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Conserved domains on  [gi|768016698|ref|XP_011527029|]
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nuclear receptor coactivator 6 isoform X10 [Homo sapiens]

Protein Classification

Nucleic_acid_bd and Med15 domain-containing protein( domain architecture ID 12155422)

protein containing domains Nucleic_acid_bd, Med15, and PHA03247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nucleic_acid_bd pfam13820
Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding ...
 48-195 2.42e-59

Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.


:

Pssm-ID: 463988  Cd Length: 143  Bit Score: 200.73  E-value: 2.42e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698    48 IFVAFKGNIDDkdFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSV 127
Cdd:pfam13820    1 TFLAVKGNLRM--FQEKLDSIRENVAELLRTEKSKLKVRKVEPWNSVRVTFSIPREAALRLRLLAQHNDPRLRDLGILSV 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768016698   128 QIEGEGAINLALA---QNRSQDVRMnGPMGAGNSVRMEAGFPMASGPGIFflgiiRMNNPATVMIPPGGNV 195
Cdd:pfam13820   79 QIEGEGPINLTLAtmvQNPADDIIL-GCSTQLNSQRAEQGWTMLSALGLI-----SDALPLHLRLAESGEY 143
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 517-831 3.84e-09

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 61.95  E-value: 3.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   517 ANPNFMQGQVPSTTATTPGNSGAPQLQANQNVqhAGGQGAGPPQNQMQVSHGPPnmmQPSLMGIHGNMNNQQAGTsGVPQ 596
Cdd:pfam09606   58 AQQQQPQGGQGNGGMGGGQQGMPDPINALQNL--AGQGTRPQMMGPMGPGPGGP---MGQQMGGPGTASNLLASL-GRPQ 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   597 VNL------SNMQGQPQQGPPSQLMGMHQQIVPSQGQ-MVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPS-PQ 668
Cdd:pfam09606  132 MPMggagfpSQMSRVGRMQPGGQAGGMMQPSSGQPGSgTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGmPG 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   669 RMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQgnm 748
Cdd:pfam09606  212 PADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPG--- 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   749 vQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPhmaQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQA 828
Cdd:pfam09606  289 -QQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQ---QQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANP 364


                   ...
gi 768016698   829 MQG 831
Cdd:pfam09606  365 MQR 367
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1049-1295 3.04e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1049 PPRGPLNPDSQRMPmqQSGSVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEA 1128
Cdd:PHA03247 2744 VPAGPATPGGPARP--ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1129 SG---------SEAPSVPGGPNNMPSHVVLPQNQLMMTGP--KPGPSPLSATQGATPQQPPVNSLPSshghhfPNVAAPT 1197
Cdd:PHA03247 2822 ASpagplppptSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRST 2895

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1198 QTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLnasiaglfPPQINIPLPPRPNLNRGFDQQGLNPttlkaig 1277
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSGAVP------- 2960

                         250
                  ....*....|....*...
gi 768016698 1278 qAPSNLTMNPSNFATPQT 1295
Cdd:PHA03247 2961 -QPWLGALVPGRVAVPRF 2977
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 190-519 8.51e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  190 PPGGNVSSSMMAPGPNPELQPRtPRPASQSDamdPLLSGLHIQQQSHPSGSLAP-----PHHPMQPVSVNRQMNPANFPQ 264
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPA-PHALVSAT---PLPPGPAAARQASPALPAAPappavPAGPATPGGPARPARPPTTAG 2765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  265 LQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHqqqqpqgirPQFTAPTQVPVPPGWNQLPSGALQPPPaqgsLGTMT 344
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS---------PWDPADPPAAVLAPAAALPPAASPAGP----LPPPT 2832

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  345 ANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSL-QGGPSRVPTPL 423
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALpPDQPERPPQPQ 2912

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  424 QQPHLTNKSPASSPssfqqgsPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVP-PNFMVMQQQPP 502
Cdd:PHA03247 2913 APPPPQPQPQPPPP-------PQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvPRFRVPQPAPS 2985

                         330
                  ....*....|....*..
gi 768016698  503 NQGPQSLHPGLGGQANP 519
Cdd:PHA03247 2986 REAPASSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
Nucleic_acid_bd pfam13820
Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding ...
 48-195 2.42e-59

Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.


