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Conserved domains on  [gi|767990515|ref|XP_011521621|]
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fatty acid 2-hydroxylase isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FA_hydroxylase super family cl01132
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
44-286 1.92e-85

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


The actual alignment was detected with superfamily member PLN02434:

Pssm-ID: 412761 [Multi-domain]  Cd Length: 237  Bit Score: 255.72  E-value: 1.92e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515  44 VDWRKPLLWQVGHLGEKYDEWVHQPVTR--PIRLFHSDLIEGLSKTVWYSVPIIWVPLVLylsWSYYRTFAQGNvrlfts 121
Cdd:PLN02434   8 VDLNKPLVFQVGHLGEDYEEWVHQPIVSkeGPRFFESDVLEFLTRTVWWAVPLIWLPVVC---WCLVKSVRMGL------ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515 122 ftteytvavPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPpsDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVI 201
Cdd:PLN02434  79 ---------PLSAVVLMVAFGVFIWTLLEYILHRFLFHIKT--KSYWGNTAHYLLHGCHHKHPMDGLRLVFPPAATAILC 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515 202 GVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGsYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHT 281
Cdd:PLN02434 148 VPFWNLIALFATPATAPALFGGGLLGYVMYDCTHYFLHHGQPSTD-VLRNLKKYHLNHHFRDQDKGFGITSSLWDRVFGT 226

                 ....*
gi 767990515 282 LTPEK 286
Cdd:PLN02434 227 LPPSK 231
 
Name Accession Description Interval E-value
PLN02434 PLN02434
fatty acid hydroxylase
44-286 1.92e-85

fatty acid hydroxylase


Pssm-ID: 178053 [Multi-domain]  Cd Length: 237  Bit Score: 255.72  E-value: 1.92e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515  44 VDWRKPLLWQVGHLGEKYDEWVHQPVTR--PIRLFHSDLIEGLSKTVWYSVPIIWVPLVLylsWSYYRTFAQGNvrlfts 121
Cdd:PLN02434   8 VDLNKPLVFQVGHLGEDYEEWVHQPIVSkeGPRFFESDVLEFLTRTVWWAVPLIWLPVVC---WCLVKSVRMGL------ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515 122 ftteytvavPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPpsDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVI 201
Cdd:PLN02434  79 ---------PLSAVVLMVAFGVFIWTLLEYILHRFLFHIKT--KSYWGNTAHYLLHGCHHKHPMDGLRLVFPPAATAILC 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515 202 GVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGsYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHT 281
Cdd:PLN02434 148 VPFWNLIALFATPATAPALFGGGLLGYVMYDCTHYFLHHGQPSTD-VLRNLKKYHLNHHFRDQDKGFGITSSLWDRVFGT 226

                 ....*
gi 767990515 282 LTPEK 286
Cdd:PLN02434 227 LPPSK 231
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
139-281 1.11e-16

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 74.77  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515  139 FMLGTFLWSLIEYLIHRfLFHMKPPsdsyylimLHFVMHGQHH--KAPFDGSRLVFPPVPASLVIGVFYLcmQLILPEAV 216
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHR-LLHRLPW--------LWRRFHKVHHssEAPNALTALRFHPLEALLFALLVLL--PLLLLGLP 69
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767990515  217 GGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHT 281
Cdd:pfam04116  70 LLAFLLGLLLGTLWYLFIHSGLLFPLPWLLKRLLGTPRFHRLHHSKNEEYNFGVTFPLWDRLFGT 134
 
Name Accession Description Interval E-value
PLN02434 PLN02434
fatty acid hydroxylase
44-286 1.92e-85

fatty acid hydroxylase


Pssm-ID: 178053 [Multi-domain]  Cd Length: 237  Bit Score: 255.72  E-value: 1.92e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515  44 VDWRKPLLWQVGHLGEKYDEWVHQPVTR--PIRLFHSDLIEGLSKTVWYSVPIIWVPLVLylsWSYYRTFAQGNvrlfts 121
Cdd:PLN02434   8 VDLNKPLVFQVGHLGEDYEEWVHQPIVSkeGPRFFESDVLEFLTRTVWWAVPLIWLPVVC---WCLVKSVRMGL------ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515 122 ftteytvavPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPpsDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVI 201
Cdd:PLN02434  79 ---------PLSAVVLMVAFGVFIWTLLEYILHRFLFHIKT--KSYWGNTAHYLLHGCHHKHPMDGLRLVFPPAATAILC 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515 202 GVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGsYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHT 281
Cdd:PLN02434 148 VPFWNLIALFATPATAPALFGGGLLGYVMYDCTHYFLHHGQPSTD-VLRNLKKYHLNHHFRDQDKGFGITSSLWDRVFGT 226

                 ....*
gi 767990515 282 LTPEK 286
Cdd:PLN02434 227 LPPSK 231
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
139-281 1.11e-16

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 74.77  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990515  139 FMLGTFLWSLIEYLIHRfLFHMKPPsdsyylimLHFVMHGQHH--KAPFDGSRLVFPPVPASLVIGVFYLcmQLILPEAV 216
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHR-LLHRLPW--------LWRRFHKVHHssEAPNALTALRFHPLEALLFALLVLL--PLLLLGLP 69
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767990515  217 GGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHT 281
Cdd:pfam04116  70 LLAFLLGLLLGTLWYLFIHSGLLFPLPWLLKRLLGTPRFHRLHHSKNEEYNFGVTFPLWDRLFGT 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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