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Conserved domains on  [gi|767985270|ref|XP_011520311|]
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little elongation complex subunit 2 isoform X1 [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 3 subunit D family protein( domain architecture ID 10564709)

eukaryotic translation initiation factor 3 subunit D family protein such as eukaryotic translation initiation factor 3 (eIF-3) subunit D, which is the mRNA cap-binding component of the eIF-3 complex and is required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 720-930 1.32e-95

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


:

Pssm-ID: 463121  Cd Length: 208  Bit Score: 300.37  E-value: 1.32e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985270  720 SEYLAPQEGNFVYKL----FSLQDLLLLVRCSVQRIETRPRSKkrkkirrQFPVYVLPKVEYQACYGVEALTESELCRLW 795
Cdd:pfam10505   1 QEYIAPAEGNVAYKLwslqVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985270  796 TESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYK 875
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767985270  876 ASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP 930
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
 
Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 720-930 1.32e-95

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


Pssm-ID: 463121  Cd Length: 208  Bit Score: 300.37  E-value: 1.32e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985270  720 SEYLAPQEGNFVYKL----FSLQDLLLLVRCSVQRIETRPRSKkrkkirrQFPVYVLPKVEYQACYGVEALTESELCRLW 795
Cdd:pfam10505   1 QEYIAPAEGNVAYKLwslqVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985270  796 TESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYK 875
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767985270  876 ASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP 930
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
 
Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 720-930 1.32e-95

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


Pssm-ID: 463121  Cd Length: 208  Bit Score: 300.37  E-value: 1.32e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985270  720 SEYLAPQEGNFVYKL----FSLQDLLLLVRCSVQRIETRPRSKkrkkirrQFPVYVLPKVEYQACYGVEALTESELCRLW 795
Cdd:pfam10505   1 QEYIAPAEGNVAYKLwslqVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985270  796 TESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYK 875
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767985270  876 ASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP 930
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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