Pssm-ID: 463988  Cd Length: 143  Bit Score: 200.73  E-value: 2.42e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698    48 IFVAFKGNIDDkdFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSV 127
Cdd:pfam13820    1 TFLAVKGNLRM--FQEKLDSIRENVAELLRTEKSKLKVRKVEPWNSVRVTFSIPREAALRLRLLAQHNDPRLRDLGILSV 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768016698   128 QIEGEGAINLALA---QNRSQDVRMnGPMGAGNSVRMEAGFPMASGPGIFflgiiRMNNPATVMIPPGGNV 195
Cdd:pfam13820   79 QIEGEGPINLTLAtmvQNPADDIIL-GCSTQLNSQRAEQGWTMLSALGLI-----SDALPLHLRLAESGEY 143
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 517-831 3.84e-09

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 61.95  E-value: 3.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   517 ANPNFMQGQVPSTTATTPGNSGAPQLQANQNVqhAGGQGAGPPQNQMQVSHGPPnmmQPSLMGIHGNMNNQQAGTsGVPQ 596
Cdd:pfam09606   58 AQQQQPQGGQGNGGMGGGQQGMPDPINALQNL--AGQGTRPQMMGPMGPGPGGP---MGQQMGGPGTASNLLASL-GRPQ 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   597 VNL------SNMQGQPQQGPPSQLMGMHQQIVPSQGQ-MVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPS-PQ 668
Cdd:pfam09606  132 MPMggagfpSQMSRVGRMQPGGQAGGMMQPSSGQPGSgTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGmPG 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   669 RMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQgnm 748
Cdd:pfam09606  212 PADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPG--- 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   749 vQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPhmaQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQA 828
Cdd:pfam09606  289 -QQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQ---QQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANP 364


                   ...
gi 768016698   829 MQG 831
Cdd:pfam09606  365 MQR 367
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1049-1295 3.04e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1049 PPRGPLNPDSQRMPmqQSGSVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEA 1128
Cdd:PHA03247 2744 VPAGPATPGGPARP--ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1129 SG---------SEAPSVPGGPNNMPSHVVLPQNQLMMTGP--KPGPSPLSATQGATPQQPPVNSLPSshghhfPNVAAPT 1197
Cdd:PHA03247 2822 ASpagplppptSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRST 2895

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1198 QTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLnasiaglfPPQINIPLPPRPNLNRGFDQQGLNPttlkaig 1277
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSGAVP------- 2960

                         250
                  ....*....|....*...
gi 768016698 1278 qAPSNLTMNPSNFATPQT 1295
Cdd:PHA03247 2961 -QPWLGALVPGRVAVPRF 2977
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 605-748 6.43e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 6.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   605 QPQQGPPSQ-LMGMHQQIVPSQGQMVQQQGTLNPQNPMilsraqLMPQGQMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQ 683
Cdd:TIGR01628  384 QLPMGSPMGgAMGQPPYYGQGPQQQFNGQPLGWPRMSM------MPTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKP 457

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768016698   684 MMAPHNQMMGPQGQVLLQQNPmieqimtnqmqgnkQQFNTQNQSNVMPGPAQIMRGPTPNMQGNM 748
Cdd:TIGR01628  458 PMQPVMYPPNYQSLPLSQDLP--------------QPQSTASQGGQNKKLAQVLASATPQMQKQV 508
PHA03247 PHA03247
large tegument protein UL36; Provisional
 190-519 8.51e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  190 PPGGNVSSSMMAPGPNPELQPRtPRPASQSDamdPLLSGLHIQQQSHPSGSLAP-----PHHPMQPVSVNRQMNPANFPQ 264
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPA-PHALVSAT---PLPPGPAAARQASPALPAAPappavPAGPATPGGPARPARPPTTAG 2765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  265 LQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHqqqqpqgirPQFTAPTQVPVPPGWNQLPSGALQPPPaqgsLGTMT 344
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS---------PWDPADPPAAVLAPAAALPPAASPAGP----LPPPT 2832

