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Conserved domains on  [gi|768025306|ref|XP_011528571|]
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coiled-coil domain-containing protein 157 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-166 2.38e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 2.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   2 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQqvcwastELDKEKARV 81
Cdd:COG1196  253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE-------RLEELEEEL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  82 DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:COG1196  326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405


                 ....*
gi 768025306 162 TTDLR 166
Cdd:COG1196  406 EEAEE 410
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 281-402 3.10e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  281 SSKGTQGATPPVQAKSTSPgPLGRQHLPSSRTGRTLLGQPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQP-SKS 359
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQP 2941

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 768025306  360 LLEGVTHLDTCTQNPIKVLVRLRKRLSPGRGQASSAHQPQERP 402
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-166 2.38e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 2.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   2 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQqvcwastELDKEKARV 81
Cdd:COG1196  253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE-------RLEELEEEL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  82 DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:COG1196  326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405


                 ....*
gi 768025306 162 TTDLR 166
Cdd:COG1196  406 EEAEE 410
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1-148 6.32e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.60  E-value: 6.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     1 MATLERELKQQRESTQAVEAKAQQLQEEG-----------ERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCW 69
Cdd:TIGR02168  791 IEQLKEELKALREALDELRAELTLLNEEAanlrerlesleRRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    70 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE---EQLQSEREQGQCQLRAQQE 146
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrlEGLEVRIDNLQERLSEEYS 950


                   ..
gi 768025306   147 LL 148
Cdd:TIGR02168  951 LT 952
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 89-168 2.86e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 43.02  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   89 ESLQAKQRALLKQLDSLDQEREELRgSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS---------LQREKQGLE 159
Cdd:PRK11448  145 HALQQEVLTLKQQLELQAREKAQSQ-ALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEkaaetsqerKQKRKEITD 223


                  ....*....
gi 768025306  160 QATTDLRLT 168
Cdd:PRK11448  224 QAAKRLELS 232
PHA03247 PHA03247
large tegument protein UL36; Provisional
 281-402 3.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  281 SSKGTQGATPPVQAKSTSPgPLGRQHLPSSRTGRTLLGQPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQP-SKS 359
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQP 2941

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 768025306  360 LLEGVTHLDTCTQNPIKVLVRLRKRLSPGRGQASSAHQPQERP 402
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
TelA pfam05816
Toxic anion resistance protein (TelA); This family consists of several prokaryotic TelA like ...
 70-168 6.00e-04

Toxic anion resistance protein (TelA); This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance and plasmid fertility inhibition.


Pssm-ID: 461748  Cd Length: 330  Bit Score: 41.35  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   70 ASTELDKEKARVDSMVRH----QESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQ-----------RARVEEQLQSER 134
Cdd:pfam05816  79 AGNKIEKYFAKYQTAGAQidkiVVELEKGQDELLKDNAMLDQMYEKNLEYFKELEKYiaagelkleelDAELLPELEAKA 158

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768025306  135 EQGQCQLRAQ--QELLQSLQRekqgLEQATTDLRLT 168
Cdd:pfam05816 159 AASGDPEDAQalRDLRQALFR----LEQRIHDLELQ 190
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 72-166 5.21e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.46  E-value: 5.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    72 TELDKEKARVDSMVrhqESLQAKQRALLKQLDSLDQEREELRgSLDEAEAQRARveEQLQSEREQGQCQLRAQQELlqsl 151
Cdd:smart00787 161 KLLMKELELLNSIK---PKLRDRKDALEEELRQLKQLEDELE-DCDPTELDRAK--EKLKKLLQEIMIKVKKLEEL---- 230

                           90
                   ....*....|....*
gi 768025306   152 QREKQGLEQATTDLR 166
Cdd:smart00787 231 EEELQELESKIEDLT 245
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 319-353 8.66e-03

