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FH2 domain-containing protein 1 isoform X1 [Homo sapiens]
Protein Classification
FH2 domain-containing protein ( domain architecture ID 13671889 )
FH2 domain-containing protein; FH2 domain-containing protein similar to formin homology proteins that control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarization; FH2 domain-containing protein; FH2 domain-containing protein similar to formin homology proteins that control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarization
List of domain hits
Name
Accession
Description
Interval
E-value
FH2
pfam02181 Formin Homology 2 Domain;
93-457
2.60e-125
Formin Homology 2 Domain;
Pssm-ID: 396655
Cd Length: 372
Bit Score: 388.94
E-value: 2.60e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 93 K KK RMRSFF W KTIPEE Q V RG kt NI W TLAARQEHHYQI D TKTI EELF GQQED T T K SS lprr GRTLN SS FREARE E ITI LD A 172
Cdd:pfam02181 7 P KK KLKPLH W DKVRPS Q D RG -- TV W DKLDDESFELDG D LSEL EELF SAKAK T K K NK ---- KSEDK SS SKKKPK E VSL LD P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 173 KR SM NI G I F L KQF K KS P RS I VED I HQ G KSEHYGS E T L REF LK FL P ES EE V KKLK AFS GD V S K L SL A DS FL YG L IQV P NYS 252
Cdd:pfam02181 81 KR AQ NI A I L L RKL K LP P EE I IQA I LE G DEDALDL E L L ENL LK MA P TK EE L KKLK EYK GD P S E L GR A EQ FL LE L SKI P RLE 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 253 L R IE A MVL K KE F LPSCSS L YTDITV L RT A IK EL MSCEELHSI L H L V L QA GN I MN A G GYA G N A V GFKLSSLLKL A DTK ANK 332
Cdd:pfam02181 161 A R LR A LLF K ST F EEEIEE L KPSLEA L EA A SE EL RNSRKFKKL L E L I L AL GN Y MN D G TRR G Q A K GFKLSSLLKL S DTK STD 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 333 PGMN LLH FVAQEAQK K DTIL L N FS EK L H HV Q K T A RLS LE NT E AELHL L FVRT K S L KENIQRDGE ------- LCQQMED FL 405
Cdd:pfam02181 241 NKTT LLH YLVKIIRE K FPEV L D FS SE L S HV K K A A KVN LE QL E KDVKQ L ERGL K K L ERELELSAL dehpddk FREVLKE FL 320
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 767932979 406 QF A I EKL RE LE CWKQ E LQDEAYT L IDF F C ED K K TMKLD E C F Q I F RDF CTK F N 457
Cdd:pfam02181 321 KS A E EKL DK LE SLLR E ALELFKE L VEY F G ED P K ETSPE E F F K I L RDF LKE F K 372
PHA03307 super family
cl33723 transcriptional regulator ICP4; Provisional
730-1136
7.29e-10
transcriptional regulator ICP4; Provisional
PHA03307 :Pssm-ID: 223039 [Multi-domain]
Cd Length: 1352
Bit Score: 63.65
E-value: 7.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 730 D A LGSLSPALEDGK A A P DEPGSAA L ---- G SVG S SDP E NKDPRPLFCI - SDTTDCSL T LDCSEGTDSR P RGGDPEEGGEG 804
Cdd:PHA03307 12 E A AAEGGEFFPRPP A T P GDAADDL L sgsq G QLV S DSA E LAAVTVVAGA a ACDRFEPP T GPPPGPGTEA P ANESRSTPTWS 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 805 DGSMSSGVGEMGD S QVSSN P t SSP PGEA P A P VSVDSE PS CKGG L PRDKPTKRKDVVA P KRGSLK - E ASP G A SKPGS A RRS 883
Cdd:PHA03307 92 LSTLAPASPAREG S PTPPG P - SSP DPPP P T P PPASPP PS PAPD L SEMLRPVGSPGPP P AASPPA a G ASP A A VASDA A SSR 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 884 Q G A VA ksvrt L TAS E NESMRKVM P it KSSRGAGWRRPEL S S R G P SQNP P S S TD tvwsrqn SVRR A STGAEEQRLPR G S S G 963
Cdd:PHA03307 171 Q A A LP ----- L SSP E ETARAPSS P -- PAEPPPSTPPAAA S P R P P RRSS P I S AS ------- ASSP A PAPGRSAADDA G A S S 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 964 S S S TRP - GRDVPLQ P RGSFKK P SAK P LRNLP R QK --- PEENKTC R AHSEGPE S PKE E PKTPSV PS V P HEL P RVP ---- S F 1035
Cdd:PHA03307 237 S D S SSS e SSGCGWG P ENECPL P RPA P ITLPT R IW eas GWNGPSS R PGPASSS S SPR E RSPSPS PS S P GSG P APS spra S S 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1036 ARNTVAS SS R S MRTDLPPVAKAPGITRTV S QRQLRVKGD P EDA A PKD S stlrra SSA R APKK R PE S AEGP SA NTEAPLK A 1115
Cdd:PHA03307 317 SSSSSRE SS S S STSSSSESSRGAAVSPGP S PSRSPSPSR P PPP A DPS S ------ PRK R PRPS R AP S SPAA SA GRPTRRR A 390
410 420
....*....|....*....|.
