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Conserved domains on  [gi|767994250|ref|XP_011522902|]
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protein TANC2 isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1063-1262 6.43e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 6.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1063 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1142
Cdd:COG0666    46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1143 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:COG0666   126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767994250 1223 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666   206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 893-1187 7.18e-19

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 7.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  893 RNLYTPNIKVS--RLLILGGANINYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDASSESGLTPLG-YAAAAG 966
Cdd:PHA03095   18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  967 YLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWTMAGQQQ-GVFKKSHAIQQaliaaas 1037
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1038 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1117
Cdd:PHA03095  168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994250 1118 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1187
Cdd:PHA03095  236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1413 1.05e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767994250 1378 RARAkRSSSRQFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG0457    82 LGLA-LQALGRYEEALEDYDKALELDPDDAEALYNL 116
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1475-1704 4.26e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1475 LQTEARPSQGLPVIQSP-PSSPPHRDSAYISSSPLGShqvfdfrsSSSVGSPTRQTYQSTSPALSPTHqnshyRPSPPht 1553
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAqPTAPPPPPGPPPPSLPLGG--------SVAPGGDVRRRPPSRSPAAKPAA-----PARPP-- 2882

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1554 spahqggSYRFSPPPVGGQGKEYPSPPpSPLRRGPQYRASPPAesmsvyRSQSGSPVRyQQETSVSQLPGRPKSPLSKMA 1633
Cdd:PHA03247 2883 -------VRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPP------QPQPQPPPP-PQPQPPPPPPPRPQPPLAPTT 2947

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1634 Q-RPYQMPQLPVAVPQQGlRLQPAKAQIVRSNQPSPA---------VHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQ 1703
Cdd:PHA03247 2948 DpAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026


                  .
gi 767994250 1704 S 1704
Cdd:PHA03247 3027 T 3027
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1063-1262 6.43e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 6.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1063 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1142
Cdd:COG0666    46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1143 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:COG0666   126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767994250 1223 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666   206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1141-1227 7.86e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.63  E-value: 7.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1141 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1220
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 767994250  1221 FLVDHGA 1227
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1046-1266 5.16e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.78  E-value: 5.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1046 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH- 1116
Cdd:PHA03095   18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1117 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVDFLLAQGASIALMDKEGLTALswACL--------------- 1179
Cdd:PHA03095   97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1180 -KG----------------HL-------SVVRSLVDNGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1233
Cdd:PHA03095  175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                         250       260       270
                  ....*....|....*....|....*....|...
gi 767994250 1234 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1266
Cdd:PHA03095  255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
 893-1187 7.18e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 7.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  893 RNLYTPNIKVS--RLLILGGANINYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDASSESGLTPLG-YAAAAG 966
Cdd:PHA03095   18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  967 YLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWTMAGQQQ-GVFKKSHAIQQaliaaas 1037
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1038 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1117
Cdd:PHA03095  168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994250 1118 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1187
Cdd:PHA03095  236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
933-1011 3.06e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 3.06e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767994250   933 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 1011
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1413 1.05e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767994250 1378 RARAkRSSSRQFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG0457    82 LGLA-LQALGRYEEALEDYDKALELDPDDAEALYNL 116
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 957-1223 3.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  957 TPLGYAAAAGYL-SIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQqqgvfkkshaiqqaliaa 1035
Cdd:cd22192    19 SPLLLAAKENDVqAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNE------------------ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1036 asmgytEIVSyllDLPEkdeeeveraqinsfdslwGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV--------- 1106
Cdd:cd22192    81 ------PMTS---DLYQ------------------GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknli 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1107 -----PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTV----DFLLAqgasialMDKEgltalswa 1177
Cdd:cd22192   134 yygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFAcqmyDLILS-------YDKE-------- 198

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 767994250 1178 clkghlsvvrslvDNGAATDH-ADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd22192   199 -------------DDLQPLDLvPNNQGLTPFKLAAKEGNIVMFQHLV 232
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1202-1230 1.43e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.43e-04
                            10        20
                    ....*....|....*....|....*....
gi 767994250   1202 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1053-1230 3.77e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 3.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1053 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQgaavaqpNRRGAV--PLFSTVRQGHWQIVDLLLTHGADV 1130
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1131 nmADKQGRTPLMMAASeghlgTVDFllaqgasialmdKEGLTALSWACLKGHLSVVRSLVDNGAA------------TDH 1198
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 767994250  1199 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1475-1704 4.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1475 LQTEARPSQGLPVIQSP-PSSPPHRDSAYISSSPLGShqvfdfrsSSSVGSPTRQTYQSTSPALSPTHqnshyRPSPPht 1553
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAqPTAPPPPPGPPPPSLPLGG--------SVAPGGDVRRRPPSRSPAAKPAA-----PARPP-- 2882

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1554 spahqggSYRFSPPPVGGQGKEYPSPPpSPLRRGPQYRASPPAesmsvyRSQSGSPVRyQQETSVSQLPGRPKSPLSKMA 1633
Cdd:PHA03247 2883 -------VRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPP------QPQPQPPPP-PQPQPPPPPPPRPQPPLAPTT 2947

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1634 Q-RPYQMPQLPVAVPQQGlRLQPAKAQIVRSNQPSPA---------VHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQ 1703
Cdd:PHA03247 2948 DpAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026


                  .
gi 767994250 1704 S 1704
Cdd:PHA03247 3027 T 3027
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1299-1415 1.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1299 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1378
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 767994250  1379 ARAKRSSsRQFAAALEDLNEAIKLCPNNREIQRLLLR 1415
Cdd:TIGR02917  574 AQYYLGK-GQLKKALAILNEAADAAPDSPEAWLMLGR 609
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1485-1677 1.75e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1485 LPVIQSPPSSP-PHRDSAYISSSPLGSHQVFDFRSSSSVGSPtrqtyqstsPALSPTHQNSHYRPSPPHtspahqggsyr 1563
Cdd:pfam03154  352 MPHIKPPPTTPiPQLPNPQSHKHPPHLSGPSPFQMNSNLPPP---------PALKPLSSLSTHHPPSAH----------- 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1564 fsPPPVggqgkeypspppsPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQL- 1642
Cdd:pfam03154  412 --PPPL-------------QLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPIt 476

