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Conserved domains on  [gi|767998156|ref|XP_011524100|]
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N-acetyltransferase ESCO1 isoform X1 [Homo sapiens]

Protein Classification

ECO family N-acetyltransferase( domain architecture ID 10620681)

ECO family N-acetyltransferase contains a C2H2 zinc finger, is required for the establishment of sister chromatid cohesion, and may acetylate components of the cohesin complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
763-831 2.86e-37

ESCO1/2 acetyl-transferase;


:

Pssm-ID: 464015  Cd Length: 69  Bit Score: 133.76  E-value: 2.86e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998156  763 EPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVY 831
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
604-643 1.06e-14

zinc-finger of acetyl-transferase ESCO;


:

Pssm-ID: 464013  Cd Length: 40  Bit Score: 68.42  E-value: 1.06e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767998156  604 QLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQ 643
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00121 super family cl31754
MAEBL; Provisional
 5-350 2.74e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156    5 QEKSKENSSKvtKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSIN 84
Cdd:PTZ00121 1299 EEKKKADEAK--KKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156   85 KNTVtvrgysqESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRrslRSREIQGQVQAVKQSLPPTKKEQCSSTQ 164
Cdd:PTZ00121 1377 KKKA-------DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK---KADEAKKKAEEKKKADEAKKKAEEAKKA 1446

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156  165 SKSNKTSQKHVKRKVLEVKSDS--KEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPV 242
Cdd:PTZ00121 1447 DEAKKKAEEAKKAEEAKKKAEEakKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE 1526

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156  243 TSEVKRSKMATSVvpKKNEMKKSVHtQVNTNTTLPKSPQPSVPEQSDNELEQAGKS-KRGSILQLCEEIAGEIESDNVEV 321
Cdd:PTZ00121 1527 AKKAEEAKKADEA--KKAEEKKKAD-ELKKAEELKKAEEKKKAEEAKKAEEDKNMAlRKAEEAKKAEEARIEEVMKLYEE 1603

                         330       340
                  ....*....|....*....|....*....
gi 767998156  322 KKEsSQMESVKEEKPTEIKLEETSVERQI 350
Cdd:PTZ00121 1604 EKK-MKAEEAKKAEEAKIKAEELKKAEEE 1631
 
Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
763-831 2.86e-37

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 133.76  E-value: 2.86e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998156  763 EPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVY 831
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
604-643 1.06e-14

zinc-finger of acetyl-transferase ESCO;


Pssm-ID: 464013  Cd Length: 40  Bit Score: 68.42  E-value: 1.06e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767998156  604 QLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQ 643
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00121 PTZ00121
MAEBL; Provisional
 5-350 2.74e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156    5 QEKSKENSSKvtKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSIN 84
Cdd:PTZ00121 1299 EEKKKADEAK--KKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156   85 KNTVtvrgysqESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRrslRSREIQGQVQAVKQSLPPTKKEQCSSTQ 164
Cdd:PTZ00121 1377 KKKA-------DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK---KADEAKKKAEEKKKADEAKKKAEEAKKA 1446

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156  165 SKSNKTSQKHVKRKVLEVKSDS--KEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPV 242
Cdd:PTZ00121 1447 DEAKKKAEEAKKAEEAKKKAEEakKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE 1526

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156  243 TSEVKRSKMATSVvpKKNEMKKSVHtQVNTNTTLPKSPQPSVPEQSDNELEQAGKS-KRGSILQLCEEIAGEIESDNVEV 321
Cdd:PTZ00121 1527 AKKAEEAKKADEA--KKAEEKKKAD-ELKKAEELKKAEEKKKAEEAKKAEEDKNMAlRKAEEAKKAEEARIEEVMKLYEE 1603

                         330       340
                  ....*....|....*....|....*....
gi 767998156  322 KKEsSQMESVKEEKPTEIKLEETSVERQI 350
Cdd:PTZ00121 1604 EKK-MKAEEAKKAEEAKIKAEELKKAEEE 1631
 
Name Accession Description Interval E-value
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
763-831 2.86e-37

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 133.76  E-value: 2.86e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998156  763 EPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVY 831
Cdd:pfam13880   1 VPAKCGISRIWVSPSHRRKGIATRLLDAARSNFIYGYILEKDEIAFSQPTESGKAFARKYFGTDDFLVY 69
zf-C2H2_3 pfam13878
zinc-finger of acetyl-transferase ESCO;
604-643 1.06e-14

zinc-finger of acetyl-transferase ESCO;


Pssm-ID: 464013  Cd Length: 40  Bit Score: 68.42  E-value: 1.06e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767998156  604 QLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQ 643
Cdd:pfam13878   1 QLILDLGQKSFGATQCKECGMVYNPGSPEDEKLHKKYHAR 40
PTZ00121 PTZ00121
MAEBL; Provisional
 5-350 2.74e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156    5 QEKSKENSSKvtKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSIN 84
Cdd:PTZ00121 1299 EEKKKADEAK--KKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156   85 KNTVtvrgysqESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRrslRSREIQGQVQAVKQSLPPTKKEQCSSTQ 164
Cdd:PTZ00121 1377 KKKA-------DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK---KADEAKKKAEEKKKADEAKKKAEEAKKA 1446

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156  165 SKSNKTSQKHVKRKVLEVKSDS--KEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPV 242
Cdd:PTZ00121 1447 DEAKKKAEEAKKAEEAKKKAEEakKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE 1526

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998156  243 TSEVKRSKMATSVvpKKNEMKKSVHtQVNTNTTLPKSPQPSVPEQSDNELEQAGKS-KRGSILQLCEEIAGEIESDNVEV 321
Cdd:PTZ00121 1527 AKKAEEAKKADEA--KKAEEKKKAD-ELKKAEELKKAEEKKKAEEAKKAEEDKNMAlRKAEEAKKAEEARIEEVMKLYEE 1603

                         330       340
                  ....*....|....*....|....*....
gi 767998156  322 KKEsSQMESVKEEKPTEIKLEETSVERQI 350
Cdd:PTZ00121 1604 EKK-MKAEEAKKAEEAKIKAEELKKAEEE 1631
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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