solute carrier family 66 member 2 isoform X12 [Homo sapiens]
Protein Classification
PQ-loop repeat-containing protein( domain architecture ID 10514679)
PQ-loop repeat-containing protein functions as a membrane-bound transporter
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| PQ-loop | pfam04193 | PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of ... |
52-112 | 1.56e-15 | ||
PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of repeats each spanning two transmembrane helices connected by a loop. The PQ motif found on loop 2 is critical for the localization of cystinosin to lysosomes. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought likely to possess a more general function. Most probably this involves a glutamine residue. Family members are membrane transporters since two members, cystinosin and PQLC2, transport cystine and cationic amino acids, respectively, across the lysosomal membrane. The 2nd PQ-loop of cystinosin hosts the substrate-coupled H+ binding site underlying its H+ symport mechanism, suggesting that PQ-loop repeats have functional significance. It is thus likely that PQ-loop-containing proteins act as a family of membrane transporters. Some transport cystine and cationic amino acids, respectively, across the lysosomal membrane. Others transport lysine and or arginine across the lysosomal membrane in order to maintain the acidic homoeostasis. : Pssm-ID: 461220 [Multi-domain] Cd Length: 61 Bit Score: 66.37 E-value: 1.56e-15
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| Name | Accession | Description | Interval | E-value | ||
| PQ-loop | pfam04193 | PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of ... |
52-112 | 1.56e-15 | ||
PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of repeats each spanning two transmembrane helices connected by a loop. The PQ motif found on loop 2 is critical for the localization of cystinosin to lysosomes. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought likely to possess a more general function. Most probably this involves a glutamine residue. Family members are membrane transporters since two members, cystinosin and PQLC2, transport cystine and cationic amino acids, respectively, across the lysosomal membrane. The 2nd PQ-loop of cystinosin hosts the substrate-coupled H+ binding site underlying its H+ symport mechanism, suggesting that PQ-loop repeats have functional significance. It is thus likely that PQ-loop-containing proteins act as a family of membrane transporters. Some transport cystine and cationic amino acids, respectively, across the lysosomal membrane. Others transport lysine and or arginine across the lysosomal membrane in order to maintain the acidic homoeostasis. Pssm-ID: 461220 [Multi-domain] Cd Length: 61 Bit Score: 66.37 E-value: 1.56e-15
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| CTNS | smart00679 | Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, ... |
69-96 | 4.64e-08 | ||
Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins; Function unknown, but likely to be associated with the glycosylation machinery. Pssm-ID: 128923 [Multi-domain] Cd Length: 32 Bit Score: 46.29 E-value: 4.64e-08
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| Name | Accession | Description | Interval | E-value | ||
| PQ-loop | pfam04193 | PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of ... |
52-112 | 1.56e-15 | ||
PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of repeats each spanning two transmembrane helices connected by a loop. The PQ motif found on loop 2 is critical for the localization of cystinosin to lysosomes. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought likely to possess a more general function. Most probably this involves a glutamine residue. Family members are membrane transporters since two members, cystinosin and PQLC2, transport cystine and cationic amino acids, respectively, across the lysosomal membrane. The 2nd PQ-loop of cystinosin hosts the substrate-coupled H+ binding site underlying its H+ symport mechanism, suggesting that PQ-loop repeats have functional significance. It is thus likely that PQ-loop-containing proteins act as a family of membrane transporters. Some transport cystine and cationic amino acids, respectively, across the lysosomal membrane. Others transport lysine and or arginine across the lysosomal membrane in order to maintain the acidic homoeostasis. Pssm-ID: 461220 [Multi-domain] Cd Length: 61 Bit Score: 66.37 E-value: 1.56e-15
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| CTNS | smart00679 | Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, ... |
69-96 | 4.64e-08 | ||
Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins; Function unknown, but likely to be associated with the glycosylation machinery. Pssm-ID: 128923 [Multi-domain] Cd Length: 32 Bit Score: 46.29 E-value: 4.64e-08
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