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Conserved domains on  [gi|767992783|ref|XP_011522407|]
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small G protein signaling modulator 2 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RUN super family cl45896
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
18-243 7.43e-118

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


The actual alignment was detected with superfamily member cd17704:

Pssm-ID: 459241  Cd Length: 180  Bit Score: 359.63  E-value: 7.43e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704    35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767992783  178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17704   115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
302-470 8.20e-99

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 309.26  E-value: 8.20e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  302 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 375
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  376 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 454
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160
                         170
                  ....*....|....*.
gi 767992783  455 GTGRATDYVFRIIYPG 470
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
840-1008 5.89e-43

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 155.93  E-value: 5.89e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    840 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 916
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    917 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 994
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201
                           170
                    ....*....|....
gi 767992783    995 FIALALVEAYREII 1008
Cdd:smart00164  202 RVALALLKLHRDVL 215
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
18-243 7.43e-118

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 359.63  E-value: 7.43e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704    35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767992783  178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17704   115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
302-470 8.20e-99

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 309.26  E-value: 8.20e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  302 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 375
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  376 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 454
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160
                         170
                  ....*....|....*.
gi 767992783  455 GTGRATDYVFRIIYPG 470
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
303-438 1.11e-50

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.39  E-value: 1.11e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   303 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 371
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767992783   372 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 438
Cdd:pfam12068   81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
840-1008 5.89e-43

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 155.93  E-value: 5.89e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    840 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 916
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    917 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 994
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201
                           170
                    ....*....|....
gi 767992783    995 FIALALVEAYREII 1008
Cdd:smart00164  202 RVALALLKLHRDVL 215
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
90-235 5.89e-31

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 118.53  E-value: 5.89e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    90 ASAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasg 163
Cdd:pfam02759    3 CAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY------------------ 64
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992783   164 kapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTA 235
Cdd:pfam02759   65 -----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
841-1008 1.06e-29

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 116.58  E-value: 1.06e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   841 HRIDKDVQRCDRNYWYFT-PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKR------M 913
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   914 SQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAArhiSSEHFV 993
Cdd:pfam00566   90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162
                          170
                   ....*....|....*
gi 767992783   994 LFIALALVEAYREII 1008
Cdd:pfam00566  163 FRVALAILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
840-1037 9.67e-21

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 97.18  E-value: 9.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  840 LHRIDKDVQRCDRNYWYF---TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMK--RMS 914
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  915 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarHISSEHFV 993
Cdd:COG5210   337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 767992783  994 LFIALALVEAYREIIRDNNMDFTDIIKFFNALHVSPQNVLSITM 1037
Cdd:COG5210   414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKF 457
RUN smart00593
domain involved in Ras-like GTPase signaling;
174-230 4.57e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 67.64  E-value: 4.57e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    174 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 230
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
18-243 7.43e-118

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 359.63  E-value: 7.43e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704    35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767992783  178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17704   115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
302-470 8.20e-99

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 309.26  E-value: 8.20e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  302 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 375
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  376 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 454
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160
                         170
                  ....*....|....*.
gi 767992783  455 GTGRATDYVFRIIYPG 470
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
18-243 5.68e-92

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 290.76  E-value: 5.68e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   18 KEVKQIMEEAVTRKFVHEDSSHIIALCAAdphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcasaVEACL 97
Cdd:cd17703     1 KEVKQIMEEAVTRKFVHEDSSHIISFCAA----------------------------------------------VEACV 34
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSG-VSQEALRRqgsaSGKAPALSPQALKHV 176
Cdd:cd17703    35 LHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLENKRNQMqGLQENVRK----MPKLPNLSPQAIKHL 110
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767992783  177 WVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17703   111 WIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPS 177
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
18-231 1.88e-74