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 767994250  1643 -----PVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIP 1677
Cdd:pfam03154  477 ppsgpPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516
TPR_12 pfam13424
Tetratricopeptide repeat;
1298-1370 5.18e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 5.18e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994250  1298 GDMFYKKGKVKEAAQRYQYALKKFpREGFGEDlktfRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1370
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1063-1262 6.43e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 6.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1063 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1142
Cdd:COG0666    46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1143 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:COG0666   126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767994250 1223 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666   206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1071-1262 7.04e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 182.46  E-value: 7.04e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1071 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHL 1150
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1151 GTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:COG0666   167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                         170       180       190
                  ....*....|....*....|....*....|..
gi 767994250 1231 HVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666   247 AKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
905-1240 1.20e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 170.13  E-value: 1.20e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  905 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHL 984
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  985 DKNGQCALVHAALRGHLEVVKFLIQcdwtmAGqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeeverAQIN 1064
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLE-----AG--------------------------------------------ADVN 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1065 SFDSlWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1144
Cdd:COG0666   115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1145 ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVD 1224
Cdd:COG0666   194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273

                         330
                  ....*....|....*.
gi 767994250 1225 HGAMIEHVDYSGMRPL 1240
Cdd:COG0666   274 ALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
888-1207 2.37e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 163.59  E-value: 2.37e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  888 ALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGY 967
Cdd:COG0666    20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  968 LSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwtmAGqqqgvfkkshaiqqaliaaasmgyteivsyl 1047
Cdd:COG0666   100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-----AG------------------------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1048 ldlpekdeeeverAQINSFDSlWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHG 1127
Cdd:COG0666   144 -------------ADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1128 ADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPL 1207
Cdd:COG0666   210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1141-1227 7.86e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.63  E-value: 7.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1141 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1220
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 767994250  1221 FLVDHGA 1227
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1046-1266 5.16e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.78  E-value: 5.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1046 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH- 1116
Cdd:PHA03095   18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1117 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVDFLLAQGASIALMDKEGLTALswACL--------------- 1179
Cdd:PHA03095   97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1180 -KG----------------HL-------SVVRSLVDNGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1233
Cdd:PHA03095  175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                         250       260       270
                  ....*....|....*....|....*....|...
gi 767994250 1234 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1266
Cdd:PHA03095  255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
 893-1187 7.18e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 7.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  893 RNLYTPNIKVS--RLLILGGANINYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDASSESGLTPLG-YAAAAG 966
Cdd:PHA03095   18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  967 YLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWTMAGQQQ-GVFKKSHAIQQaliaaas 1037
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1038 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1117
Cdd:PHA03095  168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994250 1118 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1187
Cdd:PHA03095  236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1112-1194 2.05e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 2.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1112 VRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGAsiALMDKEGLTALSWACLKGHLSVVRSLVD 1191
Cdd:pfam12796    5 AKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVKLLLE 82


                   ...
gi 767994250  1192 NGA 1194
Cdd:pfam12796   83 KGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 948-1243 1.68e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 87.71  E-value: 1.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  948 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwtmagqqQGVfkksha 1027
Cdd:PHA02874   28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLID---------NGV------ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1028 iqqaliaaasmgyteiVSYLLDLPEKDEEEVER-----AQINSFDSLwGETALTAAAGRGKLEVCRLLLEQGAAVAQPNR 1102
Cdd:PHA02874   93 ----------------DTSILPIPCIEKDMIKTildcgIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1103 RGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1182
Cdd:PHA02874  156 NGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994250 1183 lSVVRSLVDNGAATDhADKNGRTPLDLAAFYG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1243
Cdd:PHA02874  236 -SAIELLINNASIND-QDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1075-1167 9.23e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 9.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1075 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHgADVNMADkQGRTPLMMAASEGHLGTVD 1154
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 767994250  1155 FLLAQGASIALMD 1167
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 936-1202 2.70e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 2.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  936 EMVALLLEFGANVDASSESGLTPLGYAAAAGY-----LSIVVLLCKKRAKVDHLDKNGQCALVHAALRghlevvkfliqc 1010
Cdd:PHA03100   49 DVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAISK------------ 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1011 dwtmagqqqgvfkkshaiqqaliaaaSMGYTEIVSYLLDLpekdeeeveRAQINSFDSlWGETALTAAA--GRGKLEVCR 1088
Cdd:PHA03100  117 --------------------------KSNSYSIVEYLLDN---------GANVNIKNS-DGENLLHLYLesNKIDLKILK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1089 LLLEQGAAVAQPNRrgavplfstvrqghwqiVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1168
Cdd:PHA03100  161 LLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                         250       260       270
                  ....*....|....*....|....*....|....
gi 767994250 1169 EGLTALSWACLKGHLSVVRSLVDNGAATDHADKN 1202
Cdd:PHA03100  224 YGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 900-1262 2.87e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 85.12  E-value: 2.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  900 IKVSRLLILGGANINYRtEVLNNAPILCVQSHlGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA 979
Cdd:PHA02876  158 LLIAEMLLEGGADVNAK-DIYCITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  980 KVDHLDkngqCALVHAALRGHLEVVKFLIQCDWTMagQQQGVFKKSHAIQQALIAAASmgytEIVSYLLdlpekdeeevE 1059
Cdd:PHA02876  236 NINKND----LSLLKAIRNEDLETSLLLYDAGFSV--NSIDDCKNTPLHHASQAPSLS----RLVPKLL----------E 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1060 RAQINSFDSLWGETALTAAAGRG-KLEVCRLLLEQGAAVAQPNRRGAVPLF-STVRQGHWQIVDLLLTHGADVNMADKQG 1137
Cdd:PHA02876  296 RGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCD 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1138 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA-CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYG-D 1215
Cdd:PHA02876  376 KTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcK 455

