 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 556
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  557 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 634
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  635 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 712
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  713 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 791
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
747-1006 3.41e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 3.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  747 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 823
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  824 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 896
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  897 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 973
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767977458  974 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1006
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 307-398 2.21e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  307 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 385
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 767977458  386 GTSGFSEEVLYYT 398
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 403-495 2.43e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  403 PSMPASPVLTKAGITWLSLQWSKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 481
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 767977458  482 EGKSNPSEVVEFTT 495
Cdd:cd00063    80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
801-876 2.10e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   801 DEIENPHYSP--STCLAISWEKPCDHGSEILAYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 871
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 767977458   872 AGPFS 876
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 811-883 8.76e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  811 STCLAISWEKPCDHGSEILAYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 883
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 692-774 1.02e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.02e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    692 PGPPdqcKPPQVTCRSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQAL 768
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 767977458    769 SVVGAG 774
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 203-302 2.25e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  203 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 281
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 767977458  282 KVQAEYNSIKGTPSEAEIFTT 302
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
701-777 2.58e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   701 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 777
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 307-388 8.11e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 8.11e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    307 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 384
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 767977458    385 YGTS 388
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
310-391 1.24e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   310 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 387
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 767977458   388 SGFS 391
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 811-873 3.25e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.25e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    811 STCLAISWEKPCDHG--SEILAYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 873
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
208-295 4.14e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 4.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   208 PVASDIQARTVVLTWSPPSSLiNGEtdessvpeLYGYEVLISSTGKDGKYKSVYV-GEETNITLNDLKPAMDYHAKVQAE 286
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG-NGP--------ITGYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 767977458   287 YNSIKGTPS 295
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 203-288 1.08e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 1.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    203 SNIVKPVASDIQARTVVLTWSPPSslingetDESSVPELYGYEVLISSTGKDGKYKSVyVGEETNITLNDLKPAMDYHAK 282
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-------DDGITGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 767977458    283 VQAEYN 288
Cdd:smart00060   74 VRAVNG 79
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
402-791 5.21e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 5.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  402 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 476
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  477 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 556
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  557 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 634
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  635 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 712
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  713 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 791
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
377-603 1.69e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 1.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  377 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDegiSYILEMEEETSGyGFKPKYDG 456
Cdd:COG3401   207 YRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDAT---GYRVYRSNSGDG-PFTKVATV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  457 EDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEFTTCPDKPGIPVkpSVKGKIHSHSF-KITWDPPKDNGgatINK 534
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSiTLSWTASSDAD---VTG 357

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767977458  535 YVVEMAEGSNGNkWEMIYSGATREHLCDR-LNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPCLP 603
Cdd:COG3401   358 YNVYRSTSGGGT-YTKIAETVTTTSYTDTgLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGESLT 427
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
747-1006 3.41e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 3.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  747 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 823
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  824 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 896
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  897 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 973
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767977458  974 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1006
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 307-398 2.21e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  307 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 385
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 767977458  386 GTSGFSEEVLYYT 398
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 403-495 2.43e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  403 PSMPASPVLTKAGITWLSLQWSKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 481
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 767977458  482 EGKSNPSEVVEFTT 495
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 614-690 4.91e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 4.91e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767977458  614 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT 690
Cdd:cd00063    16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
209-548 9.22e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.34  E-value: 9.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  209 VASDIQARTVVLTWSPpssliNGETDESsvpelyGYEVLISSTGkDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAE-Y 287
Cdd:COG3401   240 TATADTPGSVTLSWDP-----VTESDAT------GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdA 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  288 NSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGskIQNFVLEWDEGKGnGEFCQ-CYMGSQKQFKI 366
Cdd:COG3401   308 AGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSGG-GTYTKiAETVTTTSYTD 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  367 TKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 446
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDT 464

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  447 GYGFKPKYDGEDLAYTVKNLRRSTKYkfKVIAYNSEGKSNPSEVVEFTTcPDKPGIPVKPSVKGKIHShsfKITWDPPKD 526
Cdd:COG3401   465 GNAVPFTTTSSTVTATTTDTTTANLS--VTTGSLVGGSGASSVTNSVSV-IGASAAAAVGGAPDGTPN---VTGASPVTV 538

                         330       340
                  ....*....|....*....|..
gi 767977458  527 NGGATINKYVVEMAEGSNGNKW 548
Cdd:COG3401   539 GASTGDVLITDLVSLTTSASSS 560
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 692-784 1.50e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  692 PGPPDQckpPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV-EGSMQIC--YCGPGLSYEIKGLSPATTYYCRVQAL 768
Cdd:cd00063     1 PSPPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 767977458  769 SVVGAGPFSEVVACVT 784
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
801-876 2.10e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   801 DEIENPHYSP--STCLAISWEKPCDHGSEILAYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 871
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 767977458   872 AGPFS 876
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 500-593 4.83e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 4.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  500 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGAtINKYVVEMAEgSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCI 577
Cdd:cd00063     1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGGP-ITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 767977458  578 SDGGQSAVSESLLVQT 593
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 811-883 8.76e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  811 STCLAISWEKPCDHGSEILAYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 883
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
808-1101 4.33e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.87  E-value: 4.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  808 YSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 887
Cdd:COG3401   153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  888 PDPP-RLECVAFSHQNLKLKWGEGTpktlSTDSIQYHL-QMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEA 965
Cdd:COG3401   233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  966 G-EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWeclQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS-SFRYS 1042
Cdd:COG3401   309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTTtSYTDT 385