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  345 ANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSL-QGGPSRVPTPL 423
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALpPDQPERPPQPQ 2912

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  424 QQPHLTNKSPASSPssfqqgsPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVP-PNFMVMQQQPP 502
Cdd:PHA03247 2913 APPPPQPQPQPPPP-------PQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvPRFRVPQPAPS 2985

                         330
                  ....*....|....*..
gi 768016698  503 NQGPQSLHPGLGGQANP 519
Cdd:PHA03247 2986 REAPASSTPPLTGHSLS 3002
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1100-1395 1.06e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.14  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1100 SNSRKMVYQESPQNPSSSPLAEmaslpeASGSEAPSVPGGpnnMPSHVVLPQNQLM--MTGPK------PGPSPLSATQG 1171
Cdd:pfam05109  414 TTTHKVIFSKAPESTTTSPTLN------TTGFAAPNTTTG---LPSSTHVPTNLTApaSTGPTvstadvTSPTPAGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1172 ATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQ-TPNNRPPS---TEPSE--ISLSPERLNASIAGLF 1245
Cdd:pfam05109  485 ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTpTPNATSPTlgkTSPTSavTTPTPNATSPTPAVTT 564

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1246 P-PQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGATKRASPSNSRR 1324
Cdd:pfam05109  565 PtPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSM 644

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768016698  1325 SSPGSSRKTTPSPGRQN---SKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVPGSFPNNSGlnPQNST 1395
Cdd:pfam05109  645 SLRPSSISETLSPSTSDnstSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASG--PGNSS 716
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 385-492 1.81e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   385 SQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQ----QGSPASSPTVNQTQQQMGP 460
Cdd:pfam09770  211 AQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQrpqsPQPDPAQPSIQPQAQQFHQ 290

                           90       100       110
                   ....*....|....*....|....*....|....
gi 768016698   461 RPPQNNPLP-QGFQQP-VSSPGRNPMVQQGNVPP 492
Cdd:pfam09770  291 QPPPVPVQPtQILQNPnRLSAARVGYPQNPQPGV 324
 
Name Accession Description Interval E-value
Nucleic_acid_bd pfam13820
Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding ...
 48-195 2.42e-59

Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.


Pssm-ID: 463988  Cd Length: 143  Bit Score: 200.73  E-value: 2.42e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698    48 IFVAFKGNIDDkdFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSV 127
Cdd:pfam13820    1 TFLAVKGNLRM--FQEKLDSIRENVAELLRTEKSKLKVRKVEPWNSVRVTFSIPREAALRLRLLAQHNDPRLRDLGILSV 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768016698   128 QIEGEGAINLALA---QNRSQDVRMnGPMGAGNSVRMEAGFPMASGPGIFflgiiRMNNPATVMIPPGGNV 195
Cdd:pfam13820   79 QIEGEGPINLTLAtmvQNPADDIIL-GCSTQLNSQRAEQGWTMLSALGLI-----SDALPLHLRLAESGEY 143
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 517-831 3.84e-09

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 61.95  E-value: 3.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   517 ANPNFMQGQVPSTTATTPGNSGAPQLQANQNVqhAGGQGAGPPQNQMQVSHGPPnmmQPSLMGIHGNMNNQQAGTsGVPQ 596
Cdd:pfam09606   58 AQQQQPQGGQGNGGMGGGQQGMPDPINALQNL--AGQGTRPQMMGPMGPGPGGP---MGQQMGGPGTASNLLASL-GRPQ 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   597 VNL------SNMQGQPQQGPPSQLMGMHQQIVPSQGQ-MVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPS-PQ 668
Cdd:pfam09606  132 MPMggagfpSQMSRVGRMQPGGQAGGMMQPSSGQPGSgTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGmPG 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   669 RMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQgnm 748
Cdd:pfam09606  212 PADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPG--- 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   749 vQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPhmaQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQA 828
Cdd:pfam09606  289 -QQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQ---QQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANP 364