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 767994250 1216 AEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRntSVVVTLLKKGAKI 1262
Cdd:PHA02876  456 LDVIEMLLDNGADVNAINIQNQYPLLIALEYH--GIVNILLHYGAEL 500
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1072-1293 2.99e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 83.50  E-value: 2.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1072 ETALTAAAGRGKLEVCRLLLEQGAavaQPN---RRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEG 1148
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGI---NPNfeiYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1149 HLGTVDFLLAQGASIA-LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1227
Cdd:PHA02875   80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994250 1228 MIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI------GCQTLpsrprgpATWAMATSKPDIMIILLSK 1293
Cdd:PHA02875  160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIdyfgknGCVAA-------LCYAIENNKIDIVRLFIKR 224
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1174-1265 3.44e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 3.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1174 LSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHgAMIEHVDYsGMRPLDRAVGCRNTSVVV 1253
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|..
gi 767994250  1254 TLLKKGAKIGCQ 1265
Cdd:pfam12796   79 LLLEKGADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1083-1262 3.75e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.18  E-value: 3.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1083 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQ-----IVDLLLTHGADVNMADKQGRTPLMMAASE--GHLGTVDF 1155
Cdd:PHA03100   47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1156 LLAQGASIALMDKEGLTALSWA--CLKGHLSVVRSLVDNGA----------------ATDHADKNGRTPLDLAAFYGDAE 1217
Cdd:PHA03100  127 LLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVdinaknrvnyllsygvPINIKDVYGFTPLHYAVYNNNPE 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 767994250 1218 VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:PHA03100  207 FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1073-1256 1.53e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.55  E-value: 1.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1073 TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGAD----------------------- 1129
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1130 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1209
Cdd:PHA02874  117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 767994250 1210 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVgCRNTSVVVTLL 1256
Cdd:PHA02874  197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAIELLI 242
Ank_2 pfam12796
Ankyrin repeats (3 copies);
933-1011 3.06e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 3.06e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767994250   933 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 1011
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1118-1262 1.67e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 75.30  E-value: 1.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1118 QIVDLLLTHGADVNMADK-QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1196
Cdd:PHA02878  148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767994250 1197 DHADKNGRTPLDLAAFY-GDAEVVQFLVDHGAMIEHVDY-SGMRPLDRAVgcRNTSVVVTLLKKGAKI 1262
Cdd:PHA02878  228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADI 293
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1039-1260 8.74e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 8.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1039 GYTEIVSYLLDLpekdeeeveraQIN-SFDSLWGETALTAAAGRGKLEVCRLLLEQGAA--VAQPNRRGavPLFSTVRQG 1115
Cdd:PHA02875   13 GELDIARRLLDI-----------GINpNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIpdVKYPDIES--ELHDAVEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1116 HWQIVDLLLTHGADVN-MADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA 1194
Cdd:PHA02875   80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1195 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAmieHVDYSGMRP----LDRAVGCRNTSVVVTLLKKGA 1260
Cdd:PHA02875  160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA---NIDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
959-1095 2.46e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 2.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250   959 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIqcdwtmagqqqgvfkkshaiqqaliaaasm 1038
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL------------------------------ 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767994250  1039 gyteivsylldlpekdeeevERAQINSFDSlwGETALTAAAGRGKLEVCRLLLEQGA 1095
Cdd:pfam12796   51 --------------------EHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGA 85
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1084-1233 5.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.08  E-value: 5.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1084 LEVCRLLLEQGAAVAQPNRRGAVPLF--STVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGT--------- 1152
Cdd:PHA03100   86 KEIVKLLLEYGANVNAPDNNGITPLLyaISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidk 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1153 ---------VDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:PHA03100  166 gvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245

                         170
                  ....*....|
gi 767994250 1224 DHGAMIEHVD 1233
Cdd:PHA03100  246 NNGPSIKTII 255
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1413 1.05e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767994250 1378 RARAkRSSSRQFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG0457    82 LGLA-LQALGRYEEALEDYDKALELDPDDAEALYNL 116
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1084-1267 1.06e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 70.28  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1084 LEVCRLLLEQGAAVAQPNRrgAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASI 1163
Cdd:PLN03192  507 LNVGDLLGDNGGEHDDPNM--ASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNV 584

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1164 ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD-HAdknGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1242
Cdd:PLN03192  585 HIRDANGNTALWNAISAKHHKIFRILYHFASISDpHA---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQV 661

                         170       180
                  ....*....|....*....|....*
gi 767994250 1243 AVGCRNTSVVVTLLKKGAKIGCQTL 1267
Cdd:PLN03192  662 AMAEDHVDMVRLLIMNGADVDKANT 686
Ank_4 pfam13637
Ankyrin repeats (many copies);
1170-1223 2.01e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 60.75  E-value: 2.01e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767994250  1170 GLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1413 7.01e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.64  E-value: 7.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALELDPDD-------------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767994250 1378 RARAKRSSSRqFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG0457   116 LGLALLELGR-YDEAIEAYERALELDPDDADALYNL 150
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1112-1267 1.35e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.63  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1112 VRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD 1191
Cdd:PHA02876  153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767994250 1192 NGAatdHADKNGRTPLDlAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS-VVVTLLKKGAKIGCQTL 1267
Cdd:PHA02876  233 NRS---NINKNDLSLLK-AIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNI 305
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1298-1415 2.19e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.78  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG3914   119 GNLLLALGRLEEALAALRRALALNPDF-------------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNN 185

