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Conserved domains on  [gi|767995755|ref|XP_011523485|]
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carbonic anhydrase 4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha_CA super family cl00012
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 1-217 9.47e-96

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


The actual alignment was detected with superfamily member cd03117:

Pssm-ID: 469577  Cd Length: 234  Bit Score: 279.92  E-value: 9.47e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   1 MMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNvkEAQDPEDEIAVLAFLV 80
Cdd:cd03117   45 QVTLPDGAKISGGGLPGTYKALQFHFHWGSNGSPGSEHTIDGERYPMELHIVHIKESYNSLL--EALKDSDGLAVLGFFI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  81 EIGrmnwppplapcrlsqdpslpfqagTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEkLRHYFRYLGSLTT 160
Cdd:cd03117  123 EEG------------------------EEENTNFDPLISALSNIPQKGGSTNLTPFSLRSLLPSVL-LTKYYRYNGSLTT 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995755 161 PTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIK 217
Cdd:cd03117  178 PGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDTDNGQPMVNNFRPVQPLNGRVVYA 234
 
Name Accession Description Interval E-value
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 1-217 9.47e-96

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 279.92  E-value: 9.47e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   1 MMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNvkEAQDPEDEIAVLAFLV 80
Cdd:cd03117   45 QVTLPDGAKISGGGLPGTYKALQFHFHWGSNGSPGSEHTIDGERYPMELHIVHIKESYNSLL--EALKDSDGLAVLGFFI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  81 EIGrmnwppplapcrlsqdpslpfqagTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEkLRHYFRYLGSLTT 160
Cdd:cd03117  123 EEG------------------------EEENTNFDPLISALSNIPQKGGSTNLTPFSLRSLLPSVL-LTKYYRYNGSLTT 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995755 161 PTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIK 217
Cdd:cd03117  178 PGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDTDNGQPMVNNFRPVQPLNGRVVYA 234
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
6-218 2.75e-83

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 249.11  E-value: 2.75e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755    6 NKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGtsRNVKEAQDPEDEIAVLAFLVEIGRM 85
Cdd:pfam00194  66 DPSTISGGPLATRYRLVQFHFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSKY--KSFDEAAKHPDGLAVLGVFFEVGDE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   86 NwppplapcrlsqdpslpfqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPkeEKLRHYFRYLGSLTTPTCDE 165
Cdd:pfam00194 144 N------------------------NPYLQPIVSALDNIKYKGKSVLLPPFDLSDLLP--EDLTSYYTYNGSLTTPPCSE 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767995755  166 KVVWTVFREPIQLHREQILAFSQKLYYDK-EQTVSMKDNVRPLQQLGQRTVIKS 218
Cdd:pfam00194 198 SVTWIVFKEPISISEEQLEAFRTLLFSDGgEEPRPLVNNFRPTQPLNGRVVFAS 251
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 1-214 1.92e-72

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 221.42  E-value: 1.92e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755     1 MMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGtsrNVKEAQDPEDEIAVLAFLV 80
Cdd:smart01057  65 VNFDDDGSTLSGGPLPGRYRLKQFHFHWGGSDSEGSEHTIDGKRFPLELHLVHYNSKG---SFSEAVSKPGGLAVVAVFF 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755    81 EIGRMNwppplapcrlsqdpslpfqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPkeEKLRHYFRYLGSLTT 160
Cdd:smart01057 142 KVGAEE------------------------NPALQAILDHLPLIKYKGQETELTPFDLSSLLP--ASTRHYYTYNGSLTT 195

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767995755   161 PTCDEKVVWTVFREPIQLHREQILAFSQklYYDKEQTVSMKDNVRPLQQLGQRT 214
Cdd:smart01057 196 PPCSEGVTWIVFKEPITISTEQLEKFRT--LLPMEGNEPLVNNARPLQPLNGRV 247
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
19-218 4.38e-39