                   ...
gi 768016698   829 MQG 831
Cdd:pfam09606  365 MQR 367
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1049-1295 3.04e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1049 PPRGPLNPDSQRMPmqQSGSVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEA 1128
Cdd:PHA03247 2744 VPAGPATPGGPARP--ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1129 SG---------SEAPSVPGGPNNMPSHVVLPQNQLMMTGP--KPGPSPLSATQGATPQQPPVNSLPSshghhfPNVAAPT 1197
Cdd:PHA03247 2822 ASpagplppptSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRST 2895

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1198 QTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLnasiaglfPPQINIPLPPRPNLNRGFDQQGLNPttlkaig 1277
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSGAVP------- 2960

                         250
                  ....*....|....*...
gi 768016698 1278 qAPSNLTMNPSNFATPQT 1295
Cdd:PHA03247 2961 -QPWLGALVPGRVAVPRF 2977
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 605-775 3.19e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 52.35  E-value: 3.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   605 QPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQnpmilsraQLMPQGQMMVNPPSQNLGPSPQRmtppkqmLSQQGPQM 684
Cdd:pfam09770  209 KPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQ--------QQQPQQQPQQPQQHPGQGHPVTI-------LQRPQSPQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   685 MAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQsnvMPGPAQIMRGPTPNMQgnmvqftGQMSGQMLPQQG 764
Cdd:pfam09770  274 PDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVG---YPQNPQPGVQPAPAHQ-------AHRQQGSFGRQA 343

                          170
                   ....*....|.
gi 768016698   765 PVNNSPSQVMG 775
Cdd:pfam09770  344 PIITHPQQLAQ 354
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 272-741 2.09e-05

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 49.62  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   272 QQQQQQQQQQQQQQQQQQQLQARPpqqhqqqqpqgirpqfTAPTQVPVPPGWNQLPSGALQPPPAQ----GSLGTMTANQ 347
Cdd:pfam09606   64 QGGQGNGGMGGGQQGMPDPINALQ----------------NLAGQGTRPQMMGPMGPGPGGPMGQQmggpGTASNLLASL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   348 GWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSnPGQFTAPQMKSLQGGPSRVPTPLQQPH 427
Cdd:pfam09606  128 GRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGG-PGQGQAGGMNGGQQGPMGGQMPPQMGV 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   428 LTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQ-GFQQPVSSPGRNPMVQQGNVPPNfmvmqqqppnqGP 506
Cdd:pfam09606  207 PGMPGPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQqQGQQSQLGMGINQMQQMPQGVGG-----------GA 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   507 QSLHPGLGGQANPNFMQGQVPSTTATTPGNsgAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHG---- 582
Cdd:pfam09606  276 GQGGPGQPMGPPGQQPGAMPNVMSIGDQNN--YQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLetwn 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   583 -------NMNNQQAGTSG-VPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQM 654
Cdd:pfam09606  354 pgnfgglGANPMQRGQPGmMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQM 433

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   655 MVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQsnvMPGPA 734
Cdd:pfam09606  434 SQQPAQQRTIGQDSPGGSLNTPGQSAVNSPLNPQEEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNK---MKRLL 510


                   ....*..
gi 768016698   735 QIMRGPT 741
Cdd:pfam09606  511 EILSNPS 517
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1078-1552 3.58e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 3.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1078 PASVPPSPDkQRMPMPVNTPlgsnsrkmvyqeSPQNPSSSPLAEMASLPEASGSeaPSVPGGPNNMPSHVV----LPQNQ 1153
Cdd:PHA03247 2557 PAAPPAAPD-RSVPPPRPAP------------RPSEPAVTSRARRPDAPPQSAR--PRAPVDDRGDPRGPAppspLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1154 LMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLS 1233
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADP 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1234 PERLNASIAGLFPPQINIPLPPRPNLNRgfdqQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGA 1313
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAAR----QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA 2777

