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Conserved domains on  [gi|767992572|ref|XP_011522324|]
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dynein regulatory complex subunit 3 isoform X4 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-208 5.69e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 94.08  E-value: 5.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  75 ILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISK-------IDSL 147
Cdd:cd21340   36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdPRSL 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767992572 148 DALVK-LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDykmfICAYLPDLMYL 208
Cdd:cd21340  116 AALSNsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDLEE----LLDLLSSWPSL 170
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-208 5.69e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 94.08  E-value: 5.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  75 ILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISK-------IDSL 147
Cdd:cd21340   36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdPRSL 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767992572 148 DALVK-LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDykmfICAYLPDLMYL 208
Cdd:cd21340  116 AALSNsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDLEE----LLDLLSSWPSL 170
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-190 5.87e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 5.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  74 DILRIDNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKI-DSLDAL 150
Cdd:COG4886  102 DLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNL 181

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767992572 151 VKLQVLSLGNNRIDNMMNIIYlrRFKCLRTLSLSRNPISE 190
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTD 219
LRR_9 pfam14580
Leucine-rich repeat;
88-213 4.52e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.48  E-value: 4.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572   88 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 164
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767992572  165 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRI 213
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-208 5.69e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 94.08  E-value: 5.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  75 ILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISK-------IDSL 147
Cdd:cd21340   36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdPRSL 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767992572 148 DALVK-LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDykmfICAYLPDLMYL 208
Cdd:cd21340  116 AALSNsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDLEE----LLDLLSSWPSL 170
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-190 5.87e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 5.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  74 DILRIDNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKI-DSLDAL 150
Cdd:COG4886  102 DLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNL 181

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767992572 151 VKLQVLSLGNNRIDNMMNIIYlrRFKCLRTLSLSRNPISE 190
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-190 2.12e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  79 DNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVL 156
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767992572 157 SLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISE 190
Cdd:COG4886  256 DLSNNQLTDLPPLANLTN---LKTLDLSNNQLTD 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-209 2.45e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 2.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  90 LQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRI------ 163
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRIsvvegl 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767992572 164 DNMMNIIYLR------------RF---------KCLRTLSLSRNPISEAEDykmfiCAYLPDLMYLD 209
Cdd:cd21340   87 ENLTNLEELHienqrlppgeklTFdprslaalsNSLRVLNISGNNIDSLEP-----LAPLRNLEQLD 148
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-166 3.73e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 3.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  81 LWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLG 159
Cdd:COG4886  201 LGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLS 280


                 ....*..
gi 767992572 160 NNRIDNM 166
Cdd:COG4886  281 NNQLTDL 287
LRR_9 pfam14580
Leucine-rich repeat;
88-213 4.52e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.48  E-value: 4.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572   88 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 164
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767992572  165 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRI 213
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-189 4.87e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 4.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  75 ILRIDNLWQFENLRKLQLDNNIIEKIEGLENL------------------------------AHLVWLDLSFNNIETIEG 124
Cdd:cd21340   58 IEKIENLENLVNLKKLYLGGNRISVVEGLENLtnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSLEP 137

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767992572 125 LDTLVNLEDLSLFNNRISKIDSLDALvklqvlslgnnridnmmniiyLRRFKCLRTLSLSRNPIS 189
Cdd:cd21340  138 LAPLRNLEQLDASNNQISDLEELLDL---------------------LSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-215 1.69e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  79 DNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRIS--KIDSLDALVKLQVL 156
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSL 301

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767992572 157 SLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDD 215
Cdd:COG4886  302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360
LRR_8 pfam13855
Leucine rich repeat;
86-141 6.01e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.01e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572   86 NLRKLQLDNNIIEKIEG--LENLAHLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRI 141
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
108-163 3.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.38e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  108 HLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRISKI--DSLDALVKLQVLSLGNNRI 163
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 130-165 3.32e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 3.32e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767992572  130 NLEDLSLFNNRISKIDSLDALVKLQVLSL-GNNRIDN 165
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITD 38
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 108-148 4.55e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 4.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767992572  108 HLVWLDLSFNNIETIEGLDTLVNLEDLSL-FNNRISKIDSLD 148
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLA 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-172 1.34e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  78 IDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIET--IEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQV 155
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                         90
                 ....*....|....*..
gi 767992572 156 LSLGNNRIDNMMNIIYL 172
Cdd:COG4886  323 LLLLLLLLKGLLVTLTT 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 86-126 1.58e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767992572   86 NLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNN-IETIEGLD 126
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-190 4.57e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  40 ILFKDVLSLQLDFRRKTADEPKGEQDDGQEDSQEDILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNI 119
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767992572 120 ETIEGLDTLVNLEDLSLFNNriskiDSLDALVKLQVLSLGNNRIDNMmnIIYLRRFKCLRTLSLSRNPISE 190
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTD 150
LRR_8 pfam13855
Leucine rich repeat;
130-188 1.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767992572  130 NLEDLSLFNNRISKID--SLDALVKLQVLSLGNNRIdnmmNIIY---LRRFKCLRTLSLSRNPI 188
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLL----TTLSpgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 86-190 3.10e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  86 NLRKLQLDNNIIEK------IEGLENLAHLVWLDLSFNNI------ETIEGLDTLVNLEDLSLFNNRISK------IDSL 147
Cdd:COG5238  265 TVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaialAKAL 344

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767992572 148 DALVKLQVLSLGNNRIDN--MMNII-YLRRFKCLRTLSLSRNPISE 190
Cdd:COG5238  345 QENTTLHSLDLSDNQIGDegAIALAkYLEGNTTLRELNLGKNNIGK 390
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 87-197 3.33e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992572  87 LRKLQLDNN------IIEKIEGLENLAHLVWLDLSFNNIETI------EGLDTLVNLEDLSLFNNRISKID-------SL 147
Cdd:cd00116  167 LKELNLANNgigdagIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAGaaalasaLL 246

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767992572 148 DALVKLQVLSLGNNRI---DNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMF 197
Cdd:cd00116  247 SPNISLLTLSLSCNDItddGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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