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Conserved domains on  [gi|767914562|ref|XP_011531162|]
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latent-transforming growth factor beta-binding protein 1 isoform X13 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 632-673 3.19e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.38  E-value: 3.19e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767914562   632 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 673
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1304-1346 1.94e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 57.29  E-value: 1.94e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914562  1304 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1346
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1480-1522 1.17e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 1.17e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914562  1480 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1522
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1147-1188 1.26e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.26e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1147 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1188
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1065-1105 3.67e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.67e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1065 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1105
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1024-1055 1.31e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.31e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914562   1024 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1055
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1189-1230 3.46e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.46e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1189 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 1230
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
983-1022 5.33e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.33e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767914562    983 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1022
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-600 1.45e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.45e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767914562    570 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 600
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
860-901 1.52e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.52e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767914562    860 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 901
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1106-1136 2.57e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.57e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1106 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1136
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1607-1641 1.21e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.21e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767914562   1607 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1641
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
902-942 2.27e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.27e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562    902 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 942
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 686-813 4.97e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914562  686 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 765
Cdd:PHA03247 2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767914562  766 QPQLSPGISTIHLHPQFPG---IVIEKTSPPVPVEVAPEASTSSASQVIAP 813
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGrvaVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 511-546 5.65e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.18  E-value: 5.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767914562   511 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 546
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 943-976 2.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767914562  943 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 976
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 632-673 3.19e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.38  E-value: 3.19e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767914562   632 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 673
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1304-1346 1.94e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 57.29  E-value: 1.94e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914562  1304 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1346
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1480-1522 1.17e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 1.17e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914562  1480 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1522
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1147-1188 1.26e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.26e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1147 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1188
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1147-1188 8.15e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 8.15e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914562 1147 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1188
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1065-1105 3.67e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.67e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1065 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1105
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1065-1105 1.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.25e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914562 1065 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1105
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1024-1055 1.31e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.31e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914562   1024 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1055
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1024-1056 3.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914562 1024 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1056
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1189-1230 3.46e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.46e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1189 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 1230
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
983-1022 5.33e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.33e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767914562    983 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1022
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1189-1221 1.36e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.36e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767914562 1189 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1221
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-600 1.45e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.45e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767914562    570 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 600
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
860-901 1.52e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.52e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767914562    860 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 901
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1106-1136 2.57e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.57e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1106 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1136
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 983-1014 3.97e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.97e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767914562  983 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 1014
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1106-1146 4.23e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.23e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1106 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1146
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-600 5.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.38e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767914562  570 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 600
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
860-890 1.05e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562   860 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 890
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1607-1641 1.21e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.21e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767914562   1607 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1641
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 860-901 1.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767914562  860 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 901
Cdd:cd00054     1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
902-942 2.27e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.27e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562    902 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 942
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1607-1641 3.55e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767914562 1607 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1641
Cdd:cd00054     1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 686-813 4.97e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914562  686 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 765
Cdd:PHA03247 2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767914562  766 QPQLSPGISTIHLHPQFPG---IVIEKTSPPVPVEVAPEASTSSASQVIAP 813
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGrvaVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 511-546 5.65e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.18  E-value: 5.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767914562   511 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 546
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1106-1146 6.16e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 6.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914562 1106 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 1146
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1607-1640 1.18e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767914562  1607 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1640
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1189-1219 1.24e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.24e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1189 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 1219
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1171-1192 1.46e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 37.39  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|..
