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Conserved domains on  [gi|768025310|ref|XP_011528572|]
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coiled-coil domain-containing protein 157 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-373 3.70e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKT 355
Cdd:COG1196  318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAE 397

                         90
                 ....*....|....*...
gi 768025310 356 KMATLERELKQQRESTQA 373
Cdd:COG1196  398 LAAQLEELEEAEEALLER 415
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-373 3.70e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKT 355
Cdd:COG1196  318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAE 397

                         90
                 ....*....|....*...
gi 768025310 356 KMATLERELKQQRESTQA 373
Cdd:COG1196  398 LAAQLEELEEAEEALLER 415
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 275-372 3.11e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.09  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  275 WAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQ---EQGARRRQAEEDEQCLSEWEHDKQQLLTETS 351
Cdd:TIGR04523 308 WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNsesENSEKQRELEEKQNEIEKLKKENQSYKQEIK 387

                          90       100
                  ....*....|....*....|.
gi 768025310  352 DLKTKMATLERELKQQRESTQ 372
Cdd:TIGR04523 388 NLESQINDLESKIQNQEKLNQ 408
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 278-367 1.11e-03

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 39.32  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310   278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAgKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKM 357
Cdd:smart01071  53 YELIMNDHLNKRIDKLLKGLREEELSPETPTYNE-MLAELQDQLKKELEEANGDSEGLLEELKKHRDKLKKEQKELRKKL 131

                           90
                   ....*....|
gi 768025310   358 ATLERELKQQ 367
Cdd:smart01071 132 DELEKEEKKK 141
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 276-390 4.39e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  276 AAEQRKDLtrLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQgaRRRQAEEDEQCLSEWEHDK--QQLLTETSDL 353
Cdd:pfam17380 489 AEEQRRKI--LEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEE--RRREAEEERRKQQEMEERRriQEQMRKATEE 564

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 768025310  354 KTKMATLERElkqqRESTQAVVSAGQAASPAKAAGQP 390
Cdd:pfam17380 565 RSRLEAMERE----REMMRQIVESEKARAEYEATTPI 597
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
278-367 6.50e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.89  E-value: 6.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKleqaLKQEQGARRRQAEEDEqclsewehDKQQLLTETSDLKTKM 357
Cdd:PRK03918 663 ELREEYLELSRELAGLRAELEELEKRREEIKKTLEK----LKEELEEREKAKKELE--------KLEKALERVEELREKV 730

                         90
                 ....*....|
gi 768025310 358 ATLERELKQQ 367
Cdd:PRK03918 731 KKYKALLKER 740
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-373 3.70e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKT 355
Cdd:COG1196  318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAE 397

                         90
                 ....*....|....*...
gi 768025310 356 KMATLERELKQQRESTQA 373
Cdd:COG1196  398 LAAQLEELEEAEEALLER 415
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-387 4.93e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEH---DKQQLLTETSD 352
Cdd:COG1196  241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARleeRRRELEERLEE 320

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 768025310 353 LKTKMATLERELKQQRESTQAVVSAGQAASPAKAA 387
Cdd:COG1196  321 LEEELAELEEELEELEEELEELEEELEEAEEELEE 355
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
253-382 9.46e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.99  E-value: 9.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  253 QFQQLVQDSMGLRPLpAATVGRWAAEQRKDL-----TRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR 327
Cdd:COG4913   263 RYAAARERLAELEYL-RAALRLWFAQRRLELleaelEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLE 341

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 768025310  328 QAEED----EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVVSAGQAAS 382
Cdd:COG4913   342 QLEREierlERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEEL 400
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
282-373 2.71e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.45  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  282 DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTE---TSDLKTKMA 358
Cdd:COG4913   686 DLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEErfaAALGDAVER 765

                          90
                  ....*....|....*
gi 768025310  359 TLERELKQQRESTQA 373
Cdd:COG4913   766 ELRENLEERIDALRA 780
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-377 5.01e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 5.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKT 355
Cdd:COG1196  297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376

                         90       100
                 ....*....|....*....|..
gi 768025310 356 KMATLERELKQQRESTQAVVSA 377
Cdd:COG1196  377 AEEELEELAEELLEALRAAAEL 398
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 272-373 5.74e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 5.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 272 VGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETS 351
Cdd:COG4942  144 LAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223

