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Conserved domains on  [gi|767993631|ref|XP_011522656|]
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alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X4 [Homo sapiens]

Protein Classification

glycosyltransferase family 18 protein( domain architecture ID 142204)

glycosyltransferase family 18 protein may act as alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase that contributes to the creation of branches in complex-type N-glycans

CAZY:  GT18
Gene Ontology:  GO:0006487

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_18 super family cl20900
Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1, ...
 184-341 2.10e-82

Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.


The actual alignment was detected with superfamily member pfam15024:

Pssm-ID: 434401  Cd Length: 557  Bit Score: 262.22  E-value: 2.10e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993631  184 CYAFFGVDGTECSFLIYLSEVEWFCPPLPWRNQTAAqraPKPLPKVQAVFRSNLSHLLDLMGSGKEsLIFMKKRTKRLTA 263
Cdd:pfam15024   1 CYAFYGVDGSECSFLIYLSEVENWCPPLPWRNKTTA---PTRKKPGQAVIRTSLTRLLEIIGSSEE-FKWMKQRIRRMWE 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767993631  264 QWALAAQRLAQKLGATQRDQKQILVHIGFLTEESGDVFSPRVLKGGPLGEMVQWADILTALYVLGHGLRVTVSLKELQ 341
Cdd:pfam15024  77 QWLEAARSLAEKYNLTMRKQKKILVHLGFLANESGFKIAEKAFKGGPLGELVQWSDLIAALYILGHHLKVSTSLEELR 154
 
Name Accession Description Interval E-value
Glyco_transf_18 pfam15024
Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1, ...
 184-341 2.10e-82

Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.


Pssm-ID: 434401  Cd Length: 557  Bit Score: 262.22  E-value: 2.10e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993631  184 CYAFFGVDGTECSFLIYLSEVEWFCPPLPWRNQTAAqraPKPLPKVQAVFRSNLSHLLDLMGSGKEsLIFMKKRTKRLTA 263
Cdd:pfam15024   1 CYAFYGVDGSECSFLIYLSEVENWCPPLPWRNKTTA---PTRKKPGQAVIRTSLTRLLEIIGSSEE-FKWMKQRIRRMWE 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767993631  264 QWALAAQRLAQKLGATQRDQKQILVHIGFLTEESGDVFSPRVLKGGPLGEMVQWADILTALYVLGHGLRVTVSLKELQ 341
Cdd:pfam15024  77 QWLEAARSLAEKYNLTMRKQKKILVHLGFLANESGFKIAEKAFKGGPLGELVQWSDLIAALYILGHHLKVSTSLEELR 154
 
Name Accession Description Interval E-value
Glyco_transf_18 pfam15024
Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1, ...
 184-341 2.10e-82

Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.


Pssm-ID: 434401  Cd Length: 557  Bit Score: 262.22  E-value: 2.10e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767993631  184 CYAFFGVDGTECSFLIYLSEVEWFCPPLPWRNQTAAqraPKPLPKVQAVFRSNLSHLLDLMGSGKEsLIFMKKRTKRLTA 263
Cdd:pfam15024   1 CYAFYGVDGSECSFLIYLSEVENWCPPLPWRNKTTA---PTRKKPGQAVIRTSLTRLLEIIGSSEE-FKWMKQRIRRMWE 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767993631  264 QWALAAQRLAQKLGATQRDQKQILVHIGFLTEESGDVFSPRVLKGGPLGEMVQWADILTALYVLGHGLRVTVSLKELQ 341
Cdd:pfam15024  77 QWLEAARSLAEKYNLTMRKQKKILVHLGFLANESGFKIAEKAFKGGPLGELVQWSDLIAALYILGHHLKVSTSLEELR 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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