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Conserved domains on  [gi|767931582|ref|XP_011530120|]
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ELMO domain-containing protein 2 isoform X2 [Homo sapiens]

Protein Classification

ELMO domain-containing protein( domain architecture ID 10520379)

ELMO domain-containing protein acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family

Gene Ontology:  GO:0005096

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 124-257 3.25e-57

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


:

Pssm-ID: 461411  Cd Length: 161  Bit Score: 181.27  E-value: 3.25e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931582  124 VESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQI 203
Cdd:pfam04727   3 LRKRRKTPFDSENPEHERLLKELWKALFPDEPLESRISEKWKRLGFQGEDPATDFRGMGLLGLENLLYFARNHPDSFQKI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767931582  204 LSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFY 257
Cdd:pfam04727  83 LLEQSHRPQRYPFAVASINLTSLLYELLKIGKLDPEENKSYLFFPLLLAFEELY 136
 
Name Accession Description Interval E-value
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 124-257 3.25e-57

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


Pssm-ID: 461411  Cd Length: 161  Bit Score: 181.27  E-value: 3.25e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931582  124 VESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQI 203
Cdd:pfam04727   3 LRKRRKTPFDSENPEHERLLKELWKALFPDEPLESRISEKWKRLGFQGEDPATDFRGMGLLGLENLLYFARNHPDSFQKI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767931582  204 LSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFY 257
Cdd:pfam04727  83 LLEQSHRPQRYPFAVASINLTSLLYELLKIGKLDPEENKSYLFFPLLLAFEELY 136
 
Name Accession Description Interval E-value
ELMO_CED12 pfam04727
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ...
 124-257 3.25e-57

ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.


Pssm-ID: 461411  Cd Length: 161  Bit Score: 181.27  E-value: 3.25e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931582  124 VESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQI 203
Cdd:pfam04727   3 LRKRRKTPFDSENPEHERLLKELWKALFPDEPLESRISEKWKRLGFQGEDPATDFRGMGLLGLENLLYFARNHPDSFQKI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767931582  204 LSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFY 257
Cdd:pfam04727  83 LLEQSHRPQRYPFAVASINLTSLLYELLKIGKLDPEENKSYLFFPLLLAFEELY 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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