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Conserved domains on  [gi|767978972|ref|XP_011519430|]
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protein ABHD13 isoform X1 [Homo sapiens]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
76-317 1.11e-53

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 176.64  E-value: 1.11e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  76 LYVPMPtGIPHENIFIRTKDGIRLNLILIRYTGDNSPYsPTIIYFHGNAGNIGHRLP----------NALLMlvnlkvnl 145
Cdd:COG1073    1 IFPPSD-KVNKEDVTFKSRDGIKLAGDLYLPAGASKKY-PAVVVAHGNGGVKEQRALyaqrlaelgfNVLAF-------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 146 llvDYRGYGKSEGEASEEGLY--LDSEAVLDYVMTRPDLDKTKIFLFGRSLGGAVAIHLASENsHRISAIMVENTFLSIP 223
Cdd:COG1073   71 ---DYRGYGESEGEPREEGSPerRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATD-PRVKAVILDSPFTSLE 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 224 HMASTLFSFFPMRYLPLWCYK----------NKFLSYRKISQCRMPSLFISGLSDQLIPPVMMKQLYELSPSRtKRLAIF 293
Cdd:COG1073  147 DLAAQRAKEARGAYLPGVPYLpnvrlasllnDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEP-KELLIV 225
                        250       260
                 ....*....|....*....|....*.
gi 767978972 294 PDGTHNDT-WQCQG-YFTALEQFIKE 317
Cdd:COG1073  226 PGAGHVDLyDRPEEeYFDKLAEFFKK 251
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
76-317 1.11e-53

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 176.64  E-value: 1.11e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  76 LYVPMPtGIPHENIFIRTKDGIRLNLILIRYTGDNSPYsPTIIYFHGNAGNIGHRLP----------NALLMlvnlkvnl 145
Cdd:COG1073    1 IFPPSD-KVNKEDVTFKSRDGIKLAGDLYLPAGASKKY-PAVVVAHGNGGVKEQRALyaqrlaelgfNVLAF-------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 146 llvDYRGYGKSEGEASEEGLY--LDSEAVLDYVMTRPDLDKTKIFLFGRSLGGAVAIHLASENsHRISAIMVENTFLSIP 223
Cdd:COG1073   71 ---DYRGYGESEGEPREEGSPerRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATD-PRVKAVILDSPFTSLE 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 224 HMASTLFSFFPMRYLPLWCYK----------NKFLSYRKISQCRMPSLFISGLSDQLIPPVMMKQLYELSPSRtKRLAIF 293
Cdd:COG1073  147 DLAAQRAKEARGAYLPGVPYLpnvrlasllnDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEP-KELLIV 225
                        250       260
                 ....*....|....*....|....*.
gi 767978972 294 PDGTHNDT-WQCQG-YFTALEQFIKE 317
Cdd:COG1073  226 PGAGHVDLyDRPEEeYFDKLAEFFKK 251
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
149-298 2.32e-13

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 68.78  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  149 DYRGYGKSEGE----ASEEGLYLDSEAVLDYVMTR-PDLdktKIFLFGRSLGGAVAIHLASENSHRISAIMVENTFLSIP 223
Cdd:pfam12146  38 DHRGHGRSDGKrghvPSFDDYVDDLDTFVDKIREEhPGL---PLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIK 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  224 H---------MASTLFSFFPMRYLPlWCYKNKFLS--------YRKISQC--------------------------RMPS 260
Cdd:pfam12146 115 PylappilklLAKLLGKLFPRLRVP-NNLLPDSLSrdpevvaaYAADPLVhggisartlyelldagerllrraaaiTVPL 193
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 767978972  261 LFISGLSDQLIPPVMMKQLYELSPSRTKRLAIFPDGTH 298
Cdd:pfam12146 194 LLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYH 231
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
149-298 1.04e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 40.51  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 149 DYRGYGKSEGE----ASEEGLYLDSEAVLDYVMTRPDLDKTKIFLFGRSLGGAVA--IHLASENSH----------RISA 212
Cdd:PLN02385 122 DYPGFGLSEGLhgyiPSFDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVAlkVHLKQPNAWdgailvapmcKIAD 201
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 213 IMVEN-TFLSIPHMASTLF---SFFPMRYLPLWCY----KNKFLSYRKIS---QCRM----------------------P 259
Cdd:PLN02385 202 DVVPPpLVLQILILLANLLpkaKLVPQKDLAELAFrdlkKRKMAEYNVIAykdKPRLrtavellrttqeiemqleevslP 281
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767978972 260 SLFISGLSDQLIPPVMMKQLYELSPSRTKRLAIFPDGTH 298
Cdd:PLN02385 282 LLILHGEADKVTDPSVSKFLYEKASSSDKKLKLYEDAYH 320
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
76-317 1.11e-53

