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Conserved domains on  [gi|768026667|ref|XP_011528871|]
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GATOR1 complex protein DEPDC5 isoform X16 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEPDC5_CTD pfam19418
DEPDC5 protein C-terminal region; This entry represents the C-terminal domain (CTD) (residues ...
 576-883 0e+00

DEPDC5 protein C-terminal region; This entry represents the C-terminal domain (CTD) (residues 1,291-1,603) of the DEPDC5 protein. It contains two structurally similar lobes and has a pseudo-2-fold rotational symmetry. Each half consists of a five-stranded beta-sheet, with an alpha-helix covering one side. The CTD is located in the core of DEPDC5 and contacts all the other domains of DEPDC5 except the NTD, making it the central organizer of this multi-domain protein.


:

Pssm-ID: 466071  Cd Length: 303  Bit Score: 571.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  576 WHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASyasrhsSFSRSFGGRSQAAALLAATVPEQRTVTLD 655
Cdd:pfam19418   1 WSTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRRHS------SFSRSFGGRSQAAAYLAATVPEQRTVTLD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  656 VDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRA 735
Cdd:pfam19418  75 VDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  736 QLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSK 815
Cdd:pfam19418 155 QLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAILHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSK 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  816 RKFSGQQRRRRNSTsSTNQNMF--CEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDN 883
Cdd:pfam19418 235 RKTSGQQRRRSNSE-EYITRHFsgAEERVGYLWAYNTMLTKRWRTPATGDETFADRLLKDFTDFCANEDN 303
DEP_DEPDC5-like cd04449
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ...
 477-558 5.30e-33

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.


:

Pssm-ID: 239896  Cd Length: 83  Bit Score: 122.00  E-value: 5.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667 477 EILEAMKHPST-GVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGeaWRTFIYGFYF 555
Cdd:cd04449    3 EIAEAMRDPSGiGIFDRSWHKGLPSNCFIGSEAVSWLINNFEDVDTREEAVELGQELMNEGLIEHVSG--RHPFLDGFYF 80


                 ...
gi 768026667 556 YKI 558
Cdd:cd04449   81 YYI 83
 
Name Accession Description Interval E-value
DEPDC5_CTD pfam19418
DEPDC5 protein C-terminal region; This entry represents the C-terminal domain (CTD) (residues ...
 576-883 0e+00

DEPDC5 protein C-terminal region; This entry represents the C-terminal domain (CTD) (residues 1,291-1,603) of the DEPDC5 protein. It contains two structurally similar lobes and has a pseudo-2-fold rotational symmetry. Each half consists of a five-stranded beta-sheet, with an alpha-helix covering one side. The CTD is located in the core of DEPDC5 and contacts all the other domains of DEPDC5 except the NTD, making it the central organizer of this multi-domain protein.


Pssm-ID: 466071  Cd Length: 303  Bit Score: 571.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  576 WHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASyasrhsSFSRSFGGRSQAAALLAATVPEQRTVTLD 655
Cdd:pfam19418   1 WSTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRRHS------SFSRSFGGRSQAAAYLAATVPEQRTVTLD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  656 VDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRA 735
Cdd:pfam19418  75 VDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  736 QLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSK 815
Cdd:pfam19418 155 QLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAILHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSK 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  816 RKFSGQQRRRRNSTsSTNQNMF--CEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDN 883
Cdd:pfam19418 235 RKTSGQQRRRSNSE-EYITRHFsgAEERVGYLWAYNTMLTKRWRTPATGDETFADRLLKDFTDFCANEDN 303
DEP_DEPDC5-like cd04449
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ...
 477-558 5.30e-33

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.


Pssm-ID: 239896  Cd Length: 83  Bit Score: 122.00  E-value: 5.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667 477 EILEAMKHPST-GVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGeaWRTFIYGFYF 555
Cdd:cd04449    3 EIAEAMRDPSGiGIFDRSWHKGLPSNCFIGSEAVSWLINNFEDVDTREEAVELGQELMNEGLIEHVSG--RHPFLDGFYF 80


                 ...
gi 768026667 556 YKI 558
Cdd:cd04449   81 YYI 83
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 485-560 2.31e-15

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 71.55  E-value: 2.31e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768026667   485 PSTGVQLLSEQKGLS--PYCFISAEVVHWLVNHVEgIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVT 560
Cdd:smart00049   1 PETGLKLRDRKYFLKtyPNCFTGSELVDWLMDNLE-IIDREEAVHLGQLLLDEGLIHHVNGPNKHTFKDSKALYRFTT 77
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 488-558 2.05e-12

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 62.99  E-value: 2.05e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768026667  488 GVQLLSEQKGLS--PYCFISAEVVHWLVNHVEgIQTQAMAIDIMQKMLEEQLITHASGEaWRTFIYGFYFYKI 558
Cdd:pfam00610   1 GVKLKDRRKHLKtyPNCFTGSEAVDWLMDNLE-IITREEAVELGQLLLDQGLIHHVGDK-HGLFKDSYYFYRF 71
 
Name Accession Description Interval E-value
DEPDC5_CTD pfam19418
DEPDC5 protein C-terminal region; This entry represents the C-terminal domain (CTD) (residues ...
 576-883 0e+00

DEPDC5 protein C-terminal region; This entry represents the C-terminal domain (CTD) (residues 1,291-1,603) of the DEPDC5 protein. It contains two structurally similar lobes and has a pseudo-2-fold rotational symmetry. Each half consists of a five-stranded beta-sheet, with an alpha-helix covering one side. The CTD is located in the core of DEPDC5 and contacts all the other domains of DEPDC5 except the NTD, making it the central organizer of this multi-domain protein.