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1314 TKRASPSNSRRSSPGSSRKTTPS---PGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVPGSFPNNSGLN 1390
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSpwdPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1391 PQNSTVSVAAVGGVVEDNKESLNVPQDSdcqnsqsrkeqvnIELKAVPAQEVKMVVPEDQSKKDGQPSDPNK--LPSVEE 1468
Cdd:PHA03247 2858 PGGDVRRRPPSRSPAAKPAAPARPPVRR-------------LARPAVSRSTESFALPPDQPERPPQPQAPPPpqPQPQPP 2924

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1469 NKNLVSPAMREAPTSLSQL---LDNSGAPNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHS 1545
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLaptTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRV 3004


                  ....*..
gi 768016698 1546 NELCSSL 1552
Cdd:PHA03247 3005 SSWASSL 3011
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 605-748 6.43e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 6.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   605 QPQQGPPSQ-LMGMHQQIVPSQGQMVQQQGTLNPQNPMilsraqLMPQGQMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQ 683
Cdd:TIGR01628  384 QLPMGSPMGgAMGQPPYYGQGPQQQFNGQPLGWPRMSM------MPTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKP 457

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768016698   684 MMAPHNQMMGPQGQVLLQQNPmieqimtnqmqgnkQQFNTQNQSNVMPGPAQIMRGPTPNMQGNM 748
Cdd:TIGR01628  458 PMQPVMYPPNYQSLPLSQDLP--------------QPQSTASQGGQNKKLAQVLASATPQMQKQV 508
PHA03247 PHA03247
large tegument protein UL36; Provisional
 190-519 8.51e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  190 PPGGNVSSSMMAPGPNPELQPRtPRPASQSDamdPLLSGLHIQQQSHPSGSLAP-----PHHPMQPVSVNRQMNPANFPQ 264
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPA-PHALVSAT---PLPPGPAAARQASPALPAAPappavPAGPATPGGPARPARPPTTAG 2765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  265 LQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHqqqqpqgirPQFTAPTQVPVPPGWNQLPSGALQPPPaqgsLGTMT 344
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS---------PWDPADPPAAVLAPAAALPPAASPAGP----LPPPT 2832

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  345 ANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSL-QGGPSRVPTPL 423
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALpPDQPERPPQPQ 2912

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  424 QQPHLTNKSPASSPssfqqgsPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVP-PNFMVMQQQPP 502
Cdd:PHA03247 2913 APPPPQPQPQPPPP-------PQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvPRFRVPQPAPS 2985

                         330
                  ....*....|....*..
gi 768016698  503 NQGPQSLHPGLGGQANP 519
Cdd:PHA03247 2986 REAPASSTPPLTGHSLS 3002
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 612-763 1.76e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 46.72  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   612 SQLMGMHQQIVPSQGQMVQqqgtLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMtPPKQMLSQQGPQMMAPhnqm 691
Cdd:TIGR01628  369 AHLQDQFMQLQPRMRQLPM----GSPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMP-TPMGPGGPLRPNGLAP---- 439

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768016698   692 MGPQGQVLLQQNPMIEQimtNQMQGNKQQFNTQNQSNVMPGPAQimrGPTPNMQGNMvQFTGQMSGQMLPQQ 763
Cdd:TIGR01628  440 MNAVRAPSRNAQNAAQK---PPMQPVMYPPNYQSLPLSQDLPQP---QSTASQGGQN-KKLAQVLASATPQM 504
PHA03247 PHA03247
large tegument protein UL36; Provisional
 922-1483 2.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  922 DLNTPDTRPAgleeadqpPLPGEQGINLDNSGPKLPEFSNRP--PGYPS-QPVEQRPLQQMPPQLMQHVAPPPQPPQQQP 998
Cdd:PHA03247 2565 DRSVPPPRPA--------PRPSEPAVTSRARRPDAPPQSARPraPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN 2636