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 176.64  E-value: 1.11e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  76 LYVPMPtGIPHENIFIRTKDGIRLNLILIRYTGDNSPYsPTIIYFHGNAGNIGHRLP----------NALLMlvnlkvnl 145
Cdd:COG1073    1 IFPPSD-KVNKEDVTFKSRDGIKLAGDLYLPAGASKKY-PAVVVAHGNGGVKEQRALyaqrlaelgfNVLAF-------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 146 llvDYRGYGKSEGEASEEGLY--LDSEAVLDYVMTRPDLDKTKIFLFGRSLGGAVAIHLASENsHRISAIMVENTFLSIP 223
Cdd:COG1073   71 ---DYRGYGESEGEPREEGSPerRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATD-PRVKAVILDSPFTSLE 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 224 HMASTLFSFFPMRYLPLWCYK----------NKFLSYRKISQCRMPSLFISGLSDQLIPPVMMKQLYELSPSRtKRLAIF 293
Cdd:COG1073  147 DLAAQRAKEARGAYLPGVPYLpnvrlasllnDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEP-KELLIV 225
                        250       260
                 ....*....|....*....|....*.
gi 767978972 294 PDGTHNDT-WQCQG-YFTALEQFIKE 317
Cdd:COG1073  226 PGAGHVDLyDRPEEeYFDKLAEFFKK 251
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
91-320 2.08e-28

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 110.11  E-value: 2.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  91 IRTKDGIRLNLILIRYTgDNSPYsPTIIYFHGNAGNI-GHRLPNA----------LLMlvnlkvnlllvDYRGYGKSEGE 159
Cdd:COG1506    2 FKSADGTTLPGWLYLPA-DGKKY-PVVVYVHGGPGSRdDSFLPLAqalasrgyavLAP-----------DYRGYGESAGD 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 160 ASEEGLYlDSEAVLDYVMTRPDLDKTKIFLFGRSLGGAVAIHLASENSHRISAIMVENTFLSIPHMASTLFSFFPMRYLP 239
Cdd:COG1506   69 WGGDEVD-DVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTREYTERLMGG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 240 LWcykNKFLSYRKIS------QCRMPSLFISGLSDQLIPPVMMKQLYE--LSPSRTKRLAIFPDGTHNDTWQCQ-GYFTA 310
Cdd:COG1506  148 PW---EDPEAYAARSplayadKLKTPLLLIHGEADDRVPPEQAERLYEalKKAGKPVELLVYPGEGHGFSGAGApDYLER 224
                        250
                 ....*....|
gi 767978972 311 LEQFIKEVVK 320
Cdd:COG1506  225 ILDFLDRHLK 234
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
85-317 9.05e-22