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 36.57  E-value: 8.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 768025306  319 QPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPC 353
Cdd:pfam02389   7 QPCQPPPQEPCVPTTKEPCHSKVPEPCNPKVPEPC 41
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-166 2.38e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 2.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   2 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQqvcwastELDKEKARV 81
Cdd:COG1196  253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE-------RLEELEEEL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  82 DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:COG1196  326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405


                 ....*
gi 768025306 162 TTDLR 166
Cdd:COG1196  406 EEAEE 410
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-161 2.49e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   4 LERELKQQRES--TQAVEA-KAQQLQEEGERRAAAERQVQ--QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEK 78
Cdd:COG1196  194 ILGELERQLEPleRQAEKAeRYRELKEELKELEAELLLLKlrELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  79 ARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGL 158
Cdd:COG1196  274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353


                 ...
gi 768025306 159 EQA 161
Cdd:COG1196  354 EEA 356
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-166 4.79e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.33  E-value: 4.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   2 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARV 81
Cdd:COG1196  295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  82 DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454


                 ....*
gi 768025306 162 TTDLR 166
Cdd:COG1196  455 EEEEE 459
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 5-161 8.82e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 8.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   5 ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSM 84
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768025306  85 VRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:COG1196  301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1-148 6.32e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.60  E-value: 6.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     1 MATLERELKQQRESTQAVEAKAQQLQEEG-----------ERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCW 69
Cdd:TIGR02168  791 IEQLKEELKALREALDELRAELTLLNEEAanlrerlesleRRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    70 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE---EQLQSEREQGQCQLRAQQE 146
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrlEGLEVRIDNLQERLSEEYS 950


                   ..
gi 768025306   147 LL 148
Cdd:TIGR02168  951 LT 952
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
6-176 6.57e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.45  E-value: 6.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    6 RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLeaQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMV 85
Cdd:COG4913   245 EDAREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQR--RLELLEAELEELRAELARLEAELERLEARLDALR 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   86 RHQESLQAKQRAL-LKQLDSLDQEREELRGSLDEAEAQRARVEEQLQS-------EREQGQCQLRAQQELLQSLQREKQG 157
Cdd:COG4913   323 EELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAAlglplpaSAEEFAALRAEAAALLEALEEELEA 402

                         170
                  ....*....|....*....
gi 768025306  158 LEQATTDLRLTILELEREL 176
Cdd:COG4913   403 LEEALAEAEAALRDLRREL 421
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1-166 7.39e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.60  E-value: 7.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     1 MATLERELKQQRESTQAVEAKAQQLQEEGERRAAaerqvqqleeqvqqleaQVQLLVGRLEGAGQQVCWASTELDKEKAR 80
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEE-----------------ELEQLRKELEELSRQISALRKDLARLEAE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    81 VDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE---EQLQSEREQGQCQLRAQQELLQSLQREKQG 157
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEaqiEQLKEELKALREALDELRAELTLLNEEAAN 821


                   ....*....
gi 768025306   158 LEQATTDLR 166
Cdd:TIGR02168  822 LRERLESLE 830
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-161 1.64e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 1.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     2 ATLERELKQQRESTQAVEAKAQQLQE--EGERRAAAERQVQQLEEQVQQLEAQVQL--LVGRLEGAGQQVCWASTELDKE 77
Cdd:TIGR02168  326 EELESKLDELAEELAELEEKLEELKEelESLEAELEELEAELEELESRLEELEEQLetLRSKVAQLELQIASLNNEIERL 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    78 KARVDSMVRHQESLQAKQRALLKQLDSLDQER-----EELRGSLDEAEAQRARVEEQLQSEREQ-------------GQC 139
Cdd:TIGR02168  406 EARLERLEDRRERLQQEIEELLKKLEEAELKElqaelEELEEELEELQEELERLEEALEELREEleeaeqaldaaerELA 485