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 135.78  E-value: 4.38e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  19 YQAKQLHLHwsdlpyKGSEHSLDGEHFAMEMHIVHekekgtsrnvkeaQDPEDEIAVLAFLVEIGrmnwppplapcrlsq 98
Cdd:COG3338  106 YELKQFHFH------TPSEHTINGKSYPMEAHLVH-------------KDADGELAVVGVLFEEG--------------- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  99 dpslpfqagtQVNEGFQPLveaLSNIPKPEMSTTMAESS--LLDLLPKEeklRHYFRYLGSLTTPTCDEKVVWTVFREPI 176
Cdd:COG3338  152 ----------AENPALAKL---WANLPLEAGEEVALDATidLNDLLPED---RSYYRYSGSLTTPPCSEGVLWIVLKQPI 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 767995755 177 QLHREQILAFsQKLYYdkeqtvsmkDNVRPLQQLGQRTVIKS 218
Cdd:COG3338  216 TVSAEQIEAF-ARLYP---------NNARPVQPLNGRLILES 247
PLN02202 PLN02202
carbonate dehydratase
 24-215 9.98e-15

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 71.63  E-value: 9.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  24 LHLHWsdlpYKGSEHSLDGEHFAMEMHIVHEKEKGTsrnvkeaqdpedeIAVLAFLVEIGrmnwppplapcrlSQDPSLp 103
Cdd:PLN02202 116 LQMHW----HTPSEHHLHGVQYAAELHMVHQAKDGS-------------FAVVASLFKIG-------------TEEPFL- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755 104 fqagTQVNEGFQPLVEALSNipkpEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQI 183
Cdd:PLN02202 165 ----SQMKDKLVKLKEERFK----GNHTAQVEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQV 236

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767995755 184 LAFSQKLyyDKeqtvSMKDNVRPLQQLGQRTV 215
Cdd:PLN02202 237 ELLRSPL--DK----SFKNNSRPCQPLNGRRV 262
 
Name Accession Description Interval E-value
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 1-217 9.47e-96

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 279.92  E-value: 9.47e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   1 MMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNvkEAQDPEDEIAVLAFLV 80
Cdd:cd03117   45 QVTLPDGAKISGGGLPGTYKALQFHFHWGSNGSPGSEHTIDGERYPMELHIVHIKESYNSLL--EALKDSDGLAVLGFFI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  81 EIGrmnwppplapcrlsqdpslpfqagTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEkLRHYFRYLGSLTT 160
Cdd:cd03117  123 EEG------------------------EEENTNFDPLISALSNIPQKGGSTNLTPFSLRSLLPSVL-LTKYYRYNGSLTT 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995755 161 PTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIK 217
Cdd:cd03117  178 PGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDTDNGQPMVNNFRPVQPLNGRVVYA 234
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
6-218 2.75e-83

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 249.11  E-value: 2.75e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755    6 NKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGtsRNVKEAQDPEDEIAVLAFLVEIGRM 85
Cdd:pfam00194  66 DPSTISGGPLATRYRLVQFHFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSKY--KSFDEAAKHPDGLAVLGVFFEVGDE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   86 NwppplapcrlsqdpslpfqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPkeEKLRHYFRYLGSLTTPTCDE 165
Cdd:pfam00194 144 N------------------------NPYLQPIVSALDNIKYKGKSVLLPPFDLSDLLP--EDLTSYYTYNGSLTTPPCSE 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767995755  166 KVVWTVFREPIQLHREQILAFSQKLYYDK-EQTVSMKDNVRPLQQLGQRTVIKS 218
Cdd:pfam00194 198 SVTWIVFKEPISISEEQLEAFRTLLFSDGgEEPRPLVNNFRPTQPLNGRVVFAS 251
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 1-214 1.92e-72

