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Conserved domains on  [gi|767930637|ref|XP_011532669|]
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neuromedin-U isoform X1 [Homo sapiens]

Protein Classification

NMU domain-containing protein( domain architecture ID 10638104)

NMU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
 125-149 8.67e-11

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


:

Pssm-ID: 197507  Cd Length: 25  Bit Score: 53.68  E-value: 8.67e-11
                           10        20
                   ....*....|....*....|....*
gi 767930637   125 FRVDEEFQSPFASQSRGYFLFRPRN 149
Cdd:smart00084   1 FKVDEEFQGPIASQSRGYFLFRPRN 25
MobM_relaxase super family cl03088
relaxase domain of MobM and similar proteins; With some plasmids, recombination can occur in a ...
 40-118 5.73e-03

relaxase domain of MobM and similar proteins; With some plasmids, recombination can occur in a site-specific manner that is independent of RecA. In such cases, the recombination event requires another protein called Pre (plasmid recombination enzyme), also known as Mob (conjugative mobilization). The best characterized member of this family is encoded by the streptococcal plasmid pMV158 that recognizes the plasmid origin of transfer. MobM converts supercoiled plasmid DNA into relaxed DNA by cleaving a phosphodiester bond of a specific dinucleotide and remains bound to the 5'-end of the nick site.


The actual alignment was detected with superfamily member NF041497:

Pssm-ID: 470731  Cd Length: 187  Bit Score: 35.62  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930637  40 NQRIPTVLIIYRRILFQASNALEelcFMI------MGMLPKPQEQDE--KDNTKrFLfhyskTQKLGKSNVVSSVVHpLL 111
Cdd:NF041497  61 KERIAENAGIKRKIRKDAVRAVE---FILtgspefFKELADPGELKEwfEDNYD-FL-----ADRYGEENIVSAVVH-LD 130


                 ....*..
gi 767930637 112 QLVPHLH 118
Cdd:NF041497 131 ETTPHIH 137
 
Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
 125-149 8.67e-11

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


Pssm-ID: 197507  Cd Length: 25  Bit Score: 53.68  E-value: 8.67e-11
                           10        20
                   ....*....|....*....|....*
gi 767930637   125 FRVDEEFQSPFASQSRGYFLFRPRN 149
Cdd:smart00084   1 FKVDEEFQGPIASQSRGYFLFRPRN 25
NMU pfam02070
Neuromedin U;
125-149 2.92e-10

Neuromedin U;


Pssm-ID: 460435  Cd Length: 25  Bit Score: 52.17  E-value: 2.92e-10
                          10        20
                  ....*....|....*....|....*
gi 767930637  125 FRVDEEFQSPFASQSRGYFLFRPRN 149
Cdd:pfam02070   1 FKVDEELQGPGAIQSRGYFLFRPRN 25
MobV NF041497
MobV family relaxase;
40-118 5.73e-03

MobV family relaxase;


Pssm-ID: 469385  Cd Length: 187  Bit Score: 35.62  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930637  40 NQRIPTVLIIYRRILFQASNALEelcFMI------MGMLPKPQEQDE--KDNTKrFLfhyskTQKLGKSNVVSSVVHpLL 111
Cdd:NF041497  61 KERIAENAGIKRKIRKDAVRAVE---FILtgspefFKELADPGELKEwfEDNYD-FL-----ADRYGEENIVSAVVH-LD 130


                 ....*..
gi 767930637 112 QLVPHLH 118
Cdd:NF041497 131 ETTPHIH 137
 
Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
 125-149 8.67e-11

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


Pssm-ID: 197507  Cd Length: 25  Bit Score: 53.68  E-value: 8.67e-11
                           10        20
                   ....*....|....*....|....*
gi 767930637   125 FRVDEEFQSPFASQSRGYFLFRPRN 149
Cdd:smart00084   1 FKVDEEFQGPIASQSRGYFLFRPRN 25
NMU pfam02070
Neuromedin U;
125-149 2.92e-10

Neuromedin U;


Pssm-ID: 460435  Cd Length: 25  Bit Score: 52.17  E-value: 2.92e-10
                          10        20
                  ....*....|....*....|....*
gi 767930637  125 FRVDEEFQSPFASQSRGYFLFRPRN 149
Cdd:pfam02070   1 FKVDEELQGPGAIQSRGYFLFRPRN 25
MobV NF041497
MobV family relaxase;
40-118 5.73e-03

MobV family relaxase;


Pssm-ID: 469385  Cd Length: 187  Bit Score: 35.62  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767930637  40 NQRIPTVLIIYRRILFQASNALEelcFMI------MGMLPKPQEQDE--KDNTKrFLfhyskTQKLGKSNVVSSVVHpLL 111
Cdd:NF041497  61 KERIAENAGIKRKIRKDAVRAVE---FILtgspefFKELADPGELKEwfEDNYD-FL-----ADRYGEENIVSAVVH-LD 130


                 ....*..
gi 767930637 112 QLVPHLH 118
Cdd:NF041497 131 ETTPHIH 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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