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Conserved domains on  [gi|767950134|ref|XP_011533046|]
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zinc finger protein 596 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
326-467 3.21e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 326 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 397
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767950134 398 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 467
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
KRAB super family cl42959
krueppel associated box;
1-32 2.32e-05

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 41.81  E-value: 2.32e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767950134     1 MLENISHLVSIGKQLCKSVVLSQLEQVEKLST 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 212-294 9.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 212 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqichlCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQ 289
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 767950134 290 HeRTH 294
Cdd:COG5189  417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 1.76e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 767950134  286 YLRQHERTHNGEKPYECHLCGKAFSH 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-199 9.42e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 767950134  174 NLRRHEMIHTGEKPHGCHLCGKAFTH 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
326-467 3.21e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 326 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 397
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767950134 398 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 467
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
KRAB smart00349
krueppel associated box;
1-32 2.32e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 41.81  E-value: 2.32e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767950134     1 MLENISHLVSIGKQLCKSVVLSQLEQVEKLST 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 1.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 767950134  370 DLRRHERTHTGEKPYECHLCGKAFNH 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 212-294 9.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 212 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqichlCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQ 289
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 767950134 290 HeRTH 294
Cdd:COG5189  417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 1.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 767950134  286 YLRQHERTHNGEKPYECHLCGKAFSH 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-199 9.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 767950134  174 NLRRHEMIHTGEKPHGCHLCGKAFTH 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
326-467 3.21e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 326 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 397
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767950134 398 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 467
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
298-464 1.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 298 KPYECHLCGKAFSHCSHLRQHERS--HNGE--KPHGC--HLCGKAFTESSVLKRHERIHTGEKPYECH--VCGKAFTESS 369
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 370 DLRRHERTH-----TGEKPYEC--HLCGKAFNHSSVLRRHERTHTGEKPYECN--ICGKAFNRSYNFRLHRRVHTgEKPY 440
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAP 446

                        170       180
                 ....*....|....*....|....
gi 767950134 441 VCPLCgkafSKFFNLRQHERTHTK 464
Cdd:COG5048  447 LLCSI----LKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-424 5.58e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 5.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 269 DKPYGCLLCGKAFSKCSYLRQHERT--HNGE--KPYEC--HLCGKAFSHCSHLRQHERSHNGEKPHGCHL--CGKAFTES 340
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPL 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 341 SVLKRHERIH-----TGEKPYEC--HVCGKAFTESSDLRRHERTHTGEKPYECH--LCGKAFNHSSVLRRHERTHTGEKP 411
Cdd:COG5048  367 LNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|...
gi 767950134 412 YECNICGKAFNRS 424
Cdd:COG5048  447 LLCSILKSFRRDL 459
KRAB smart00349
krueppel associated box;
1-32 2.32e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 41.81  E-value: 2.32e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767950134     1 MLENISHLVSIGKQLCKSVVLSQLEQVEKLST 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 1.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 767950134  370 DLRRHERTHTGEKPYECHLCGKAFNH 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-423 2.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....*
gi 767950134  399 LRRHERTHTGEKPYECNICGKAFNR 423
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 296-379 3.12e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 296 GEKPYECHL--CGKAFshcshlrqheRSHNGEKPHGCH-LCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLR 372
Cdd:COG5189  346 DGKPYKCPVegCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 767950134 373 RHeRTHT 379
Cdd:COG5189  416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-366 3.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.37e-04
                          10        20
                  ....*....|....*....|....
gi 767950134  343 LKRHERIHTGEKPYECHVCGKAFT 366
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-465 3.39e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 186 KPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEMIHT----REKAQICHLCGKAFTHCSDL 259
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHnnpsDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 260 RKHERTHLGDKPYGCLLCGKAF--------SKCSYLRQHERTHNGEK-----------PYECHLCGKAFSHCSHLRQHER 320
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRdpqlpdllSISNLRNNPLPGNNSSSvntpqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 321 SHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRH------ERTHTGEKPYECHLCGKAFN 394
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767950134 395 HSSVLRRHERTHTG-EKPYECNICGKAFNRSYNFRLHRR--VHTGE--KPYVCP--LCGKAFSKFFNLRQHERTHTKK 465
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSI 349
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 308-407 5.64e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 5.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 308 AFSHCSHLRQHERSHN----GEKPHGCHL--CGKAFTESSVLKRHERihtgekpyECHvCGKAFTESSDLRRHERTHTGE 381
Cdd:COG5189  326 KLAHGGERNIDTPSRMlkvkDGKPYKCPVegCNKKYKNQNGLKYHML--------HGH-QNQKLHENPSPEKMNIFSAKD 396

                         90       100
                 ....*....|....*....|....*.
gi 767950134 382 KPYECHLCGKAFNHSSVLRRHeRTHT 407
Cdd:COG5189  397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 212-294 9.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 212 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqichlCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQ 289
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 767950134 290 HeRTH 294
Cdd:COG5189  417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 337-463 1.53e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 337 FTESSVLKRHERIH--TGEKPYECHVCGKaftESSDLRRHERTHTGEKPYECHLCGKAFNHSSvlrRHERThTGEKPYEC 414
Cdd:COG5189  280 FEESSLGFDYEFIHksVGNKEIRGGISTG---EMIDVRKLPCTNSSSNGKLAHGGERNIDTPS---RMLKV-KDGKPYKC 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950134 415 NI--CGKAFNRSYNFRLHRR-------------------VHTGEKPYVCPLCGKAFSKFFNLRQHeRTHT 463
Cdd:COG5189  353 PVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 1.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 767950134  286 YLRQHERTHNGEKPYECHLCGKAFSH 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-451 8.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 767950134  426 NFRLHRRVHTGEKPYVCPLCGKAFSK 451
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-199 9.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 767950134  174 NLRRHEMIHTGEKPHGCHLCGKAFTH 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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