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 242.58  E-value: 1.88e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   18 KEVKQIMEEAVTRKFVHEDSSHIIALCAAdphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcasaVEACL 97
Cdd:cd17687     1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGA----------------------------------------------VDACL 34
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSqealrrqGSASGKAPALSPQALKHVW 177
Cdd:cd17687    35 LHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENLSENKRSSSSS-------GSNSSNSHGNSSSNRKILW 107
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767992783  178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTK 231
Cdd:cd17687   108 IRIALFEKVLDKIVDYLVENASKYYEKEALMADPVDGPLLASLLVGPCALDYTK 161
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
303-438 1.11e-50

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.39  E-value: 1.11e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   303 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 371
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767992783   372 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 438
Cdd:pfam12068   81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
840-1008 5.89e-43

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 155.93  E-value: 5.89e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    840 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 916
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    917 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 994
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201
                           170
                    ....*....|....
gi 767992783    995 FIALALVEAYREII 1008
Cdd:smart00164  202 RVALALLKLHRDVL 215
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
90-235 5.89e-31

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 118.53  E-value: 5.89e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    90 ASAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasg 163
Cdd:pfam02759    3 CAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY------------------ 64
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992783   164 kapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTA 235
Cdd:pfam02759   65 -----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
841-1008 1.06e-29

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 116.58  E-value: 1.06e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   841 HRIDKDVQRCDRNYWYFT-PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKR------M 913
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrdfY 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   914 SQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAArhiSSEHFV 993
Cdd:pfam00566   90 TPDFPG---LKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE---GEKFVL 162
                          170
                   ....*....|....*
gi 767992783   994 LFIALALVEAYREII 1008
Cdd:pfam00566  163 FRVALAILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
840-1037 9.67e-21

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 97.18  E-value: 9.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  840 LHRIDKDVQRCDRNYWYF---TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMK--RMS 914
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  915 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarHISSEHFV 993
Cdd:COG5210   337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 767992783  994 LFIALALVEAYREIIRDNNMDFTDIIKFFNALHVSPQNVLSITM 1037
Cdd:COG5210   414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKF 457
RUN smart00593
domain involved in Ras-like GTPase signaling;
174-230 4.57e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 67.64  E-value: 4.57e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783    174 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 230
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
91-227 5.15e-12

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 64.75  E-value: 5.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   91 SAVEACLLHQLRRRAAGFLRSDkmaalftkvgktcpvageICHKVQELQQQAEGRKPSGVSQEA--LRRQGSASGKApal 168
Cdd:cd17671    36 AALEAILSHGLKPKRFGGGKVS------------------FWDFLEALEKLLPAPSLKQAIRDInsLSNVKTDDGRG--- 94
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767992783  169 spqalkHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVGPCAL 227
Cdd:cd17671    95 ------RAWIRLALNEKSLESYLAALLSDqslLRKYYEPWALLRDPEEAELFLSLLVGLSSL 150
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
308-413 6.39e-07

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 48.16  E-value: 6.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783  308 KNHVLVQPKEDMEAVPGYLSLHQSaeslTLKWTPNQLMngtlgdseleksvywDYALVVPFSQVVCIHCHQQ-KSGGTLV 386
Cdd:cd00900     2 KFRAVRVYREPTKRVEGTLYITSD----RLILRDKNDG---------------GLELSIPISDIVNVNVSPQgPSSRYLV 62
                          90       100
                  ....*....|....*....|....*..
gi 767992783  387 LVSQDGIQRPPLHFPQGGHLLSFLSCL 413
Cdd:cd00900    63 LVLKDRGEFVGFSFPKEEDAIEISDAL 89
RUN_RUFY3 cd17696
RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; ...
93-223 2.77e-03

RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. This model represents the RUN domain of RUFY3.


Pssm-ID: 439058  Cd Length: 156  Bit Score: 39.59  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992783   93 VEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELqqqaegrkpsgvsqealrrqgsasgkaPAL-SPQ 171
Cdd:cd17696    41 MEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDL---------------------------PGLkTPV 93
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767992783  172 ALKHVWVRTALIEKVLDKVVQYL---AENCSKYYEKEALLADPVfGPILASLLVG 223
Cdd:cd17696    94 GRGRAWLRLALMQKKLSEYMKALinrKDLLSEFYEPNALMMEEE-GAIIAGLLVG 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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