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Conserved domains on  [gi|768010182|ref|XP_011525450|]
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zinc finger protein 471 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 8.47e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 8.47e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182    14 VTFKDVAIDFSQEEWQWMNPAQKRLYRSMMLENYQSLVSLGLCISKPYVISLLEQGREPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-602 4.99e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 4.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 288 KPYKCKECRKAFRQPAHLAQHQRIHTGEKPYEC--KECGKAFSDGSSFARHQRCHTGKRPYECIECGKAFRYNTSFIRHW 365
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 366 RSYHTGEKPFNCIDCGKAFSVHIGLILHRRIHTGEKPYKCGVCgktFSSGSSRTVHQRIHtgeKPYECDICGKDFSHHAS 445
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 446 LTQHQRVHSGEKPYECKECGKAFRQNVHLVSHLRIHTGEKPYECKECGKAFRISSQLATHQRIHTGEKPYECIECGNAFK 525
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 526 QRSHLAQHQKTHTGE-------KPYECNECGKAFSQTSNLTQHQR--IHTGE--KPYKCTE--CGKAFSDSSSCAQHQRL 592
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 768010182 593 HTGQRPYQCF 602
Cdd:COG5048  346 HTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-245 8.14e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010182  220 SLTVHFRIHTGEKPYACEECGKAFKQ 245
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 199-257 1.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 199 VYVGKKLFKCN--ECDKTFTHSSSLTVHfRIH--------------------TGEKPYACEECGKAFKQRQHLaQHHRTH 256
Cdd:COG5189  343 KVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGL-KYHRKH 420


                 .
gi 768010182 257 T 257
Cdd:COG5189  421 S 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-273 4.63e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010182  248 HLAQHHRTHTGEKLFECKECRKAFKQ 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 8.47e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 8.47e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182    14 VTFKDVAIDFSQEEWQWMNPAQKRLYRSMMLENYQSLVSLGLCISKPYVISLLEQGREPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-54 4.86e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 4.86e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768010182   13 LVTFKDVAIDFSQEEWQWMNPAQKRLYRSMMLENYQSLVSLG 54
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 2.58e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.58e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768010182  14 VTFKDVAIDFSQEEWQWMNPAQKRLYRSMMLENYQSLVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-602 4.99e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 4.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 288 KPYKCKECRKAFRQPAHLAQHQRIHTGEKPYEC--KECGKAFSDGSSFARHQRCHTGKRPYECIECGKAFRYNTSFIRHW 365
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 366 RSYHTGEKPFNCIDCGKAFSVHIGLILHRRIHTGEKPYKCGVCgktFSSGSSRTVHQRIHtgeKPYECDICGKDFSHHAS 445
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 446 LTQHQRVHSGEKPYECKECGKAFRQNVHLVSHLRIHTGEKPYECKECGKAFRISSQLATHQRIHTGEKPYECIECGNAFK 525
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 526 QRSHLAQHQKTHTGE-------KPYECNECGKAFSQTSNLTQHQR--IHTGE--KPYKCTE--CGKAFSDSSSCAQHQRL 592
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 768010182 593 HTGQRPYQCF 602
Cdd:COG5048  346 HTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
557-581 1.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.73e-04
                          10        20
                  ....*....|....*....|....*
gi 768010182  557 NLTQHQRIHTGEKPYKCTECGKAFS 581
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-245 8.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010182  220 SLTVHFRIHTGEKPYACEECGKAFKQ 245
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 199-257 1.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 199 VYVGKKLFKCN--ECDKTFTHSSSLTVHfRIH--------------------TGEKPYACEECGKAFKQRQHLaQHHRTH 256
Cdd:COG5189  343 KVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGL-KYHRKH 420