gi 767932979 1116 R G A GERASL RR KDSS R TTL GR 1136
Cdd:PHA03307 391 R A A VAGRAR RR DATG R FPA GR 411
Name
Accession
Description
Interval
E-value
FH2
pfam02181 Formin Homology 2 Domain;
93-457
2.60e-125
Formin Homology 2 Domain;
Pssm-ID: 396655
Cd Length: 372
Bit Score: 388.94
E-value: 2.60e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 93 K KK RMRSFF W KTIPEE Q V RG kt NI W TLAARQEHHYQI D TKTI EELF GQQED T T K SS lprr GRTLN SS FREARE E ITI LD A 172
Cdd:pfam02181 7 P KK KLKPLH W DKVRPS Q D RG -- TV W DKLDDESFELDG D LSEL EELF SAKAK T K K NK ---- KSEDK SS SKKKPK E VSL LD P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 173 KR SM NI G I F L KQF K KS P RS I VED I HQ G KSEHYGS E T L REF LK FL P ES EE V KKLK AFS GD V S K L SL A DS FL YG L IQV P NYS 252
Cdd:pfam02181 81 KR AQ NI A I L L RKL K LP P EE I IQA I LE G DEDALDL E L L ENL LK MA P TK EE L KKLK EYK GD P S E L GR A EQ FL LE L SKI P RLE 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 253 L R IE A MVL K KE F LPSCSS L YTDITV L RT A IK EL MSCEELHSI L H L V L QA GN I MN A G GYA G N A V GFKLSSLLKL A DTK ANK 332
Cdd:pfam02181 161 A R LR A LLF K ST F EEEIEE L KPSLEA L EA A SE EL RNSRKFKKL L E L I L AL GN Y MN D G TRR G Q A K GFKLSSLLKL S DTK STD 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 333 PGMN LLH FVAQEAQK K DTIL L N FS EK L H HV Q K T A RLS LE NT E AELHL L FVRT K S L KENIQRDGE ------- LCQQMED FL 405
Cdd:pfam02181 241 NKTT LLH YLVKIIRE K FPEV L D FS SE L S HV K K A A KVN LE QL E KDVKQ L ERGL K K L ERELELSAL dehpddk FREVLKE FL 320
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 767932979 406 QF A I EKL RE LE CWKQ E LQDEAYT L IDF F C ED K K TMKLD E C F Q I F RDF CTK F N 457
Cdd:pfam02181 321 KS A E EKL DK LE SLLR E ALELFKE L VEY F G ED P K ETSPE E F F K I L RDF LKE F K 372
FH2
smart00498 Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
94-480
3.02e-57
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.