                          170       180
                   ....*....|....*....|..
gi 768025306   140 QLRAQQELLQSLQREKQGLEQA 161
Cdd:TIGR02168  486 QLQARLDSLERLQENLEGFSEG 507
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-166 4.74e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 4.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     2 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARV 81
Cdd:TIGR02168  740 AEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA 819

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    82 DSMVRHQESLQAKQRALLKQLDSLDQEREELR-------GSLDEAEAQRARVEEQLQS---EREQGQCQLRAQQELLQSL 151
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELSedieslaAEIEELEELIEELESELEAllnERASLEEALALLRSELEEL 899

                          170
                   ....*....|....*
gi 768025306   152 QREKQGLEQATTDLR 166
Cdd:TIGR02168  900 SEELRELESKRSELR 914
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2-166 5.10e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 5.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   2 ATLERELKQQRESTQAVEAKAQQLQEE----GERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKE 77
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEekalLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  78 KARVDSMVR---------------HQES----------LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEE---Q 129
Cdd:COG4942  103 KEELAELLRalyrlgrqpplalllSPEDfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELEAllaE 182

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 768025306 130 LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLR 166
Cdd:COG4942  183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2-169 5.11e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.76  E-value: 5.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    2 ATLERELKQQRESTQAVEAKAQQLQEEG----ERRAAAERQVQQLEEQVQQLEAQVQLL-----VGRLEGAGQQVCWAST 72
Cdd:COG4913   613 AALEAELAELEEELAEAEERLEALEAELdalqERREALQRLAEYSWDEIDVASAEREIAeleaeLERLDASSDDLAALEE 692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   73 ELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAE-----AQRARVEEQLQSEREQGQcQLRAQQEL 147
Cdd:COG4913   693 QLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEdlarlELRALLEERFAAALGDAV-ERELRENL 771

                         170       180
                  ....*....|....*....|..
gi 768025306  148 LQSLQREKQGLEQATTDLRLTI 169
Cdd:COG4913   772 EERIDALRARLNRAEEELERAM 793
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
6-166 5.90e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.23  E-value: 5.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   6 RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLL--VGRLEGAGQQVCWASTELDKEKARVDS 83
Cdd:COG4717   71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekLLQLLPLYQELEALEAELAELPERLEE 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  84 MVRHQESLQAKQRallkQLDSLDQEREELRGSLDEAEAQ-RARVEEQLQS---EREQGQCQLRAQQELLQSLQREKQGLE 159
Cdd:COG4717  151 LEERLEELRELEE----ELEELEAELAELQEELEELLEQlSLATEEELQDlaeELEELQQRLAELEEELEEAQEELEELE 226


                 ....*..
gi 768025306 160 QATTDLR 166
Cdd:COG4717  227 EELEQLE 233
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-174 8.10e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.14  E-value: 8.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     2 ATLERELKQQRESTQA----VEAKAQQLQEEGER-RAAAERQVQQLEEQVQQLEAQVQLLVG-------RLEGAGQQVCW 69
Cdd:TIGR02169  247 ASLEEELEKLTEEISElekrLEEIEQLLEELNKKiKDLGEEEQLRVKEKIGELEAEIASLERsiaekerELEDAEERLAK 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    70 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDE--AEAQRARVE--------EQLQSEREQGQC 139
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEvdKEFAETRDElkdyreklEKLKREINELKR 406

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 768025306   140 QLRAQQELLQSLQREKQGLEQATTDLRLTILELER 174
Cdd:TIGR02169  407 ELDRLQEELQRLSEELADLNAAIAGIEAKINELEE 441
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
15-166 1.16e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   15 TQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWAST-----ELDKEKARVDSMVRHQE 89
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAereiaELEAELERLDASSDDLA 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   90 SLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ-GQCQLRAQQELLQSL--QREKQGLEQATTDLR 166
Cdd:COG4913   689 ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRlEAAEDLARLELRALLeeRFAAALGDAVERELR 768
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 6-166 1.34e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     6 RELKQQRESTQAVEAKAQQLQEEGERRAAaerqvqqleeqvqQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMV 85
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQ-------------ELEEKLEELRLEVSELEEEIEELQKELYALANEISRLE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    86 RHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREqgqcQLRAQQELLQSLQREKQGLEQATTDL 165
Cdd:TIGR02168  302 QQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKE----ELESLEAELEELEAELEELESRLEEL 377


