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Conserved domains on  [gi|767983779|ref|XP_011519725|]
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leucine-rich repeat-containing protein 57 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-225 1.20e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 1.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  38 SNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSG 117
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISvKISCCPRLKILRLEENclELSMLPQS 196
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN--QLTDLPPL 268

                        170       180
                 ....*....|....*....|....*....
gi 767983779 197 iLSDSQICLLAVEGNLFEIKKLRELEGYD 225
Cdd:COG4886  269 -ANLTNLKTLDLSNNQLTDLKLKELELLL 296
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-225 1.20e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 1.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  38 SNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSG 117
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISvKISCCPRLKILRLEENclELSMLPQS 196
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN--QLTDLPPL 268

                        170       180
                 ....*....|....*....|....*....
gi 767983779 197 iLSDSQICLLAVEGNLFEIKKLRELEGYD 225
Cdd:COG4886  269 -ANLTNLKTLDLSNNQLTDLKLKELELLL 296
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-211 3.70e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 3.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  21 LKDRGLTEFPADLQKltsNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEICNlkKLETLSLNNNHLREL 100
Cdd:PRK15370 185 LKILGLTTIPACIPE---QITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATLPD--TIQEMELSINRITEL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 101 PSTFGqlSALKTLSLSGNQLGALPPQLC-SLRHLDVMDlskNQIRSIPDSVGElQVIELNLNQNQISQISVKISccPRLK 179
Cdd:PRK15370 257 PERLP--SALQSLDLFHNKISCLPENLPeELRYLSVYD---NSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLK 328

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767983779 180 ILRLEENCleLSMLPQSILSDSQIclLAVEGN 211
Cdd:PRK15370 329 TLEAGENA--LTSLPASLPPELQV--LDVSKN 356
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 21-188 2.71e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 2.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  21 LKDRGLTEFpaDLQKLTSNLRTIDLSNNKIESLPPLliGKFTLLKSLSLNNNKLTVLpDEICNLKKLETLSLNNNHLREL 100
Cdd:cd21340    9 LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 101 pSTFGQLSALKTLSLSGNQLgALPPQLC-----------SLRHLDVmdlSKNQIRSIPDSVGELQVIELNLNQNQIS--- 166
Cdd:cd21340   84 -EGLENLTNLEELHIENQRL-PPGEKLTfdprslaalsnSLRVLNI---SGNNIDSLEPLAPLRNLEQLDASNNQISdle 158

                        170       180
                 ....*....|....*....|..
gi 767983779 167 QISVKISCCPRLKILRLEENCL 188
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
38-97 4.77e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 4.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767983779   38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL-PDEICNLKKLETLSLNNNHL 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-225 1.20e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 1.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  38 SNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSG 117
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISvKISCCPRLKILRLEENclELSMLPQS 196
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN--QLTDLPPL 268

                        170       180
                 ....*....|....*....|....*....
gi 767983779 197 iLSDSQICLLAVEGNLFEIKKLRELEGYD 225
Cdd:COG4886  269 -ANLTNLKTLDLSNNQLTDLKLKELELLL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
21-221 9.50e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.86  E-value: 9.50e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  21 LKDRGLTEFPADLQKLTsNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLREL 100
Cdd:COG4886  143 LSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 101 PSTFGQLSALKTLSLSGNQLGALPpQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKI 180
Cdd:COG4886  221 PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767983779 181 LRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLREL 221
Cdd:COG4886  300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-222 1.44e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  32 DLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNkltvlpDEICNLKKLETLSLNNNHLRELPSTFGQLSALK 111
Cdd:COG4886   66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 112 TLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILRLEENclEL 190
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN--QL 217