Pssm-ID: 214697 [Multi-domain]
Cd Length: 392
Bit Score: 203.35
E-value: 3.02e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 94 KK RMRSFF W KTIPEEQVR G ktniw T LAARQEHHYQI D TKTI EELF GQQ E D T TKS S LPR - RGRTLNS sf RE A RE E IT ILD A 172
Cdd:smart00498 7 KK KLKPLH W DKLNPSDLS G ----- T VWDKIDEESEG D LDEL EELF SAK E K T KSA S KDV s EKKSILK -- KK A SQ E FK ILD P 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 173 KRS M N IG I F L KQFKK S PRS I V E D I HQ G KSEHYGSET L REF LK FL P ES EE V KKL KAFSG - D VSK L SL A DS FL YGLIQV P NY 251
Cdd:smart00498 80 KRS Q N LA I L L RKLHM S YEE I K E A I LE G DEDVLSVDL L EQL LK YA P TK EE L KKL REYKE e D PEE L AR A EQ FL LLISNI P YL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 252 SL R IE A MVL K KE F LPSCSS L YTD I TVLRT A IK EL MSCEELHSI L H L V L QA GN I MN A G GYA G N A V GFKLSSLLKL A D T K AN 331
Cdd:smart00498 160 EE R LN A LLF K AN F EEEVED L KPQ I EKVEA A CE EL RESKKFRKL L E L I L AI GN Y MN G G SRR G Q A Y GFKLSSLLKL S D V K SA 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 332 KPGMN LLHF VAQEAQ KK D ti L LNF S EKLHH vqktarlslenteaelhllfvrtkslkeniqr D GELCQQ M ED FL QF A I EK 411
Cdd:smart00498 240 DNKTT LLHF LVKIIR KK Y -- L GGL S DPENL -------------------------------- D DKFIEV M KP FL KA A K EK 285
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 412 LRE L ECWKQE L QDEAYT L IDFFC ED K K TMKLD E C F QI F RD F CTK F N KA VKD N HDR - E AQ E L R QLQRL KE Q 480
Cdd:smart00498 286 YDK L QKDLSD L KTRFEK L VEYYG ED P K DTSPE E F F KD F NE F LKE F S KA AEE N IKK e E EE E E R RKKLV KE T 355
PHA03307
PHA03307 transcriptional regulator ICP4; Provisional
730-1136
7.29e-10
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain]
Cd Length: 1352
Bit Score: 63.65
E-value: 7.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 730 D A LGSLSPALEDGK A A P DEPGSAA L ---- G SVG S SDP E NKDPRPLFCI - SDTTDCSL T LDCSEGTDSR P RGGDPEEGGEG 804
Cdd:PHA03307 12 E A AAEGGEFFPRPP A T P GDAADDL L sgsq G QLV S DSA E LAAVTVVAGA a ACDRFEPP T GPPPGPGTEA P ANESRSTPTWS 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 805 DGSMSSGVGEMGD S QVSSN P t SSP PGEA P A P VSVDSE PS CKGG L PRDKPTKRKDVVA P KRGSLK - E ASP G A SKPGS A RRS 883
Cdd:PHA03307 92 LSTLAPASPAREG S PTPPG P - SSP DPPP P T P PPASPP PS PAPD L SEMLRPVGSPGPP P AASPPA a G ASP A A VASDA A SSR 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 884 Q G A VA ksvrt L TAS E NESMRKVM P it KSSRGAGWRRPEL S S R G P SQNP P S S TD tvwsrqn SVRR A STGAEEQRLPR G S S G 963
Cdd:PHA03307 171 Q A A LP ----- L SSP E ETARAPSS P -- PAEPPPSTPPAAA S P R P P RRSS P I S AS ------- ASSP A PAPGRSAADDA G A S S 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 964 S S S TRP - GRDVPLQ P RGSFKK P SAK P LRNLP R QK --- PEENKTC R AHSEGPE S PKE E PKTPSV PS V P HEL P RVP ---- S F 1035
Cdd:PHA03307 237 S D S SSS e SSGCGWG P ENECPL P RPA P ITLPT R IW eas GWNGPSS R PGPASSS S SPR E RSPSPS PS S P GSG P APS spra S S 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1036 ARNTVAS SS R S MRTDLPPVAKAPGITRTV S QRQLRVKGD P EDA A PKD S stlrra SSA R APKK R PE S AEGP SA NTEAPLK A 1115
Cdd:PHA03307 317 SSSSSRE SS S S STSSSSESSRGAAVSPGP S PSRSPSPSR P PPP A DPS S ------ PRK R PRPS R AP S SPAA SA GRPTRRR A 390
410 420
....*....|....*....|.
