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Conserved domains on  [gi|767992796|ref|XP_011522412|]
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small G protein signaling modulator 2 isoform X19 [Homo sapiens]

Protein Classification

RUN superfamily-containing protein( domain architecture ID 1908546)

RUN superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN super family cl45896
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 18-224 8.70e-101

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


The actual alignment was detected with superfamily member cd17704:

Pssm-ID: 459241  Cd Length: 180  Bit Score: 301.08  E-value: 8.70e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704    1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704   35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767992796 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLGEP 224
Cdd:cd17704  115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGP 161
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 18-224 8.70e-101

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 301.08  E-value: 8.70e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704    1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704   35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767992796 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLGEP 224
Cdd:cd17704  115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGP 161
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 90-221 4.01e-27

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 106.21  E-value: 4.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796   90 ASAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasg 163
Cdd:pfam02759   3 CAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY------------------ 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992796  164 kapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLL 221
Cdd:pfam02759  65 -----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLL 120
RUN smart00593
domain involved in Ras-like GTPase signaling;
174-221 3.36e-11

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 58.78  E-value: 3.36e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767992796   174 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLL 221
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLL 51
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 18-224 8.70e-101

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 301.08  E-value: 8.70e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704    1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704   35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767992796 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLGEP 224
Cdd:cd17704  115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGP 161
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 18-224 5.92e-76

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 237.21  E-value: 5.92e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  18 KEVKQIMEEAVTRKFVHEDSSHIIALCAAdphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcasaVEACL 97
Cdd:cd17703    1 KEVKQIMEEAVTRKFVHEDSSHIISFCAA----------------------------------------------VEACV 34

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSG-VSQEALRRqgsaSGKAPALSPQALKHV 176
Cdd:cd17703   35 LHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLENKRNQMqGLQENVRK----MPKLPNLSPQAIKHL 110

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767992796 177 WVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLGEP 224
Cdd:cd17703  111 WIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGP 158
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 18-221 1.04e-69

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 220.62  E-value: 1.04e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  18 KEVKQIMEEAVTRKFVHEDSSHIIALCAAdphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcasaVEACL 97
Cdd:cd17687    1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGA----------------------------------------------VDACL 34

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSqealrrqGSASGKAPALSPQALKHVW 177
Cdd:cd17687   35 LHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENLSENKRSSSSS-------GSNSSNSHGNSSSNRKILW 107

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767992796 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLL 221
Cdd:cd17687  108 IRIALFEKVLDKIVDYLVENASKYYEKEALMADPVDGPLLASLL 151
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 90-221 4.01e-27

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 106.21  E-value: 4.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796   90 ASAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasg 163
Cdd:pfam02759   3 CAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY------------------ 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992796  164 kapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLL 221
Cdd:pfam02759  65 -----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLL 120
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 91-221 7.15e-12

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 63.60  E-value: 7.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992796  91 SAVEACLLHQLRRRAAGFLRSDkmaalftkvgktcpvageICHKVQELQQQAEGRKPSGVSQEA--LRRQGSASGKApal 168
Cdd:cd17671   36 AALEAILSHGLKPKRFGGGKVS------------------FWDFLEALEKLLPAPSLKQAIRDInsLSNVKTDDGRG--- 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767992796 169 spqalkHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLL 221
Cdd:cd17671   95 ------RAWIRLALNEKSLESYLAALLSDqslLRKYYEPWALLRDPEEAELFLSLL 144
RUN smart00593
domain involved in Ras-like GTPase signaling;
174-221 3.36e-11

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 58.78  E-value: 3.36e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767992796   174 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLL 221
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLL 51
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 178-221 7.05e-03

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 37.21  E-value: 7.05e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767992796 178 VRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLL 221
Cdd:cd17682   94 IRYALNKKCLHDPVQQLVKNpklLSDYYSPDSILGNEILSEILLSLL 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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