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Conserved domains on  [gi|767995501|ref|XP_011523396|]
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DNA repair protein RAD51 homolog 3 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
1-214 1.29e-103

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


:

Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 297.98  E-value: 1.29e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFmvdrvvdlataciqhlqliaekhkgeehrkale 80
Cdd:cd19492    1 GKITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF--------------------------------- 47
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  81 dftldnilsHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHR 160
Cdd:cd19492   48 ---------NIHYFRVHDYVELLALINSLPKFLEDHPKVKLIVVDSIAFPFRHDFDDLAQRTRLLNGLAQLLHSLARQHN 118
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767995501 161 LAVILTNQMTTKIDRN-QALLVPALGESWGHAATIRLIFHWDRKQsRLATLYKSP 214
Cdd:cd19492  119 LAVVLTNQVTTKISEDgQSQLVPALGESWSHACTTRLFLTWDEKQ-RFAHLYKSP 172
 
Name Accession Description Interval E-value
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
1-214 1.29e-103

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 297.98  E-value: 1.29e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFmvdrvvdlataciqhlqliaekhkgeehrkale 80
Cdd:cd19492    1 GKITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF--------------------------------- 47
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  81 dftldnilsHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHR 160
Cdd:cd19492   48 ---------NIHYFRVHDYVELLALINSLPKFLEDHPKVKLIVVDSIAFPFRHDFDDLAQRTRLLNGLAQLLHSLARQHN 118
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767995501 161 LAVILTNQMTTKIDRN-QALLVPALGESWGHAATIRLIFHWDRKQsRLATLYKSP 214
Cdd:cd19492  119 LAVVLTNQVTTKISEDgQSQLVPALGESWSHACTTRLFLTWDEKQ-RFAHLYKSP 172
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
1-232 5.14e-38

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 133.58  E-value: 5.14e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501    1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAEKHK--GEEhrka 78
Cdd:pfam08423  37 GSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVA-----------IAERYGldPED---- 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   79 ledfTLDNILShiyyfrCRDYT-----ELLAQvylLPDFLSEhSKVRLVIVDGIAFPFRHD---LDDLSLRTRLLNGLAQ 150
Cdd:pfam08423 102 ----VLDNVAY------ARAYNsehqmQLLQQ---AAAMMSE-SRFALLIVDSATALYRTDfsgRGELAERQQHLAKFLR 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  151 QMISLANNHRLAVILTNQMTTKIDRNQALLV-----PALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQI 225
Cdd:pfam08423 168 TLQRLADEFGVAVVITNQVVAQVDGAAGMFSgdpkkPIGGHIMAHASTTRLSLRKGRGEQRICKIYDSPCLPESEAVFAI 247

                  ....*..
gi 767995501  226 KPQGFRD 232
Cdd:pfam08423 248 GSGGIID 254
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
4-232 1.48e-33

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 123.70  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501    4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliaekhkgeEHRKALEDFT 83
Cdd:TIGR02236  98 TEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMA-----------------EARGLDPDEV 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   84 LDNilshIYYFRCRDYTELLAQVYLLPDFLSEHSK-VRLVIVDGIAFPFRHDL---DDLSLRTRLLNGLAQQMISLANNH 159
Cdd:TIGR02236 161 LKN----IYVARAYNSNHQMLLVEKAEDLIKELNNpVKLLIVDSLTSHFRAEYvgrGALAERQQKLNKHLHDLLRLADLY 236
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767995501  160 RLAVILTNQMTTKIDrnqAL----LVPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRD 232
Cdd:TIGR02236 237 NAAVVVTNQVMARPD---AFfgdpTRPIGGHILGHAATFRVYLRKGKGDKRIARLVDSPHLPEGEAVFRITEKGIED 310
radA PRK04301
DNA repair and recombination protein RadA; Validated
4-232 2.06e-32

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 120.75  E-value: 2.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliaekhkgeEHRKALEDFT 83
Cdd:PRK04301 105 TEFYGEFGSGKTQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMA-----------------EALGLDPDEV 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 LDNilshIYYFRCR--DYTELLAQVylLPDFLSEHSKVRLVIVDGIAFPFRHD---LDDLSLRTRLLNGLAQQMISLANN 158
Cdd:PRK04301 168 LDN----IHVARAYnsDHQMLLAEK--AEELIKEGENIKLVIVDSLTAHFRAEyvgRGNLAERQQKLNKHLHDLLRLADL 241
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767995501 159 HRLAVILTNQMTTKIDrnqAL----LVPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRD 232
Cdd:PRK04301 242 YNAAVVVTNQVMARPD---AFfgdpTQPIGGHILGHTATFRIYLRKSKGNKRIARLVDSPHLPEGEAVFRITEEGIRD 316
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
4-47 1.09e-03