gi 767932979 1116 R G A GERASL RR KDSS R TTL GR 1136
Cdd:PHA03307 391 R A A VAGRAR RR DATG R FPA GR 411
Name
Accession
Description
Interval
E-value
FH2
pfam02181 Formin Homology 2 Domain;
93-457
2.60e-125
Formin Homology 2 Domain;
Pssm-ID: 396655
Cd Length: 372
Bit Score: 388.94
E-value: 2.60e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 93 K KK RMRSFF W KTIPEE Q V RG kt NI W TLAARQEHHYQI D TKTI EELF GQQED T T K SS lprr GRTLN SS FREARE E ITI LD A 172
Cdd:pfam02181 7 P KK KLKPLH W DKVRPS Q D RG -- TV W DKLDDESFELDG D LSEL EELF SAKAK T K K NK ---- KSEDK SS SKKKPK E VSL LD P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 173 KR SM NI G I F L KQF K KS P RS I VED I HQ G KSEHYGS E T L REF LK FL P ES EE V KKLK AFS GD V S K L SL A DS FL YG L IQV P NYS 252
Cdd:pfam02181 81 KR AQ NI A I L L RKL K LP P EE I IQA I LE G DEDALDL E L L ENL LK MA P TK EE L KKLK EYK GD P S E L GR A EQ FL LE L SKI P RLE 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 253 L R IE A MVL K KE F LPSCSS L YTDITV L RT A IK EL MSCEELHSI L H L V L QA GN I MN A G GYA G N A V GFKLSSLLKL A DTK ANK 332
Cdd:pfam02181 161 A R LR A LLF K ST F EEEIEE L KPSLEA L EA A SE EL RNSRKFKKL L E L I L AL GN Y MN D G TRR G Q A K GFKLSSLLKL S DTK STD 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 333 PGMN LLH FVAQEAQK K DTIL L N FS EK L H HV Q K T A RLS LE NT E AELHL L FVRT K S L KENIQRDGE ------- LCQQMED FL 405
Cdd:pfam02181 241 NKTT LLH YLVKIIRE K FPEV L D FS SE L S HV K K A A KVN LE QL E KDVKQ L ERGL K K L ERELELSAL dehpddk FREVLKE FL 320
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 767932979 406 QF A I EKL RE LE CWKQ E LQDEAYT L IDF F C ED K K TMKLD E C F Q I F RDF CTK F N 457
Cdd:pfam02181 321 KS A E EKL DK LE SLLR E ALELFKE L VEY F G ED P K ETSPE E F F K I L RDF LKE F K 372
FH2
smart00498 Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
94-480
3.02e-57
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.
Pssm-ID: 214697 [Multi-domain]
Cd Length: 392
Bit Score: 203.35
E-value: 3.02e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 94 KK RMRSFF W KTIPEEQVR G ktniw T LAARQEHHYQI D TKTI EELF GQQ E D T TKS S LPR - RGRTLNS sf RE A RE E IT ILD A 172
Cdd:smart00498 7 KK KLKPLH W DKLNPSDLS G ----- T VWDKIDEESEG D LDEL EELF SAK E K T KSA S KDV s EKKSILK -- KK A SQ E FK ILD P 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 173 KRS M N IG I F L KQFKK S PRS I V E D I HQ G KSEHYGSET L REF LK FL P ES EE V KKL KAFSG - D VSK L SL A DS FL YGLIQV P NY 251
