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Conserved domains on  [gi|767983647|ref|XP_011519674|]
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fanconi-associated nuclease 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDDEXK_nuclease-like super family cl40440
PDDEXK family nucleases; Superfamily of PDDEXK nucleases including very short patch repair ...
 373-604 5.07e-74

PDDEXK family nucleases; Superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


The actual alignment was detected with superfamily member cd22326:

Pssm-ID: 477358 [Multi-domain]  Cd Length: 652  Bit Score: 249.31  E-value: 5.07e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 373 PYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKL-SWIKMTKLEYEE---IALDLTPVIE 448
Cdd:cd22326    1 PYYLRSFLEILKTVLENEDHRSLFDEEELGLLDKFLSLSDPAQKLFVRLFQRKLkSWLRLSKLKYPEialIALDLSPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 449 ELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQL--VDAFLKLAKQRSVCTwgknkpgIGAVILKR 526
Cdd:cd22326   81 ELVEAGFLESDTDLLDLSELLELLSAPELKELAKEFKLKKKKKKKKRLllLEALLKLAKQRSSGL-------LGAALLKR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 527 AKALAG--QSVRIC---KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDD 601
Cdd:cd22326  154 AKALAGleQSLRLCllsRLPRAVLSRVLLLFSLLDLLVYERSTLGGEDLLTTLLLVRLGKRKYPSYTVSRTTPIFASRDE 233


                 ...
gi 767983647 602 LIR 604
Cdd:cd22326  234 LLR 236
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 41-62 1.10e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 42.21  E-value: 1.10e-05
                           10        20
                   ....*....|....*....|..
gi 767983647    41 KLACPVCSKMVPRYDLNRHLDE 62
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDS 22
 
Name Accession Description Interval E-value
FAN1-like cd22326
repair nuclease FAN1; This model characterizes a set of nucleases that resemble ...
 373-604 5.07e-74

repair nuclease FAN1; This model characterizes a set of nucleases that resemble Holliday-junction resolving enzymes. They belong to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411730 [Multi-domain]  Cd Length: 652  Bit Score: 249.31  E-value: 5.07e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 373 PYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKL-SWIKMTKLEYEE---IALDLTPVIE 448
Cdd:cd22326    1 PYYLRSFLEILKTVLENEDHRSLFDEEELGLLDKFLSLSDPAQKLFVRLFQRKLkSWLRLSKLKYPEialIALDLSPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 449 ELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQL--VDAFLKLAKQRSVCTwgknkpgIGAVILKR 526
Cdd:cd22326   81 ELVEAGFLESDTDLLDLSELLELLSAPELKELAKEFKLKKKKKKKKRLllLEALLKLAKQRSSGL-------LGAALLKR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 527 AKALAG--QSVRIC---KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDD 601
Cdd:cd22326  154 AKALAGleQSLRLCllsRLPRAVLSRVLLLFSLLDLLVYERSTLGGEDLLTTLLLVRLGKRKYPSYTVSRTTPIFASRDE 233


                 ...
gi 767983647 602 LIR 604
Cdd:cd22326  234 LLR 236
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 41-62 1.10e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 42.21  E-value: 1.10e-05
                           10        20
                   ....*....|....*....|..
gi 767983647    41 KLACPVCSKMVPRYDLNRHLDE 62
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDS 22
 
Name Accession Description Interval E-value
FAN1-like cd22326
repair nuclease FAN1; This model characterizes a set of nucleases that resemble ...
 373-604 5.07e-74

repair nuclease FAN1; This model characterizes a set of nucleases that resemble Holliday-junction resolving enzymes. They belong to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411730 [Multi-domain]  Cd Length: 652  Bit Score: 249.31  E-value: 5.07e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 373 PYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKL-SWIKMTKLEYEE---IALDLTPVIE 448
Cdd:cd22326    1 PYYLRSFLEILKTVLENEDHRSLFDEEELGLLDKFLSLSDPAQKLFVRLFQRKLkSWLRLSKLKYPEialIALDLSPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 449 ELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQL--VDAFLKLAKQRSVCTwgknkpgIGAVILKR 526
Cdd:cd22326   81 ELVEAGFLESDTDLLDLSELLELLSAPELKELAKEFKLKKKKKKKKRLllLEALLKLAKQRSSGL-------LGAALLKR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983647 527 AKALAG--QSVRIC---KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDD 601
Cdd:cd22326  154 AKALAGleQSLRLCllsRLPRAVLSRVLLLFSLLDLLVYERSTLGGEDLLTTLLLVRLGKRKYPSYTVSRTTPIFASRDE 233


                 ...
gi 767983647 602 LIR 604
Cdd:cd22326  234 LLR 236
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 41-62 1.10e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 42.21  E-value: 1.10e-05
                           10        20
                   ....*....|....*....|..
gi 767983647    41 KLACPVCSKMVPRYDLNRHLDE 62
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDS 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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