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Conserved domains on  [gi|768009298|ref|XP_011525282|]
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zinc finger protein 772 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-409 2.59e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 103 HLAEHQETHPGQKPYMC--VLCGKQFCFSANLHQHQKQHSGEKPFRSDKSRP--------FLLNNCAVQSMEMSFVTGEA 172
Cdd:COG5048   48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassSSLSSSSSNSNDNNLLSSHS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 173 CKD--------FLASSSIFEHHAphNEWKPHSNTKCEEASHCGKRHYKCSECGKTFSRKDSLVQHQRVHTGERPYECGEC 244
Cdd:COG5048  128 LPPssrdpqlpDLLSISNLRNNP--LPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 245 GKtFSRKPILAQHQRIHTGEMPYECGICGKVFNHSSNLIVHQRVHTGARPYKCSECGkaysHKSTLVQHESIHTGERPYE 324
Cdd:COG5048  206 SS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP----RSSLPTASSQSSSPNESDS 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 325 CSECGKYfghkyrlikhwsvhtgaRPYECIACGKFFSQSSDLIAHQR--VHNGE--KPYVCSE--CGKAFSHKHVLVQHH 398
Cdd:COG5048  281 SSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330
                 ....*....|.
gi 768009298 399 RIHTGERPYKC 409
Cdd:COG5048  344 LLHTSISPAKE 354
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-409 2.59e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 103 HLAEHQETHPGQKPYMC--VLCGKQFCFSANLHQHQKQHSGEKPFRSDKSRP--------FLLNNCAVQSMEMSFVTGEA 172
Cdd:COG5048   48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassSSLSSSSSNSNDNNLLSSHS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 173 CKD--------FLASSSIFEHHAphNEWKPHSNTKCEEASHCGKRHYKCSECGKTFSRKDSLVQHQRVHTGERPYECGEC 244
Cdd:COG5048  128 LPPssrdpqlpDLLSISNLRNNP--LPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 245 GKtFSRKPILAQHQRIHTGEMPYECGICGKVFNHSSNLIVHQRVHTGARPYKCSECGkaysHKSTLVQHESIHTGERPYE 324
Cdd:COG5048  206 SS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP----RSSLPTASSQSSSPNESDS 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 325 CSECGKYfghkyrlikhwsvhtgaRPYECIACGKFFSQSSDLIAHQR--VHNGE--KPYVCSE--CGKAFSHKHVLVQHH 398
Cdd:COG5048  281 SSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330
                 ....*....|.
gi 768009298 399 RIHTGERPYKC 409
Cdd:COG5048  344 LLHTSISPAKE 354
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 162-345 4.82e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 45.63  E-value: 4.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 162 SMEMSFVTGEACKDFLASSSIFEHHA---PHNEWKPHSNT----KCEEAshcgKRHYKCSECGKTFSRKDsLVQHQRVHt 234
Cdd:PLN03086 402 SMDVDTVECRNCKHYIPSRSIALHEAycsRHNVVCPHDGCgivlRVEEA----KNHVHCEKCGQAFQQGE-MEKHMKVF- 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 235 gERPYECGeCGKTFsRKPILAQHQRIHTGEMPYECGICGKVfnhssnlivhqrVHTGarpykcSECGKAYSHKSTLVQHE 314
Cdd:PLN03086 476 -HEPLQCP-CGVVL-EKEQMVQHQASTCPLRLITCRFCGDM------------VQAG------GSAMDVRDRLRGMSEHE 534

