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Conserved domains on  [gi|767994390|ref|XP_011522953|]
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gasdermin-A isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
 112-276 2.88e-49

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


:

Pssm-ID: 407590  Cd Length: 174  Bit Score: 161.76  E-value: 2.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390  112 HEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALE--------GALDKGHEVTLEALPKD-VLL 182
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEdlcgggelGPLDGPDGAILLELVGDsGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390  183 SKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALV 262
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQRLL 160

                         170
                  ....*....|....
gi 767994390  263 GLSGLEVQRSGPQY 276
Cdd:pfam17708 161 ESCGLELELDSPKA 174
Gasdermin super family cl20270
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
 1-91 2.74e-35

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


The actual alignment was detected with superfamily member pfam04598:

Pssm-ID: 398339  Cd Length: 240  Bit Score: 127.47  E-value: 2.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390    1 MQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGS----INHKEAVTIPKGCVLAFRVRQLMVKGKDEW 76
Cdd:pfam04598 146 CRERGENLYVVTEVIETTQEVVLTEHSQVEGSGKGMLPGTKTVQGSgqghKDKKVAVTIPKGTVLAYRVIQLVIKSDGQW 225

                          90
                  ....*....|....*
gi 767994390   77 DIPHICNDNMQTFPP 91
Cdd:pfam04598 226 EILLLDDDKQGTFEP 240
 
Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
 112-276 2.88e-49

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 161.76  E-value: 2.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390  112 HEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALE--------GALDKGHEVTLEALPKD-VLL 182
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEdlcgggelGPLDGPDGAILLELVGDsGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390  183 SKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALV 262
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQRLL 160

                         170
                  ....*....|....
gi 767994390  263 GLSGLEVQRSGPQY 276
Cdd:pfam17708 161 ESCGLELELDSPKA 174
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
 1-91 2.74e-35

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 127.47  E-value: 2.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390    1 MQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGS----INHKEAVTIPKGCVLAFRVRQLMVKGKDEW 76
Cdd:pfam04598 146 CRERGENLYVVTEVIETTQEVVLTEHSQVEGSGKGMLPGTKTVQGSgqghKDKKVAVTIPKGTVLAYRVIQLVIKSDGQW 225

                          90
                  ....*....|....*
gi 767994390   77 DIPHICNDNMQTFPP 91
Cdd:pfam04598 226 EILLLDDDKQGTFEP 240
 
Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
 112-276 2.88e-49

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 161.76  E-value: 2.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390  112 HEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALE--------GALDKGHEVTLEALPKD-VLL 182
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEdlcgggelGPLDGPDGAILLELVGDsGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390  183 SKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALV 262
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQRLL 160

                         170
                  ....*....|....
gi 767994390  263 GLSGLEVQRSGPQY 276
Cdd:pfam17708 161 ESCGLELELDSPKA 174
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
 1-91 2.74e-35

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 127.47  E-value: 2.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994390    1 MQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGS----INHKEAVTIPKGCVLAFRVRQLMVKGKDEW 76
Cdd:pfam04598 146 CRERGENLYVVTEVIETTQEVVLTEHSQVEGSGKGMLPGTKTVQGSgqghKDKKVAVTIPKGTVLAYRVIQLVIKSDGQW 225

                          90
                  ....*....|....*
gi 767994390   77 DIPHICNDNMQTFPP 91
Cdd:pfam04598 226 EILLLDDDKQGTFEP 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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