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767977458 1043 SLQLNCEYRFRVCAIrqcqDSLGhqdLVGPYSTTVLFISQRTEPPASTNRDTVESTRTR 1101
Cdd:COG3401   386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESLTASVDAVPLTD 437
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 692-774 1.02e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.02e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    692 PGPPdqcKPPQVTCRSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQAL 768
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 767977458    769 SVVGAG 774
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 203-302 2.25e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  203 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 281
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 767977458  282 KVQAEYNSIKGTPSEAEIFTT 302
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
701-777 2.58e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   701 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 777
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 598-680 3.86e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.86e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    598 PGPclPPRLQGRPKAKE-IQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAAN 675
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 767977458    676 KMGFG 680
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 307-388 8.11e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 8.11e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    307 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 384
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 767977458    385 YGTS 388
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
310-391 1.24e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   310 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 387
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 767977458   388 SGFS 391
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 403-485 1.94e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.94e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    403 PSMPASPVLTKAGITWLSLQWSKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 479
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 767977458    480 NSEGKS 485
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
614-683 2.19e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 2.19e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767977458   614 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREVYQ--GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 683
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 811-873 3.25e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.25e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    811 STCLAISWEKPCDHG--SEILAYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 873
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 888-978 9.35e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 9.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  888 PDPPR-LECVAFSHQNLKLKWGEgtPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC---HTYKVQRLNESTSYKFCIQACN 963
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 767977458  964 EAGEGPLSQEYIFTT 978
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 500-583 3.36e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.36e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    500 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGatiNKYVVE--MAEGSNGNKWEMIY-SGATREHLCDRLNPGCFYRLRVYC 576
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPDDGI---TGYIVGyrVEYREEGSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                    ....*..
gi 767977458    577 ISDGGQS 583
Cdd:smart00060   77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
208-295 4.14e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 4.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   208 PVASDIQARTVVLTWSPPSSLiNGEtdessvpeLYGYEVLISSTGKDGKYKSVYV-GEETNITLNDLKPAMDYHAKVQAE 286
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG-NGP--------ITGYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 767977458   287 YNSIKGTPS 295
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 887-968 6.53e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 6.53e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    887 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-YKVQRLNESTSYKFCIQACNEA 965
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 767977458    966 GEG 968
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
514-586 1.39e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.39e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767977458   514 SHSFKITWDPPKDNGGaTINKYVVEMAEGSNGNKW-EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 586
Cdd:pfam00041   13 STSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
406-488 1.57e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   406 PASPVLTKAGITWLSLQWSKPSgTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSEGK 484
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 767977458   485 SNPS 488
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 203-288 1.08e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 1.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458    203 SNIVKPVASDIQARTVVLTWSPPSslingetDESSVPELYGYEVLISSTGKDGKYKSVyVGEETNITLNDLKPAMDYHAK 282
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-------DDGITGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 767977458    283 VQAEYN 288
Cdd:smart00060   74 VRAVNG 79
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
646-772 6.76e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.78  E-value: 6.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  646 REVYQGSEVECTVSSLLPGkTYSFRLRAANKMG---FGPFSEKCDITTAPGPPdqckpPQVTCRSATC----AQVNWEVP 718
Cdd:COG4733   579 VSVPRTSGTSFEVPGIYAG-DYEVRVRAINALGvssAWAASSETTVTGKTAPP-----PAPTGLTATGglggITLSWSFP 652

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767977458  719 lsNGTDVTEYRLEWGGV---EGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 772
Cdd:COG4733   653 --VDADTLRTEIRYSTTgdwASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
711-871 1.28e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  711 AQVNWEVPlsngTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLsPATTYYCRVQALSVVG------AGPFSEVVACVT 784
Cdd:COG4733   554 LTVSWDAP----AGAVAYEVEWRRDDGNWVSVPRTSGTSFEVPGI-YAGDYEVRVRAINALGvssawaASSETTVTGKTA 628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458  785 PPSVP-GIVTclqEISDDEIEnphyspstclaISWEKPCDhgSEILAYSI---DFGDKQSLTV----GKVTSYIINNLQP 856
Cdd:COG4733   629 PPPAPtGLTA---TGGLGGIT-----------LSWSFPVD--ADTLRTEIrysTTGDWASATVaqalYPGNTYTLAGLKA 692

                         170
                  ....*....|....*
gi 767977458  857 DTTYRIRIQALNSLG 871
Cdd:COG4733   693 GQTYYYRARAVDRSG 707
fn3 pfam00041
Fibronectin type III domain;
888-971 6.29e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 6.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977458   888 PDPPRLECVAFSHQNLKLKWGEgtPKTLSTDSIQYHLQMEDKNGRFVSLYR---GPCHTYKVQRLNESTSYKFCIQACNE 964
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTP--PPDGNGPITGYEVEYRPKNSGEPWNEItvpGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 767977458   965 AGEGPLS 971
Cdd:pfam00041   79 GGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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