Cdd:smart00498 80 KRS Q N LA I L L RKLHM S YEE I K E A I LE G DEDVLSVDL L EQL LK YA P TK EE L KKL REYKE e D PEE L AR A EQ FL LLISNI P YL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 252 SL R IE A MVL K KE F LPSCSS L YTD I TVLRT A IK EL MSCEELHSI L H L V L QA GN I MN A G GYA G N A V GFKLSSLLKL A D T K AN 331
Cdd:smart00498 160 EE R LN A LLF K AN F EEEVED L KPQ I EKVEA A CE EL RESKKFRKL L E L I L AI GN Y MN G G SRR G Q A Y GFKLSSLLKL S D V K SA 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 332 KPGMN LLHF VAQEAQ KK D ti L LNF S EKLHH vqktarlslenteaelhllfvrtkslkeniqr D GELCQQ M ED FL QF A I EK 411
Cdd:smart00498 240 DNKTT LLHF LVKIIR KK Y -- L GGL S DPENL -------------------------------- D DKFIEV M KP FL KA A K EK 285
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 412 LRE L ECWKQE L QDEAYT L IDFFC ED K K TMKLD E C F QI F RD F CTK F N KA VKD N HDR - E AQ E L R QLQRL KE Q 480
Cdd:smart00498 286 YDK L QKDLSD L KTRFEK L VEYYG ED P K DTSPE E F F KD F NE F LKE F S KA AEE N IKK e E EE E E R RKKLV KE T 355
PHA03307
PHA03307 transcriptional regulator ICP4; Provisional
730-1136
7.29e-10
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain]
Cd Length: 1352
Bit Score: 63.65
E-value: 7.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 730 D A LGSLSPALEDGK A A P DEPGSAA L ---- G SVG S SDP E NKDPRPLFCI - SDTTDCSL T LDCSEGTDSR P RGGDPEEGGEG 804
Cdd:PHA03307 12 E A AAEGGEFFPRPP A T P GDAADDL L sgsq G QLV S DSA E LAAVTVVAGA a ACDRFEPP T GPPPGPGTEA P ANESRSTPTWS 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 805 DGSMSSGVGEMGD S QVSSN P t SSP PGEA P A P VSVDSE PS CKGG L PRDKPTKRKDVVA P KRGSLK - E ASP G A SKPGS A RRS 883
Cdd:PHA03307 92 LSTLAPASPAREG S PTPPG P - SSP DPPP P T P PPASPP PS PAPD L SEMLRPVGSPGPP P AASPPA a G ASP A A VASDA A SSR 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 884 Q G A VA ksvrt L TAS E NESMRKVM P it KSSRGAGWRRPEL S S R G P SQNP P S S TD tvwsrqn SVRR A STGAEEQRLPR G S S G 963
Cdd:PHA03307 171 Q A A LP ----- L SSP E ETARAPSS P -- PAEPPPSTPPAAA S P R P P RRSS P I S AS ------- ASSP A PAPGRSAADDA G A S S 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 964 S S S TRP - GRDVPLQ P RGSFKK P SAK P LRNLP R QK --- PEENKTC R AHSEGPE S PKE E PKTPSV PS V P HEL P RVP ---- S F 1035
Cdd:PHA03307 237 S D S SSS e SSGCGWG P ENECPL P RPA P ITLPT R IW eas GWNGPSS R PGPASSS S SPR E RSPSPS PS S P GSG P APS spra S S 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1036 ARNTVAS SS R S MRTDLPPVAKAPGITRTV S QRQLRVKGD P EDA A PKD S stlrra SSA R APKK R PE S AEGP SA NTEAPLK A 1115
Cdd:PHA03307 317 SSSSSRE SS S S STSSSSESSRGAAVSPGP S PSRSPSPSR P PPP A DPS S ------ PRK R PRPS R AP S SPAA SA GRPTRRR A 390
410 420
....*....|....*....|.