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767994250 1378 RARAKRSSSRqFAAALEDLNEAIKLCPNNREIQRLLLR 1415
Cdd:COG3914   186 LGNALQDLGR-LEEAIAAYRRALELDPDNADAHSNLLF 222
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1298-1406 2.96e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.21  E-value: 2.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG4783    45 GEILLQLGDLDEAIVLLHEALELDPDE-------------PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR 111

                          90       100
                  ....*....|....*....|....*....
gi 767994250 1378 RARAKRsSSRQFAAALEDLNEAIKLCPNN 1406
Cdd:COG4783   112 LARAYR-ALGRPDEAIAALEKALELDPDD 139
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 901-1233 4.59e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 4.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  901 KVSRLLILGGANinyrTEVLnnaPILCVQShlgytEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAK 980
Cdd:PHA02874   82 DIIKLLIDNGVD----TSIL---PIPCIEK-----DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  981 VDHLDKNGqCALVHAALRGhlevvkfliqcdwtmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeever 1060
Cdd:PHA02874  150 VNIEDDNG-CYPIHIAIKH------------------------------------------------------------- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1061 aqiNSFDslwgetaltaaagrgkleVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1140
Cdd:PHA02874  168 ---NFFD------------------IIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTP 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1141 LMMAASegHLGTVDFLLAQGASIALMDKEGLTALSWA----CLKghlSVVRSLVDNGAATDHADKNGRTPLDLAAFY-GD 1215
Cdd:PHA02874  227 LHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinppCDI---DIIDILLYHKADISIKDNKGENPIDTAFKYiNK 301

                         330
                  ....*....|....*...
gi 767994250 1216 AEVVQFLVDHGAMIEHVD 1233
Cdd:PHA02874  302 DPVIKDIIANAVLIKEAD 319
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1301-1408 4.68e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.26  E-value: 4.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1301 FYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFaTKALELKPKSYEAYYARAR 1380
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAE 67

                          90       100
                  ....*....|....*....|....*...
gi 767994250 1381 AKRsSSRQFAAALEDLNEAIKLCPNNRE 1408
Cdd:COG3063    68 LLL-ELGDYDEALAYLERALELDPSALR 94
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1291-1419 5.99e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 5.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1291 LSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1370
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767994250 1371 SYEAYYARARAKRsSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEE 1419
Cdd:COG4783    71 EPEARLNLGLALL-KAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1294-1419 9.89e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 9.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1373
Cdd:COG2956    79 LLELAQDYLKAGLLDRAEELLEKLLELDPDD-------------AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767994250 1374 AYYARARAKRSSSrQFAAALEDLNEAIKLCPNNREIQRLLLRVEEE 1419
Cdd:COG2956   146 AYCELAELYLEQG-DYDEAIEALEKALKLDPDCARALLLLAELYLE 190
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1301-1413 9.99e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 9.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1301 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARAR 1380
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767994250 1381 AkRSSSRQFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG3914   155 A-LRRLGRLEEAIAALRRALELDPDNAEALNNL 186
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 897-1136 1.66e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.38  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  897 TPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGY--LSIVVLL 974
Cdd:PHA03100   83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  975 CKKRAKVDHLDKngqcalvhaalrghlevVKFLIqcdwtmagqqqgvfkkshaiqqaliaaasmgyteivSYLLDLPEKD 1054
Cdd:PHA03100  163 IDKGVDINAKNR-----------------VNYLL------------------------------------SYGVPINIKD 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1055 EeeveraqinsfdslWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1134
Cdd:PHA03100  190 V--------------YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255


                  ..
gi 767994250 1135 KQ 1136
Cdd:PHA03100  256 ET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1083-1262 3.86e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 3.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1083 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVD-------- 1154
Cdd:PHA02876  157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsn 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1155 ---------------------FLLAQGASIALMDKEGLTALSWACLKGHLS-VVRSLVDNGAATDHADKNGRTPLDLAAF 1212
Cdd:PHA02876  237 inkndlsllkairnedletslLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAK 316

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767994250 1213 YG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC-RNTSVVVTLLKKGAKI 1262
Cdd:PHA02876  317 NGyDTENIRTLIMLGADVNAADRLYITPLHQASTLdRNKDIVITLLELGANV 368
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1083-1235 4.41e-09

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 61.39  E-value: 4.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1083 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVR-----QGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLL 1157
Cdd:PHA02798   50 STDIVKLFINLGANVNGLDNEYSTPLCTILSnikdyKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1158 ---AQGASIALMDKEGLTALSWACLKGH---LSVVRSLVDNGAATD-HADKNGRTPLDLAAFYG----DAEVVQFLVDHG 1226
Cdd:PHA02798  130 fmiENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINtHNNKEKYDTLHCYFKYNidriDADILKLFVDNG 209


                  ....*....
gi 767994250 1227 AMIEHVDYS 1235
Cdd:PHA02798  210 FIINKENKS 218
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1143-1225 4.84e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.45  E-value: 4.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1143 MAASEGHLGtVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:PTZ00322   89 LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                  ...
gi 767994250 1223 VDH 1225
Cdd:PTZ00322  168 SRH 170
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1309-1413 6.30e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.17  E-value: 6.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1309 EAAQRYQYALKKFPREGFGedlktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSSrQ 1388
Cdd:COG4235     1 EAIARLRQALAANPNDAEG-------------WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAG-D 66