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 221.42  E-value: 1.92e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755     1 MMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGtsrNVKEAQDPEDEIAVLAFLV 80
Cdd:smart01057  65 VNFDDDGSTLSGGPLPGRYRLKQFHFHWGGSDSEGSEHTIDGKRFPLELHLVHYNSKG---SFSEAVSKPGGLAVVAVFF 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755    81 EIGRMNwppplapcrlsqdpslpfqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPkeEKLRHYFRYLGSLTT 160
Cdd:smart01057 142 KVGAEE------------------------NPALQAILDHLPLIKYKGQETELTPFDLSSLLP--ASTRHYYTYNGSLTT 195

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767995755   161 PTCDEKVVWTVFREPIQLHREQILAFSQklYYDKEQTVSMKDNVRPLQQLGQRT 214
Cdd:smart01057 196 PPCSEGVTWIVFKEPITISTEQLEKFRT--LLPMEGNEPLVNNARPLQPLNGRV 247
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 1-216 7.04e-69

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 211.37  E-value: 7.04e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   1 MMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSrnvKEAQDPEDEIAVLAFLv 80
Cdd:cd00326   44 VNFDDDGGTLSGGGLPGRYKLVQFHFHWGSENSPGSEHTIDGKRYPLELHLVHYNSDYYS---SEAAKKPGGLAVLGVF- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  81 eigrmnwppplapcrlsqdpslpFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEekLRHYFRYLGSLTT 160
Cdd:cd00326  120 -----------------------FEVGEKENPFLKKILDALPKIKYKGKETTLPPFDLSDLLPSS--LRDYYTYEGSLTT 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767995755 161 PTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEqtvSMKDNVRPLQQLGQRTVI 216
Cdd:cd00326  175 PPCSEGVTWIVFKEPITISKEQLEAFRSLLDREGK---PLVNNYRPVQPLNGRVVY 227
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
 12-215 4.88e-47

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 156.31  E-value: 4.88e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  12 GGGLPAPYQAKQLHLHW--SDLPyKGSEHSLDGEHFAMEMHIVHEKEKGTSrNVKEAQDPEDEIAVLAFLVEIGrmnwpp 89
Cdd:cd03123   69 RGGPGTEYTAAQLHLHWggRGSL-SGSEHTIDGIRFAAELHIVHYNSDKYS-SFDEAADKPDGLAVLAILIEVG------ 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  90 plapcrlsqdpsLPFqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPkeEKLRHYFRYLGSLTTPTCDEKVVW 169
Cdd:cd03123  141 ------------YPE------NTYYEKIISHLHEIKYKGQETTVPGFNVRELLP--EDLSHYYRYEGSLTTPPCYESVLW 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767995755 170 TVFREPIQLHREQILAFSQKLYYDKEQTvsMKDNVRPLQQLGQRTV 215
Cdd:cd03123  201 TVFRDPVTLSKEQLETLENTLMDTHNKT--LQNNYRATQPLNGRVV 244
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 13-218 6.41e-41

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 140.74  E-value: 6.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  13 GGLPAPYQAKQLHLHWSDL-PYKGSEHSLDGEHFAMEMHIVHEKEKGTSrNVKEAQDPEDEIAVLAFLVEIGrmnwpppl 91
Cdd:cd03126   69 GGLPFKYTASQLHLHWGQRgSPEGSEHTISGKHFAAELHIVHYNSDKYP-DISTAMNKSQGLAVLGILIEVG-------- 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  92 apcrlsqdpslPFqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKeeKLRHYFRYLGSLTTPTCDEKVVWTV 171
Cdd:cd03126  140 -----------PF------NPSYEKIFSHLHEVKYKDQKVSVPGFNVQELLPK--RLDEYYRYEGSLTTPPCYPSVLWTV 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767995755 172 FREPIQLHREQILAFSQKLY-YDKEQTVSMKDNVRPLQQLGQRTVIKS 218
Cdd:cd03126  201 FRNPVQISQEQLLALETALYsTEEDESREMVNNYRQVQPFNERLVFAS 248
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
19-218 4.38e-39