gi 767932979 1116 R G A GERASL RR KDSS R TTL GR 1136
Cdd:PHA03307 391 R A A VAGRAR RR DATG R FPA GR 411
PHA03307
PHA03307 transcriptional regulator ICP4; Provisional
708-997
1.46e-08
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain]
Cd Length: 1352
Bit Score: 59.41
E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 708 S V G HRGPQ S LS A SSS S LTPMGR DA LG S LSP AL ----- E DGKA AP DE P GSAALG S VGSSDPENKD PR PLFC IS DTTDCSLT 782
Cdd:PHA03307 143 S P G PPPAA S PP A AGA S PAAVAS DA AS S RQA AL plssp E ETAR AP SS P PAEPPP S TPPAAASPRP PR RSSP IS ASASSPAP 222
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 783 LDCSEGT D SRPRGGDPEEGG E GD G SMSSGVG E MGDSQVSSNPTSSPPG EA PAPVSVD S E P SCKG gl PRDK P TK R KDVVA P 862
Cdd:PHA03307 223 APGRSAA D DAGASSSDSSSS E SS G CGWGPEN E CPLPRPAPITLPTRIW EA SGWNGPS S R P GPAS -- SSSS P RE R SPSPS P 300
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 863 KRGSLKE A SPGASKPG S ARR S QGAVAK S vr T LTA SE NESMRK V M P ------ ITKS SR GAGWRR P ELSSRG P SQNPPS S TD 936
Cdd:PHA03307 301 SSPGSGP A PSSPRASS S SSS S RESSSS S -- T SSS SE SSRGAA V S P gpspsr SPSP SR PPPPAD P SSPRKR P RPSRAP S SP 378
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767932979 937 TVWSRQNSV RRA STGAEEQRLP R G ssgssst RP GR DVPLQ PR G S FKKPS A KPLRNLP R QKP 997
Cdd:PHA03307 379 AASAGRPTR RRA RAAVAGRARR R D ------- AT GR FPAGR PR P S PLDAG A ASGAFYA R YPL 432
PHA03247
PHA03247 large tegument protein UL36; Provisional
572-1123
5.16e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 51.09
E-value: 5.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 572 P RSS P RQ ARP TIACLEPAEV R HQDSS ------- F A HK P QASGGQEE A PN P PSAQAHQLAAAQPENHAS A FP R AR R QGVSV 644
Cdd:PHA03247 2589 P DAP P QS ARP RAPVDDRGDP R GPAPP splppdt H A PD P PPPSPSPA A NE P DPHPPPTVPPPERPRDDP A PG R VS R PRRAR 2668
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 645 LRK R YSEPV S LGSAQSPPLSPLAL G I kehel V T G LA QFNLQGSQGMEETSQ L TLSDFS P MELESVGHRG P QSLS A SSSSL 724
Cdd:PHA03247 2669 RLG R AAQAS S PPQRPRRRAARPTV G S ----- L T S LA DPPPPPPTPEPAPHA L VSATPL P PGPAAARQAS P ALPA A PAPPA 2743
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 725 T P M G RDAL G sl S PA LEDGKAAPDE P GSA A LGSVGSSD P ENKDP RP lfcisdttdcs LTLDC SE GTD S R P RGG DP EEGGEG 804
Cdd:PHA03247 2744 V P A G PATP G -- G PA RPARPPTTAG P PAP A PPAAPAAG P PRRLT RP ----------- AVASL SE SRE S L P SPW DP ADPPAA 2810
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 805 DGSMSSGV gemgdsqvss N P TS SP P G EA P A P V S VDSEPSCKGGL P RDKPTKRKDV VAP KRGSLKEASPGASKPGS A RRSQ 884
Cdd:PHA03247 2811 VLAPAAAL ---------- P P AA SP A G PL P P P T S AQPTAPPPPPG P PPPSLPLGGS VAP GGDVRRRPPSRSPAAKP A APAR 2880
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 885 gavaksvrtltasenesmrkv M P ITKSS R G A GW R RP E LSSRG P S Q NPP sstdtvw SR Q NSVRRASTGAEEQRL P RGSSGS 964
Cdd:PHA03247 2881 --------------------- P P VRRLA R P A VS R ST E SFALP P D Q PER ------- PP Q PQAPPPPQPQPQPPP P PQPQPP 2932
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 965 SSTR P GRDV PL Q P R ---- G SFKKPS A K P LRN L PRQK P EENKTC R AHSEG P ESPK E E P KTPSV P SVP H E L P RV P S F A rntv 1040
Cdd:PHA03247 2933 PPPP P RPQP PL A P T tdpa G AGEPSG A V P QPW L GALV P GRVAVP R FRVPQ P APSR E A P ASSTP P LTG H S L S RV S S W A ---- 3008
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1041 A S SSRSMR TD L PPV A kapgitrtv SQRQ L RVKG D P ED A apk D SST L RRAS S A R ---- A PKKR P ESAEG P S A NTEA P l KAR 1116
Cdd:PHA03247 3009 S S LALHEE TD P PPV S --------- LKQT L WPPD D T ED S --- D ADS L FDSD S E R sdle A LDPL P PEPHD P F A HEPD P - ATP 3075
....*..