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 39.77  E-value: 1.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPecfGGVageAVFIDTEGSF 47
Cdd:COG0468   66 VEIYGPESSGKTTLALHAIAEAQKA---GGI---AAFIDAEHAL 103
 
Name Accession Description Interval E-value
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
1-214 1.29e-103

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 297.98  E-value: 1.29e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFmvdrvvdlataciqhlqliaekhkgeehrkale 80
Cdd:cd19492    1 GKITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF--------------------------------- 47
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  81 dftldnilsHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHR 160
Cdd:cd19492   48 ---------NIHYFRVHDYVELLALINSLPKFLEDHPKVKLIVVDSIAFPFRHDFDDLAQRTRLLNGLAQLLHSLARQHN 118
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767995501 161 LAVILTNQMTTKIDRN-QALLVPALGESWGHAATIRLIFHWDRKQsRLATLYKSP 214
Cdd:cd19492  119 LAVVLTNQVTTKISEDgQSQLVPALGESWSHACTTRLFLTWDEKQ-RFAHLYKSP 172
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
2-200 1.42e-50

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 163.68  E-value: 1.42e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   2 KTTEICGAPGVGKTQLCMQLAVDVQIPEcfggvaGEAVFIDTEGSFMVDRVVDLATACIQhlqliaekhkgeehrkalED 81
Cdd:cd01393    2 KITEIYGPPGSGKTQLALQLAANALLLG------GGVVWIDTEGAFPPSRLVQILEASPS------------------SE 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  82 FTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDD-------LSLRTRLLNGLAQQMIS 154
Cdd:cd01393   58 LELAEALSRLLYFRPPDTLAHLLALDSLPESLFPPPNTSLVVVDSVSALFRKAFPRggdgdssSSLRARLLSQLARALQK 137
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767995501 155 LANNHRLAVILTNQMTTKID--RNQALLVPALGESWGHAATIRLIFHW 200
Cdd:cd01393  138 LAAQFNLAVVVTNQVTTKIRggSGASLVPPALGNTWEHSVSTRLLLYR 185
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
4-221 1.65e-41

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 142.43  E-value: 1.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLatACIQHLQLIAEKHKgeehrkaledft 83
Cdd:cd19491   15 TEIAGESGAGKTQLCLQLALTVQLPRELGGLGGGAVYICTESSFPSKRLQQL--ASSLPKRYHLEKAK------------ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 ldNILSHIYYFRCRDYTELLAQV-YLLPDFLsEHSKVRLVIVDGIAFPFRHDLD----DLSLRTRLLNGLAQQMISLANN 158
Cdd:cd19491   81 --NFLDNIFVEHVADLETLEHCLnYQLPALL-ERGPIRLVVIDSIAALFRSEFDtsrsDLVERAKYLRRLADHLKRLADK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501 159 HRLAVILTNQMTTKIDRN-----------------------QALLVPALGESWGHAATIRLIFhwdrkqSRLATLYKSPS 215
Cdd:cd19491  158 YNLAVVVVNQVTDRFDSSsdasglgvldylsqfssfsggvsGNRKVPALGLTWANLVNTRLML------SRTPKRITDSS 231

                 ....*.
gi 767995501 216 QKECTV 221
Cdd:cd19491  232 AASISV 237
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
1-232 5.14e-38

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 133.58  E-value: 5.14e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501    1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAEKHK--GEEhrka 78
Cdd:pfam08423  37 GSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVA-----------IAERYGldPED---- 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   79 ledfTLDNILShiyyfrCRDYT-----ELLAQvylLPDFLSEhSKVRLVIVDGIAFPFRHD---LDDLSLRTRLLNGLAQ 150
Cdd:pfam08423 102 ----VLDNVAY------ARAYNsehqmQLLQQ---AAAMMSE-SRFALLIVDSATALYRTDfsgRGELAERQQHLAKFLR 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  151 QMISLANNHRLAVILTNQMTTKIDRNQALLV-----PALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQI 225
Cdd:pfam08423 168 TLQRLADEFGVAVVITNQVVAQVDGAAGMFSgdpkkPIGGHIMAHASTTRLSLRKGRGEQRICKIYDSPCLPESEAVFAI 247