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 135.78  E-value: 4.38e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  19 YQAKQLHLHwsdlpyKGSEHSLDGEHFAMEMHIVHekekgtsrnvkeaQDPEDEIAVLAFLVEIGrmnwppplapcrlsq 98
Cdd:COG3338  106 YELKQFHFH------TPSEHTINGKSYPMEAHLVH-------------KDADGELAVVGVLFEEG--------------- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  99 dpslpfqagtQVNEGFQPLveaLSNIPKPEMSTTMAESS--LLDLLPKEeklRHYFRYLGSLTTPTCDEKVVWTVFREPI 176
Cdd:COG3338  152 ----------AENPALAKL---WANLPLEAGEEVALDATidLNDLLPED---RSYYRYSGSLTTPPCSEGVLWIVLKQPI 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 767995755 177 QLHREQILAFsQKLYYdkeqtvsmkDNVRPLQQLGQRTVIKS 218
Cdd:COG3338  216 TVSAEQIEAF-ARLYP---------NNARPVQPLNGRLILES 247
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 14-215 5.15e-39

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 135.68  E-value: 5.15e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  14 GLPAPYQAKQLHLHWS--DLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSrnVKEAQDPEDEIAVLAFLVEIGrmNWPPpl 91
Cdd:cd03125   70 GDGTVYTAVQMHFHWGgrDSEISGSEHTIDGMRYVAELHIVHYNSKYKS--YEEAKDKPDGLAVLAFLYKVG--HYAE-- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  92 apcrlsqdpslpfqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPkeEKLRHYFRYLGSLTTPTCDEKVVWTV 171
Cdd:cd03125  144 -------------------NTYYSDFISKLAKIKYAGQTTTLTSLDVRDMLP--ENLHHYYTYQGSLTTPPCTENVLWFV 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767995755 172 FREPIQLHREQILAFSQKLYYDKEQTVsmKDNVRPLQQLGQRTV 215
Cdd:cd03125  203 FDDPVTLSKTQIVKLENTLMDHHNKTI--RNDYRRTQPLNHRVV 244
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 19-217 8.58e-39

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 133.94  E-value: 8.58e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  19 YQAKQLHLHwsdLPykgSEHSLDGEHFAMEMHIVHEKEKGtsrnvkeaqdpedEIAVLAFLVEIGRmnwppplapcrlsq 98
Cdd:cd03124   75 YQLLQFHFH---SP---SEHLINGKRYPLEAHLVHKSKDG-------------QLAVVAVLFEEGK-------------- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  99 dpslpfqagtqVNEGFQPLVEalsNIPKPEMSTTM--AESSLLDLLPKEeklRHYFRYLGSLTTPTCDEKVVWTVFREPI 176
Cdd:cd03124  122 -----------ENPFLKKILD---NMPKKEGTEVNlpAILDPNELLPES---RSYYRYEGSLTTPPCSEGVRWIVLKQPI 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767995755 177 QLHREQILAFSQklyydkeqtVSMKDNVRPLQQLGQRTVIK 217
Cdd:cd03124  185 TISKEQLAKFRA---------AVYPNNARPVQPLNGREVLL 216
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 9-215 1.68e-35

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 126.70  E-value: 1.68e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   9 SISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRnvKEAQDPEDEIAVLAFLveigrmnwp 88
Cdd:cd03122   70 FVSGGPLLGRYKFSEITFHWGTCNSDGSEHSIDGHKFPLEMQILHRNTDFFDS--FEAIKSPGGVLALAYL--------- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  89 pplapcrlsqdpslpFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKlrHYFRYLGSLTTPTCDEKVV 168
Cdd:cd03122  139 ---------------FELSHEDNPFLDPIIEGLRNVSRPGKEVELPPFPLSDLLPPFTD--KYYSYEGSLTTPPCSETVE 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767995755 169 WTVFREPIQLHREQILAFSQKLYYDKEQTVSMK---DNVRPLQQLGQRTV 215
Cdd:cd03122  202 WIVFREPVPISSRQLEAFRELLTRRQDGVMSGDylpNNGRPQQPLGSRTV 251
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
 5-215 1.48e-34