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767983779 191 SMLPQSILSDSQICLLAVEGN----LFEIKKLRELE 222
Cdd:COG4886  218 TDLPEPLANLTNLETLDLSNNqltdLPELGNLTNLE 253
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-211 3.70e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 3.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  21 LKDRGLTEFPADLQKltsNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEICNlkKLETLSLNNNHLREL 100
Cdd:PRK15370 185 LKILGLTTIPACIPE---QITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATLPD--TIQEMELSINRITEL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 101 PSTFGqlSALKTLSLSGNQLGALPPQLC-SLRHLDVMDlskNQIRSIPDSVGElQVIELNLNQNQISQISVKISccPRLK 179
Cdd:PRK15370 257 PERLP--SALQSLDLFHNKISCLPENLPeELRYLSVYD---NSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLK 328

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767983779 180 ILRLEENCleLSMLPQSILSDSQIclLAVEGN 211
Cdd:PRK15370 329 TLEAGENA--LTSLPASLPPELQV--LDVSKN 356
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-188 1.71e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLSL 115
Cdd:PLN00113 140 PNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYL 219

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767983779 116 SGNQL-GALPPQ---LCSLRHLDVmdLSKNQIRSIPDSVGELQVIE-LNLNQNQIS-QISVKISCCPRLKILRLEENCL 188
Cdd:PLN00113 220 GYNNLsGEIPYEiggLTSLNHLDL--VYNNLTGPIPSSLGNLKNLQyLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
18-197 1.07e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  18 VFQLKDRGLTEFPadlQKLTSNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEICNlkKLETLSLNNNHL 97
Cdd:PRK15370 245 EMELSINRITELP---ERLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSL 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  98 RELPSTFGQlsALKTLSLSGNQLGALPPQLCSlrHLDVMDLSKNQIRSIPDSVGElQVIELNLNQNQISQISVKISCCpr 177
Cdd:PRK15370 317 TALPETLPP--GLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETLPP-TITTLDVSRNALTNLPENLPAA-- 389

                        170       180
                 ....*....|....*....|
gi 767983779 178 LKILRLEENclELSMLPQSI 197
Cdd:PRK15370 390 LQIMQASRN--NLVRLPESL 407
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 21-188 2.71e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 2.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  21 LKDRGLTEFpaDLQKLTSNLRTIDLSNNKIESLPPLliGKFTLLKSLSLNNNKLTVLpDEICNLKKLETLSLNNNHLREL 100
Cdd:cd21340    9 LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 101 pSTFGQLSALKTLSLSGNQLgALPPQLC-----------SLRHLDVmdlSKNQIRSIPDSVGELQVIELNLNQNQIS--- 166
Cdd:cd21340   84 -EGLENLTNLEELHIENQRL-PPGEKLTfdprslaalsnSLRVLNI---SGNNIDSLEPLAPLRNLEQLDASNNQISdle 158

                        170       180
                 ....*....|....*....|..
gi 767983779 167 QISVKISCCPRLKILRLEENCL 188
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-147 6.43e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 6.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  37 TSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLS 114
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLD 553

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767983779 115 LSGNQL-GALPPQLCSLRHLDVMDLSKNQIR-SIP 147
Cdd:PLN00113 554 LSQNQLsGEIPKNLGNVESLVQVNISHNHLHgSLP 588
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
6-221 3.74e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.41  E-value: 3.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779   6 LRAHVETaqktgvFQLKDRGLTEFPAdlqkLTSNLRTIDLSNNKIESLPPLLIGkftlLKSLSLNNNKLT---VLPDEIC 82
Cdd:PRK15387 220 LPAHITT------LVIPDNNLTSLPA----LPPELRTLEVSGNQLTSLPVLPPG----LLELSIFSNPLThlpALPSGLC 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  83 NL--------------KKLETLSLNNNHLRELPSTFGQL-----------------SALKTLSLSGNQLGALPP------ 125
Cdd:PRK15387 286 KLwifgnqltslpvlpPGLQELSVSDNQLASLPALPSELcklwaynnqltslptlpSGLQELSVSDNQLASLPTlpsely 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 126 -------QLCSL----RHLDVMDLSKNQIRSIPDSVGELQviELNLNQNQISQISVKISCCPRLKILRleencLELSMLP 194
Cdd:PRK15387 366 klwaynnRLTSLpalpSGLKELIVSGNRLTSLPVLPSELK--ELMVSGNRLTSLPMLPSGLLSLSVYR-----NQLTRLP 438