                   .
gi 768025306   166 R 166
Cdd:TIGR02168  378 E 378
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 13-164 1.62e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    13 ESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ 92
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELE 371

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768025306    93 AKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE---EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTD 164
Cdd:TIGR02168  372 SRLEELEEQLETLRSKVAQLELQIASLNNEIERLEarlERLEDRRERLQQEIEELLKKLEEAELKELQAELEELE 446
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1-161 3.02e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.91  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   1 MATLERELKQQRESTQAVEAKAQQLQEE-GERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVcwastelDKEKA 79
Cdd:COG4942   78 LAALEAELAELEKEIAELRAELEAQKEElAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLA-------PARRE 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  80 RVDSMVRHQESLQAKQRALLKQLDSLD---QEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQ 156
Cdd:COG4942  151 QAEELRADLAELAALRAELEAERAELEallAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230


                 ....*
gi 768025306 157 GLEQA 161
Cdd:COG4942  231 RLEAE 235
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-177 4.59e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 4.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     2 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARV 81
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    82 DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQS---EREQGQCQLRAQQELLQSLQREKQGL 158
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAllnERASLEEALALLRSELEELSEELREL 906

                          170
                   ....*....|....*....
gi 768025306   159 EQATTDLRLTILELERELE 177
Cdd:TIGR02168  907 ESKRSELRRELEELREKLA 925
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 76-176 4.71e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 4.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    76 KEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE---EQLQSEREQGQCQLRAQQELLQSLQ 152
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEkeiEQLEQEEEKLKERLEELEEDLSSLE 750

                           90       100
                   ....*....|....*....|....
gi 768025306   153 REKQGLEQATTDLRLTILELEREL 176
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDL 774
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-162 1.08e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     2 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARV 81
Cdd:TIGR02168  698 KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    82 DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESL 857


                   .
gi 768025306   162 T 162
Cdd:TIGR02168  858 A 858
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 89-168 2.86e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 43.02  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   89 ESLQAKQRALLKQLDSLDQEREELRgSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS---------LQREKQGLE 159
Cdd:PRK11448  145 HALQQEVLTLKQQLELQAREKAQSQ-ALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEkaaetsqerKQKRKEITD 223


                  ....*....
gi 768025306  160 QATTDLRLT 168
Cdd:PRK11448  224 QAAKRLELS 232
PHA03247 PHA03247
large tegument protein UL36; Provisional
 281-402 3.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  281 SSKGTQGATPPVQAKSTSPgPLGRQHLPSSRTGRTLLGQPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQP-SKS 359
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQP 2941

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 768025306  360 LLEGVTHLDTCTQNPIKVLVRLRKRLSPGRGQASSAHQPQERP 402
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
4-165 4.23e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 4.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   4 LERELKQQRESTQAVEAKAQQLQEEgerraaaerqvqqleEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDS 83
Cdd:COG3206  180 LEEQLPELRKELEEAEAALEEFRQK---------------NGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAA 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  84 MVRHQESLQAKQ---------RALLKQLDSLDQEREELRGSLDE-------AEAQRARVEEQLQSEREQGQCQLRAQQEL 147
Cdd:COG3206  245 LRAQLGSGPDALpellqspviQQLRAQLAELEAELAELSARYTPnhpdviaLRAQIAALRAQLQQEAQRILASLEAELEA 324