                  ....*..
gi 767995501  226 KPQGFRD 232
Cdd:pfam08423 248 GSGGIID 254
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
4-215 4.68e-35

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 125.12  E-value: 4.68e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliAEKHKGEEHRKALEDFT 83
Cdd:cd19493   14 TEITGASGSGKTQFALTLASSAAMPARKGGLDGGVLYIDTESKFSAERLAEIA----------EARFPEAFSGFMEENER 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 LDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHsKVRLVIVDGIAFPFRHD----LDDLSLRTRLLNGLAQQMISLANNH 159
Cdd:cd19493   84 AEEMLKRVAVVRVTTLAQLLERLPNLEEHILSS-GVRLVVIDSIAALVRREfggsDGEVTERHNALAREASSLKRLAEEF 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501 160 RLAVILTNQMTTKIDRNQ---ALLVPALGESWGHAATIRLIFHWDRKQS-RLATLYKSPS 215
Cdd:cd19493  163 RIAVLVTNQATTHFGDAGdgsSGVTAALGDAWAHAVNTRLRLERCLLQLrRVLEIVKSPL 222
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
4-232 4.37e-34

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 122.86  E-value: 4.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliaeKHKGEEhrkaledft 83
Cdd:cd19515   22 TEVFGEFGSGKTQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMA------------KALGLD--------- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 LDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDL---DDLSLRTRLLNGLAQQMISLANNHR 160
Cdd:cd19515   81 PDEVLDNIYVARAYNSNHQMLLVEKAEDLIKEGNNIKLLIVDSLTSHFRAEYvgrGTLAERQQKLNKHLHDLHRLADLYN 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995501 161 LAVILTNQMTTKIDRNQAL-LVPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRD 232
Cdd:cd19515  161 IAVLVTNQVMAKPDAFFGDpTQAIGGHILGHAATFRVYLRKGKGGKRIARLVDSPHLPEGEAVFRITEKGIED 233
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
1-232 5.61e-34

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 122.85  E-value: 5.61e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAEKHkGEEHRKAle 80
Cdd:cd19514   19 MSITEVFGEFRTGKTQLSHTLCVTAQLPGSMGGGGGKVAYIDTEGTFRPDRIRP-----------IAERF-GVDHDAV-- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  81 dftLDNILshiyYFRCrdYT-----ELLAQVyllPDFLSEHSKVRLVIVDGIAFPFRHDLD---DLSLRTRLLNGLAQQM 152
Cdd:cd19514   85 ---LDNIL----YARA--YTsehqmELLDYV---AAKFHEEAVFRLLIIDSIMALFRVDFSgrgELAERQQKLAQMLSRL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501 153 ISLANNHRLAVILTNQMTTkiDRNQALLV------PALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIK 226
Cdd:cd19514  153 QKISEEYNVAVFITNQVTA--DPGAAMTFqadpkkPIGGHILAHASTTRISLRKGRGEERIAKIYDSPDLPENEATFAIT 230

                 ....*.
gi 767995501 227 PQGFRD 232
Cdd:cd19514  231 AGGIAD 236
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
4-232 1.48e-33

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 123.70  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501    4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliaekhkgeEHRKALEDFT 83
Cdd:TIGR02236  98 TEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMA-----------------EARGLDPDEV 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   84 LDNilshIYYFRCRDYTELLAQVYLLPDFLSEHSK-VRLVIVDGIAFPFRHDL---DDLSLRTRLLNGLAQQMISLANNH 159
Cdd:TIGR02236 161 LKN----IYVARAYNSNHQMLLVEKAEDLIKELNNpVKLLIVDSLTSHFRAEYvgrGALAERQQKLNKHLHDLLRLADLY 236
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767995501  160 RLAVILTNQMTTKIDrnqAL----LVPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRD 232
Cdd:TIGR02236 237 NAAVVVTNQVMARPD---AFfgdpTRPIGGHILGHAATFRVYLRKGKGDKRIARLVDSPHLPEGEAVFRITEKGIED 310
radA PRK04301
DNA repair and recombination protein RadA; Validated
4-232 2.06e-32

