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Conserved domains on  [gi|767984525|ref|XP_011520015|]
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intermembrane lipid transfer protein VPS13C isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1366 1.58e-89

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 328.00  E-value: 1.58e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043     2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEeaLQKAAEKGTHSgefiyglenfvykdikpgrkrkkhkkhfkk 162
Cdd:COG5043    82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWE--ILRETLEESSS------------------------------ 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  163 pfkgldrskdKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Cdd:COG5043   130 ----------SPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVST 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  242 ADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNEILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKL 320
Cdd:COG5043   200 DSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENFQPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  321 DCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIK 399
Cdd:COG5043   275 RGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKYRPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFK 352

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  400 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVfniilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGL 477
Cdd:COG5043   353 ERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL-------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGL 425

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  478 WGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG----YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEIL 553
Cdd:COG5043   426 WNGKPQA---------QDEDTLASTDKTAAELTDQEqkdfFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLI 496

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  554 KIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPV 632
Cdd:COG5043   497 SQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTL 576

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  633 EVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEK 710
Cdd:COG5043   577 VIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPK 655

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  711 SDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVE 789
Cdd:COG5043   656 SPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRFTISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEIN 734

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  790 LAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDT 869
Cdd:COG5043   735 VEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLMSNI-LPTISVDEINGDYQQF-----------------SSA 796

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  870 VESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELINLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATM 948
Cdd:COG5043   797 SLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQIFAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVA 867

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  949 RTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL--DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLN 1024
Cdd:COG5043   868 RKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNNfdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLI 943

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1025 LLLQTQALVASINYL--TTIIPSDDQSIS-----VAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIV 1097
Cdd:COG5043   944 LNLEPTSFLTLIDFIrsTFTSPNDEYMIGedpelTRKISDVENIKIEDANVRLDNNDIFLYDCIQLFATVLSYGAFMHME 1023

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1098 CNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTDVDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSKV 1177
Cdd:COG5043  1024 EREKFFL-QLRLMDLE--------------LKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDC 1077

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1178 DGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLSAATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQss 1256
Cdd:COG5043  1078 DCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFSSIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD-- 1145

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1257 istnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvqlTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVNR 1329
Cdd:COG5043  1146 ------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN----SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLTI 1215

                        1370      1380      1390
                  ....*....|....*....|....*....|....*..
gi 767984525 1330 NLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1366
Cdd:COG5043  1216 DANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2766-2942 5.60e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.03  E-value: 5.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  2766 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2837
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  2838 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2912
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 767984525  2913 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2942
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1046-2612 6.10e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 75.69  E-value: 6.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1046 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1125
Cdd:COG5043   435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1126 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1197
Cdd:COG5043   515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1198 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1264
Cdd:COG5043   586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1265 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1331
Cdd:COG5043   662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1332 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1411
Cdd:COG5043   740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1412 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1486
Cdd:COG5043   811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1487 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1566
Cdd:COG5043   891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1567 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1640
Cdd:COG5043   964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1641 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1717
Cdd:COG5043  1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1718 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1794
Cdd:COG5043  1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1795 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1874
Cdd:COG5043  1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1875 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1949
Cdd:COG5043  1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1950 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 2029
Cdd:COG5043  1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2030 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2109
Cdd:COG5043  1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2110 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2186
Cdd:COG5043  1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2187 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2262
Cdd:COG5043  1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2263 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2341
Cdd:COG5043  1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2342 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2421
Cdd:COG5043  1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2422 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2497
Cdd:COG5043  1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2498 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2573
Cdd:COG5043  1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                        1610      1620      1630
                  ....*....|....*....|....*....|....*....
gi 767984525 2574 RPEEEFHVPLDsYRCQLFIQPAGILEHQYKESTTYISWK 2612
Cdd:COG5043  1893 SPEESCSLPIE-TAYLYSIRIRPVSEDKFNWSSQAISWK 1930
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1366 1.58e-89