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  999 QPQLPQQQQPPPPSQPQSQQQqqqqqqmmmmlmmqqdPKSVRLP--VSQNVHPPRGPLNPDSQRMPMQQSGSVPVmVSLQ 1076
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPA----------------PGRVSRPrrARRLGRAAQASSPPQRPRRRAARPTVGSL-TSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1077 GPASVPPSPDKQRMPMPVNTPL--GSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEA-PSVPGGPNNmPSHVVLPQNQ 1153
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLppGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPA-PAPPAAPAAG 2778

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1154 LMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVaAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLS 1233
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1234 PERLNASIAGLFPPQINIPLPPRPNLNRgfdqqglnpTTLKAIGQAPSNLTMNPSNFATPQTHKLDsvvvnSGKQSNSGA 1313
Cdd:PHA03247 2858 PGGDVRRRPPSRSPAAKPAAPARPPVRR---------LARPAVSRSTESFALPPDQPERPPQPQAP-----PPPQPQPQP 2923

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1314 TKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQ-NVELPRNVLVSPTPLANPPVPGSFPNNSGLNPQ 1392
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPgRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698 1393 NSTVSVAAVGGVVEDN-----KESLNVPQDSDCQNSQSRKEQVNIELkavpaqevkmvvpeDQSKKDGQPSDPNKLPSVE 1467
Cdd:PHA03247 3004 VSSWASSLALHEETDPppvslKQTLWPPDDTEDSDADSLFDSDSERS--------------DLEALDPLPPEPHDPFAHE 3069

                         570
                  ....*....|....*.
gi 768016698 1468 ENKNLVSPAMREAPTS 1483
Cdd:PHA03247 3070 PDPATPEAGARESPSS 3085
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1100-1395 1.06e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.14  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1100 SNSRKMVYQESPQNPSSSPLAEmaslpeASGSEAPSVPGGpnnMPSHVVLPQNQLM--MTGPK------PGPSPLSATQG 1171
Cdd:pfam05109  414 TTTHKVIFSKAPESTTTSPTLN------TTGFAAPNTTTG---LPSSTHVPTNLTApaSTGPTvstadvTSPTPAGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1172 ATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQ-TPNNRPPS---TEPSE--ISLSPERLNASIAGLF 1245
Cdd:pfam05109  485 ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTpTPNATSPTlgkTSPTSavTTPTPNATSPTPAVTT 564

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1246 P-PQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGATKRASPSNSRR 1324
Cdd:pfam05109  565 PtPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSM 644

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768016698  1325 SSPGSSRKTTPSPGRQN---SKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVPGSFPNNSGlnPQNST 1395
Cdd:pfam05109  645 SLRPSSISETLSPSTSDnstSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASG--PGNSS 716
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 385-492 1.81e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698   385 SQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQ----QGSPASSPTVNQTQQQMGP 460
Cdd:pfam09770  211 AQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQrpqsPQPDPAQPSIQPQAQQFHQ 290

                           90       100       110
                   ....*....|....*....|....*....|....
gi 768016698   461 RPPQNNPLP-QGFQQP-VSSPGRNPMVQQGNVPP 492
Cdd:pfam09770  291 QPPPVPVQPtQILQNPnRLSAARVGYPQNPQPGV 324
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 1073-1287 2.49e-03

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 42.49  E-value: 2.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1073 VSLQGPASVPPSPDKQRMPMPVNTPLGS--NSRKMVYQESPQNPSSSPLAEMASLPEASGSEAPSVPGGPNNMPSHVVLP 1150
Cdd:pfam15279   91 ESVSPGPSSSASPSSSPTSSNSSKPLISvaSSSKLLAPKPHEPPSLPPPPLPPKKGRRHRPGLHPPLGRPPGSPPMSMTP 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  1151 QNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHhfPNVAAPTQTSRPKTPNRASPRPYYPQT-PNNRPP-----S 1224
Cdd:pfam15279  171 RGLLGKPQQHPPPSPLPAFMEPSSMPPPFLRPPPSIPQ--PNSPLSNPMLPGIGPPPKPPRNLGPPSnPMHRPPfsphhP 248