gi 767932979 1117 G AG E R A S 1123
Cdd:PHA03247 3076 E AG A R E S 3082
PHA03247
PHA03247 large tegument protein UL36; Provisional
812-1142
8.62e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 50.32
E-value: 8.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 812 V GEM GD SQVSSN P TSS PP G ------ EA P A P VSVDS EP SCKGGLPRDK P TKRK D VV AP K R G S LK easpgaskpgsa RR SQ g 885
Cdd:PHA03247 2602 V DDR GD PRGPAP P SPL PP D thapdp PP P S P SPAAN EP DPHPPPTVPP P ERPR D DP AP G R V S RP ------------ RR AR - 2668
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 886 avaksvrtltasenesm R KVMPITK SS RGAGW RR PELS srgpsqnppsst D TV W S RQNSVRRASTGAEEQRL P RGSSGSS 965
Cdd:PHA03247 2669 ----------------- R LGRAAQA SS PPQRP RR RAAR ------------ P TV G S LTSLADPPPPPPTPEPA P HALVSAT 2719
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 966 STR PG rdv P LQP R GSFKKPS A K P lrn L P RQK P EENK T crahs E G PESPKEE P K T PSV P SV P HE l P RV P sfarnt V A SSS R 1045
Cdd:PHA03247 2720 PLP PG --- P AAA R QASPALP A A P --- A P PAV P AGPA T ----- P G GPARPAR P P T TAG P PA P AP - P AA P ------ A A GPP R 2781
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1046 S mrtd L PPV A K A PGITRTV S QRQLRVKG DP ED A APKDSST L RR A S S ARA P KKR P E SA -------- E GP SANTEAPLKARG 1117
Cdd:PHA03247 2782 R ---- L TRP A V A SLSESRE S LPSPWDPA DP PA A VLAPAAA L PP A A S PAG P LPP P T SA qptapppp P GP PPPSLPLGGSVA 2857
330 340
....*....|....*....|....*
gi 767932979 1118 A G er ASL RR KDS SR TTLGRILN P L R 1142
Cdd:PHA03247 2858 P G -- GDV RR RPP SR SPAAKPAA P A R 2880
PTZ00449
PTZ00449 104 kDa microneme/rhoptry antigen; Provisional
809-1138
1.25e-03
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain]
Cd Length: 943
Bit Score: 43.14
E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 809 SSGV GE MG DS QV S SN P TS - SP PGE AP apvsv DS E PSC K G G LPRD - KP T K RK dv VAP K RGSLKEASPGASK P GSARRSQGA 886
Cdd:PTZ00449 528 EGEE GE HE DS KE S DE P KE g GK PGE TK ----- EG E VGK K P G PAKE h KP S K IP -- TLS K KPEFPKDPKHPKD P EEPKKPKRP 600
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 887 VAKSVR T LTA S EN es MRKVMP I T KS SR gagwr RPE l S SRG P s QN PP SST dtvws R QN S VR R A stga E EQRLPRGSSGSS S 966
Cdd:PTZ00449 601 RSAQRP T RPK S PK -- LPELLD I P KS PK ----- RPE - S PKS P - KR PP PPQ ----- R PS S PE R P ---- E GPKIIKSPKPPK S 662
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 967 TR P GR D VPLQPR -- GSFKKPS AK PLRNLPRQKPE E NKTCRAHSEG PE S P KEE -------- PK T P SVPSV P H E LPRV P S fa 1036
Cdd:PTZ00449 663 PK P PF D PKFKEK fy DDYLDAA AK SKETKTTVVLD E SFESILKETL PE T P GTP fttprplp PK L P RDEEF P F E PIGD P D -- 740
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1037 rntv A SSSRSMRTDL PP VAKAPGITR T VSQRQ L R vkg D PEDAAP K DSSTLRRASSARAPK KRP E S aeg PS ANTEA P L --- 1113
Cdd:PTZ00449 741 ---- A EQPDDIEFFT PP EEERTFFHE T PADTP L P --- D ILAEEF K EEDIHAETGEPDEAM KRP D S --- PS EHEDK P P gdh 810
330 340
....*....|....*....|....*....