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 328.00  E-value: 1.58e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043     2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEeaLQKAAEKGTHSgefiyglenfvykdikpgrkrkkhkkhfkk 162
Cdd:COG5043    82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWE--ILRETLEESSS------------------------------ 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  163 pfkgldrskdKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Cdd:COG5043   130 ----------SPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVST 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  242 ADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNEILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKL 320
Cdd:COG5043   200 DSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENFQPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  321 DCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIK 399
Cdd:COG5043   275 RGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKYRPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFK 352

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  400 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVfniilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGL 477
Cdd:COG5043   353 ERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL-------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGL 425

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  478 WGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG----YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEIL 553
Cdd:COG5043   426 WNGKPQA---------QDEDTLASTDKTAAELTDQEqkdfFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLI 496

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  554 KIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPV 632
Cdd:COG5043   497 SQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTL 576

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  633 EVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEK 710
Cdd:COG5043   577 VIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPK 655

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  711 SDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVE 789
Cdd:COG5043   656 SPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRFTISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEIN 734

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  790 LAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDT 869
Cdd:COG5043   735 VEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLMSNI-LPTISVDEINGDYQQF-----------------SSA 796

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  870 VESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELINLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATM 948
Cdd:COG5043   797 SLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQIFAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVA 867

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  949 RTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL--DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLN 1024
Cdd:COG5043   868 RKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNNfdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLI 943

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1025 LLLQTQALVASINYL--TTIIPSDDQSIS-----VAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIV 1097
Cdd:COG5043   944 LNLEPTSFLTLIDFIrsTFTSPNDEYMIGedpelTRKISDVENIKIEDANVRLDNNDIFLYDCIQLFATVLSYGAFMHME 1023

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1098 CNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTDVDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSKV 1177
Cdd:COG5043  1024 EREKFFL-QLRLMDLE--------------LKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDC 1077

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1178 DGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLSAATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQss 1256
Cdd:COG5043  1078 DCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFSSIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD-- 1145

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1257 istnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvqlTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVNR 1329
Cdd:COG5043  1146 ------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN----SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLTI 1215

                        1370      1380      1390
                  ....*....|....*....|....*....|....*..
gi 767984525 1330 NLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1366
Cdd:COG5043  1216 DANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 182-413 4.63e-89

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 290.31  E-value: 4.63e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   182 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNV 261
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   262 NC---SMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPISASAKLYMNPYAESElKTPKLDCNIEIQNIAIELTKPQY 338
Cdd:pfam16908   81 DSeslELLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767984525   339 LSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYtQMWSWSNIKKHRQLLKSYKIAYK 413
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERR-RKWSWDYIKKRRDDRKEYIELYK 233
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2766-2942 5.60e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.03  E-value: 5.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  2766 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2837
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  2838 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2912
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 767984525  2913 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2942
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1046-2612 6.10e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 75.69  E-value: 6.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1046 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1125
Cdd:COG5043   435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1126 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1197
Cdd:COG5043   515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1198 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1264
Cdd:COG5043   586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1265 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1331
Cdd:COG5043   662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1332 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1411
Cdd:COG5043   740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1412 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1486
Cdd:COG5043   811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1487 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1566
Cdd:COG5043   891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1567 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1640
Cdd:COG5043   964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1641 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1717
Cdd:COG5043  1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1718 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1794
Cdd:COG5043  1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1795 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1874
Cdd:COG5043  1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1875 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1949
Cdd:COG5043  1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1950 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 2029
Cdd:COG5043  1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2030 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2109
Cdd:COG5043  1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2110 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2186
Cdd:COG5043  1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2187 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2262
Cdd:COG5043  1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2263 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2341
Cdd:COG5043  1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2342 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2421
Cdd:COG5043  1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2422 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2497
Cdd:COG5043  1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2498 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2573
Cdd:COG5043  1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                        1610      1620      1630
                  ....*....|....*....|....*....|....*....
gi 767984525 2574 RPEEEFHVPLDsYRCQLFIQPAGILEHQYKESTTYISWK 2612
Cdd:COG5043  1893 SPEESCSLPIE-TAYLYSIRIRPVSEDKFNWSSQAISWK 1930
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1690-1882 1.60e-06