                 .
gi 768010182 257 T 257
Cdd:COG5189  421 S 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-273 4.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010182  248 HLAQHHRTHTGEKLFECKECRKAFKQ 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 8.47e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 8.47e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182    14 VTFKDVAIDFSQEEWQWMNPAQKRLYRSMMLENYQSLVSLGLCISKPYVISLLEQGREPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-54 4.86e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 4.86e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768010182   13 LVTFKDVAIDFSQEEWQWMNPAQKRLYRSMMLENYQSLVSLG 54
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 2.58e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.58e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 768010182  14 VTFKDVAIDFSQEEWQWMNPAQKRLYRSMMLENYQSLVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-602 4.99e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 4.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 288 KPYKCKECRKAFRQPAHLAQHQRIHTGEKPYEC--KECGKAFSDGSSFARHQRCHTGKRPYECIECGKAFRYNTSFIRHW 365
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 366 RSYHTGEKPFNCIDCGKAFSVHIGLILHRRIHTGEKPYKCGVCgktFSSGSSRTVHQRIHtgeKPYECDICGKDFSHHAS 445
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 446 LTQHQRVHSGEKPYECKECGKAFRQNVHLVSHLRIHTGEKPYECKECGKAFRISSQLATHQRIHTGEKPYECIECGNAFK 525
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 526 QRSHLAQHQKTHTGE-------KPYECNECGKAFSQTSNLTQHQR--IHTGE--KPYKCTE--CGKAFSDSSSCAQHQRL 592
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 768010182 593 HTGQRPYQCF 602
Cdd:COG5048  346 HTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
260-626 1.11e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 260 KLFECKECRKAFKQSEHLIQHQRIHTGEKPYKC--KECRKAFRQPAHLAQHQRIHTGEKPYECKECG----------KAF 327
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskasssSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 328 SDGSSFARHQRCHTgkrPYECIECGKAFRYNTSFIRHWRSYHTGEKPFNCIDCGKAFSVHIGLILHRRIHTGEKPYKCGV 407
Cdd:COG5048  112 SSSSNSNDNNLLSS---HSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 408 CG---------KTFSSGSSRTV------HQRIHTGEKPYECDICGKDFSHHASLTQHQRVHSGEKPYECKECGKAFRQNV 472
Cdd:COG5048  189 SSnvstsipssSENSPLSSSYSipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 473 HLVSHLRIHTGE-------KPYECKECGKAFRISSQLATHQR--IHTGE--KPYEC--IECGNAFKQRSHLAQHQKTHTG 539
Cdd:COG5048  269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 540 EKPYEC--NECGKAFSQ--TSNLTQHQRIHTGEKPYKCTEC----GKAFSDSSSCAQ-HQRLHTGQRPYQC--FECGKAF 608
Cdd:COG5048  349 ISPAKEklLNSSSKFSPllNNEPPQSLQQYKDLKNDKKSETlsnsCIRNFKRDSNLSlHIITHLSFRPYNCknPPCSKSF 428

                        410
                 ....*....|....*...
gi 768010182 609 RRKLSLICHQRSHTGEEP 626
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-610 1.49e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 203 KKLFKCNECDKTFTHSSSLTVHFRIHTGEKPYAC--EECGKAFKQRQHLAQHHRTHTGEKLFECKecrkafkqsehliqH 280
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--------------K 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 281 QRIHTGEKPYKCKE--CRKAFRQPAHLAQH---QRIHTGEKPYECKEC---GKAFSDGSSFARHQRCHTGKR-PYECIEC 351
Cdd:COG5048   97 SLPLSNSKASSSSLssSSSNSNDNNLLSSHslpPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHpPLPANSL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 352 GKAFRYNTSFIRHWRSYHTGEKPFNCIDCGKAFSVHIGLILHRRIHTgEKPYKC----GVCGKTFSSGSSRTVHQRIHTG 427
Cdd:COG5048  177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLttnsQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 428 EKPyECDICGKDFSHHASlTQHQRVHSGE-----KPYECKECGKAFRQNVHLVSHLR--IHTGE--KPYECKE--CGKAF 496
Cdd:COG5048  256 SAS-ESPRSSLPTASSQS-SSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 497 RISSQLATHQRIHTGEKPYECI--ECGNAFKQRSH-----LAQHQKTHTGEKPYEC--NECGKAFSQTSNLTQHQRIHTG 567
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLS 413

