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Conserved domains on  [gi|767932173|ref|XP_011530355|]
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probable E3 ubiquitin-protein ligase HERC6 isoform X2 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18804227)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 648-990 2.88e-135

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 410.80  E-value: 2.88e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 648 FILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG-SCMWFPAK 726
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 727 PKP---EKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirF 803
Cdd:cd00078   81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELT--F 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 804 SIH-----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG 878
Cdd:cd00078  159 TIEldssfGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 879 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPET-FSERDHPT 957
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVgSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|...
gi 767932173 958 SITCHNILSLPKYSTMERMEEALQVAINNNRGF 990
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGF 351
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-325 3.41e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 229.09  E-value: 3.41e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfvlfpkepiqaLETlIVDlVSCGKEHSLAVCHKG 106
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG------------LSN-VVA-VAAGGDHTCALKADG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 107 RVFAWGAGSEGQLGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQR 186
Cdd:COG5184   68 TVWCWGNNSYGQLGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 187 VR-SLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQ 265
Cdd:COG5184  144 VDaGLSGV--VAIAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAyVHTTGQVVSFG 325
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCA-LKSDGTVWCWG 274
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 648-990 2.88e-135

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 410.80  E-value: 2.88e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 648 FILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG-SCMWFPAK 726
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 727 PKP---EKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirF 803
Cdd:cd00078   81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELT--F 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 804 SIH-----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG 878
Cdd:cd00078  159 TIEldssfGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 879 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPET-FSERDHPT 957
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVgSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|...
gi 767932173 958 SITCHNILSLPKYSTMERMEEALQVAINNNRGF 990
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGF 351
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 702-990 3.69e-78

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 257.54  E-value: 3.69e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  702 EEMTKPEYGMFMYPEMGSC-MWF----PAKPKPEKKRYF-LFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKE 775
Cdd:pfam00632   5 KELFDPNYGLFEYETEDDRtYWFnpssSESPDLELLDYFkFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLES 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  776 LSPRLGKSLQEvLDDAADDIGDALCIRFSI--HWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQR 853
Cdd:pfam00632  85 IDPELYKSLKS-LLNMDNDDDEDLGLTFTIpvFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  854 GFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 933
Cdd:pfam00632 164 GFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLP 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932173  934 ARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 990
Cdd:pfam00632 244 VGGFKSLPKFTIVRKGGDDDDRlPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGF 301
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 675-990 1.77e-74

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 248.30  E-value: 1.77e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   675 KVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYF-LFGMLCGLSLFNLNV 750
Cdd:smart00119   5 RVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSgfaNEEHLSYFrFIGRVLGKALYDNRL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   751 ANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirFSIHwDQND------VDLIPNGISIPVD 824
Cdd:smart00119  85 LDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLLLNNDTSEELDLT--FSIV-LTSEfgqvkvVELKPGGSNIPVT 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   825 QTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTI 904
Cdd:smart00119 162 EENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQTI 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   905 QLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVA 983
Cdd:smart00119 242 KWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSPKFTIRKAGSDDERlPTAHTCFNRLKLPPYSSKEILREKLLLA 321


                   ....*..
gi 767932173   984 INNNRGF 990
Cdd:smart00119 322 INEGKGF 328
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
346-990 4.34e-69

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 248.14  E-value: 4.34e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 346 ISCLISAEDFVDVQVKHifagtyanFVTTHQDTSSTRA----PGKTLPEISR-ISQSMAEKWIAVK-------RRSTEHE 413
Cdd:COG5021  192 VKSRKLAVSNVEKSEPD--------NVLFGLPYRSALTmrtnFLKLDTGNLSgEVQALLARYISIKlvikklyLGPGPDA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 414 MAKSEIRMIFSSPACLTaSFLKKRGTGETT--------------------SIDVDLEMARDTFKKLTKKEWISSMITTCL 473
Cdd:COG5021  264 SSRISTLIIRLSNTNLN-RRLSYILSHSSFedsllrlnslfstradsfgrTYYLDHDRILTQYSRPLLEETLGESTSFLV 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 474 EDDLLRALPCHSPHQEALSvflllPECPVMHD-SKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSL-------NP 545
Cdd:COG5021  343 VNNDDSSSIKDLPHQVGSN-----PFLEAHPEfSELLKNQSRGTTRDFRNKPTGWSSSIEDLGQFLFSDFLtssstyeDL 417

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 546 LIQMLKAAIISQLLHQTKTEQDHCNVKALLGM-----MKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNh 620
Cdd:COG5021  418 RREQLGRESDESFYVASNVQQQRASREGPLLSgwktrLNNLYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDK- 496

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 621 lmSEKKAYMLmhetiLQKKDEFPPspRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCM 700
Cdd:COG5021  497 --RRKLFYSL-----KQKAKIFDP--YLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLL 567

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 701 FEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKEL 776
Cdd:COG5021  568 SKEMFNPDYGLFEYITEDLYTLPINPLssiNPEHLSYFKFlGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESL 647