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 52.13  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  1690 SKVDGKLSFKVGCIQIVYVHKFFMSLLNFL---NNFQTAKEALSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKA 1762
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDFFkppESHLELIGALMAAAEATLEgikeQTRAGLEYALEEHKTLDLDIDLQA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  1763 PVIIIPQS--SVSPNAVIADLGLIRVENKfsLVPMEHYS--------------LPPVI----DKMNIEL--TQLKLSRTI 1820
Cdd:pfam16910   88 PLIIVPEDytSKDSPCLILDAGHISVTSD--LVDKSTIKeikskqsqqyteedLKELEslmyDKFSLKLsdTQVLIGPSG 165

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767984525  1821 --LQASLPQNDIE---ILKPVNMLLSIQRNLAAAwYVQIPGMEIKGKLKPMQVALSEDDLTVLMKIL 1882
Cdd:pfam16910  166 edWKEALTEDDSSplhILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1366 1.58e-89

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 328.00  E-value: 1.58e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043     2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEeaLQKAAEKGTHSgefiyglenfvykdikpgrkrkkhkkhfkk 162
Cdd:COG5043    82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWE--ILRETLEESSS------------------------------ 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  163 pfkgldrskdKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Cdd:COG5043   130 ----------SPNISRKQSFIESLITKLIDNIQIYIEDIHLRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVST 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  242 ADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNEILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKL 320
Cdd:COG5043   200 DSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENFQPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  321 DCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIK 399
Cdd:COG5043   275 RGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKYRPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFK 352

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  400 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVfniilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGL 477
Cdd:COG5043   353 ERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL-------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGL 425

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  478 WGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG----YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEIL 553
Cdd:COG5043   426 WNGKPQA---------QDEDTLASTDKTAAELTDQEqkdfFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLI 496

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  554 KIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPV 632
Cdd:COG5043   497 SQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTL 576

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  633 EVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEK 710
Cdd:COG5043   577 VIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPK 655

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  711 SDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVE 789
Cdd:COG5043   656 SPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRFTISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEIN 734

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  790 LAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDT 869
Cdd:COG5043   735 VEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLMSNI-LPTISVDEINGDYQQF-----------------SSA 796

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  870 VESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELINLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATM 948
Cdd:COG5043   797 SLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQIFAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVA 867

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  949 RTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL--DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLN 1024
Cdd:COG5043   868 RKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNNfdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLI 943

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1025 LLLQTQALVASINYL--TTIIPSDDQSIS-----VAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIV 1097
Cdd:COG5043   944 LNLEPTSFLTLIDFIrsTFTSPNDEYMIGedpelTRKISDVENIKIEDANVRLDNNDIFLYDCIQLFATVLSYGAFMHME 1023

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1098 CNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTDVDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSKV 1177
Cdd:COG5043  1024 EREKFFL-QLRLMDLE--------------LKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDC 1077

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1178 DGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLSAATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQss 1256
Cdd:COG5043  1078 DCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFSSIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD-- 1145

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1257 istnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvqlTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVNR 1329
Cdd:COG5043  1146 ------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN----SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLTI 1215

                        1370      1380      1390
                  ....*....|....*....|....*....|....*..
gi 767984525 1330 NLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1366
Cdd:COG5043  1216 DANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 182-413 4.63e-89

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 290.31  E-value: 4.63e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   182 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNV 261
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   262 NC---SMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPISASAKLYMNPYAESElKTPKLDCNIEIQNIAIELTKPQY 338
Cdd:pfam16908   81 DSeslELLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767984525   339 LSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYtQMWSWSNIKKHRQLLKSYKIAYK 413
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERR-RKWSWDYIKKRRDDRKEYIELYK 233
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 612-833 9.84e-79

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 260.91  E-value: 9.84e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   612 FETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLD--LEQITSATLMKLEEIKERTATGLTHIIETRKVLD 689
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525   690 LRINLKPSYLVVPQtGFHHEKSDLLILDFGTFQLNS-----------KDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQL 758
Cdd:pfam16910   81 LDIDLQAPLIIVPE-DYTSKDSPCLILDAGHISVTSdlvdkstikeiKSKQSQQYTEEDLKELESLMYDKFSLKLSDTQV 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767984525   759 LFARAEETWKKCRFQ-HPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLM-NSIP 833
Cdd:pfam16910  160 LIGPSGEDWKEALTEdDSSPLHILEPINLDLTLEKSILPKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLIdVSIP 236
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 3-115 2.01e-41

