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Conserved domains on  [gi|768000960|ref|XP_011526018|]
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zinc finger protein 555 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768000960    5 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-597 2.76e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 200 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 276
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 277 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 355
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 356 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 429
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 430 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 502
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 503 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 571
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 768000960 572 GKAFNCSSSLRRHVRIHTTEKQYKCN 597
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768000960    5 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-50 4.46e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.46e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 768000960     6 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 2.13e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.13e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 768000960   8 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 44
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-597 2.76e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 200 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 276
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 277 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 355
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 356 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 429
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 430 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 502
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 503 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 571
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 768000960 572 GKAFNCSSSLRRHVRIHTTEKQYKCN 597
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-464 1.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....*
gi 768000960  440 SLRKHMRTHTREKPYECKQCGKAFS 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 201-249 7.81e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 768000960 201 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 249
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768000960    5 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-50 4.46e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.46e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 768000960     6 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 2.13e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.13e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 768000960   8 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 44
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-597 2.76e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 200 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 276
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 277 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 355
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 356 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 429
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 430 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 502
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 503 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 571
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 768000960 572 GKAFNCSSSLRRHVRIHTTEKQYKCN 597
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-470 1.29e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 209 KTFPRTSSLNRHVRIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTITHTGEKPYKC 288
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 289 KECAEAFSYSSTFRRHMISHTGE-------KPHKCKECGEAFSYSSAFRRHM--ITHTGE--KPYEC--KQCGKTFIYLQ 355
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 356 SFRRHERIHTGEKPYECK--QCGKTF-----IYPQSFRRHERTHGGEKPYEC--NQCGKAFSHPSSFRGHMRVHTGEKPY 426
Cdd:COG5048  338 ALKRHILLHTSISPAKEKllNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 768000960 427 ECK--QCGKTFNWPISLRKHMRTHTREKPYECKQCGKAFSLSACFR 470
Cdd:COG5048  418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
123-389 1.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 123 GEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLKSPITVHTGHK---PYQCQECGQAYSCRSHLRMHVRTHNGE 199
Cdd:COG5048  173 ANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 200 RPYVCKLCG------KTFPRTSSLNRHVRIHTAEKT-YECKQCGKAFIDFSSLTSHLRS--HTGE--KPYKCKE--CGKA 266
Cdd:COG5048  253 SSSSASESPrsslptASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 267 FSYSSTFRRHTITHTGEKPYKCKEC-----------AEAFSYSSTFRRHMISHTGEKPHKCKEcgEAFSYSSAFRRHMIT 335
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEKLLnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCI--RNFKRDSNLSLHIIT 410

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768000960 336 HTGEKPYECK--QCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHE 389
Cdd:COG5048  411 HLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-361 1.18e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960  89 IWDSLSIEDQTTNQGRNLSRNHGLERLCESNDQCGEALSQIPHLNLYKKIPPGVKQYEYNTYGKVF-----MHRRTSLKS 163
Cdd:COG5048  171 LPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllSQSPSSLSS 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 164 PITVHTGHKPYQCQECGQAYSCRSHLRMHVRTHNGER-PYVCKLCGKTFPRTSSLNRHVR--IHTAE--KTYEC--KQCG 236
Cdd:COG5048  251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCG 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 237 KAFIDFSSLTSHLRSHTGEKPYKCK--ECGKAFSYSSTFRRHTIT--HTGEKPYKCKECA-----EAFSYSSTFRRHMIS 307
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLsnsciRNFKRDSNLSLHIIT 410

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768000960 308 HTGEKPH--KCKECGEAFSYSSAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHE 361
Cdd:COG5048  411 HLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-602 6.50e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 284 KPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYS--SAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHE 361
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 362 RIHTGE-KPYECKQCGKTFIYPQSFRRHERTH---GGEKPYECNQCGKAFSHPSSFRGHMRVHTgekpyeckQCGKTFNW 437
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPANS--------LSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 438 PISLRKHMRTHTREKPYECKQCGKAFSLSACFREHVRMHPEDkSYECKLCGKAfyCHISLQKHMRRHTAEKLYK--CKQC 515
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQL--SPKSLLSQSPSSLSSSDSSssASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 516 GKAFSWPELLQQ--HVRTHTVE-----KPYECKECGKVFKWPSSLPIHMR--LHTGE--KPYQCKH--CGKAFNCSSSLR 582
Cdd:COG5048  261 PRSSLPTASSQSssPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340
                 ....*....|....*....|
gi 768000960 583 RHVRIHTTEKQYKCNVGHPP 602
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSS 360
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-464 1.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....*
gi 768000960  440 SLRKHMRTHTREKPYECKQCGKAFS 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
536-629 1.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768000960 536 KPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKHCGKAFNCS--SSLRRHVRIHTTEKQYKCNVGHPPANEF--MCSAS 611
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKasSSSLS 111

                         90
                 ....*....|....*...
gi 768000960 612 EKSHQERDLIKVVNMVLP 629
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP 129
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 1.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 768000960  328 AFRRHMITHTGEKPYECKQCGKTFIY 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-269 2.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 768000960  244 SLTSHLRSHTGEKPYKCKECGKAFSY 269
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-381 2.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.12e-04
                          10        20
                  ....*....|....*....|....*.
gi 768000960  356 SFRRHERIHTGEKPYECKQCGKTFIY 381
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-548 3.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.07e-04
                          10        20
                  ....*....|....*....|....
gi 768000960  525 LQQHVRTHTVEKPYECKECGKVFK 548
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-325 3.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.49e-04
                          10        20
                  ....*....|....*....|....*
gi 768000960  301 FRRHMISHTGEKPHKCKECGEAFSY 325
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-409 5.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.93e-04
                          10        20
                  ....*....|....*....|....*.
gi 768000960  384 SFRRHERTHGGEKPYECNQCGKAFSH 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
556-577 8.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.78e-04
                          10        20
                  ....*....|....*....|..
gi 768000960  556 HMRLHTGEKPYQCKHCGKAFNC 577
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-436 1.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|.
gi 768000960  416 HMRVHTGEKPYECKQCGKTFN 436
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-520 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|....*
gi 768000960  496 SLQKHMRRHTAEKLYKCKQCGKAFS 520
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-239 3.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.27e-03
                          10        20
                  ....*....|....*....|....
gi 768000960  216 SLNRHVRIHTAEKTYECKQCGKAF 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-211 4.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.31e-03
                          10        20
                  ....*....|....*....|....
gi 768000960  188 HLRMHVRTHNGERPYVCKLCGKTF 211
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-297 5.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.73e-03
                          10        20
                  ....*....|....*....|....*
gi 768000960  273 FRRHTITHTGEKPYKCKECAEAFSY 297
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 201-249 7.81e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 768000960 201 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 249
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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