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 91.60  E-value: 9.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  85 PHENIFIRTKDGIRLNLIliRYTGDNSPySPTIIYFHGNAGNIG--HRLPNAL-------LMLvnlkvnlllvDYRGYGK 155
Cdd:COG2267    2 TRRLVTLPTRDGLRLRGR--RWRPAGSP-RGTVVLVHGLGEHSGryAELAEALaaagyavLAF----------DLRGHGR 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 156 SEGE----ASEEGLYLDSEAVLDYVMTRPDLdktKIFLFGRSLGGAVAIHLASENSHRISAIMventfLSIPHMASTLFS 231
Cdd:COG2267   69 SDGPrghvDSFDDYVDDLRAALDALRARPGL---PVVLLGHSMGGLIALLYAARYPDRVAGLV-----LLAPAYRADPLL 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 232 FFPMRYLplwcykNKFLSYRKISQCRMPSLFISGLSDQLIPPVMMKQLYELSPSRtKRLAIFPDGTH---NDTWQCQgYF 308
Cdd:COG2267  141 GPSARWL------RALRLAEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPD-VELVLLPGARHellNEPAREE-VL 212

                 ....*....
gi 767978972 309 TALEQFIKE 317
Cdd:COG2267  213 AAILAWLER 221
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
149-298 2.32e-13

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 68.78  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  149 DYRGYGKSEGE----ASEEGLYLDSEAVLDYVMTR-PDLdktKIFLFGRSLGGAVAIHLASENSHRISAIMVENTFLSIP 223
Cdd:pfam12146  38 DHRGHGRSDGKrghvPSFDDYVDDLDTFVDKIREEhPGL---PLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIK 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  224 H---------MASTLFSFFPMRYLPlWCYKNKFLS--------YRKISQC--------------------------RMPS 260
Cdd:pfam12146 115 PylappilklLAKLLGKLFPRLRVP-NNLLPDSLSrdpevvaaYAADPLVhggisartlyelldagerllrraaaiTVPL 193
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 767978972  261 LFISGLSDQLIPPVMMKQLYELSPSRTKRLAIFPDGTH 298
Cdd:pfam12146 194 LLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYH 231
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
149-318 2.40e-13

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 68.10  E-value: 2.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 149 DYRGYGKSEGEASEEGLYLDSEAVLDyVMTRpdLDKTKIFLFGRSLGGAVAIHLASENSHRISAIMVENTFLSIPHMAST 228
Cdd:COG0596   56 DLRGHGRSDKPAGGYTLDDLADDLAA-LLDA--LGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPLR 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 229 LFSFFPMRYLPLWCYKNKFLSYRKISQCRMPSLFISGLSDQLIPPVMMKQLYELSPsrTKRLAIFPDGTHNDTWQCQGYF 308
Cdd:COG0596  133 RPGLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLP--NAELVVLPGAGHFPPLEQPEAF 210
                        170
                 ....*....|.
gi 767978972 309 T-ALEQFIKEV 318
Cdd:COG0596  211 AaALRDFLARL 221
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
149-320 9.40e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 52.25  E-value: 9.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 149 DYRGYGKSEGEASE---EGLYLDSEAVLDYVMTRPDldktKIFLFGRSLGGAVAIHLASENSHrISAIMVENTFLSIPHM 225
Cdd:COG1647   49 RLPGHGTSPEDLLKttwEDWLEDVEEAYEILKAGYD----KVIVIGLSMGGLLALLLAARYPD-VAGLVLLSPALKIDDP 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 226 ASTLFSFFPM----------------------RYLPLWCYKN--KFLSY--RKISQCRMPSLFISGLSDQLIPPVMMKQL 279
Cdd:COG1647  124 SAPLLPLLKYlarslrgigsdiedpevaeyayDRTPLRALAElqRLIREvrRDLPKITAPTLIIQSRKDEVVPPESARYI 203
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767978972 280 YELSPSRTKRLAIFPDGTHNDT--WQCQGYFTALEQFIKEVVK 320
Cdd:COG1647  204 YERLGSPDKELVWLEDSGHVITldKDREEVAEEILDFLERLAA 246
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
84-298 1.18e-07