                          90       100
                  ....*....|....*....|....*
gi 767994250 1389 FAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG4235    67 TEEAEELLERALALDPDNPEALYLL 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1298-1418 6.42e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.17  E-value: 6.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767994250 1378 RARAkRSSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEE 1418
Cdd:COG4235    91 LGLA-AFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1107-1260 8.69e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.98  E-value: 8.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1107 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALmdkegltaLSWACLKGHLsvV 1186
Cdd:PHA02874   38 PLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI--------LPIPCIEKDM--I 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767994250 1187 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1260
Cdd:PHA02874  108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181
Ank_4 pfam13637
Ankyrin repeats (many copies);
1137-1190 1.16e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 1.16e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767994250  1137 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1190
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1120-1240 1.44e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1120 VDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVdnGAATDHA 1199
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS--RHSQCHF 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767994250 1200 DKNGRTPLDlaAFYGdaeVVQFLVDHGAMIEHVDYSGM-RPL 1240
Cdd:PTZ00322  176 ELGANAKPD--SFTG---KPPSLEDSPISSHHPDFSAVpQPM 212
Ank_4 pfam13637
Ankyrin repeats (many copies);
955-1008 2.11e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 2.11e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767994250   955 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 1008
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1309-1416 2.42e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.35  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1309 EAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRsSSRQ 1388
Cdd:COG5010    25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYS-RSGD 103

                          90       100
                  ....*....|....*....|....*...
gi 767994250 1389 FAAALEDLNEAIKLCPNNREIQRLLLRV 1416
Cdd:COG5010   104 KDEAKEYYEKALALSPDNPNAYSNLAAL 131
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1061-1225 2.61e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.74  E-value: 2.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1061 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1140
Cdd:PHA02878  158 ADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1141 LMMAASE-GHLGTVDFLLAQGASI-ALMDKEGLTALswaclkgHLS-----VVRSLVDNGAATDHADKNGRTPLDLAAF- 1212
Cdd:PHA02878  238 LHISVGYcKDYDILKLLLEHGVDVnAKSYILGLTAL-------HSSikserKLKLLLEYGADINSLNSYKLTPLSSAVKq 310

                         170
                  ....*....|...
gi 767994250 1213 YGDAEVVQFLVDH 1225
Cdd:PHA02878  311 YLCINIGRILISN 323
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1341-1406 3.34e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.55  E-value: 3.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767994250 1341 LLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAkRSSSRQFAAALEDLNEAIKLCPNN 1406
Cdd:COG0457    11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLA-YLRLGRYEEALADYEQALELDPDD 75
Ank_4 pfam13637
Ankyrin repeats (many copies);
1203-1256 3.48e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 3.48e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767994250  1203 GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1256
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1300-1404 3.87e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1300 MFYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARA 1379
Cdd:COG5010    63 LYNKLGDFEESLALLEQALQLDPNNP-------------ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129

                          90       100
                  ....*....|....*....|....*
gi 767994250 1380 RAKRSSSRqFAAALEDLNEAIKLCP 1404
Cdd:COG5010   130 ALLLSLGQ-DDEAKAALQRALGTSP 153
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1298-1383 4.03e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 53.46  E-value: 4.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG1729    37 GEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDA----------LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                  ....*.
gi 767994250 1378 RARAKR 1383
Cdd:COG1729   107 RARLAR 112
Ank_2 pfam12796
Ankyrin repeats (3 copies);
904-985 5.83e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 5.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250   904 RLLILGGANINYRTEVLNNAPILCVQShlGYTEMVALLLEFgANVDASSEsGLTPLGYAAAAGYLSIVVLLCKKRAKVDH 983
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 767994250   984 LD 985
Cdd:pfam12796   90 KD 91
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1267-1406 6.11e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 55.31  E-value: 6.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1267 LPSRPRGPATWAMATSKPDIMiillSKLMEEGDMFYKkgkVKEAAQRYQYALKKFPREGFGEDLKTFRELK----VSLLL 1342
Cdd:COG4785     5 ALALLLALALAAAAASKAAIL----LAALLFAAVLAL---AIALADLALALAAAALAAAALAAERIDRALAlpdlAQLYY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767994250 1343 NLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAkRSSSRQFAAALEDLNEAIKLCPNN 1406
Cdd:COG4785    78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLA-YLLLGDYDAALEDFDRALELDPDY 140
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 899-1134 8.48e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.57  E-value: 8.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  899 NIKVSRLLilgGANINYRTEVLNNAPILCVQShLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKR 978
Cdd:PLN03192  506 DLNVGDLL---GDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  979 AKVDHLDKNGQCALVHAALRGHLEVVKFLIQCdwtmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeev 1058
Cdd:PLN03192  582 CNVHIRDANGNTALWNAISAKHHKIFRILYHF------------------------------------------------ 613

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767994250 1059 erAQINsfDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1134
Cdd:PLN03192  614 --ASIS--DPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1294-1408 9.03e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 54.92  E-value: 9.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1373
Cdd:COG4785    76 YYERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY 142

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767994250 1374 AYYARARAKRSSSRqFAAALEDLNEAIKLCPNNRE 1408
Cdd:COG4785   143 AYLNRGIALYYLGR-YELAIADLEKALELDPNDPE 176
Ank_4 pfam13637
Ankyrin repeats (many copies);
1107-1157 1.16e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.16e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767994250  1107 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLL 1157
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1466 1.57e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.63  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1378 RARAKRSSSRqFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPEPQHEDIYSVQD 1457
Cdd:COG0457   150 LGIALEKLGR-YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALA 228


                  ....*....
gi 767994250 1458 IFEEEYLEQ 1466
Cdd:COG0457   229 LLLALRLAA 237
Ank_4 pfam13637
Ankyrin repeats (many copies);
924-974 2.33e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 2.33e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767994250   924 PILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLL 974
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
1123-1174 9.57e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 9.57e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767994250  1123 LLTHG-ADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTAL 1174
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
1167-1210 1.44e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 1.44e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767994250  1167 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLA 1210
Cdd:pfam13857   13 DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1286-1416 1.57e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1286 IMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKAL 1365
Cdd:COG2956     3 LPVAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPET-------------VEAHLALGNLYRRRGEYDRAIRIHQKLL 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767994250 1366 ELKPKSYEAYYARARAKRsSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1416
Cdd:COG2956    70 ERDPDRAEALLELAQDYL-KAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1337-1413 1.76e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.42  E-value: 1.76e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767994250 1337 KVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAkRSSSRQFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG4783     3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEI-LLQLGDLDEAIVLLHEALELDPDEPEARLNL 78
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 957-1223 3.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  957 TPLGYAAAAGYL-SIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQqqgvfkkshaiqqaliaa 1035
Cdd:cd22192    19 SPLLLAAKENDVqAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNE------------------ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1036 asmgytEIVSyllDLPEkdeeeveraqinsfdslwGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV--------- 1106
Cdd:cd22192    81 ------PMTS---DLYQ------------------GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknli 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1107 -----PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTV----DFLLAqgasialMDKEgltalswa 1177
Cdd:cd22192   134 yygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFAcqmyDLILS-------YDKE-------- 198