                         90       100
                 ....*....|....*....|..
gi 768025310 352 DLKTKMATLERELKQQRESTQA 373
Cdd:COG4942  224 ELEALIARLEAEAAAAAERTPA 245
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 274-387 5.81e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 5.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 274 RWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDL 353
Cdd:COG1196  260 AELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL 339

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768025310 354 KTKMATLERELKQQRESTQAVVSAGQAASPAKAA 387
Cdd:COG1196  340 EELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 266-382 1.25e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 266 PLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKqeQGARRRQAEEDEQclsewehdkQQ 345
Cdd:COG4942   12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIA--ALARRIRALEQEL---------AA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768025310 346 LLTETSDLKTKMATLERELKQQRESTQAVVSAGQAAS 382
Cdd:COG4942   81 LEAELAELEKEIAELRAELEAQKEELAELLRALYRLG 117
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 277-382 1.55e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTK 356
Cdd:COG1196  277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEA 356

                         90       100
                 ....*....|....*....|....*.
gi 768025310 357 MATLERELKQQRESTQAVVSAGQAAS 382
Cdd:COG1196  357 EAELAEAEEALLEAEAELAEAEEELE 382
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
278-373 1.88e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAgkleQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKM 357
Cdd:COG4372   84 ELNEQLQAAQAELAQAQEELESLQEEAEELQEEL----EELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQL 159

                         90
                 ....*....|....*.
gi 768025310 358 ATLERELKQQRESTQA 373
Cdd:COG4372  160 ESLQEELAALEQELQA 175
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
276-369 2.92e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQA--EEDEQCLSEWEHDKQQlLTETSDL 353
Cdd:COG4717   83 AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEAleAELAELPERLEELEER-LEELREL 161

                         90
                 ....*....|....*.
gi 768025310 354 KTKMATLERELKQQRE 369
Cdd:COG4717  162 EEELEELEAELAELQE 177
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 275-372 3.11e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.09  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  275 WAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQ---EQGARRRQAEEDEQCLSEWEHDKQQLLTETS 351
Cdd:TIGR04523 308 WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNsesENSEKQRELEEKQNEIEKLKKENQSYKQEIK 387

                          90       100
                  ....*....|....*....|.
gi 768025310  352 DLKTKMATLERELKQQRESTQ 372
Cdd:TIGR04523 388 NLESQINDLESKIQNQEKLNQ 408
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
276-369 4.41e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  276 AAEQRKDLTRLSKHVEALRAQ---LEEAEGQKDGLRKQAGKLEQalkQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSD 352
Cdd:COG4913   230 LVEHFDDLERAHEALEDAREQielLEPIRELAERYAAARERLAE---LEYLRAALRLWFAQRRLELLEAELEELRAELAR 306

                          90
                  ....*....|....*..
gi 768025310  353 LKTKMATLERELKQQRE 369
Cdd:COG4913   307 LEAELERLEARLDALRE 323
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
277-369 5.35e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.15  E-value: 5.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEqclsewehdkqqlltETSDLKTK 356
Cdd:COG2433  409 TEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDR---------------EISRLDRE 473

                         90
                 ....*....|...
gi 768025310 357 MATLERELKQQRE 369
Cdd:COG2433  474 IERLERELEEERE 486
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 286-389 6.50e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 6.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 286 LSKHVEALRAQLEEAEGQKDGLRKQAGKLE---QALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLER 362
Cdd:COG4942  148 RREQAEELRADLAELAALRAELEAERAELEallAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEA 227

                         90       100
                 ....*....|....*....|....*..
gi 768025310 363 ELKQQRESTQAVVSAGQAASPAKAAGQ 389
Cdd:COG4942  228 LIARLEAEAAAAAERTPAAGFAALKGK 254
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 281-381 7.13e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 7.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 281 KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEqgarRRQAEEDEQCLSEWEHDK--QQLLTETSDLKTKMA 358
Cdd:COG1579   31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEV----EARIKKYEEQLGNVRNNKeyEALQKEIESLKRRIS 106

                         90       100
                 ....*....|....*....|....*.
gi 768025310 359 TLE---RELKQQRESTQAVVSAGQAA 381
Cdd:COG1579  107 DLEdeiLELMERIEELEEELAELEAE 132
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
278-369 7.86e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQC-------LSEWEHDKQQLLTET 350
Cdd:COG4717  122 EKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELeelleqlSLATEEELQDLAEEL 201