gi 767932979 1114 ---- K A R GAGERAS L RRK D s SRTTL GRI L 1138
Cdd:PTZ00449 811 pslp K K R HRLDGLA L STT D - LESDA GRI A 838
PRK12323
PRK12323 DNA polymerase III subunit gamma/tau;
923-1134
5.43e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain]
Cd Length: 700
Bit Score: 41.01
E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 923 SSR G PSQN P PSSTDTVWSRQNSVRR A STG A EEQRLPRGSSGSSSTRPGRDVPLQPRGSFKKPS A KPLRNLP RQ KPEENK - 1001
Cdd:PRK12323 366 GQS G GGAG P ATAAAAPVAQPAPAAA A PAA A APAPAAPPAAPAAAPAAAAAARAVAAAPARRSP A PEALAAA RQ ASARGP g 445
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1002 - TCRAHSEGPES P KEEPKTPSVPSV P HELPRVPSF AR NTV A SSSRSMRT D L PP VAKA P GITRTVSQ rqlrvkg DPE DAAP 1080
Cdd:PRK12323 446 g APAPAPAPAAA P AAAARPAAAGPR P VAAAAAAAP AR AAP A AAPAPADD D P PP WEEL P PEFASPAP ------- AQP DAAP 518
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 767932979 1081 K -- DSSTLRRASS A RAPKKRPES A EG P S A n TE AP LK A RGAGERASL R RKDS S RTT L 1134
Cdd:PRK12323 519 A gw VAESIPDPAT A DPDDAFETL A PA P A A - AP AP RA A AATEPVVAP R PPRA S ASG L 573
PHA03247
PHA03247 large tegument protein UL36; Provisional
816-1055
5.47e-03
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 41.08
E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 816 GD SQVSSN P TSSPP G EAP AP VSVDSEP sck G GL P RDKPTKRKDVV AP KR G SLKE A SP GA -- SK P GSARRSQG A V A KSVRT 893
Cdd:PHA03247 250 GD IAAPAP P PVVGE G ADR AP ETARGAT --- G PP P PPEAAAPNGAA AP PD G VWGA A LA GA pl AL P APPDPPPP A P A GDAEE 326
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 894 l TAS E NES M RK V M P ITKSSRGAGWRR P E ls S R G P SQN PPSS TDTVWSRQNSVR RAS TGAEEQ R LP R GSSGSSSTR PG R D V 973
Cdd:PHA03247 327 - EDD E DGA M EV V S P LPRPRQHYPLGF P K -- R R R P TWT PPSS LEDLSAGRHHPK RAS LPTRKR R SA R HAATPFARG PG G D D 403
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 974 pl Q P R GSFKK P SAK P LRNLP ----- RQK P EENKTCR A HSEGPES P KEE P - KT P SV P SVPHELP r V P SF A RNTVASSS R SM 1047
Cdd:PHA03247 404 -- Q T R PAAPV P ASV P TPAPT pvpas APP P PATPLPS A EPGSDDG P APP P e RQ P PA P ATEPAPD - D P DD A TRKALDAL R ER 480
....*...
gi 767932979 1048 R TDL PP V A 1055
Cdd:PHA03247 481 R PPE PP G A 488
PHA03378
PHA03378 EBNA-3B; Provisional
973-1143
8.05e-03
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain]
Cd Length: 991
Bit Score: 40.44
E-value: 8.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 973 V P L QP R gsfkkp SAKPLRN LP R Q KPEENKTCRAHSEG P ES P KEE P KTPSVPSVPHELPRV P SF A RNTV A SSSRSMRTDLP 1052
Cdd:PHA03378 672 I P Y QP S ------ PTGANTM LP I Q WAPGTMQPPPRAPT P MR P PAA P PGRAQRPAAATGRAR P PA A APGR A RPPAAAPGRAR 745
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932979 1053 P V A K APG IT R TVSQRQL R VK gd P ED AAP KDSSTLRRASSAR AP KK RP ES A EG P SANTE A PLKARGAGE RA SLRRKDSSRT 1132
Cdd:PHA03378 746 P P A A APG RA R PPAAAPG R AR -- P PA AAP GAPTPQPPPQAPP AP QQ RP RG A PT P QPPPQ A GPTSMQLMP RA APGQQGPTKQ 823
170
....*....|.
gi 767932979 1133 T L GRI L NPLR K 1143
Cdd:PHA03378 824 I L RQL L TGGV K 834
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