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 120.75  E-value: 2.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliaekhkgeEHRKALEDFT 83
Cdd:PRK04301 105 TEFYGEFGSGKTQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMA-----------------EALGLDPDEV 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 LDNilshIYYFRCR--DYTELLAQVylLPDFLSEHSKVRLVIVDGIAFPFRHD---LDDLSLRTRLLNGLAQQMISLANN 158
Cdd:PRK04301 168 LDN----IHVARAYnsDHQMLLAEK--AEELIKEGENIKLVIVDSLTAHFRAEyvgRGNLAERQQKLNKHLHDLLRLADL 241
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767995501 159 HRLAVILTNQMTTKIDrnqAL----LVPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRD 232
Cdd:PRK04301 242 YNAAVVVTNQVMARPD---AFfgdpTQPIGGHILGHTATFRIYLRKSKGNKRIARLVDSPHLPEGEAVFRITEEGIRD 316
Rad51_DMC1_archRadA cd01123
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ...
1-229 3.12e-30

recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .


Pssm-ID: 410868 [Multi-domain]  Cd Length: 234  Bit Score: 113.01  E-value: 3.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliaeKHKGEEHrkale 80
Cdd:cd01123   19 GSITEMFGEFRTGKTQLCHTLAVTCQLPIDRGGGEGKAIYIDTEGTFRPERLRAIA------------QRFGLDP----- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  81 dftlDNILSHIYYFRCRDYTELLAQVYLLPDFLSEhSKVRLVIVDGIAFPFRHDLD---DLSLRTRLLNGLAQQMISLAN 157
Cdd:cd01123   82 ----DDVLDNVAYARAFNSDHQTQLLDQAAAMMVE-SRFKLLIVDSATALYRTDYSgrgELSARQMHLAKFLRMLQRLAD 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767995501 158 NHRLAVILTNQMTTKIDRNQALLV----PALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQG 229
Cdd:cd01123  157 EFGVAVVVTNQVVAQVDGAMMFAAdpkkPIGGNILAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAVFAITADG 232
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
1-232 7.60e-28

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 108.33  E-value: 7.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501    1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAEKHkGEEHrkale 80
Cdd:TIGR02238  96 MSITEVFGEFRCGKTQLSHTLCVTAQLPREMGGGNGKVAYIDTEGTFRPDRIRA-----------IAERF-GVDP----- 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   81 DFTLDNILshiyYFRCRDYTELLAQVYLLPDFLSEhSKVRLVIVDGIAFPFRHDLD---DLSLRTRLLNGLAQQMISLAN 157
Cdd:TIGR02238 159 DAVLDNIL----YARAYTSEHQMELLDYLAAKFSE-EPFRLLIVDSIMALFRVDFSgrgELSERQQKLAQMLSRLNKISE 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  158 NHRLAVILTNQMTTkiDRNQALLV------PALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFR 231
Cdd:TIGR02238 234 EFNVAVFVTNQVQA--DPGATMTFiadpkkPIGGHVLAHASTTRILLRKGRGEERVAKLYDSPDMPEAEASFQITEGGIA 311

                  .
gi 767995501  232 D 232
Cdd:TIGR02238 312 D 312
PTZ00035 PTZ00035
Rad51 protein; Provisional
1-232 7.95e-28

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 108.93  E-value: 7.95e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   1 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAEKHK--GEEhrka 78
Cdd:PTZ00035 118 GSITELFGEFRTGKTQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERIVQ-----------IAERFGldPED---- 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  79 ledfTLDNILshiyYFRCrdYT-----ELLAQVyllPDFLSEhSKVRLVIVDGIAFPFRHDLD---DLSLRTRLLNGLAQ 150
Cdd:PTZ00035 183 ----VLDNIA----YARA--YNhehqmQLLSQA---AAKMAE-ERFALLIVDSATALFRVDYSgrgELAERQQHLGKFLR 248
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501 151 QMISLANNHRLAVILTNQMTTKIDRNQALL----VPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIK 226
Cdd:PTZ00035 249 ALQKLADEFNVAVVITNQVMADVDGASMFVadpkKPIGGHIIAHASTTRLSLRKGRGEQRICKIYDSPNLPESEAVFAIS 328

                 ....*.
gi 767995501 227 PQGFRD 232
Cdd:PTZ00035 329 EGGIID 334
Rad51 cd19513
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ...
4-232 1.90e-26

RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.