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 768010182 568 EKPY--KCTECGKAFSDSSSCAQHQRLHTGQRPYQCFECGKAFRR 610
Cdd:COG5048  414 FRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-479 3.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 176 SIYNHTSDKKSFSKNSMVIKHKKVYVGKKLFKCNECDKTFTHSSSLTVHFRIHTGEKPYACEECGKAFKQRQHLAQHHRT 255
Cdd:COG5048  169 PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 256 HTGEKLFECKECRKAFKQSEHLIQHQRIHTGE-------KPYKCKECRKAFRQPAHLAQHQR--IHTGE--KPYECKE-- 322
Cdd:COG5048  249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYsl 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 323 CGKAFSDGSSFARHQRCHTGKRPYECIECGkafryntsfirhwrsyHTGEKPFNCIDCGKAFSVHIGLILHRRIHTGEKP 402
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEKLLN----------------SSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSN 392

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768010182 403 YKCgvcgKTFSSGSSRTVHQRIHTGEKPYECD--ICGKDFSHHASLTQHQRVHSGEKPYECkECGKAFRQNVHLVSHLR 479
Cdd:COG5048  393 SCI----RNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 366-454 1.47e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 366 RSYHTGEKPFNC--IDCGKAFSVHIGLILHRrihtgekpyKCGVCGKTFSSGSSRTVHQRIHTGEKPYECDICGKDFSHH 443
Cdd:COG5189  341 MLKVKDGKPYKCpvEGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNL 411

                         90
                 ....*....|.
gi 768010182 444 ASLTQHqRVHS 454
Cdd:COG5189  412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
557-581 1.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.73e-04
                          10        20
                  ....*....|....*....|....*
gi 768010182  557 NLTQHQRIHTGEKPYKCTECGKAFS 581
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
529-554 2.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010182  529 HLAQHQKTHTGEKPYECNECGKAFSQ 554
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-328 2.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.23e-04
                          10        20
                  ....*....|....*....|....*
gi 768010182  304 HLAQHQRIHTGEKPYECKECGKAFS 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 3.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010182  276 HLIQHQRIHTGEKPYKCKECRKAFRQ 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
473-496 3.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.86e-04
                          10        20
                  ....*....|....*....|....
gi 768010182  473 HLVSHLRIHTGEKPYECKECGKAF 496
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-245 8.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010182  220 SLTVHFRIHTGEKPYACEECGKAFKQ 245
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 199-257 1.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010182 199 VYVGKKLFKCN--ECDKTFTHSSSLTVHfRIH--------------------TGEKPYACEECGKAFKQRQHLaQHHRTH 256
Cdd:COG5189  343 KVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGL-KYHRKH 420


                 .
gi 768010182 257 T 257
Cdd:COG5189  421 S 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-526 1.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|....*
gi 768010182  502 LATHQRIHTGEKPYECIECGNAFKQ 526
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
445-470 1.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010182  445 SLTQHQRVHSGEKPYECKECGKAFRQ 470
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-357 3.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010182  332 SFARHQRCHTGKRPYECIECGKAFRY 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
421-442 3.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.52e-03
                          10        20
                  ....*....|....*....|..
gi 768010182  421 HQRIHTGEKPYECDICGKDFSH 442
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-273 4.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010182  248 HLAQHHRTHTGEKLFECKECRKAFKQ 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 543-565 5.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.89e-03
                          10        20
                  ....*....|....*....|...
gi 768010182  543 YECNECGKAFSQTSNLTQHQRIH 565
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
390-414 7.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|....*
gi 768010182  390 LILHRRIHTGEKPYKCGVCGKTFSS 414
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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