gi 767914562  1171 HCVCQQGFSISADGRTCEDIDE 1192
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 902-934 1.93e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914562  902 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 934
Cdd:cd00054     1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
570-599 2.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562   570 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 599
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 943-976 2.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767914562  943 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 976
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1065-1094 3.66e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.66e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1065 DIDEC-QHRHLC-AHGQCRNTEGSFQCVCDQG 1094
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
943-975 4.66e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.66e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 767914562    943 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFR 975
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1024-1053 8.89e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.89e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1024 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1053
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 632-673 3.19e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.38  E-value: 3.19e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767914562   632 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 673
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1304-1346 1.94e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 57.29  E-value: 1.94e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914562  1304 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1346
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1480-1522 1.17e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 1.17e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767914562  1480 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1522
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1147-1188 1.26e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.26e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1147 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 1188
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1147-1188 8.15e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 8.15e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914562 1147 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 1188
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1065-1105 3.67e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.67e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1065 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 1105
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1065-1105 1.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.25e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914562 1065 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 1105
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1024-1055 1.31e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.31e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914562   1024 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 1055
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1024-1056 3.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914562 1024 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 1056
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1189-1230 3.46e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.46e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1189 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 1230
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
983-1022 5.33e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.33e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767914562    983 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 1022
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1189-1221 1.36e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.36e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767914562 1189 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1221
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
570-600 1.45e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.45e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 767914562    570 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 600
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
860-901 1.52e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.52e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767914562    860 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 901
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1106-1136 2.57e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.57e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1106 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 1136
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 983-1014 3.97e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.97e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767914562  983 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 1014
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1106-1146 4.23e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.23e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562   1106 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 1146
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-600 5.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.38e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767914562  570 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 600
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
860-890 1.05e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562   860 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 890
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1607-1641 1.21e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.21e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767914562   1607 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1641
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 860-901 1.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767914562  860 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 901
Cdd:cd00054     1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
902-942 2.27e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.27e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767914562    902 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 942
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1607-1641 3.55e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767914562 1607 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1641
Cdd:cd00054     1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 686-813 4.97e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767914562  686 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 765
Cdd:PHA03247 2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767914562  766 QPQLSPGISTIHLHPQFPG---IVIEKTSPPVPVEVAPEASTSSASQVIAP 813
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGrvaVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 511-546 5.65e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.18  E-value: 5.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767914562   511 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 546
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1106-1146 6.16e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 6.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767914562 1106 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 1146
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
EGF smart00181
Epidermal growth factor-like domain;
1027-1057 1.10e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 1.10e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 767914562   1027 ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 1057
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGD 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1607-1640 1.18e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767914562  1607 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1640
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1189-1219 1.24e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.24e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1189 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 1219
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1171-1192 1.46e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 37.39  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|..
gi 767914562  1171 HCVCQQGFSISADGRTCEDIDE 1192
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF smart00181
Epidermal growth factor-like domain;
1068-1096 1.69e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.69e-03
                            10        20
                    ....*....|....*....|....*....
gi 767914562   1068 ECQHRHLCAHGQCRNTEGSFQCVCDQGYR 1096
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF smart00181
Epidermal growth factor-like domain;
573-605 1.83e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.83e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767914562    573 ECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT 605
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 902-934 1.93e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767914562  902 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 934
Cdd:cd00054     1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
570-599 2.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562   570 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 599
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 943-976 2.23e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767914562  943 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 976
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1150-1179 3.11e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 767914562 1150 ECEHPGLCGPQGECLNTEGSFHCVCQQGFS 1179
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF smart00181
Epidermal growth factor-like domain;
986-1014 3.40e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 3.40e-03
                            10        20
                    ....*....|....*....|....*....
gi 767914562    986 ECLEPNVCANGDCSNLEGSYMCSCHKGYT 1014
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA pfam07645
Calcium-binding EGF domain;
1065-1094 3.66e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.66e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1065 DIDEC-QHRHLC-AHGQCRNTEGSFQCVCDQG 1094
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
943-975 4.66e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.66e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 767914562    943 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFR 975
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1131-1150 6.43e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.46  E-value: 6.43e-03
                           10        20
                   ....*....|....*....|.
gi 767914562  1131 CTCPDGFQLD-DNKTCQDINE 1150
Cdd:pfam12662    2 CSCPPGYQLDpDGRTCVDIDE 22
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 854-897 6.59e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.06  E-value: 6.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767914562  854 QQRKCVDIDECTQVQHLCSQGrCENTEGSFLCICPAGFMASEEG 897
Cdd:cd01475   180 QGKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA pfam07645
Calcium-binding EGF domain;
1147-1177 8.63e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1147 DINECEHPG-LCGPQGECLNTEGSFHCVCQQG 1177
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1024-1053 8.89e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.89e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767914562  1024 DIDECQQG-NLC-VNGQCKNTEGSFRCTCGQG 1053
Cdd:pfam07645    1 DVDECATGtHNCpANTVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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