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768016698  1225 TEPSEISLSPERLNASIAGLFPPQINIPLPPrpnLNRGFDQQGLNPTTLKAIGQAPSNLTMNP 1287
Cdd:pfam15279  249 PPPPTPPGPPPGLPPPPPRGFTPPFGPPFPP---VNMMPNPPEMNFGLPSLAPLVPPVTVLVP 308
PHA03247 PHA03247
large tegument protein UL36; Provisional
 182-547 3.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  182 NNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGL----------------------HIQQQSHPSG 239
Cdd:PHA03247 2596 ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPptvppperprddpapgrvsrprRARRLGRAAQ 2675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  240 SLAPPHHP---------------MQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQP 304
Cdd:PHA03247 2676 ASSPPQRPrrraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA 2755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  305 QGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMqQQLQARPSLATVQTPSHPPPPYPFG 384
Cdd:PHA03247 2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPA-AVLAPAAALPPAASPAGPLPPPTSA 2834

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  385 SQQASQAHTNFPQMSNP-GQFTAPqmkslqGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPP 463
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPlGGSVAP------GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERP 2908

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  464 qnnPLPQGFQQPVSSPGRNPMVQQGNVPPnfmvmqQQPPNQGPQSLHPGLGGQANPnfmQGQVPSTT--ATTPGNSGAPQ 541
Cdd:PHA03247 2909 ---PQPQAPPPPQPQPQPPPPPQPQPPPP------PPPRPQPPLAPTTDPAGAGEP---SGAVPQPWlgALVPGRVAVPR 2976


                  ....*.
gi 768016698  542 LQANQN 547
Cdd:PHA03247 2977 FRVPQP 2982
PHA03247 PHA03247
large tegument protein UL36; Provisional
 204-673 8.05e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 8.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  204 PNPELQPRTPRPASQSDAMDPllsGLHIQQQS--HPSGSLAPPHHPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQ 281
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRP---DAPPQSARprAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  282 QQQQQQQQQLQA-RPPQQHQQQQPQGIRPQFTAPTQVPVPPGwnqlpsgalqPPPAQGSLGTMTANQGWKKAPLPGPmqq 360
Cdd:PHA03247 2646 VPPPERPRDDPApGRVSRPRRARRLGRAAQASSPPQRPRRRA----------ARPTVGSLTSLADPPPPPPTPEPAP--- 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  361 qlqarpslatvqTPSHPPPPYPFGSQQASQAHTNFPqmSNPGQFTAPQMKSLQGGPSRVPTPlqqphltnKSPASSPSSF 440
Cdd:PHA03247 2713 ------------HALVSATPLPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPARPARP--------PTTAGPPAPA 2770

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  441 QQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQ---QPVSSPGRNPMVQQGNVP------PNFMVMQQQPPNQGPQSLHP 511
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDpadPPAAVLAPAAALPPAASPagplppPTSAQPTAPPPPPGPPPPSL 2850

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  512 GLGGQANP--NFMQGQVPSTTATTPGNSGAPQLQanqnvQHAGGQGAGPPQNQMQVSHGPPNMMQPSLmgihgnmNNQQA 589
Cdd:PHA03247 2851 PLGGSVAPggDVRRRPPSRSPAAKPAAPARPPVR-----RLARPAVSRSTESFALPPDQPERPPQPQA-------PPPPQ 2918

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768016698  590 GTSGVPQVNLSNMQGQPQQGPPSQLmgmhQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQnlgPSPQR 669
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPL----APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSR---EAPAS 2991


                  ....
gi 768016698  670 MTPP 673
Cdd:PHA03247 2992 STPP 2995
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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