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Conserved domains on  [gi|768002739|ref|XP_011526364|]
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zinc finger protein 44 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 41-82 1.87e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.87e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768002739   41 SVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIG 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-645 1.26e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 234 PYKCELCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAF-PVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 310
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 311 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 386
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 387 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQC-- 464
Cdd:COG5048  185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpr 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 465 ---GKAFRTSSS-LRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 532
Cdd:COG5048  263 sslPTASSQSSSpNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 533 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 601
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768002739 602 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 645
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 41-82 1.87e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.87e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768002739   41 SVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIG 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-78 8.29e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 8.29e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 768002739  42 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 78
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
42-78 5.20e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 72.63  E-value: 5.20e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 768002739    42 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-645 1.26e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 234 PYKCELCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAF-PVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 310
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 311 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 386
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 387 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQC-- 464
Cdd:COG5048  185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpr 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 465 ---GKAFRTSSS-LRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 532
Cdd:COG5048  263 sslPTASSQSSSpNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 533 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 601
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768002739 602 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 645
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-470 2.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.72e-04
                          10        20
                  ....*....|....*....|....*
gi 768002739  446 FQRHERTHTGEKPYECKQCGKAFRT 470
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 41-82 1.87e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.87e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768002739   41 SVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIG 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-78 8.29e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 8.29e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 768002739  42 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 78
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
42-78 5.20e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 72.63  E-value: 5.20e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 768002739    42 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-645 1.26e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 234 PYKCELCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAF-PVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 310
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 311 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 386
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 387 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQC-- 464
Cdd:COG5048  185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpr 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 465 ---GKAFRTSSS-LRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 532
Cdd:COG5048  263 sslPTASSQSSSpNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 533 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 601
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768002739 602 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 645
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-648 3.38e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 3.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 261 KPYECKQCSKAFPVYSSYLRHEKIHTGEKPYEC--KQCSKAFPDYSSYLRHERTHTGEKPYKC-KQCGKAFSVSGSLRVH 337
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 338 ERIHTGEKPYTCKQCGKAFCHLGSFQRHMIMHSGDGPHKCKIC-GKGFDFPGSARIHEGTHTLEKPyeckqcgKLLSHRS 416
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 417 SFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTSSSLR-------KHETTHTGEQPYKC 489
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslssSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 490 KCGKAFSDLFSFQSHETTHS-EEEPYECKECGKAFSSFKYFCRHERT--HSEEKSYECQ----ICGKAFSRFSYLKTHER 562
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFScpysLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 563 THTAEKPYECKQCR-------KAFFWPSFLLRHERTHTGERPYECKH--CGKAFSRSSFCREHERTHTGEKPYECK--EC 631
Cdd:COG5048  345 LHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410
                 ....*....|....*..
gi 768002739 632 GKAFSSLSSFNRHKRTH 648
Cdd:COG5048  425 SKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-354 3.55e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 151 MGHSSLNCYIRVDTGHKHRecHEYAEKSYTHKQCGKGLSYRHSFQTCERPHTGK-KPYDCKECGKTFSSPGNLRRHM--V 227
Cdd:COG5048  235 LSPKSLLSQSPSSLSSSDS--SSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLrsV 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 228 VKGGDG--PYKC--ELCGKAFFWPSLLRMHERTHTGEKPYECK--QCSKAFPVYS-----SYLRHEKIHTGEKPYEC--K 294
Cdd:COG5048  313 NHSGESlkPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsN 392

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768002739 295 QCSKAFPDYSSYLRHERTHTGEKP--YKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGK 354
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
317-651 4.32e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 317 KPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTC--KQCGKAFCHLGSFQRHMIMHSGDGPHKCKICGKG--FDFPGSARI 392
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 393 HEGTHTLEKPYECkQCGKLLSHRSSFRRHMMAHTGDGPHKCTVC-GKAFDSPSVFQRHERTHTGEkpyeckQCGKAFRTS 471
Cdd:COG5048  112 SSSSNSNDNNLLS-SHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 472 SSLRKHETTHTGEQPYKCKCGKAFSDLFSFQSHETTHSEEEPYECkecgkafssfkyfcrHERTHSEEKSYECQicgkaf 551
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPL---------------TTNSQLSPKSLLSQ------ 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002739 552 sRFSYLKTHERTHTAEKPYECKQCRKAFFWPSFLLRHERTHTGER-PYECKHCGKAFSRSSFCREHERT--HTGE--KPY 626
Cdd:COG5048  244 -SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPF 322

                        330       340
                 ....*....|....*....|....*..
gi 768002739 627 ECKE--CGKAFSSLSSFNRHKRTHWKD 651
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSI 349
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-470 2.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.72e-04
                          10        20
                  ....*....|....*....|....*
gi 768002739  446 FQRHERTHTGEKPYECKQCGKAFRT 470
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
585-609 3.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.99e-04
                          10        20
                  ....*....|....*....|....*
gi 768002739  585 LLRHERTHTGERPYECKHCGKAFSR 609
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-272 5.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.00e-04
                          10        20
                  ....*....|....*....|...
gi 768002739  250 LRMHERTHTGEKPYECKQCSKAF 272
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-329 5.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.40e-04
                          10        20
                  ....*....|....*....|..
gi 768002739  308 RHERTHTGEKPYKCKQCGKAFS 329
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-637 5.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.51e-04
                          10        20
                  ....*....|....*....|....
gi 768002739  614 REHERTHTGEKPYECKECGKAFSS 637
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-356 7.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.77e-04
                          10        20
                  ....*....|....*....|....
gi 768002739  333 SLRVHERIHTGEKPYTCKQCGKAF 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-300 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|.
gi 768002739  280 RHEKIHTGEKPYECKQCSKAF 300
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
556-579 2.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|....
gi 768002739  556 YLKTHERTHTAEKPYECKQCRKAF 579
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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