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 777 SPRLGKSLQEVLDDAADDIGdaLCIRFSI-HWDQND---VDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQ 852
Cdd:COG5021  648 DPELYRSLVWLLNNDIDETI--LDLTFTVeDDSFGEsrtVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFK 725

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 853 RGFYRVCEKEILRHFYPEELMTAIIG-NTDYDWKQFEQNSKYeQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDR 931
Cdd:COG5021  726 SGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAY-HGYTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSR 804

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932173 932 LHARGIQ----KMEIVFRCPETFSERDH--PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 990
Cdd:COG5021  805 IPINGFKdlqgSDGVRKFTIEKGGTDDDrlPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGF 869
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-325 3.41e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 229.09  E-value: 3.41e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfvlfpkepiqaLETlIVDlVSCGKEHSLAVCHKG 106
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG------------LSN-VVA-VAAGGDHTCALKADG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 107 RVFAWGAGSEGQLGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQR 186
Cdd:COG5184   68 TVWCWGNNSYGQLGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 187 VR-SLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQ 265
Cdd:COG5184  144 VDaGLSGV--VAIAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAyVHTTGQVVSFG 325
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCA-LKSDGTVWCWG 274
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
105-155 1.47e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 74.09  E-value: 1.47e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767932173  105 KGRVFAWGAGSEGQLGIGEFKEiSFTPKKIMTLNDIKIIQVSCGHYHSLAL 155
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 648-990 2.88e-135

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 410.80  E-value: 2.88e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 648 FILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG-SCMWFPAK 726
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 727 PKP---EKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirF 803
Cdd:cd00078   81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELT--F 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 804 SIH-----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG 878
Cdd:cd00078  159 TIEldssfGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 879 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPET-FSERDHPT 957
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVgSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|...
gi 767932173 958 SITCHNILSLPKYSTMERMEEALQVAINNNRGF 990
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGF 351
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 702-990 3.69e-78

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 257.54  E-value: 3.69e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  702 EEMTKPEYGMFMYPEMGSC-MWF----PAKPKPEKKRYF-LFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKE 775
Cdd:pfam00632   5 KELFDPNYGLFEYETEDDRtYWFnpssSESPDLELLDYFkFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLES 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  776 LSPRLGKSLQEvLDDAADDIGDALCIRFSI--HWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQR 853
Cdd:pfam00632  85 IDPELYKSLKS-LLNMDNDDDEDLGLTFTIpvFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  854 GFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 933
Cdd:pfam00632 164 GFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLP 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767932173  934 ARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 990
Cdd:pfam00632 244 VGGFKSLPKFTIVRKGGDDDDRlPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGF 301
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 675-990 1.77e-74

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 248.30  E-value: 1.77e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   675 KVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYF-LFGMLCGLSLFNLNV 750
Cdd:smart00119   5 RVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSgfaNEEHLSYFrFIGRVLGKALYDNRL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   751 ANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirFSIHwDQND------VDLIPNGISIPVD 824
Cdd:smart00119  85 LDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLLLNNDTSEELDLT--FSIV-LTSEfgqvkvVELKPGGSNIPVT 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   825 QTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTI 904
Cdd:smart00119 162 EENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQTI 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   905 QLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVA 983
Cdd:smart00119 242 KWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSPKFTIRKAGSDDERlPTAHTCFNRLKLPPYSSKEILREKLLLA 321


                   ....*..
gi 767932173   984 INNNRGF 990
Cdd:smart00119 322 INEGKGF 328
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
346-990 4.34e-69

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 248.14  E-value: 4.34e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 346 ISCLISAEDFVDVQVKHifagtyanFVTTHQDTSSTRA----PGKTLPEISR-ISQSMAEKWIAVK-------RRSTEHE 413
Cdd:COG5021  192 VKSRKLAVSNVEKSEPD--------NVLFGLPYRSALTmrtnFLKLDTGNLSgEVQALLARYISIKlvikklyLGPGPDA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 414 MAKSEIRMIFSSPACLTaSFLKKRGTGETT--------------------SIDVDLEMARDTFKKLTKKEWISSMITTCL 473
Cdd:COG5021  264 SSRISTLIIRLSNTNLN-RRLSYILSHSSFedsllrlnslfstradsfgrTYYLDHDRILTQYSRPLLEETLGESTSFLV 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 474 EDDLLRALPCHSPHQEALSvflllPECPVMHD-SKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSL-------NP 545
Cdd:COG5021  343 VNNDDSSSIKDLPHQVGSN-----PFLEAHPEfSELLKNQSRGTTRDFRNKPTGWSSSIEDLGQFLFSDFLtssstyeDL 417

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 546 LIQMLKAAIISQLLHQTKTEQDHCNVKALLGM-----MKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNh 620
Cdd:COG5021  418 RREQLGRESDESFYVASNVQQQRASREGPLLSgwktrLNNLYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDK- 496

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 621 lmSEKKAYMLmhetiLQKKDEFPPspRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCM 700
Cdd:COG5021  497 --RRKLFYSL-----KQKAKIFDP--YLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLL 567

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 701 FEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKEL 776
Cdd:COG5021  568 SKEMFNPDYGLFEYITEDLYTLPINPLssiNPEHLSYFKFlGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESL 647