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 767994250 1178 clkghlsvvrslvDNGAATDH-ADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd22192   199 -------------DDLQPLDLvPNNQGLTPFKLAAKEGNIVMFQHLV 232
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1347-1419 5.04e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.70  E-value: 5.04e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994250 1347 CRRKMNDFGMAEEFATKALELKPKSYEAYYARARAkRSSSRQFAAALEdLNEAIKLCPNNREIQRLLLRVEEE 1419
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLL-LLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE 71
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1294-1419 1.21e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1373
Cdd:COG2956   147 YCELAELYLEQGDYDEAIEALEKALKLDPD-------------CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767994250 1374 AYYARARAKRSSSrQFAAALEDLNEAIKLCPNNREIQRLLLRVEEE 1419
Cdd:COG2956   214 ALPRLAELYEKLG-DPEEALELLRKALELDPSDDLLLALADLLERK 258
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 897-1130 1.78e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.06  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  897 TPNIkvsRLLILGGANINyRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCK 976
Cdd:PHA02876  321 TENI---RTLIMLGADVN-AADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLD 396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  977 KRAKVDHLDKNGQCALvHAALRGhlevvkfliqcdwtmagqqqgvfkkshaiqqaliaaaSMGYTEiVSYLLDlpekdee 1056
Cdd:PHA02876  397 YGADIEALSQKIGTAL-HFALCG-------------------------------------TNPYMS-VKTLID------- 430

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767994250 1057 evERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFstVRQGHWQIVDLLLTHGADV 1130
Cdd:PHA02876  431 --RGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLL--IALEYHGIVNILLHYGAEL 500
PHA02946 PHA02946
ankyin-like protein; Provisional
 1090-1240 4.58e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.13  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1090 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPL--MMAASEGHLGTVDFLLAQGASI-ALM 1166
Cdd:PHA02946   58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInNSV 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767994250 1167 DKEGLTALsWACLKGHLSVVRSLVDNGAATDHADKNGRTPL--DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1240
Cdd:PHA02946  138 DEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1106-1262 5.85e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1106 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLA--------------------QGASIAL 1165
Cdd:PHA02878   39 IPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRsinkcsvfytlvaikdafnnRNVEIFK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1166 M------DKEGLTALSWACLKGH-----LSVVRSLVDNGAATDHADKN-GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVD 1233
Cdd:PHA02878  119 IiltnryKNIQTIDLVYIDKKSKddiieAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPD 198

                         170       180
                  ....*....|....*....|....*....
gi 767994250 1234 YSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:PHA02878  199 KTNNSPLHHAVKHYNKPIVHILLENGAST 227
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1088-1157 8.03e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 8.03e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994250 1088 RLLLEQGAavaQPNRR---GAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLL 1157
Cdd:PTZ00322   99 RILLTGGA---DPNCRdydGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1301-1411 8.36e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 43.83  E-value: 8.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1301 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSY---EAYYA 1377
Cdd:COG1729     3 LLKAGDYDEAIAAFKAFLKRYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLK 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767994250 1378 RARAkRSSSRQFAAALEDLNEAIKLCPNNREIQR 1411
Cdd:COG1729    73 LGLS-YLELGDYDKARATLEELIKKYPDSEAAKE 105
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1202-1230 1.43e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.43e-04
                            10        20
                    ....*....|....*....|....*....
gi 767994250   1202 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1202-1233 2.29e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 2.29e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767994250  1202 NGRTPLDLAA-FYGDAEVVQFLVDHGAMIEHVD 1233
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1136-1168 2.42e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.42e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767994250  1136 QGRTPLMMAA-SEGHLGTVDFLLAQGASIALMDK 1168
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1053-1230 3.77e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 3.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1053 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQgaavaqpNRRGAV--PLFSTVRQGHWQIVDLLLTHGADV 1130
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1131 nmADKQGRTPLMMAASeghlgTVDFllaqgasialmdKEGLTALSWACLKGHLSVVRSLVDNGAA------------TDH 1198
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 767994250  1199 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1475-1704 4.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1475 LQTEARPSQGLPVIQSP-PSSPPHRDSAYISSSPLGShqvfdfrsSSSVGSPTRQTYQSTSPALSPTHqnshyRPSPPht 1553
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAqPTAPPPPPGPPPPSLPLGG--------SVAPGGDVRRRPPSRSPAAKPAA-----PARPP-- 2882

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1554 spahqggSYRFSPPPVGGQGKEYPSPPpSPLRRGPQYRASPPAesmsvyRSQSGSPVRyQQETSVSQLPGRPKSPLSKMA 1633
Cdd:PHA03247 2883 -------VRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPP------QPQPQPPPP-PQPQPPPPPPPRPQPPLAPTT 2947

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1634 Q-RPYQMPQLPVAVPQQGlRLQPAKAQIVRSNQPSPA---------VHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQ 1703
Cdd:PHA03247 2948 DpAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026


                  .
gi 767994250 1704 S 1704
Cdd:PHA03247 3027 T 3027
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1294-1401 5.04e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1373
Cdd:COG2956   181 LLLLAELYLEQGDYEEAIAALERALEQDPD-------------YLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL 247

