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Conserved domains on  [gi|767998591|ref|XP_011524234|]
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cadherin-19 isoform X3 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 9.44e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 9.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591 152 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 767998591 230 IGQPgaLSGTTSVLIKLSDVNDN 252
Cdd:cd11304   78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 261-366 2.19e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 2.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591 261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*..
gi 767998591 340 HVPEQlmkyhteASTTFIKIQVEDVDE 366
Cdd:cd11304   78 GGPPL-------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-144 3.80e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 3.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  49 QFFVPEEMnTTSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGR 126
Cdd:cd11304    3 EVSVPENA-PPGTVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GP 80

                         90
                 ....*....|....*...
gi 767998591 127 AVEPESEFVIKVSDINDN 144
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 375-445 4.28e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 4.28e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767998591 375 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEK 445
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDG 77
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 9.44e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 9.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591 152 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 767998591 230 IGQPgaLSGTTSVLIKLSDVNDN 252
Cdd:cd11304   78 GGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 4.50e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 4.50e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591   171 TASDADdpsSGNNARLLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSD 248
Cdd:smart00112   1 SATDAD---SGENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 767998591   249 VNDNKP 254
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 261-366 2.19e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 2.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591 261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*..
gi 767998591 340 HVPEQlmkyhteASTTFIKIQVEDVDE 366
Cdd:cd11304   78 GGPPL-------SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
153-246 2.55e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 2.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  153 YEAIVPEMSPEGTLVIQVTASDADDpssGNNARLLYSLLQGQPY--FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMI 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 767998591  231 GQPgaLSGTTSVLIKL 246
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-144 3.80e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 3.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  49 QFFVPEEMnTTSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGR 126
Cdd:cd11304    3 EVSVPENA-PPGTVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GP 80

                         90
                 ....*....|....*...
gi 767998591 127 AVEPESEFVIKVSDINDN 144
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 375-445 4.28e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 4.28e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767998591 375 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEK 445
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 68-146 6.54e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 6.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591    68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAVEPESEFVIKVSDINDNEP 146
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
375-443 7.43e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 7.43e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767998591  375 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITAT 443
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
49-121 1.05e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.05e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767998591   49 QFFVPEEMNTTSHhIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 121
Cdd:pfam00028   2 SASVPENAPVGTE-VLTVTaTDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
Cadherin pfam00028
Cadherin domain;
261-362 1.88e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 767998591  340 HVPEQlmkyhteASTTFIKIQVE 362
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 280-368 2.52e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 2.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591   280 AYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIK 358
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVT 70

                           90
                   ....*....|.
gi 767998591   359 IQVEDV-DEPP 368
Cdd:smart00112  71 ITVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 393-443 8.90e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 8.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767998591   393 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITAT 443
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEAT 56
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 9.44e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 9.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591 152 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 229
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 767998591 230 IGQPgaLSGTTSVLIKLSDVNDN 252
Cdd:cd11304   78 GGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 4.50e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 4.50e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591   171 TASDADdpsSGNNARLLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSD 248
Cdd:smart00112   1 SATDAD---SGENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 767998591   249 VNDNKP 254
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 261-366 2.19e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 2.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591 261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....*..
gi 767998591 340 HVPEQlmkyhteASTTFIKIQVEDVDE 366
Cdd:cd11304   78 GGPPL-------SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
153-246 2.55e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 2.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  153 YEAIVPEMSPEGTLVIQVTASDADDpssGNNARLLYSLLQGQPY--FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMI 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 767998591  231 GQPgaLSGTTSVLIKL 246
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-144 3.80e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 3.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  49 QFFVPEEMnTTSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGR 126
Cdd:cd11304    3 EVSVPENA-PPGTVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GP 80

                         90
                 ....*....|....*...
gi 767998591 127 AVEPESEFVIKVSDINDN 144
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 375-445 4.28e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 4.28e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767998591 375 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEK 445
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 68-146 6.54e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 6.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591    68 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAVEPESEFVIKVSDINDNEP 146
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
375-443 7.43e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 7.43e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767998591  375 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITAT 443
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
49-121 1.05e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.05e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767998591   49 QFFVPEEMNTTSHhIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 121
Cdd:pfam00028   2 SASVPENAPVGTE-VLTVTaTDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
Cadherin pfam00028
Cadherin domain;
261-362 1.88e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  261 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 339
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 767998591  340 HVPEQlmkyhteASTTFIKIQVE 362
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 280-368 2.52e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 2.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591   280 AYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIK 358
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVT 70

                           90
                   ....*....|.
gi 767998591   359 IQVEDV-DEPP 368
Cdd:smart00112  71 ITVLDVnDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 52-144 6.02e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 50.42  E-value: 6.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998591  52 VPEEMNTTSHhIGQLRSDLDNGNNSFqYKLLGAGA---GSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAV 128
Cdd:cd00031    6 AVEGRSRGSF-RVSIPTDLIASSGEI-IKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAAS-LGANVP 82

                         90
                 ....*....|....*.
gi 767998591 129 EPESEFVIKVSDINDN 144
Cdd:cd00031   83 QTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 393-443 8.90e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 8.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767998591   393 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITAT 443
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEAT 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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