BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208   6 VLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVA 85
Cdd:cd18211    1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 768014208  86 DFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208   6 VLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVA 85
Cdd:cd18211    1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 768014208  86 DFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208    32 DVTVSVEYqgvrKDFMAHKAVLAATSKFFKEVFLNEKSVDGTrTNVYLNEVQVADFASFLEFVYTAKVQVEEDRVQRMLE 111
Cdd:smart00225   1 DVTLVVGG----KKFHAHKAVLAAHSPYFKALFSSDFKESDK-SEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 768014208   112 VAEKLKCLDLSETCFQLKKQML 133
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 768014208  449 ALKTHMRIHTGEKPFVCDECGARFTQ 474
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208   6 VLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVA 85
Cdd:cd18211    1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 768014208  86 DFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  30 LCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTnVYLNEVQVADFASFLEFVYTAKVQVEEDRVQRM 109
Cdd:cd18186    1 LCDVTLVVG----GREFPAHRAVLAARSPYFRAMFSSGMKESSSSE-IELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

                 ....*..
gi 768014208 110 LEVAEKL 116
Cdd:cd18186   76 LAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEyqGVrkDFMAHKAVLAATSKFFKEVFLNEKSVdgtrtnVYLNEVQVADFASFLEFVYT 96
Cdd:cd18206    9 VLEQLNQQRQLGLLCDCTFVVD--GV--DFKAHKAVLAACSEYFRMLFVDQKDV------VHLDISNAAGLGQVLEFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 768014208  97 AKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLK 129
Cdd:cd18206   79 AKLSLSPENVDDVLAVATFLQMQDIVTACHALK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  21 MHELRLLGHLCDVTVSVEYQGVRKDFMAHKAVLAATSKFFKEVFLN-----EKSVdgtrtnVYLNEVQVADFASFLEFVY 95
Cdd:cd18248   12 MNELRLSQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSglrecGMEV------VPIEGVHPCVMSRLIEFAY 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768014208  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLE 134
Cdd:cd18248   86 TASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSV-DGTRTNVYLNEVQVADFASFLEFVY 95
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVG----GEEIPVQKNVLAAASPYFRAKLNYNPPKdDGSTYKIELEGISVEVMEEILDYIY 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 768014208  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18245   77 TGQIKLSEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208   9 ESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEksVDGTRTNVYLNEVQVADFA 88
Cdd:cd18277    6 ESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQ----RFRAHRSVLAACSSYFHSRIVGQ--ADAELNITLPEEVTVKGFE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768014208  89 SFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQL 128
Cdd:cd18277   80 PLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQF 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  30 LCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDgtrTNVYL-NEVQVADFASFLEFVYTAKVQVEEDRVQR 108
Cdd:cd18955    1 LCDVTIVVE----DQRFRAHRAVLAACSDYFLSRVVGQTDGD---LVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLE 73

                         90
                 ....*....|....*....
gi 768014208 109 MLEVAEKLKCLDLSETCFQ 127
Cdd:cd18955   74 VCRCAEFLGVHNIEKACFD 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  12 SSPFNLLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVF---LNEKSVDgtrtNVYLNEVQVADFA 88
Cdd:cd18250    3 AHALHLLRGLSELRAERKFFDVTLCAG----GREFPCHRTVLAAASSYFRAMFageLRESRAD----RVVLHGVSAEILG 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 768014208  89 SFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLE 134
Cdd:cd18250   75 LLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEKSVDGtrTNVY-LNEVQVADFASFLEFVY 95
Cdd:cd18198   12 ILSGLNEQRTQGLLCDVVILVQGR----EYRTHRSVLAACSQYFKKLFTSGAVVDQ--QNVYeIDFVSPEALTALLEFAY 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 768014208  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQL 128
Cdd:cd18198   86 TATLTVSTANVGDILSAARLLEIPCVSHVCAEI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  16 NLLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTnVYLNEVQVADFASFLEFVY 95
Cdd:cd18306    4 SVLAKLNALRKNRQFCDVILQVGGH----EIPAHRAVLACASPYLFELFSSDSDGESILT-VKLDGLDPDAVEVLVNYAY 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 768014208  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18306   79 TSRLEVPADLVKSVYSAAKKLKMDRVKKAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVeyQGVRkdFMAHKAVLAATSKFFKEVFLNEKsvdGTRTNVYLNEVQ-VADFASFLEFVY 95
Cdd:cd18233    5 LLQQLHEQRIQGLLCDCMLVV--KGVC--FKAHKNVLAAFSQYFRSLFQNSS---SQKNDVFHLDIKnVGGIGQILDFMY 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 768014208  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKK 130
Cdd:cd18233   78 TSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  16 NLLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVADFASFLEFVY 95
Cdd:cd18230    7 HLLRELNEQRQHGILCDVCIIVE----GKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768014208  96 TAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLE 134
Cdd:cd18230   83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALD 121