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 148.87  E-value: 2.01e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525     3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVIE 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 767984525    83 LEGLYLLVVPGA-SIKYDAVKEEKSLQDVKQKEL 115
Cdd:pfam12624   81 IEDVYLLAVPKDeSEEYDEEEEEKRELAAKKEKL 114
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2766-2942 5.60e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.03  E-value: 5.60e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  2766 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2837
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  2838 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2912
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 767984525  2913 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2942
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1046-2612 6.10e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 75.69  E-value: 6.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1046 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1125
Cdd:COG5043   435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1126 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1197
Cdd:COG5043   515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1198 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1264
Cdd:COG5043   586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1265 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1331
Cdd:COG5043   662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1332 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1411
Cdd:COG5043   740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1412 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1486
Cdd:COG5043   811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1487 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1566
Cdd:COG5043   891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1567 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1640
Cdd:COG5043   964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1641 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1717
Cdd:COG5043  1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1718 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1794
Cdd:COG5043  1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1795 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1874
Cdd:COG5043  1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1875 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1949
Cdd:COG5043  1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 1950 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 2029
Cdd:COG5043  1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2030 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2109
Cdd:COG5043  1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2110 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2186
Cdd:COG5043  1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2187 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2262
Cdd:COG5043  1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2263 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2341
Cdd:COG5043  1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2342 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2421
Cdd:COG5043  1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2422 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2497
Cdd:COG5043  1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525 2498 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2573
Cdd:COG5043  1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                        1610      1620      1630
                  ....*....|....*....|....*....|....*....
gi 767984525 2574 RPEEEFHVPLDsYRCQLFIQPAGILEHQYKESTTYISWK 2612
Cdd:COG5043  1893 SPEESCSLPIE-TAYLYSIRIRPVSEDKFNWSSQAISWK 1930
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1690-1882 1.60e-06

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 52.13  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  1690 SKVDGKLSFKVGCIQIVYVHKFFMSLLNFL---NNFQTAKEALSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKA 1762
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDFFkppESHLELIGALMAAAEATLEgikeQTRAGLEYALEEHKTLDLDIDLQA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  1763 PVIIIPQS--SVSPNAVIADLGLIRVENKfsLVPMEHYS--------------LPPVI----DKMNIEL--TQLKLSRTI 1820
Cdd:pfam16910   88 PLIIVPEDytSKDSPCLILDAGHISVTSD--LVDKSTIKeikskqsqqyteedLKELEslmyDKFSLKLsdTQVLIGPSG 165

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767984525  1821 --LQASLPQNDIE---ILKPVNMLLSIQRNLAAAwYVQIPGMEIKGKLKPMQVALSEDDLTVLMKIL 1882
Cdd:pfam16910  166 edWKEALTEDDSSplhILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1175-1367 2.31e-05

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 48.28  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  1175 SKVDGVLSLNVGCIQIVYLHKFLMSLLNFlnnFQTAKESLSAATAQAAERAATsVKDLAQRSF-----------RVSINI 1243
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDF---FKPPESHLELIGALMAAAEAT-LEGIKEQTRagleyaleehkTLDLDI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984525  1244 DLKAPVIVIPQS--SISTNAVVVDLGLIRVH--------------NQFSLVSDEDY--LNPPVIDRMDVQL--------- 1296
Cdd:pfam16910   84 DLQAPLIIVPEDytSKDSPCLILDAGHISVTsdlvdkstikeiksKQSQQYTEEDLkeLESLMYDKFSLKLsdtqvligp 163

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767984525  1297 ----TKLTLYRTVIQPgiYHpdiqLLHPINLEFLVNRNLAASwYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRIL 1367
Cdd:pfam16910  164 sgedWKEALTEDDSSP--LH----ILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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