                        170       180
                 ....*....|....*....|..
gi 768025306 148 LQ----SLQREKQGLEQATTDL 165
Cdd:COG3206  325 LQareaSLQAQLAQLEARLAEL 346
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 4-166 5.69e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 5.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     4 LERELKQQRESTQAVEAKAQQLQEegeRRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG-------QQVCWASTELDK 76
Cdd:TIGR02168  724 LSRQISALRKDLARLEAEVEQLEE---RIAQLSKELTELEAEIEELEERLEEAEEELAEAEaeieeleAQIEQLKEELKA 800

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    77 EKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQS---EREQGQCQLRAQQELLQSLQR 153
Cdd:TIGR02168  801 LREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaEIEELEELIEELESELEALLN 880

                          170
                   ....*....|...
gi 768025306   154 EKQGLEQATTDLR 166
Cdd:TIGR02168  881 ERASLEEALALLR 893
TelA pfam05816
Toxic anion resistance protein (TelA); This family consists of several prokaryotic TelA like ...
 70-168 6.00e-04

Toxic anion resistance protein (TelA); This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance and plasmid fertility inhibition.


Pssm-ID: 461748  Cd Length: 330  Bit Score: 41.35  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   70 ASTELDKEKARVDSMVRH----QESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQ-----------RARVEEQLQSER 134
Cdd:pfam05816  79 AGNKIEKYFAKYQTAGAQidkiVVELEKGQDELLKDNAMLDQMYEKNLEYFKELEKYiaagelkleelDAELLPELEAKA 158

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768025306  135 EQGQCQLRAQ--QELLQSLQRekqgLEQATTDLRLT 168
Cdd:pfam05816 159 AASGDPEDAQalRDLRQALFR----LEQRIHDLELQ 190
Filament pfam00038
Intermediate filament protein;
86-148 9.47e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 40.67  E-value: 9.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768025306   86 RHQ-ESLQAKQRALLKQLDSLDQEREEL--RGSLDEAEAQR--ARVEEQLQSEREQGQCQLRAQQELL 148
Cdd:pfam00038 223 RRTiQSLEIELQSLKKQKASLERQLAETeeRYELQLADYQEliSELEAELQETRQEMARQLREYQELL 290
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1-154 9.70e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 9.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   1 MATLERELK-QQRESTQAVEAKAQQLQEEGERRAAAERqvqqlEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKE-- 77
Cdd:COG4717  356 AEELEEELQlEELEQEIAALLAEAGVEDEEELRAALEQ-----AEEYQELKEELEELEEQLEELLGELEELLEALDEEel 430

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768025306  78 KARVDSMVRHQESLQAKQRALLKQLDSLDQEREELR--GSLDEAEAQRARVEEQLQSEREQGQcQLRAQQELLQSLQRE 154
Cdd:COG4717  431 EEELEELEEELEELEEELEELREELAELEAELEQLEedGELAELLQELEELKAELRELAEEWA-ALKLALELLEEAREE 508
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-166 1.06e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     2 ATLERELKQQRESTQAVEAKAQQLQEE-GERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGagqqvcwastELDKEKAR 80
Cdd:TIGR02169  240 EAIERQLASLEEELEKLTEEISELEKRlEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEA----------EIASLERS 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    81 VDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREqgqcQLRAQQELLQSLQREKQGLEQ 160
Cdd:TIGR02169  310 IAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKE----ELEDLRAELEEVDKEFAETRD 385


                   ....*.
gi 768025306   161 ATTDLR 166
Cdd:TIGR02169  386 ELKDYR 391
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
48-166 1.23e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  48 QLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE 127
Cdd:COG4372   49 QLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLE 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 768025306 128 EQ---LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLR 166
Cdd:COG4372  129 QQrkqLEAQIAELQSEIAEREEELKELEEQLESLQEELAALE 170
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3-161 1.25e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   3 TLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVD 82
Cdd:COG4372   32 QLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  83 SMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ-GQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:COG4372  112 ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEElAALEQELQALSEAEAEQALDELLKE 191
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 4-169 3.64e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.67  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     4 LERELKQQRESTQAVEAKAQQLQEE-GERRAAAE----RQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEK 78
Cdd:TIGR02169  749 LEQEIENVKSELKELEARIEELEEDlHKLEEALNdleaRLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEK 828