                        170       180       190
                 ....*....|....*....|....*....|.
gi 768009298 315 SIhTGERPYECSECGKYFGHKYRLIKHWSVH 345
Cdd:PLN03086 535 SI-CGSRTAPCDSCGRSVMLKEMDIHQIAVH 564
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-418 6.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.16e-04
                          10        20
                  ....*....|....*....|....*
gi 768009298  394 LVQHHRIHTGERPYKCSECGKAFRQ 418
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-409 2.59e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 103 HLAEHQETHPGQKPYMC--VLCGKQFCFSANLHQHQKQHSGEKPFRSDKSRP--------FLLNNCAVQSMEMSFVTGEA 172
Cdd:COG5048   48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassSSLSSSSSNSNDNNLLSSHS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 173 CKD--------FLASSSIFEHHAphNEWKPHSNTKCEEASHCGKRHYKCSECGKTFSRKDSLVQHQRVHTGERPYECGEC 244
Cdd:COG5048  128 LPPssrdpqlpDLLSISNLRNNP--LPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 245 GKtFSRKPILAQHQRIHTGEMPYECGICGKVFNHSSNLIVHQRVHTGARPYKCSECGkaysHKSTLVQHESIHTGERPYE 324
Cdd:COG5048  206 SS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP----RSSLPTASSQSSSPNESDS 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 325 CSECGKYfghkyrlikhwsvhtgaRPYECIACGKFFSQSSDLIAHQR--VHNGE--KPYVCSE--CGKAFSHKHVLVQHH 398
Cdd:COG5048  281 SSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330
                 ....*....|.
gi 768009298 399 RIHTGERPYKC 409
Cdd:COG5048  344 LLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-425 5.63e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 175 DFLASSSIFEHHAPHNewkPHSNTKCEEASHCGKRHYKCSECGKTFSRKdslvQHQRVHTGER-----PYECGECGKTFS 249
Cdd:COG5048  228 PLTTNSQLSPKSLLSQ---SPSSLSSSDSSSSASESPRSSLPTASSQSS----SPNESDSSSEkgfslPIKSKQCNISFS 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 250 RKPILAQHQR--IHTGE--MPYECGI--CGKVFNHSSNLIVHQRVHTGARPYKC--SECGKAYSHKST-----LVQHESI 316
Cdd:COG5048  301 RSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKD 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 317 HTGERPYEC--SECGKYFGHKYRLIKHWSVHTGARPYECIacgkffsqssdliahqrvhngekpyvCSECGKAFSHKHVL 394
Cdd:COG5048  381 LKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK--------------------------NPPCSKSFNRHYNL 434

                        250       260       270
                 ....*....|....*....|....*....|.
gi 768009298 395 VQHHRIHTGERPYKCSECGKaFRQRASLIRH 425
Cdd:COG5048  435 IPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-333 3.91e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 127 CFSANLHQHQKQHSGEKPFRSDKSRPFLLNNCAVQSMEMSFVTGEACKDFLASSSIFehhaphnewKPHSNTKCEEASHC 206
Cdd:COG5048  231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFS---------LPIKSKQCNISFSR 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 207 G---KRHYKC---------------SECGKTFSRKDSLVQHQRVHTGERPYEC--GECGKTFSRKPI-----LAQHQRIH 261
Cdd:COG5048  302 SsplTRHLRSvnhsgeslkpfscpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDL 381

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768009298 262 TGEMPYEC--GICGKVFNHSSNLIVHQRVHTGARP--YKCSECGKAYSHKSTLVQHESIHTGERPYECSECGKYFG 333
Cdd:COG5048  382 KNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 162-345 4.82e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 45.63  E-value: 4.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 162 SMEMSFVTGEACKDFLASSSIFEHHA---PHNEWKPHSNT----KCEEAshcgKRHYKCSECGKTFSRKDsLVQHQRVHt 234
Cdd:PLN03086 402 SMDVDTVECRNCKHYIPSRSIALHEAycsRHNVVCPHDGCgivlRVEEA----KNHVHCEKCGQAFQQGE-MEKHMKVF- 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768009298 235 gERPYECGeCGKTFsRKPILAQHQRIHTGEMPYECGICGKVfnhssnlivhqrVHTGarpykcSECGKAYSHKSTLVQHE 314
Cdd:PLN03086 476 -HEPLQCP-CGVVL-EKEQMVQHQASTCPLRLITCRFCGDM------------VQAG------GSAMDVRDRLRGMSEHE 534

                        170       180       190
                 ....*....|....*....|....*....|.
gi 768009298 315 SIhTGERPYECSECGKYFGHKYRLIKHWSVH 345
Cdd:PLN03086 535 SI-CGSRTAPCDSCGRSVMLKEMDIHQIAVH 564
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-418 6.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.16e-04
                          10        20
                  ....*....|....*....|....*
gi 768009298  394 LVQHHRIHTGERPYKCSECGKAFRQ 418
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 211-233 1.50e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|...
gi 768009298  211 YKCSECGKTFSRKDSLVQHQRVH 233
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-250 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 768009298  225 SLVQHQRVHTGERPYECGECGKTFSR 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 267-289 2.50e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.50e-03
                          10        20
                  ....*....|....*....|...
gi 768009298  267 YECGICGKVFNHSSNLIVHQRVH 289
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-278 4.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*
gi 768009298  254 LAQHQRIHTGEMPYECGICGKVFNH 278
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-281 9.76e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 9.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768009298 208 KRHYKCSECGKTFSRKDSLVQHQRVHTGERPYECG--ECGKTFSRKPILAQHQRIHTGEMPYECGICGKVFNHSSN 281
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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