Pssm-ID: 410921 [Multi-domain]  Cd Length: 235  Bit Score: 102.78  E-value: 1.90e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRvvdlataciqhLQLIAEKHK--GEEhrkaled 81
Cdd:cd19513   22 TELFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPER-----------LLAIAERYGlnGED------- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  82 fTLDNIlSHIYYFRCRDYTELLAQVYLLpdfLSEhSKVRLVIVDGIAFPFRHDLD---DLSLRTRLLNGLAQQMISLANN 158
Cdd:cd19513   84 -VLDNV-AYARAYNTDHQMQLLIQASAM---MAE-SRYALLIVDSATALYRTDYSgrgELSARQMHLAKFLRMLQRLADE 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767995501 159 HRLAVILTNQMTTKIDRNQALLVPAL----GESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRD 232
Cdd:cd19513  158 FGVAVVITNQVVAQVDGAAMFAGDPKkpigGNIMAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAVFAITEDGIGD 235
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
5-199 1.77e-25

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 100.11  E-value: 1.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   5 EICGAPGVGKTQLCMQLAVDVQIPECFGGVA-----GEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRkal 79
Cdd:cd19490    5 EITGPSGSGKTELLYHLAARCILPSSWGGVPlggleAAVVFIDTDGRFDILRLRSILEARIRAAIQAANSSDDEEDV--- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  80 eDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFL---SEHSKVRLVIVDGIAFPFRHD-------LDDLSLRTRLLNGLA 149
Cdd:cd19490   82 -EEIARECLQRLHIFRCHSSLQLLATLLSLENYLlslSANPELGLLLIDSISAFYWQDrfsaelaRAAPLLQEAALRAIL 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767995501 150 QQMISLANNHRLAVILTNQM--------TTKIDRNQALLVP-------ALGESWGHAATIRLIFH 199
Cdd:cd19490  161 RELRRLRRRFQLVVIATKQAlfpgksasTDNPAANNAVSKAsapshreYLPRPWQRLVTHRLVLS 225
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
4-232 3.31e-25

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 101.78  E-value: 3.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliaekhkgeehrkalEDFT 83
Cdd:PLN03187 129 TEAFGEFRSGKTQLAHTLCVTTQLPTEMGGGNGKVAYIDTEGTFRPDRIVPIA-----------------------ERFG 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 LDN--ILSHIYYFRCRDYTELLAQVYLLPDFLSEHSkVRLVIVDGIAFPFRHDL---DDLSLRTRLLNGLAQQMISLANN 158
Cdd:PLN03187 186 MDAdaVLDNIIYARAYTYEHQYNLLLGLAAKMAEEP-FRLLIVDSVIALFRVDFtgrGELAERQQKLAQMLSRLTKIAEE 264
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501 159 HRLAVILTNQ-------MTTKIDRNQallvPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFR 231
Cdd:PLN03187 265 FNVAVYMTNQviadpggGMFISDPKK----PAGGHVLAHAATIRLMLRKGKGEQRVCKVFDAPNLPEAEAEFQITSGGIM 340

                 .
gi 767995501 232 D 232
Cdd:PLN03187 341 D 341
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
4-213 4.22e-25

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 98.48  E-value: 4.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQipeCFGGVAgeAVFIDTEGSFMVDRVVDLATACIQHLQLIAEkhkgeehrkaledft 83
Cdd:cd19489   10 TELVGESSSGKTQLCLTAAANVA---SRSGQN--VLYIDTKSSFSARRLAQILKSRAQDAEEIDK--------------- 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 ldnILSHIYYFRCRDYTELLAQVYLLPDFLS-----EHSKVRLVIVDGIAFPFRHDLDDLSLR--TRLLNGLAQQMISLA 156
Cdd:cd19489   70 ---ALQRIRVVRVFDPYELLDLLEELRNTLSqqqenLYSRLKLVIIDSLSALISPLLGGSKHSegHALLASLARLLKKLA 146
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995501 157 NNHRLAVILTNQMTTKID-RNQALLVPALGESWGHAATIRLIF-----HWDRKQSRLATLYKS 213
Cdd:cd19489  147 AEYQIAVLVTNLTVRGGDgGQQGSTKPALGEYWESVPSTRLLLsrdenDPEESGVCTATLLKS 209
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
4-233 8.74e-25