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 777 SPRLGKSLQEVLDDAADDIGdaLCIRFSI-HWDQND---VDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQ 852
Cdd:COG5021  648 DPELYRSLVWLLNNDIDETI--LDLTFTVeDDSFGEsrtVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFK 725

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 853 RGFYRVCEKEILRHFYPEELMTAIIG-NTDYDWKQFEQNSKYeQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDR 931
Cdd:COG5021  726 SGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAY-HGYTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSR 804

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767932173 932 LHARGIQ----KMEIVFRCPETFSERDH--PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 990
Cdd:COG5021  805 IPINGFKdlqgSDGVRKFTIEKGGTDDDrlPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGF 869
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-325 3.41e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 229.09  E-value: 3.41e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfvlfpkepiqaLETlIVDlVSCGKEHSLAVCHKG 106
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG------------LSN-VVA-VAAGGDHTCALKADG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 107 RVFAWGAGSEGQLGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQR 186
Cdd:COG5184   68 TVWCWGNNSYGQLGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 187 VR-SLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQ 265
Cdd:COG5184  144 VDaGLSGV--VAIAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAyVHTTGQVVSFG 325
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCA-LKSDGTVWCWG 274
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-327 1.67e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.09  E-value: 1.67e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   3 FCWGADSR-ELQRRRTAGSPGAELL-------QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfv 74
Cdd:COG5184   20 WCWGDNSYgQLGDGTTTDRSTPVRVpglsnvvAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPG--- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  75 lfpkepiqaLETliVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEiSFTPKKImTLNDIKIIQVSCGHYHSLA 154
Cdd:COG5184   97 ---------LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN-RLTPVQV-DAGLSGVVAIAAGGYHTCA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 155 LSKDSQVFSWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPV 234
Cdd:COG5184  164 LKSDGTVWCWGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQL---GDGTTT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 235 QSNKPLSVGALKNlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAy 314
Cdd:COG5184  238 DRATPVQVAGLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG-VVAVAAGSSHTCA- 313

                        330
                 ....*....|...
gi 767932173 315 VHTTGQVVSFGHG 327
Cdd:COG5184  314 LLTDGTVWCWGDN 326
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-292 1.89e-57

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 201.74  E-value: 1.89e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173   3 FCWGADSR------ELQRRRT----AGSPGAEllQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGgc 72
Cdd:COG5184   70 WCWGNNSYgqlgdgTTTDRTTpvkvPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVD-- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173  73 fvlfpkepiQALETlIVDlVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISfTPKKIMTLNDIkiIQVSCGHYHS 152
Cdd:COG5184  146 ---------AGLSG-VVA-IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRP-TPVQVGGLSGV--VAVAAGGDHS 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 153 LALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNV 232
Cdd:COG5184  212 CALKSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGV--VAIAAGGSHTCALKSDGTVWCWGDNSYGQL---GDGT 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 233 PVQSNKPLSVGALKNlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQ 292
Cdd:COG5184  286 TTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-329 5.32e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 157.45  E-value: 5.32e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 143 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSqASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSA 222
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGLSNV--VAVAAGGDHTCALKADGTVWCWGNNSY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932173 223 GQLalsGRNVPVQSNKPLSVGALKNlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVS 302
Cdd:COG5184   78 GQL---GDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSGVV 152

                        170       180
                 ....*....|....*....|....*..
gi 767932173 303 QIDCGSYHTLAyVHTTGQVVSFGHGPS 329
Cdd:COG5184  153 AIAAGGYHTCA-LKSDGTVWCWGANSY 178
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
105-155 1.47e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 74.09  E-value: 1.47e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767932173  105 KGRVFAWGAGSEGQLGIGEFKEiSFTPKKIMTLNDIKIIQVSCGHYHSLAL 155
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
158-208 3.27e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 67.54  E-value: 3.27e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767932173  158 DSQVFSWGKNSHGQLGLGKEFpSQASPQRVRSLEGIPLAQVAAGGAHSFAL 208
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
266-313 2.94e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.37  E-value: 2.94e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767932173  266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLA 313
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNkVVQVACGGDHTVA 49
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
142-171 1.35e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.97  E-value: 1.35e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 767932173  142 IIQVSCGHYHSLALSKDSQVFSWGKNSHGQ 171
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
250-279 7.41e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 52.04  E-value: 7.41e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 767932173  250 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 279
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
215-263 5.12e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.21  E-value: 5.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767932173  215 FGWGSNSAGQLalsGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVL 263
Cdd:pfam00415   5 YTWGRNDYGQL---GLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
27-54 2.48e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 2.48e-05
                          10        20
                  ....*....|....*....|....*...
gi 767932173   27 QAASGERHSLLLLTNHRVLSCGDNSRGQ 54
Cdd:pfam13540   3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
89-118 1.00e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 40.10  E-value: 1.00e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767932173   89 VDLVSCGKEHSLAVCHKGRVFAWGAGSEGQ 118
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
196-224 1.48e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 39.71  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|....*....
gi 767932173  196 AQVAAGGAHSFALSLCGTSFGWGSNSAGQ 224
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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