                        250       260
                 ....*....|....*....|....*..
gi 767983779 195 QSILSDSQICLLAVEGNLFEIKKLREL 221
Cdd:PRK15387 439 ESLIHLSSETTVNLEGNPLSERTLQAL 465
PLN03150 PLN03150
hypothetical protein; Provisional
 67-166 1.69e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.13  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  67 LSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLSLSGNQLGAlppqlcslrhldvmdlsknqir 144
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNG---------------------- 480

                         90       100
                 ....*....|....*....|...
gi 767983779 145 SIPDSVGELQVIE-LNLNQNQIS 166
Cdd:PLN03150 481 SIPESLGQLTSLRiLNLNGNSLS 503
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
4-131 5.37e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 5.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779   4 SALRAHVetaqKTGVFQL--KDRGLTEFPAdlqKLTSNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEI 81
Cdd:PRK15370 296 RTLPAHL----PSGITHLnvQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLPPE---LQVLDVSKNQITVLPETL 365

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767983779  82 CnlKKLETLSLNNNHLRELPSTFGqlSALKTLSLSGNQLGALPPQLCSLR 131
Cdd:PRK15370 366 P--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESLPHFR 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-166 1.70e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  26 LTEFPADLQKLTsNLRTIDLSNNKIESLPPLliGKFTLLKSLSLNNNKLTVLPDEiCNLKKLETLSLNNNHLRELPSTFG 105
Cdd:COG4886  217 LTDLPEPLANLT-NLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKEL 292

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767983779 106 QLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQIS 166
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 18-188 1.72e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  18 VFQLKDRGLT-EFPADLQKlTSNLRTIDLSNNKIES-LPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNN 95
Cdd:PLN00113 336 VLQLWSNKFSgEIPKNLGK-HNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  96 HLR-ELPSTFGQL------------------------SALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIR-SIPDS 149
Cdd:PLN00113 415 SFSgELPSEFTKLplvyfldisnnnlqgrinsrkwdmPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRK 494

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767983779 150 VGEL-QVIELNLNQNQIS-QISVKISCCPRLKILRLEENCL 188
Cdd:PLN00113 495 LGSLsELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQL 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-166 1.77e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  32 DLQKLTSnlrtIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSA 109
Cdd:PLN00113 282 SLQKLIS----LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNN 357

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 110 LKTLSLSGNQL-GALPPQLCSLRHLDVMDLSKNQIRS-IPDSVGELQVIE-LNLNQNQIS 166
Cdd:PLN00113 358 LTVLDLSTNNLtGEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRrVRLQDNSFS 417
LRR_8 pfam13855
Leucine rich repeat;
38-97 4.77e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 4.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767983779   38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL-PDEICNLKKLETLSLNNNHL 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 21-105 6.75e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 6.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  21 LKDRGLTEF-PADLQKLtSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR 98
Cdd:PLN03150 425 LDNQGLRGFiPNDISKL-RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503


                 ....*...
gi 767983779  99 -ELPSTFG 105
Cdd:PLN03150 504 gRVPAALG 511
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-197 8.07e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 8.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  31 ADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSAL 110
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 111 KTLS-----------------LSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKI 172
Cdd:COG4886   99 TELDlsgneelsnltnlesldLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLtNLKSLDLSNNQLTDLPEEL 178