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 100.58  E-value: 8.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAEKhkgeehrkaledFT 83
Cdd:PLN03186 126 TEIYGEFRTGKTQLCHTLCVTCQLPLDQGGGEGKAMYIDTEGTFRPQRLIQ-----------IAER------------FG 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 LD--NILSHIYYFRCRDyTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLD---DLSLRTRLLNGLAQQMISLANN 158
Cdd:PLN03186 183 LNgaDVLENVAYARAYN-TDHQSELLLEAASMMAETRFALMIVDSATALYRTEFSgrgELSARQMHLGKFLRSLQRLADE 261
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995501 159 HRLAVILTNQMTTKIDRNQ----ALLVPALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRDT 233
Cdd:PLN03186 262 FGVAVVITNQVVAQVDGSAffagPQLKPIGGNIMAHASTTRLALRKGRGENRICKVISSPCLPEAEARFSISSEGVTDV 340
radB PRK09361
DNA repair and recombination protein RadB; Provisional
4-232 2.25e-24

DNA repair and recombination protein RadB; Provisional


Pssm-ID: 236482 [Multi-domain]  Cd Length: 225  Bit Score: 97.24  E-value: 2.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPEcfggvaGEAVFIDTEGsFMVDRVVDLATaciqhlqliaekhkgeehrkalEDFt 83
Cdd:PRK09361  26 TQIYGPPGSGKTNICLQLAVEAAKNG------KKVIYIDTEG-LSPERFKQIAG----------------------EDF- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 lDNILSHIYYFRCRDYTELLAQVYLLPDFLSEhsKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQM---ISLANNHR 160
Cdd:PRK09361  76 -EELLSNIIIFEPSSFEEQSEAIRKAEKLAKE--NVGLIVLDSATSLYRLELEDEEDNSKLNRELGRQLthlLKLARKHD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501 161 LAVILTNQMTTKIDRNQallVPALGEswghaatiRLIFHW---------DRKQSRLATLYKSPSQKEC-TVLFQIKPQGF 230
Cdd:PRK09361 153 LAVVITNQVYSDIDSDG---LRPLGG--------HTLEHWsktilrlekFRNGKRRATLEKHRSRPEGeSAEFRITDRGI 221

                 ..
gi 767995501 231 RD 232
Cdd:PRK09361 222 EI 223
recomb_RAD51 TIGR02239
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ...
4-232 7.06e-24

DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).


Pssm-ID: 274048 [Multi-domain]  Cd Length: 316  Bit Score: 97.87  E-value: 7.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501    4 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAEKHK--GEEhrkaled 81
Cdd:TIGR02239  99 TEIFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLA-----------IAERYGlnPED------- 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   82 fTLDNIlSHIYYFRCRDYTELLAQVYLLpdfLSEhSKVRLVIVDGIAFPFRHDLD---DLSLRTRLLNGLAQQMISLANN 158
Cdd:TIGR02239 161 -VLDNV-AYARAYNTDHQLQLLQQAAAM---MSE-SRFALLIVDSATALYRTDFSgrgELSARQMHLARFLRSLQRLADE 234
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995501  159 HRLAVILTNQMTTKIDRNQALLV-----PALGESWGHAATIRLIFHWDRKQSRLATLYKSPSQKECTVLFQIKPQGFRD 232
Cdd:TIGR02239 235 FGVAVVITNQVVAQVDGAGSMFAgdpkkPIGGNIMAHASTTRLSLRKGRGEQRICKIYDSPCLPESEAMFAIYEDGIGD 313
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
4-231 8.82e-21