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 124.47  E-value: 1.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   5 ENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKgtSRNVKEAQDPEDEIAVLAFLVEIGR 84
Cdd:cd03119   74 DDRSVLRGGPLTGSYRLRQFHFHWGSSDDHGSEHTVDGVKYAAELHLVHWNSK--YGSFGEAAKQPDGLAVVGVFLKVGE 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  85 mnwppplapcrlsqdpslpfqagtqVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEeklRHYFRYLGSLTTPTCD 164
Cdd:cd03119  152 -------------------------ANPELQKVLDALDSIKTKGKQAPFTNFDPSCLLPAS---LDYWTYPGSLTTPPLL 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767995755 165 EKVVWTVFREPIQLHREQILAFsQKLYYDKE--QTVSMKDNVRPLQQLGQRTV 215
Cdd:cd03119  204 ECVTWIVLKEPISVSSEQMAKF-RSLLFNAEgePPCPMVDNWRPPQPLKGRKV 255
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 5-218 4.39e-33

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 119.94  E-value: 4.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   5 ENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSrNVKEAQDPEDEIAVLAFLVEIGR 84
Cdd:cd03149   50 DDKTVITGGPLENPYRLKQFHFHWGAKHGSGSEHTVDGKTFPSELHLVHWNAKKYK-SFGEAAAAPDGLAVLGVFLETGD 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  85 MNwpPPLApcRLSQDPSLPFQAGTQVN-EGFQPLVealsnipkpemsttmaesslldLLPKEeklRHYFRYLGSLTTPTC 163
Cdd:cd03149  129 EH--PGLN--RLTDALYMVRFKGTKAQfLDFNPKC----------------------LLPKS---LDYWTYPGSLTTPPL 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767995755 164 DEKVVWTVFREPIQLHREQILAFSQKLYY-DKEQTVSMKDNVRPLQQLGQRTVIKS 218
Cdd:cd03149  180 NESVTWIVLKEPIPVSEKQMGKFRELLFTsEEDQRNHMVNNFRPPQPLKGRTVRAS 235
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 6-218 1.71e-30

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 113.01  E-value: 1.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   6 NKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKgTSRNVKEAQDPEDEIAVLAFLVEIGRM 85
Cdd:cd03118   51 DKSGISGGPLENHYRLKQFHFHWGANNEWGSEHTVDGHTYPAELHLVHWNSV-KYENFEEAVMEENGLAVIGVFLKLGAH 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  86 nwppplapcrlsqdpslpfqagtqvNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPkeeKLRHYFRYLGSLTTPTCDE 165
Cdd:cd03118  130 -------------------------HEGLQKLVDALPEVRHKDTVVEFNPFDPSCLLP---ACRDYWTYPGSLTTPPLTE 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767995755 166 KVVWTVFREPIQLHREQILAFSQKLYY-DKEQTVSMKDNVRPLQQLGQRTVIKS 218
Cdd:cd03118  182 SVTWIIQKQPIEVSPSQLSVFRTLLFTsRGEEEKVMVNNFRPLQPLMNRKVRSS 235
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 19-221 2.69e-27

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 105.04  E-value: 2.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  19 YQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKgtSRNVKEAQDPEDEIAVLAFLVEIGRmnwppplapcrlsq 98
Cdd:cd03150   76 YRALQLHLHWGAAGRPGSEHTVDGHRFPAEIHVVHLSTA--FANLDEALGRPGGLAVLAAFLAEGL-------------- 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  99 dpslpfqagtQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEekLRHYFRYLGSLTTPTCDEKVVWTVFREPIQL 178
Cdd:cd03150  140 ----------HENSAYEQLLSRLSEISEEESETVVPGLDVSALLPSD--LSRYFRYEGSLTTPPCAQGVIWTVFNQTVRL 207

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767995755 179 HREQILAFSQKLYYDKEQTVSMkdNVRPLQQLGQRtVIKSGAP 221
Cdd:cd03150  208 SAKQLHTLSDSLWGPHDSRLQL--NFRATQPLNGR-KIEASFP 247
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 2-215 3.26e-21

