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Conserved domains on  [gi|767997894|ref|XP_011524046|]
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nucleoporin SEH1 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-348 2.48e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 2.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDvmNLSQWSLQHEIScklSCSCISW 170
Cdd:COG2319  194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 171 NPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPN 250
Cdd:COG2319  255 SPD-------------------------GRLLASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 251 lGRsfhILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAn 328
Cdd:COG2319  300 -GK---LLASGSDDgtVRLWDLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL- 359

                        330       340
                 ....*....|....*....|
gi 767997894 329 ymDNWKCTGILKGNGSPVNG 348
Cdd:COG2319  360 --ATGELLRTLTGHTGAVTS 377
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-348 2.48e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 2.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDvmNLSQWSLQHEIScklSCSCISW 170
Cdd:COG2319  194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 171 NPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPN 250
Cdd:COG2319  255 SPD-------------------------GRLLASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 251 lGRsfhILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAn 328
Cdd:COG2319  300 -GK---LLASGSDDgtVRLWDLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL- 359

                        330       340
                 ....*....|....*....|
gi 767997894 329 ymDNWKCTGILKGNGSPVNG 348
Cdd:COG2319  360 --ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-326 4.22e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 4.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSesgDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200   50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  91 GESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKHMglMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCIS 169
Cdd:cd00200  125 GKCLTTLRGHTDWV------------NSVAFSPDGT--FVASSSQDGTIKLW------DLRTGKCVATLTGhTGEVNSVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 170 WNPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakVQIFEynenTRKYAKAETLMTVTDPVHDIAFAP 249
Cdd:cd00200  185 FSPD-------------------------GEKLLSSSSDGT------IKLWD----LSTGKCLGTLRGHENGVNSVAFSP 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767997894 250 NLgrsfHILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 326
Cdd:cd00200  230 DG----YLLASGSEDgtIRVWDLRTGE---------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 291-326 5.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.55e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767997894   291 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 326
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
291-325 2.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767997894  291 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 325
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-348 2.48e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 2.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDvmNLSQWSLQHEIScklSCSCISW 170
Cdd:COG2319  194 GKLLRTLTGHTGA------------VRSVAFSPD--GKLLASGSADGTVRLWDLAT--GKLLRTLTGHSG---SVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 171 NPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPN 250
Cdd:COG2319  255 SPD-------------------------GRLLASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 251 lGRsfhILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAn 328
Cdd:COG2319  300 -GK---LLASGSDDgtVRLWDLATGK---------------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL- 359

                        330       340
                 ....*....|....*....|
gi 767997894 329 ymDNWKCTGILKGNGSPVNG 348
Cdd:COG2319  360 --ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-326 4.22e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 4.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSesgDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200   50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  91 GESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKHMglMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCIS 169
Cdd:cd00200  125 GKCLTTLRGHTDWV------------NSVAFSPDGT--FVASSSQDGTIKLW------DLRTGKCVATLTGhTGEVNSVA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 170 WNPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakVQIFEynenTRKYAKAETLMTVTDPVHDIAFAP 249
Cdd:cd00200  185 FSPD-------------------------GEKLLSSSSDGT------IKLWD----LSTGKCLGTLRGHENGVNSVAFSP 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767997894 250 NLgrsfHILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 326
Cdd:cd00200  230 DG----YLLASGSEDgtIRVWDLRTGE---------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-348 2.23e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 2.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894   4 ARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESgdwHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTA 83
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---LLLRTLTGHTGAVRSVAF-SPD-GKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  84 AVWEEIVGESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKhmGLMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-K 162
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAV------------TSVAFSPD--GKLLASGSDDGTVRLW------DLATGKLLRTLTGhT 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 163 LSCSCISWNPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakVQIfeYNENTRKYAKaeTLMTVTDPV 242
Cdd:COG2319  205 GAVRSVAFSPD-------------------------GKLLASGSADGT------VRL--WDLATGKLLR--TLTGHSGSV 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 243 HDIAFAPNlGRsfhILAIATKD--VRIFTLKPvRKELTSSGGptkfeihivaqfdnHNSQVWRVSWNITGTVLASSGDDG 320
Cdd:COG2319  250 RSVAFSPD-GR---LLASGSADgtVRLWDLAT-GELLRTLTG--------------HSGGVNSVAFSPDGKLLASGSDDG 310

                        330       340
                 ....*....|....*....|....*...
gi 767997894 321 CVRLWKAnymDNWKCTGILKGNGSPVNG 348
Cdd:COG2319  311 TVRLWDL---ATGKLLRTLTGHTGAVRS 335
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-347 1.36e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 1.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESgdwHCTASWKTHSGSVWRVTWAHpeFGQVLASCSFDRTAAVWEEIV 90
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPDVMNLSQWSlqheiSCKLSCSCISW 170
Cdd:cd00200   83 GECVRTLTGHTSY------------VSSVAFSPD--GRILSSSSRDKTIKVWDVETGKCLTTLR-----GHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 171 NPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakvqIFEYNENTRKYAKaeTLMTVTDPVHDIAFAPN 250
Cdd:cd00200  144 SPD-------------------------GTFVASSSQDGT--------IKLWDLRTGKCVA--TLTGHTGEVNSVAFSPD 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 251 LGRsfHILAIATKDVRIFTLKpvrkeltssggptkfEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKanyM 330
Cdd:cd00200  189 GEK--LLSSSSDGTIKLWDLS---------------TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD---L 248