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 87.37  E-value: 8.82e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVqipecfGGVAGEAVFIDTEGsFMVDRVVDLAtaciqhlqliaekhkGEEHRKaledft 83
Cdd:cd01394   22 TQIYGPPGSGKTNICLQLAVEA------AKQGKKVVYIDTEG-LSPERFQQIA---------------GERFES------ 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  84 ldnILSHIYYFRCRDYTELLAQVYLLPDFLSEHsKVRLVIVDGIAFPFRHDLDDLSlrtRLLNGLAQQMI---SLANNHR 160
Cdd:cd01394   74 ---IASNIIVFEPYSFDEQGVAIQEAEKLLKSD-KVDLVVVDSATALYRLELGDDS---EANRELSRQMSkllSIARKYD 146
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767995501 161 LAVILTNQMTTKIDRNQALLVPalGESWGHA--ATIRLifhwDRKQ--SRLATLYKSPSQKE-CTVLFQIKPQGFR 231
Cdd:cd01394  147 IPVVITNQVYSDIDDDRLKPVG--GTLLEHWskAIIRL----EKSPpgLRRATLEKHRSRPEgQSAGFRITDRGIR 216
recomb_radB TIGR02237
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB ...
4-229 1.33e-14

DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239) and DMC1 (TIGR02238), and archaeal RadA (TIGR02236).


Pssm-ID: 274047 [Multi-domain]  Cd Length: 209  Bit Score: 70.52  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501    4 TEICGAPGVGKTQLCMQLAVDVQipecfgGVAGEAVFIDTEGsFMVDRVVDLATAciqhlqliaekhkgeehrkaledfT 83
Cdd:TIGR02237  15 TQIYGPPGSGKTNICMILAVNAA------RQGKKVVYIDTEG-LSPERFKQIAED------------------------R 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   84 LDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHsKVRLVIVDGIAFPFRHDL-DDLSLRTRLLNGLAQQMISLANNHRLA 162
Cdd:TIGR02237  64 PERALSNFIVFEVFDFDEQGVAIQKTSKFIDRD-SASLVVVDSFTALYRLELsDDRISRNRELARQLTLLLSLARKKNLA 142
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995501  163 VILTNQMTTKIDRNQALlvPALGESWGHAAtiRLIFHWDR-KQSRLATLYKSPSQKEC-TVLFQIKPQG 229
Cdd:TIGR02237 143 VVITNQVYTDVNNGTLR--PLGGHLLEHWS--KVILRLEKfRGRRLATLEKHRSRPEGeSVYFRITDDG 207
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
4-47 1.09e-03

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 39.77  E-value: 1.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767995501   4 TEICGAPGVGKTQLCMQLAVDVQIPecfGGVageAVFIDTEGSF 47
Cdd:COG0468   66 VEIYGPESSGKTTLALHAIAEAQKA---GGI---AAFIDAEHAL 103
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
6-171 1.52e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 38.74  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   6 ICGAPGVGKTQLCMQLAVDvqipecfGGVAGE-AVFIDTEGSfmVDRVVDLAtaciqhlqliaeKHKGEEHRKALEDFTL 84
Cdd:COG0467   25 LSGPPGTGKTTLALQFLAE-------GLRRGEkGLYVSFEES--PEQLLRRA------------ESLGLDLEEYIESGLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  85 dNILSHIYYFRCRDYTELLAQvylLPDFLSEHsKVRLVIVDGIAfPFRHDLDDLSLRTRLLNGLaqqmISLANNHRLAVI 164
Cdd:COG0467   84 -RIIDLSPEELGLDLEELLAR---LREAVEEF-GAKRVVIDSLS-GLLLALPDPERLREFLHRL----LRYLKKRGVTTL 153

                 ....*..
gi 767995501 165 LTNQMTT 171
Cdd:COG0467  154 LTSETGG 160
RepA COG3598
RecA-family ATPase [Replication, recombination and repair];
2-165 5.10e-03

RecA-family ATPase [Replication, recombination and repair];


Pssm-ID: 442817 [Multi-domain]  Cd Length: 313  Bit Score: 37.57  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501   2 KTTEICGAPGVGKTQLCMQLAVDVQIPECFGGV---AGEAVFIDTEGSF--MVDRVVDLATACiqhlqliaekhkgeehr 76
Cdd:COG3598   14 GVTLLAGPPGTGKSFLALQLAAAVAAGGPWLGRrvpPGKVLYLAAEDDRgeLRRRLKALGADL----------------- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995501  77 kaleDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLsEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQqmisLA 156
Cdd:COG3598   77 ----GLPFADLDGRLRLLSLAGDLDDTDDLEALERAI-EEEGPDLVVIDPLARVFGGDENDAEEMRAFLNPLDR----LA 147

                 ....*....
gi 767995501 157 NNHRLAVIL 165
Cdd:COG3598  148 ERTGAAVLL 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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