                          90       100
                  ....*....|....*....|....*....
gi 767994250 1374 A-YYARARAKRsssRQFAAALEDLNEAIK 1401
Cdd:COG2956   248 LlALADLLERK---EGLEAALALLERQLR 273
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1298-1406 5.18e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG3914   153 GEALRRLGRLEEAIAALRRALELDPDN-------------AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219

                          90       100       110
                  ....*....|....*....|....*....|
gi 767994250 1378 RARAKRSSSR-QFAAALEDLNEAIKLCPNN 1406
Cdd:COG3914   220 LLFALRQACDwEVYDRFEELLAALARGPSE 249
Ank_5 pfam13857
Ankyrin repeats (many copies);
1090-1144 5.84e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 5.84e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767994250  1090 LLEQG-AAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1144
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 898-1009 7.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 7.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  898 PNIKVSRLLILGGANINYrTEVLNNAPILCVQSHLGyTEMVALLLEFGANVDASSESGLTPLGYaaAAGYL---SIVVLL 974
Cdd:PHA02878  179 KDQRLTELLLSYGANVNI-PDKTNNSPLHHAVKHYN-KPIVHILLENGASTDARDKCGNTPLHI--SVGYCkdyDILKLL 254

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767994250  975 CKKRAKVDHLDKNGQCALVHAALRGHlEVVKFLIQ 1009
Cdd:PHA02878  255 LEHGVDVNAKSYILGLTALHSSIKSE-RKLKLLLE 288
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1137-1229 8.46e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 8.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1137 GRTPLMMAASEGHLGTVD--FLLAQGASIALMDKE------------GLTALSWACLKGHLSVVRSLVDNGAATdHADKN 1202
Cdd:cd21882    26 GKTCLHKAALNLNDGVNEaiMLLLEAAPDSGNPKElvnapctdefyqGQTALHIAIENRNLNLVRLLVENGADV-SARAT 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767994250 1203 GRT--------------PLDLAAFYGDAEVVQFLVDHGAMI 1229
Cdd:cd21882   105 GRFfrkspgnlfyfgelPLSLAACTNQEEIVRLLLENGAQP 145
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1186-1256 9.52e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 9.52e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767994250 1186 VRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGcRNTSVVVTLL 1256
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE-NGFREVVQLL 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
1189-1243 1.20e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 1.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767994250  1189 LVDNG-AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1243
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1299-1415 1.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1299 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1378
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 767994250  1379 ARAKRSSsRQFAAALEDLNEAIKLCPNNREIQRLLLR 1415
Cdd:TIGR02917  574 AQYYLGK-GQLKKALAILNEAADAAPDSPEAWLMLGR 609
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1071-1223 1.37e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 43.72  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1071 GETALTAAA---GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH-----------WQIVDLLLTHGADVNMA--- 1133
Cdd:cd21882    26 GKTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKELVNAPCTDEFYQGQtalhiaienrnLNLVRLLVENGADVSARatg 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1134 ---DKQGRT-------PLMMAASEGHLGTVDFLL---AQGASIALMDKEGLTALSWACLKGHLSVVRS---------LVD 1191
Cdd:cd21882   106 rffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVLHALVLQADNTPENSafvcqmynlLLS 185

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767994250 1192 NGAATDH-------ADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd21882   186 YGAHLDPtqqleeiPNHQGLTPLKLAAVEGKIVMFQHIL 224
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1136-1163 1.40e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.40e-03
                            10        20
                    ....*....|....*....|....*...
gi 767994250   1136 QGRTPLMMAASEGHLGTVDFLLAQGASI 1163
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 900-1008 1.57e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  900 IKVSRLLILGganiNYRTEVL---NNAPiLCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCK 976
Cdd:PHA02875   82 KAVEELLDLG----KFADDVFykdGMTP-LHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID 156

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767994250  977 KRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 1008
Cdd:PHA02875  157 HKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 926-1010 1.58e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  926 LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 1005
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                  ....*
gi 767994250 1006 FLIQC 1010
Cdd:PTZ00322  166 LLSRH 170
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1071-1258 1.63e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.46  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1071 GETALTAAAGRGKLEVCRLLLEqgaavaqpnrrgAVPlfstvrqghwqivDLllthgadVNMADK----QGRTPLMMAAS 1146
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLME------------AAP-------------EL-------VNEPMTsdlyQGETALHIAVV 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1147 EGHLGTVDFLLAQGASIA---------LMDKEGLT-----ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAF 1212
Cdd:cd22192    99 NQNLNLVRELIARGADVVspratgtffRPGPKNLIyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVL 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767994250 1213 YGDA----EVVQFLV-----DHGAMIEHV-DYSGMRPLDRAVGCRNTSVVVTLLKK 1258
Cdd:cd22192   179 QPNKtfacQMYDLILsydkeDDLQPLDLVpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1485-1677 1.75e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1485 LPVIQSPPSSP-PHRDSAYISSSPLGSHQVFDFRSSSSVGSPtrqtyqstsPALSPTHQNSHYRPSPPHtspahqggsyr 1563
Cdd:pfam03154  352 MPHIKPPPTTPiPQLPNPQSHKHPPHLSGPSPFQMNSNLPPP---------PALKPLSSLSTHHPPSAH----------- 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1564 fsPPPVggqgkeypspppsPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQL- 1642
Cdd:pfam03154  412 --PPPL-------------QLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPIt 476

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 767994250  1643 -----PVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIP 1677
Cdd:pfam03154  477 ppsgpPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1202-1227 1.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|....*.
gi 767994250  1202 NGRTPLDLAAFYGDAEVVQFLVDHGA 1227
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGA 26
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 904-988 2.36e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  904 RLLILGGANINYRTevLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDH 983
Cdd:PTZ00322   99 RILLTGGADPNCRD--YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176


