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Conserved domains on  [gi|767932233|ref|XP_011530379|]
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la-related protein 1B isoform X37 [Homo sapiens]

Protein Classification

LAM and DM15 domain-containing protein( domain architecture ID 10251725)

LAM and DM15 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LAM super family cl02755
LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins ...
 1-47 1.91e-23

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


The actual alignment was detected with superfamily member cd08038:

Pssm-ID: 470666  Cd Length: 73  Bit Score: 94.25  E-value: 1.91e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRK 47
Cdd:cd08038   27 MDLQGFLPISLIAGFYRVQALTTNVDLILEALKDSTEVEIVDQKIRR 73
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 535-573 7.18e-16

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


:

Pssm-ID: 128927  Cd Length: 39  Bit Score: 71.63  E-value: 7.18e-16
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767932233   535 HFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEK 573
Cdd:smart00684   1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 494-534 8.42e-12

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


:

Pssm-ID: 128927  Cd Length: 39  Bit Score: 60.08  E-value: 8.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767932233   494 FTQQVYHKYRRRCLSERKRLGigqSQEMNTLFRFWSFFLRD 534
Cdd:smart00684   2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
 
Name Accession Description Interval E-value
LARP_2 cd08038
La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related ...
 1-47 1.91e-23

La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related protein 2 (LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153407  Cd Length: 73  Bit Score: 94.25  E-value: 1.91e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRK 47
Cdd:cd08038   27 MDLQGFLPISLIAGFYRVQALTTNVDLILEALKDSTEVEIVDQKIRR 73
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 535-573 7.18e-16

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 71.63  E-value: 7.18e-16
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767932233   535 HFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEK 573
Cdd:smart00684   1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
1-48 1.18e-13

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 66.49  E-value: 1.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767932233     1 MDEQ-GFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRKK 48
Cdd:smart00715  30 MDKNdGYVPISTIASFKRVKSLTTDVNLIVEALRSSPKLEVSEDGLKVR 78
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 494-534 8.42e-12

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 60.08  E-value: 8.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767932233   494 FTQQVYHKYRRRCLSERKRLGigqSQEMNTLFRFWSFFLRD 534
Cdd:smart00684   2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 2-34 2.03e-09

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 53.96  E-value: 2.03e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767932233    2 DEQGFLPISLIAGFQRVQALTTNLNLILEALKD 34
Cdd:pfam05383  27 DPDGYVPISVIASFKRMKKLTTDIDLIAEALRE 59
 
Name Accession Description Interval E-value
LARP_2 cd08038
La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related ...
 1-47 1.91e-23

La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related protein 2 (LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153407  Cd Length: 73  Bit Score: 94.25  E-value: 1.91e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRK 47
Cdd:cd08038   27 MDLQGFLPISLIAGFYRVQALTTNVDLILEALKDSTEVEIVDQKIRR 73
LARP_1_2 cd08034
La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in ...
 1-47 1.05e-21

La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in proteins similar to vertebrate La-related proteins 1 and 2 (LARP1, LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153403  Cd Length: 73  Bit Score: 89.41  E-value: 1.05e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRK 47
Cdd:cd08034   27 MDPEGYLPIALIASFHRVQALTTDVNLILEALKDSTVVELVDEKVRC 73
LARP_1 cd08037
La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related ...
 1-47 6.78e-18

La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related protein 1 (LARP1). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153406  Cd Length: 73  Bit Score: 78.41  E-value: 6.78e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRK 47
Cdd:cd08037   27 MDEDGFLPVTLIASFHRVQALTTDISLIIKALKDSKVVEIIDMKIRR 73
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 535-573 7.18e-16

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 71.63  E-value: 7.18e-16
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767932233   535 HFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEK 573
Cdd:smart00684   1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
1-48 1.18e-13

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 66.49  E-value: 1.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767932233     1 MDEQ-GFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRKK 48
Cdd:smart00715  30 MDKNdGYVPISTIASFKRVKSLTTDVNLIVEALRSSPKLEVSEDGLKVR 78
LAM cd07323
LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins ...
 1-44 1.29e-13

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153396  Cd Length: 75  Bit Score: 66.40  E-value: 1.29e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEK 44
Cdd:cd07323   27 MDDDGWVPLSLLASFNRVKKLTTDVELILEALRDSSVVEVSEDG 70
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 494-534 8.42e-12

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 60.08  E-value: 8.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767932233   494 FTQQVYHKYRRRCLSERKRLGigqSQEMNTLFRFWSFFLRD 534
Cdd:smart00684   2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
LARP_4_5_like cd08031
La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found ...
 1-47 1.21e-09

La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found in proteins similar to La-related proteins 4 and 5 (LARP4, LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153400  Cd Length: 75  Bit Score: 55.14  E-value: 1.21e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEiVDEKMRK 47
Cdd:cd08031   27 MDSDQYVPIWTIANFNKIKKLTTDIDLIVEALRESPNVQ-VDEKGEK 72
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 2-34 2.03e-09

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 53.96  E-value: 2.03e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767932233    2 DEQGFLPISLIAGFQRVQALTTNLNLILEALKD 34
Cdd:pfam05383  27 DPDGYVPISVIASFKRMKKLTTDIDLIAEALRE 59
LARP_6 cd08033
La RNA-binding domain of La-related protein 6; This domain is found in animal and plant ...
 2-47 7.17e-06

La RNA-binding domain of La-related protein 6; This domain is found in animal and plant proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153402  Cd Length: 77  Bit Score: 44.58  E-value: 7.17e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 767932233   2 DEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDE--KMRK 47
Cdd:cd08033   30 NKEGYVPIKLIASFKKVKALTRDWRVVAAALRRSSKLVVSEDgkKVRR 77
LARP_7 cd08032
La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key ...
 5-46 2.01e-05

La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key factor in the regulation of RNA polymerase II transcription. 7SK functionality is dependent on the presence of LARP7, which is thought to stabilize the 7SK RNA by interacting with its 3' end. The release of 7SK RNA from P-TEFb/HEXIM/7SK complexes activates the cyclin-dependent kinase P-TEFb, which in turn phosphorylates the C-terminal domain of RNA pol II and mediates a transition into productive transcription elongation.


Pssm-ID: 153401  Cd Length: 82  Bit Score: 43.39  E-value: 2.01e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767932233   5 GFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMR 46
Cdd:cd08032   38 GYIDISLLVSFNKMKKLTTDGKLIARALKNSSVVELNLEGTR 79
LARP_4 cd08035
La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related ...
 1-47 2.82e-05

La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related protein 4 (LARP4), also known as c-MPL binding protein. La-type domains often co-occur with RNA-recognition motifs (RRMs). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153404  Cd Length: 75  Bit Score: 42.73  E-value: 2.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767932233   1 MDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEiVDEKMRK 47
Cdd:cd08035   27 MDSDQFVPIWTVANMEGIKKLTTDMDLILDVLRSSPMVQ-VDETGEK 72
LA_like_fungal cd08029
La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in ...
 2-43 2.04e-03

La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in fungal proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153398  Cd Length: 76  Bit Score: 37.28  E-value: 2.04e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767932233   2 DEQGFLPISLIAGFQRVQALtTNLNLILEALKDSTEVEIVDE 43
Cdd:cd08029   30 SNNGWVPIKTIASFKRMRRF-QPLEAVVEALRESELLEVSED 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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