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208 405 ERHRCGQCGKGLSSKTALRLHERTHTG-DRPYGCTECGARFSQPSALKTHMR--IHTGE--KPFVCDE--CGARFTQNHM 477
Cdd:COG5048  259 ESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDA 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208 478 LIYHKRCHTGERPFMC--ETCGKSFASK------EYLKHHNRIHTgSKPFKCEV--CFRTFAQRNSLYQHIKVHTGERPY 547
Cdd:COG5048  339 LKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPY 417

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 768014208 548 CCD--QCGKQFTQLNALQRHRRIHTGERPFMCNACGRTFTDKSTLRRH 593
Cdd:COG5048  418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEYQGvrkdFMAHKAVLAATSKFFKEVFlneksVDGTR----TNVYLNEVQVADFASFLE 92
Cdd:cd18255    5 LLQGLNALRAKGQLLDVTLIADGQR----FQAHKVVLASCSDYFRAMF-----TGGMRessqDEIELKGVSAKGLKHILD 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 768014208  93 FVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQ-LKKQM 132
Cdd:cd18255   76 FAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEfLKSAM 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208   3 SGAVLLESKSSPFNLLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFlNEKSVDGTRTNVYLNEV 82
Cdd:cd18261    1 TGQRLCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQ----KFHAHKAVLAACSDYFRAMF-SLCMVESEADEVNLHGV 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768014208  83 QVADFASFLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQMLES 135
Cdd:cd18261   76 TSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNS 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVeyqGVRKdFMAHKAVLAATSKFFKEVF---LNEKSvdgtRTNVYLNEVQVADFASFLEF 93
Cdd:cd18257    5 LLQGLNLLRQHHELCDVVLRV---GDVK-IHAHKVVLASCSPYFKAMFtgnLSEKE----NSEVEFQCIDETALQAIVEY 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768014208  94 VYTAKVQVEEDRVQRMLEVAEKLKC-LDLSETCFQLKKQM 132
Cdd:cd18257   77 AYTGTVFISQATVESLLPAANLLQIkLVLKECCDFLESQL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYLNEVQVADFASFLEFVYT 96
Cdd:cd18202    6 VLDQLNQQRLNNQFCDVTLLIEGE----EYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 768014208  97 AKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQM 132
Cdd:cd18202   82 SELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQM 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  23 ELRLLGHLCDVTVSVeyQGVRkdFMAHKAVLAATSKFFKEVFLNEKSVdGTRTNVYLNEVQVADFASFLEFVYTAKVQVE 102
Cdd:cd18240   10 ELRLEGKLCDVVIRV--NGVE--FPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPGVSPEMMELIIEYAYTRTVPIT 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 768014208 103 EDRVQRMLEVAEKLKCLDLSETCFQ-LKKQM 132
Cdd:cd18240   85 AENVEELLPAADQFNIMGIVKACCDfLEDQL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  14 PFNLLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFlNEKSVDGTRTNVYLNEVQVADFASFLEF 93
Cdd:cd18237    5 LADFMGVMNNMRKQKTLCDVILIVE----GREIKAHRVVLAAASHFFHLMF-TSNMTESKSSEVELKDAEPDIIELLVEF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768014208  94 VYTAKVQVEEDRVQRMLEVAEKLKCLDLSETCFQLKKQML 133
Cdd:cd18237   80 AYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEyqgvRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTN------------VYLNEVQV 84
Cdd:cd18195    5 LLLQLNEQRLRGLFCDVTLIAG----DTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAaapgatqspervLELPGVKA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 768014208  85 ADFASFLEFVYTAKVQVEEDRVQRML-EVAEKL--KCL 119
Cdd:cd18195   81 GVFSDVLNFIYSSRVALPGSAAAKELgAAGKRLgiPFL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  21 MHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEKsVDGTRTNVYLNEVQVADFASFLEFVYTAKVQ 100
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQ----KFSAHRIVLAATIPYFHAMFTHDM-VESKQDEITMQGIEPSALEALINFAYSGRIA 84

                         90       100
                 ....*....|....*....|....*
gi 768014208 101 VEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18247   85 IDTSNVQSLLVGASFLQLQSVKDAC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEYQGVRKD----FMAHKAVLAATSKFFKEVF---LNEKSvdgtRTNVYLNEVQVADFAS 89
Cdd:cd18273   13 LLAQLKSFYDARLLTDVTIEVNGPGSGPGsgrlFPCNRNVLAAASPYFKSMFtggLYESK----QETVTIHDVDSESMAL 88

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 768014208  90 FLEFVYTAKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18273   89 IIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREAC 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768014208  17 LLHEMHELRLLGHLCDVTVSVEYQgvrkDFMAHKAVLAATSKFFKEVFLNEksvdGTRTNVYLNEVQVADFASFLEFVYT 96
Cdd:cd18218    5 LLHLAARLRPAGALCDTLITVGSQ----EFPAHSLVLAGASQQLGRQLTNP----NPGQWCLGEGISPSTFKQLLDFVYG 76

                         90       100
                 ....*....|....*....|....*....
gi 768014208  97 AKVQVEEDRVQRMLEVAEKLKCLDLSETC 125
Cdd:cd18218   77 ESVEVQPGELRPLLEAARALEVESLEEAC 105