                  ....*
gi 767994250  984 LDKNG 988
Cdd:PTZ00322  177 LGANA 181
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1071-1223 2.41e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1071 GETALTAAAGRGKLEVCRLLLEQGAAV-AQPN-----RRGAVPLFSTVRQ--------GHWQIVDLLLTHGADVNMADKQ 1136
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVpARACgdffvKSQGVDSFYHGESplnaaaclGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1137 GRTPLMMAASEGhlgtvDFllaqgasialmdKEGLTALSWAC---LKGHLSVVRSLVDNGAATDHadkNGRTPLDLAAFY 1213
Cdd:TIGR00870  208 GNTLLHLLVMEN-----EF------------KAEYEELSCQMynfALSLLDKLRDSKELEVILNH---QGLTPLKLAAKE 267

                          170
                   ....*....|
gi 767994250  1214 GDAEVVQFLV 1223
Cdd:TIGR00870  268 GRIVLFRLKL 277
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 920-1009 2.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 41.34  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  920 LNNAPIL-CVQSHLGYTEMVALLLEFGANVD-ASSESGLTPLGYaaaagYLS--------IVVLLCKKRAKVDHLDKNGQ 989
Cdd:PHA02859   50 LYETPIFsCLEKDKVNVEILKFLIENGADVNfKTRDNNLSALHH-----YLSfnknvepeILKILIDSGSSITEEDEDGK 124

                          90       100
                  ....*....|....*....|...
gi 767994250  990 cALVHAALRG---HLEVVKFLIQ 1009
Cdd:PHA02859  125 -NLLHMYMCNfnvRINVIKLLID 146
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1486-1655 3.24e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1486 PVIQS------PPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTyQSTSPALSPTHQNSHYR----PSP----- 1550
Cdd:pfam03154  172 PVLQAqsgaasPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT-QSTAAPHTLIQQTPTLHpqrlPSPhpplq 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250  1551 --PHTSPAHQGGSYRFSPPPVGGQGKEypspPPSPLRRGPQYRASPPAEsmsvyrsqsgSPVRYQQETSVSQLPGRPKSP 1628
Cdd:pfam03154  251 pmTQPPPPSQVSPQPLPQPSLHGQMPP----MPHSLQTGPSHMQHPVPP----------QPFPLTPQSSQSQVPPGPSPA 316

                          170       180
                   ....*....|....*....|....*...
gi 767994250  1629 LSKMA-QRPYQMPQLPVAVPQQGLRLQP 1655
Cdd:pfam03154  317 APGQSqQRIHTPPSQSQLQSQQPPREQP 344
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1349-1423 3.81e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 42.29  E-value: 3.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767994250 1349 RKMNDFGMAEEFATKALELKPKSYEAYYARARAkRSSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQM 1423
Cdd:COG3914    89 QALGRYEEALALYRRALALNPDNAEALFNLGNL-LLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRL 162
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 1083-1163 4.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 42.04  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1083 KLEVCRLLLEQGAAVaqpNRRGAV--PLFSTVRQGHW------QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVD 1154
Cdd:PHA02989   49 KIKIVKLLIDNGADV---NYKGYIetPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCD 125

                          90
                  ....*....|..
gi 767994250 1155 ---FLLAQGASI 1163
Cdd:PHA02989  126 mlrFLLSKGINV 137
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 1335-1416 4.48e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 41.43  E-value: 4.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1335 ELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA-YYARARAKRSSsRQFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG3071    47 EAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAvLLTRAELLLDQ-GQAEQALATLEALRAGAPRHPQVLRLL 125


                  ...
gi 767994250 1414 LRV 1416
Cdd:COG3071   126 LQA 128
TPR_12 pfam13424
Tetratricopeptide repeat;
1298-1370 5.18e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 5.18e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994250  1298 GDMFYKKGKVKEAAQRYQYALKKFpREGFGEDlktfRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1370
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1137-1163 5.72e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 5.72e-03
                           10        20
                   ....*....|....*....|....*..
gi 767994250  1137 GRTPLMMAASEGHLGTVDFLLAQGASI 1163
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADI 28
TPR_14 pfam13428
Tetratricopeptide repeat;
1373-1416 6.08e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 36.63  E-value: 6.08e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767994250  1373 EAYYARARAKRSSsRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1416
Cdd:pfam13428    2 EALLALARALLAL-GDPDEALALLERALALDPDDPEAWLALAQL 44
Ank_5 pfam13857
Ankyrin repeats (many copies);
905-962 6.71e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 6.71e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994250   905 LLILGGANINYRTEVLNNApiLCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYA 962
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTP--LHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1039-1223 6.73e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1039 GYTEIVSYLLDLPEKDEEEVEraqinsfdslwgeTALTAAAGRGKLEvcRLLleqGAAVAQPNRRGAVPLFSTVRQGHWQ 1118
Cdd:cd22194    94 GKTCLMKALLNINENTKEIVR-------------ILLAFAEENGILD--RFI---NAEYTEEAYEGQTALNIAIERRQGD 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1119 IVDLLLTHGADVNMADKQ--------------GRTPLMMAASEGHLGTVDFLLAQGAS-IALMDKEG---LTALSWAC-- 1178
Cdd:cd22194   156 IVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTdITSQDSRGntvLHALVTVAed 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767994250 1179 LKGHLSVVRSLVDNgAATDHADKN--------GRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd22194   236 SKTQNDFVKRMYDM-ILLKSENKNletirnneGLTPLQLAAKMGKAEILKYIL 287
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1181-1268 7.90e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 7.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994250 1181 GHLSVVRSLVDN-GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1259
Cdd:PHA02874   12 GDIEAIEKIIKNkGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91


                  ....*....
gi 767994250 1260 AKIGCQTLP 1268
Cdd:PHA02874   92 VDTSILPIP 100
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1365-1413 8.48e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 8.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767994250 1365 LELKPKSYEAYYARARAKRSSSRqFAAALEDLNEAIKLCPNNREIQRLL 1413
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGR-YEEAIEDYEKALELDPDDAEALYNL 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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