                         90
                 ....*....|....*....
gi 768025310 351 SDLKTKMATLERELKQQRE 369
Cdd:COG4717  202 EELQQRLAELEEELEEAQE 220
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 278-387 9.52e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310   278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQeqgaRRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKM 357
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQ----LRKELEELSRQISALRKDLARLEAEVEQLEERI 749

                           90       100       110
                   ....*....|....*....|....*....|
gi 768025310   358 ATLERELKQQRESTQAVVSAGQAASPAKAA 387
Cdd:TIGR02168  750 AQLSKELTELEAEIEELEERLEEAEEELAE 779
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 281-393 9.74e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 9.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 281 KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQcLSEWEHDKQQLLTETSDLKTKMATL 360
Cdd:COG4942  136 RRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAA-LEALKAERQKLLARLEKELAELAAE 214

                         90       100       110
                 ....*....|....*....|....*....|...
gi 768025310 361 ERELKQQRESTQAVVSAGQAASPAKAAGQPGPG 393
Cdd:COG4942  215 LAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 278-367 1.11e-03

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 39.32  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310   278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAgKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKM 357
Cdd:smart01071  53 YELIMNDHLNKRIDKLLKGLREEELSPETPTYNE-MLAELQDQLKKELEEANGDSEGLLEELKKHRDKLKKEQKELRKKL 131

                           90
                   ....*....|
gi 768025310   358 ATLERELKQQ 367
Cdd:smart01071 132 DELEKEEKKK 141
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 269-369 1.19e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.09  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  269 AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEgQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLT 348
Cdd:COG3096   493 AWQTARELLRRYRSQQALAQRLQQLRAQLAELE-QRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEE 571

                          90       100
                  ....*....|....*....|.
gi 768025310  349 ETSDLKTKMATLERELKQQRE 369
Cdd:COG3096   572 QAAEAVEQRSELRQQLEQLRA 592
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
267-375 1.19e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 267 LPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKqeqgarrrQAEEDEQcLSEWEHDKQQL 346
Cdd:COG4717  411 LEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELE--------QLEEDGE-LAELLQELEEL 481

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 768025310 347 LTETSDL-----KTKMA--TLERELKQQRESTQAVV 375
Cdd:COG4717  482 KAELRELaeewaALKLAleLLEEAREEYREERLPPV 517
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
290-382 1.64e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.67  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  290 VEALRAQLEEAEGQKDGLRKQAGKLEQ---ALKQEQGARRRQAEEDEQC---------LSEWEHDKQQLLTETSDLktkm 357
Cdd:COG4913   612 LAALEAELAELEEELAEAEERLEALEAeldALQERREALQRLAEYSWDEidvasaereIAELEAELERLDASSDDL---- 687

                          90       100
                  ....*....|....*....|....*
gi 768025310  358 ATLERELKQQRESTQAVVSAGQAAS 382
Cdd:COG4913   688 AALEEQLEELEAELEELEEELDELK 712
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 277-382 2.16e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310   277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEH--------------- 341
Cdd:TIGR02168  687 EELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQlskelteleaeieel 766

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 768025310   342 --DKQQLLTETSDLKTKMATLERELKQQRESTQAVVSAGQAAS 382
Cdd:TIGR02168  767 eeRLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 276-390 4.39e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310  276 AAEQRKDLtrLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQgaRRRQAEEDEQCLSEWEHDK--QQLLTETSDL 353
Cdd:pfam17380 489 AEEQRRKI--LEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEE--RRREAEEERRKQQEMEERRriQEQMRKATEE 564

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 768025310  354 KTKMATLERElkqqRESTQAVVSAGQAASPAKAAGQP 390
Cdd:pfam17380 565 RSRLEAMERE----REMMRQIVESEKARAEYEATTPI 597
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
278-367 6.50e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.89  E-value: 6.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKleqaLKQEQGARRRQAEEDEqclsewehDKQQLLTETSDLKTKM 357
Cdd:PRK03918 663 ELREEYLELSRELAGLRAELEELEKRREEIKKTLEK----LKEELEEREKAKKELE--------KLEKALERVEELREKV 730