                        170       180
                 ....*....|....*....|....*
gi 767983779 173 SCCPRLKILRLEENclELSMLPQSI 197
Cdd:COG4886  179 GNLTNLKELDLSNN--QITDLPEPL 201
LRR_8 pfam13855
Leucine rich repeat;
64-120 3.21e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 3.21e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767983779   64 LKSLSLNNNKLTVLPDEI-CNLKKLETLSLNNNHLREL-PSTFGQLSALKTLSLSGNQL 120
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-188 4.94e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  37 TSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNL-KKLETLSLNNNHLRElPSTFGQLSALKTLS 114
Cdd:PLN00113  68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTG-SIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767983779 115 LSGNQL-GALPPQLCSLRHLDVMDLSKNQIRS-IPDSVGELQVIE-LNLNQNQ-ISQISVKISCCPRLKILRLEENCL 188
Cdd:PLN00113 147 LSNNMLsGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSLEfLTLASNQlVGQIPRELGQMKSLKWIYLGYNNL 224
PLN03150 PLN03150
hypothetical protein; Provisional
 43-127 1.42e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.66  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  43 IDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLSLSGNQL 120
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*...
gi 767983779 121 -GALPPQL 127
Cdd:PLN03150 503 sGRVPAAL 510
LRR_8 pfam13855
Leucine rich repeat;
86-143 6.95e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 6.95e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779   86 KLETLSLNNNHLREL-PSTFGQLSALKTLSLSGNQLGALPPQ-LCSLRHLDVMDLSKNQI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-166 1.02e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  23 DRGLTEFPADLQKLTSnLRTIDLSNNKIESLPPLLIGKF----TLLKSLSLNNNKLTV-----LPDEICNLKKLETLSLN 93
Cdd:COG5238  222 DEGAEILAEALKGNKS-LTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLS 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  94 NNHLRE-----LPSTFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVMDLSKNQIRSIPDS------VGELQVIE 157
Cdd:COG5238  301 VNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGaqgaiALAKALQENTTLHSLDLSDNQIGDEGAIalakylEGNTTLRE 380


                 ....*....
gi 767983779 158 LNLNQNQIS 166
Cdd:COG5238  381 LNLGKNNIG 389
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-191 1.60e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  37 TSNLRTIDLSNNkieSLPPLLIGKF------TLLKSLSLNNNKL---------TVLPDEICNLKK--LETLSLNNNHLRE 99
Cdd:cd00116   80 GCGLQELDLSDN---ALGPDGCGVLesllrsSSLQELKLNNNGLgdrglrllaKGLKDLPPALEKlvLGRNRLEGASCEA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 100 LPSTFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVMDLSKNQIRSIPDS-VGEL-----QVIELNLNQNQISQI 168
Cdd:cd00116  157 LAKALRANRDLKELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLTDEGASaLAETlaslkSLEVLNLGDNNLTDA 236

                        170       180
                 ....*....|....*....|....*....
gi 767983779 169 ------SVKISCCPRLKILRLEENCLELS 191
Cdd:cd00116  237 gaaalaSALLSPNISLLTLSLSCNDITDD 265
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-222 6.10e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 36.69  E-value: 6.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  84 LKKLETLSLNNNHLRELPStFGQLSALKTLSLSGNQLGALpPQLCSLRHLDVMDLSKNQIRSIP--DSVGELQVieLNLN 161
Cdd:cd21340    1 LKRITHLYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEnlENLVNLKK--LYLG 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779 162 QNQISQISvKISCCPRLKILRLEENCLELSML----PQSILSDSQ-ICLLAVEGN----LFEIKKLRELE 222
Cdd:cd21340   77 GNRISVVE-GLENLTNLEELHIENQRLPPGEKltfdPRSLAALSNsLRVLNISGNnidsLEPLAPLRNLE 145
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-120 8.88e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 8.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983779  39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTfGQLSALKTLSLS 116
Cdd:PLN00113 524 KLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPST-GAFLAINASAVA 602


                 ....
gi 767983779 117 GNQL 120
Cdd:PLN00113 603 GNID 606
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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