Pssm-ID: 466071  Cd Length: 303  Bit Score: 571.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  576 WHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASyasrhsSFSRSFGGRSQAAALLAATVPEQRTVTLD 655
Cdd:pfam19418   1 WSTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRRHS------SFSRSFGGRSQAAAYLAATVPEQRTVTLD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  656 VDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRA 735
Cdd:pfam19418  75 VDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  736 QLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSK 815
Cdd:pfam19418 155 QLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAILHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSK 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667  816 RKFSGQQRRRRNSTsSTNQNMF--CEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDN 883
Cdd:pfam19418 235 RKTSGQQRRRSNSE-EYITRHFsgAEERVGYLWAYNTMLTKRWRTPATGDETFADRLLKDFTDFCANEDN 303
DEP_DEPDC5-like cd04449
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ...
 477-558 5.30e-33

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.


Pssm-ID: 239896  Cd Length: 83  Bit Score: 122.00  E-value: 5.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667 477 EILEAMKHPST-GVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGeaWRTFIYGFYF 555
Cdd:cd04449    3 EIAEAMRDPSGiGIFDRSWHKGLPSNCFIGSEAVSWLINNFEDVDTREEAVELGQELMNEGLIEHVSG--RHPFLDGFYF 80


                 ...
gi 768026667 556 YKI 558
Cdd:cd04449   81 YYI 83
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 485-560 2.31e-15

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 71.55  E-value: 2.31e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768026667   485 PSTGVQLLSEQKGLS--PYCFISAEVVHWLVNHVEgIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVT 560
Cdd:smart00049   1 PETGLKLRDRKYFLKtyPNCFTGSELVDWLMDNLE-IIDREEAVHLGQLLLDEGLIHHVNGPNKHTFKDSKALYRFTT 77
DEP cd04371
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 477-557 1.81e-14

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


Pssm-ID: 239836  Cd Length: 81  Bit Score: 69.29  E-value: 1.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768026667 477 EILEAMKHPSTGVQL--LSEQKGLSPYCFISAEVVHWLVNHVEgIQTQAMAIDIMQKMLEEQLITHASGEAWrTFIYGFY 554
Cdd:cd04371    1 DLVRIMLDSDSGVPIkdRKYHLKTYPNCFTGSELVDWLLDNLE-AITREEAVELGQALLKHGLIHHVSDDKH-TFRDSYA 78


                 ...
gi 768026667 555 FYK 557
Cdd:cd04371   79 LYR 81
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 488-558 2.05e-12

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 62.99  E-value: 2.05e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768026667  488 GVQLLSEQKGLS--PYCFISAEVVHWLVNHVEgIQTQAMAIDIMQKMLEEQLITHASGEaWRTFIYGFYFYKI 558
Cdd:pfam00610   1 GVKLKDRRKHLKtyPNCFTGSEAVDWLMDNLE-IITREEAVELGQLLLDQGLIHHVGDK-HGLFKDSYYFYRF 71
DEP_Epac cd04437
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange ...
 502-570 2.48e-05

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization.


Pssm-ID: 239884  Cd Length: 125  Bit Score: 44.64  E-value: 2.48e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768026667 502 CFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEawRTFIYGFYFYKIVTDkEPDRVAMQ 570
Cdd:cd04437   30 CCVGTELVDWLLQQSPCVQSRSQAVGMWQVLLEEGVLLHVDQE--LHFQDKYQFYRFSDD-ECSPAPLE 95
DEP_1_DEP6 cd04442
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ...
 500-544 2.80e-05

DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.


Pssm-ID: 239889 [Multi-domain]  Cd Length: 82  Bit Score: 43.34  E-value: 2.80e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 768026667 500 PYCFISAEVVHWLVNHVEGiQTQAMAIDIMQKMLEEQLITHASGE 544
Cdd:cd04442   26 PNCFVGKELIDWLIEHKEA-SDRETAIKIMQKLLDHSIIHHVCDE 69
DEP_dishevelled cd04438
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. ...
 500-549 3.65e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway for cellular development and growth. They contain an N-terminal DIX domain, a central PDZ domain, and a C-terminal DEP domain.


Pssm-ID: 239885  Cd Length: 84  Bit Score: 40.02  E-value: 3.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 768026667 500 PYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEawRTF 549
Cdd:cd04438   27 PNSFIGSDLVDWLLSHVEGLTDRREARKYASSLLKLGYIRHTVNK--ITF 74
DEP_PIKfyve cd04448
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange ...
 477-538 9.97e-03

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol phosphate kinase) domain. PIKfyve-like proteins are important phosphatidylinositol (3)-monophosphate (PtdIns(3)P)-5-kinases, producing PtdIns(3,5)P2, which plays a major role in multivesicular body (MVB) sorting and control of retrograde traffic from the vacuole back to the endosome and/or Golgi. PIKfyve itself has been shown to be play a role in regulating early-endosome-to-trans-Golgi network (TGN) retrograde trafficking.


Pssm-ID: 239895  Cd Length: 81  Bit Score: 35.88  E-value: 9.97e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768026667 477 EILEAMKHPSTGVQLLSEQKGLSPY--CFISAEVVHWLVNHvEGIQTQAMAIDIMQKMLEEQLI 538
Cdd:cd04448    1 DLWEKICRSSTGIEFQDHRYRLRTYtnCILGKELVNWLIRQ-GKAATRVQAIAIGQALLDAGWI 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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