                         90
                 ....*....|
gi 768025310 358 ATLERELKQQ 367
Cdd:PRK03918 731 KKYKALLKER 740
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
262-387 6.78e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.34  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 262 MGLRPLPAATVGRWAAEQRKDLTRLSK---HVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSE 338
Cdd:COG4372   16 FGLRPKTGILIAALSEQLRKALFELDKlqeELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAE 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768025310 339 WEHDKQQLLT---ETSDLKTKMATLERE---LKQQRESTQAVVSAGQAASPAKAA 387
Cdd:COG4372   96 LAQAQEELESlqeEAEELQEELEELQKErqdLEQQRKQLEAQIAELQSEIAEREE 150
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
278-370 7.33e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.51  E-value: 7.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEqALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKM 357
Cdd:PRK03918 197 EKEKELEEVLREINEISSELPELREELEKLEKEVKELE-ELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEI 275

                         90
                 ....*....|....*.
gi 768025310 358 ATLE---RELKQQRES 370
Cdd:PRK03918 276 EELEekvKELKELKEK 291
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
277-369 7.46e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.51  E-value: 7.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQeqgaRRRQAEEDEQCLSEWEhDKQQLLTETSDLKTK 356
Cdd:PRK03918 220 REELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELE-EKVKELKELKEKAEE 294

                         90
                 ....*....|...
gi 768025310 357 MATLERELKQQRE 369
Cdd:PRK03918 295 YIKLSEFYEEYLD 307
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
278-377 7.66e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 38.51  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQA--------------EEDEQCLSEWEHDK 343
Cdd:PRK03918 321 EEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEelerlkkrltgltpEKLEKELEELEKAK 400

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768025310 344 QQLLTETSDLKTKMATLERELKQQRESTQAVVSA 377
Cdd:PRK03918 401 EEIEEEISKITARIGELKKEIKELKKAIEELKKA 434
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-381 8.30e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.38  E-value: 8.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQA---EEDEQCLSEWEHDKQQLLTETSD 352
Cdd:COG1196  364 EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLErleEELEELEEALAELEEEEEEEEEA 443

                         90       100
                 ....*....|....*....|....*....
gi 768025310 353 LKTKMATLERELKQQRESTQAVVSAGQAA 381
Cdd:COG1196  444 LEEAAEEEAELEEEEEALLELLAELLEEA 472
bMERB_dom pfam12130
Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact ...
 296-368 8.55e-03

Bivalent Mical/EHBP Rab binding domain; A variety of different effector proteins interact specifically with GTP-bound Rab proteins and mediate their versatile roles in membrane trafficking, including budding of vesicles from a donor membrane, directed transport through the cell and finally tethering and fusion with a target membrane. The 'bivalent Mical/EHBP Rab binding' (bMERB) domain is a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in endosomal trafficking. The bMERB domain displays a preference for Rab8 family proteins (Rab8, 10, 13 and 15) and at least some of the bMERB domains contain two separate binding sites for Rab-proteins, allowing Micals and EHBPs to bind two Rabs simultaneously. The strong similarity between the two binding sites within one bMRB domain strongly suggests an evolutionarily development via duplication of a common ancestor supersecondary structure element. The bMERB domain has a completely alpha-helical fold consisting of a central helix and N- and C-terminal helices folding back on this central helix.


Pssm-ID: 463467 [Multi-domain]  Cd Length: 131  Bit Score: 36.34  E-value: 8.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768025310  296 QLEEAEGQKDGLRKQAGKLEQALKQEQgarrRQAEEDEQCLSEW---EHDKQQLLTETSDLKTKMATLERELKQQR 368
Cdd:pfam12130   1 ELEEIEERQRELEERGVELEKALRGEM----SGDEEEEQLLQEWfklVNEKNALVRRESELMYLAKEQDLEERQAR 72
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-373 9.13e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.38  E-value: 9.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEdeqcLSEWEHDKQQLLTETSDLKT 355
Cdd:COG1196  220 EELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE----LEELELELEEAQAEEYELLA 295

                         90
                 ....*....|....*...
gi 768025310 356 KMATLERELKQQRESTQA 373
Cdd:COG1196  296 ELARLEQDIARLEERRRE 313
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 276-381 9.87e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.99  E-value: 9.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025310 276 AAEQRkdLTRlskhVEALRAQLEeaeGQKDGLRKQAGKLEQALKQEQGARRRQAE----EDEQCLSEWEHDKQQLLTETS 351
Cdd:COG1196  183 ATEEN--LER----LEDILGELE---RQLEPLERQAEKAERYRELKEELKELEAEllllKLRELEAELEELEAELEELEA 253

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 768025310 352 DLKTKMATLE------RELKQQRESTQAVVSAGQAA 381
Cdd:COG1196  254 ELEELEAELAeleaelEELRLELEELELELEEAQAE 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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