                        330
                 ....*....|....*..
gi 767997894 331 DNWKCTGILKGNGSPVN 347
Cdd:cd00200  249 RTGECVQTLSGHTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
11-328 1.90e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDkSESGDwhCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIV 90
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWD-LATGK--LLRTLTGHSGSVRSVAF-SPD-GRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  91 GESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYeapdvmNLSQWSLQHEIScklscscisw 170
Cdd:COG2319  278 GELLRTLTGHSGG------------VNSVAFSPD--GKLLASGSDDGTVRLW------DLATGKLLRTLT---------- 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 171 npsriskliekmnrAHlynfhipssrahspmiavgsddsspnamakvqifeynentrkyakaetlmtvTDPVHDIAFAPN 250
Cdd:COG2319  328 --------------GH----------------------------------------------------TGAVRSVAFSPD 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 251 lGRsfhILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAN 328
Cdd:COG2319  342 -GK---TLASGSDDgtVRLWDLATGE---------------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
4-348 2.20e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894   4 ARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWAHPefGQVLASCSFDRTA 83
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD---AAAGALLATLLGHTAAVLSVAFSPD--GRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  84 AVWEEIVGESNDKLRGQSHWVkrttlvdsrtsvTDVKFAPKhmGLMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-K 162
Cdd:COG2319  103 RLWDLATGLLLRTLTGHTGAV------------RSVAFSPD--GKTLASGSADGTVRLW------DLATGKLLRTLTGhS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 163 LSCSCISWNPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPV 242
Cdd:COG2319  163 GAVTSVAFSPD-------------------------GKLLASGSDDGT------VRLW----DLATGKLLRTLTGHTGAV 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 243 HDIAFAPNlGRsfhILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 320
Cdd:COG2319  208 RSVAFSPD-GK---LLASGSADgtVRLWDLATGK---------------LLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                        330       340
                 ....*....|....*....|....*...
gi 767997894 321 CVRLWKAnymDNWKCTGILKGNGSPVNG 348
Cdd:COG2319  269 TVRLWDL---ATGELLRTLTGHSGGVNS 293
WD40 COG2319
WD40 repeat [General function prediction only];
9-146 7.25e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 7.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894   9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDkseSGDWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEE 88
Cdd:COG2319  285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVRSVAF-SPD-GKTLASGSDDGTVRLWDL 359

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767997894  89 IVGESNDKLRGQSHWvkrttlvdsrtsVTDVKFAPKhmGLMLATCSADGIVRIYEAPD 146
Cdd:COG2319  360 ATGELLRTLTGHTGA------------VTSVAFSPD--GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-348 7.98e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 7.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  49 CTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSvtdvkfapkhmgl 128
Cdd:cd00200    1 LRRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 129 mLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSRiskliekmnrahlynfhipssrahsPMIAVGSD 207
Cdd:cd00200   66 -LASGSSDKTIRLW------DLETGECVRTLTGhTSYVSSVAFSPDG-------------------------RILSSSSR 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894 208 DSSpnamakVQIFEYNENTRKYakaeTLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRIFTLKpvrkeltssggptk 285
Cdd:cd00200  114 DKT------IKVWDVETGKCLT----TLRGHTDWVNSVAFSPDG----TFVASSSQDgtIKLWDLR-------------- 165

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767997894 286 fEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKanyMDNWKCTGILKGNGSPVNG 348
Cdd:cd00200  166 -TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---LSTGKCLGTLRGHENGVNS 224
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-173 1.91e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 1.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  10 DHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSEsgdWHCTASWKTHSGSVWRVTWaHPEfGQVLASCSFDRTAAVWEei 89
Cdd:cd00200  133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT---GKCVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLWD-- 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997894  90 vgesndkLRGQsHWVKrtTLVDSRTSVTDVKFAPKhmGLMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCI 168
Cdd:cd00200  206 -------LSTG-KCLG--TLRGHENGVNSVAFSPD--GYLLASGSEDGTIRVW------DLRTGECVQTLSGhTNSVTSL 267


                 ....*
gi 767997894 169 SWNPS 173
Cdd:cd00200  268 AWSPD 272
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 291-326 5.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.55e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767997894   291 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 326
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-40 1.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.80e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 767997894    11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
291-325 2.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767997894  291 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 325
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
11-40 5.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.14e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767997894   11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-87 2.29e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767997894    46 DWHCTASWKTHSGSVWRVTWAHpeFGQVLASCSFDRTAAVWE 87
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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