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 89.14  E-value: 3.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   2 MLLENKASISGGGLPA--PYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKgTSRNVKEAQDPEDEIAVLAFL 79
Cdd:cd03120   58 IILKSKSVLSGGPLPQghEFELAEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNST-LYSSLEEAMGKPHGIAIIALF 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  80 VEIGRMNwppplapcrlsqdpsLPFQAGTQVNEGFQPLVEALSnIPKPEMSTtmaesslldLLPkEEKLRHYFRYLGSLT 159
Cdd:cd03120  137 VQIGKEH---------------VGLKAVTEILQDIQYKGKSKT-IPCFNPNT---------LLP-DPLLRDYWVYEGSLT 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995755 160 TPTCDEKVVWTVFREPIQLHREQILAFSQ-KLYYDKEQTVS-----MKDNVRPLQQLGQRTV 215
Cdd:cd03120  191 TPPCSEGVTWILFRYPLTISQSQIEEFRRlRTHVKGAELVEgcdglLGDNFRPTQPLSDRVI 252
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
 5-215 3.91e-17

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 77.84  E-value: 3.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755   5 ENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVH-EKEKGTsrNVKEAQDPEDEIAVLAFLVEIG 83
Cdd:cd03121   66 DPVVNISGGPLSYRYRLEEIRLHFGREDEQGSEHTVNGQAFPGEVQLIHyNSELYP--NFSEASKSPNGLVIVSLFVKIG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  84 rmnwppplapcrlsqdpslpfqaGTQVNEGfqplvEALSNIPKPEMSTTMAESSLLDLLPKEEKL---RHYFRYLGSLTT 160
Cdd:cd03121  144 -----------------------ETSNPEL-----RRLTNRDTITSIRYKGDAYFLQDLSIELLLpetDHYITYEGSLTS 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767995755 161 PTCDEKVVWTVFREPIQLHREQILAFSqKLYYDKEQT--VSMKDNVRPLQQLGQRTV 215
Cdd:cd03121  196 PGCHETVTWIILNKPIYITKEQMHSLR-LLSQNSPSQekAPMSPNFRPVQPLNNRPV 251
PLN02202 PLN02202
carbonate dehydratase
 24-215 9.98e-15

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 71.63  E-value: 9.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  24 LHLHWsdlpYKGSEHSLDGEHFAMEMHIVHEKEKGTsrnvkeaqdpedeIAVLAFLVEIGrmnwppplapcrlSQDPSLp 103
Cdd:PLN02202 116 LQMHW----HTPSEHHLHGVQYAAELHMVHQAKDGS-------------FAVVASLFKIG-------------TEEPFL- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755 104 fqagTQVNEGFQPLVEALSNipkpEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQI 183
Cdd:PLN02202 165 ----SQMKDKLVKLKEERFK----GNHTAQVEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQV 236

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767995755 184 LAFSQKLyyDKeqtvSMKDNVRPLQQLGQRTV 215
Cdd:PLN02202 237 ELLRSPL--DK----SFKNNSRPCQPLNGRRV 262
PLN02179 PLN02179
carbonic anhydrase
 22-171 8.26e-09

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 54.22  E-value: 8.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995755  22 KQLHLHWsdlpYKGSEHSLDGEHFAMEMHIVHEKEKGTSrnvkeaqdpedeiAVLAFLVEIGrmnwppplapcrlsqdps 101
Cdd:PLN02179 121 KLVQCHW----HSPSEHTINGTSYDLELHMVHTSASGKT-------------AVVGVLYKLG------------------ 165

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995755 102 lpfqagtQVNEGFQPLVEALSNIPKPEMSTTMAEsslldllPKEEKL--RHYFRYLGSLTTPTCDEKVVWTV 171
Cdd:PLN02179 166 -------EPDEFLTKLLNGIKGVGKKEINLGIVD-------PRDIRFetNNFYRYIGSLTIPPCTEGVIWTV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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