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    79 ARVDSMVRHqesLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE----------EQLQSEREQGQCQLRAQQELL 148
Cdd:TIGR02169  829 EYLEKEIQE---LQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEaalrdlesrlGDLKKERDELEAQLRELERKI 905

                          170       180
                   ....*....|....*....|.
gi 768025306   149 QSLQREKQGLEQATTDLRLTI 169
Cdd:TIGR02169  906 EELEAQIEKKRKRLSELKAKL 926
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 72-166 5.21e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 38.46  E-value: 5.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    72 TELDKEKARVDSMVrhqESLQAKQRALLKQLDSLDQEREELRgSLDEAEAQRARveEQLQSEREQGQCQLRAQQELlqsl 151
Cdd:smart00787 161 KLLMKELELLNSIK---PKLRDRKDALEEELRQLKQLEDELE-DCDPTELDRAK--EKLKKLLQEIMIKVKKLEEL---- 230

                           90
                   ....*....|....*
gi 768025306   152 QREKQGLEQATTDLR 166
Cdd:smart00787 231 EEELQELESKIEDLT 245
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
17-169 5.91e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306   17 AVEAKAQQLQEEGERRAAAERQVQQLEEQvQQLEAQVQLLVGRLEGAGQQVcwasTELDKEKARVDSMVRHQES--LQAK 94
Cdd:COG4913   222 DTFEAADALVEHFDDLERAHEALEDAREQ-IELLEPIRELAERYAAARERL----AELEYLRAALRLWFAQRRLelLEAE 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768025306   95 QRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQS----EREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTI 169
Cdd:COG4913   297 LEELRAELARLEAELERLEARLDALREELDELEAQIRGnggdRLEQLEREIERLERELEERERRRARLEALLAALGLPL 375
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 88-160 6.37e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 36.79  E-value: 6.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768025306   88 QESLQAKQRALLKQLDS----LDQEREELRGSLDEAEAQRARVEEQLQSEREQGQcqlRAQQELLQSLQREKQGLEQ 160
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAkqkeLQKLYEELQKDGALLEEEREEKEQELQKKEQELQ---QLQQKAQQELQKKQQELLQ 94
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 4-169 6.48e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.90  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306     4 LERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEG--AGQQVCWASTELDKEKARV 81
Cdd:TIGR02169  728 LEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEArlSHSRIPEIQAELSKLEEEV 807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306    82 DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLqserEQGQCQLRAQQELLQSLQREKQGLEQA 161
Cdd:TIGR02169  808 SRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEI----ENLNGKKEELEEELEELEAALRDLESR 883


                   ....*...
gi 768025306   162 TTDLRLTI 169
Cdd:TIGR02169  884 LGDLKKER 891
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 319-353 8.66e-03

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 36.57  E-value: 8.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 768025306  319 QPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPC 353
Cdd:pfam02389   7 QPCQPPPQEPCVPTTKEPCHSKVPEPCNPKVPEPC 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 275-402 9.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 9.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768025306  275 DRLWSPSSKGTQGATPPVQAKSTSPGPLgrqhlPSSRTGRTLlGQPCTSPPRQPCTSPPrQPCTSPPRQPCTSPSRQPcS 354
Cdd:PHA03247 2565 DRSVPPPRPAPRPSEPAVTSRARRPDAP-----PQSARPRAP-VDDRGDPRGPAPPSPL-PPDTHAPDPPPPSPSPAA-N 2636

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 768025306  355 QPSKSLLEGVTHLDTCTQNPIKVLVRLRKRLSpGRGQASSAHQPQERP 402
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRP 2683
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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