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 51.89  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  84 IPHENIFIRTKDGIRLNLILIRYTGDnSPYsPTIIYFHGNAG------NIGHRL---------PNALlmlvnlkvnlllv 148
Cdd:COG0412    1 MTTETVTIPTPDGVTLPGYLARPAGG-GPR-PGVVVLHEIFGlnphirDVARRLaaagyvvlaPDLY------------- 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 149 DYRGYGKSEGEASEEGLYLDSE-------AVLDYVMTRPDLDKTKIFLFGRSLGGAVAIHLASENsHRISAImventfls 221
Cdd:COG0412   66 GRGGPGDDPDEARALMGALDPEllaadlrAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAARG-PDLAAA-------- 136
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767978972 222 iphmastlFSFFPMRYLPlwcyknkfLSYRKISQCRMPSLFISGLSDQLIPPVMMKQLYEL--SPSRTKRLAIFPDGTH 298
Cdd:COG0412  137 --------VSFYGGLPAD--------DLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAAlaAAGVDVELHVYPGAGH 199
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
115-238 2.03e-07

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 51.35  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  115 PTIIYFHGNAGNIG--HRLPNALLmlvNLKVNLLLVDYRGYGKSEGEASEEGLYLDS-EAVLDYVMTRpdLDKTKIFLFG 191
Cdd:pfam00561   1 PPVLLLHGLPGSSDlwRKLAPALA---RDGFRVIALDLRGFGKSSRPKAQDDYRTDDlAEDLEYILEA--LGLEKVNLVG 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767978972  192 RSLGGAVAIHLASENSHRISAIMVENTFLSiPHMASTLFSFFPMRYL 238
Cdd:pfam00561  76 HSMGGLIALAYAAKYPDRVKALVLLGALDP-PHELDEADRFILALFP 121
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
150-298 2.38e-07

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 50.55  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 150 YRGYGKSEGEASE-EGLYLDSEAVLDYVMTRPDLdktKIFLFGRSLGGAVAIHLASEnSHRISAimventFLSIphmaST 228
Cdd:COG2945   63 FRGVGRSEGEFDEgRGELDDAAAALDWLRAQNPL---PLWLAGFSFGAYVALQLAMR-LPEVEG------LILV----AP 128
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767978972 229 LFSFFPMRYLPLwcyknkflsyrkisqCRMPSLFISGLSDQLIPPVMMKQLYE-LSPsrTKRLAIFPDGTH 298
Cdd:COG2945  129 PVNRYDFSFLAP---------------CPAPTLVIHGEQDEVVPPAEVLDWARpLSP--PLPVVVVPGADH 182
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
78-298 3.23e-05

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 45.18  E-value: 3.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  78 VPMPTGIPHENIF---IRTKDGIRLNLILIRYTGDNsPYsPTIIYFHGNAGNIGHRLPN---------ALLMlvnlkvnl 145
Cdd:COG3458   45 TPVETGLPGVEVYdvtFTGFGGARIYGWLLRPKGEG-PL-PAVVEFHGYGGGRGLPHEDldwaaagyaVLVM-------- 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 146 llvDYRGYGKSEGEASEE-------------------------GLYLDseAV--LDYVMTRPDLDKTKIFLFGRSLGGAV 198
Cdd:COG3458  115 ---DTRGQGSSWGDTPDPggysggalpgymtrgiddpdtyyyrRVYLD--AVraVDALRSLPEVDGKRIGVTGGSQGGGL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 199 AIhLASENSHRISAIMVENTFLS-IP---HMAST-----LFSFFPMRYLPlwcYKNKF--LSY-------RKIsqcRMPS 260
Cdd:COG3458  190 AL-AAAALDPRVKAAAADVPFLCdFRralELGRAgpypeIRRYLRRHRER---EPEVFetLSYfdavnfaRRI---KAPV 262
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767978972 261 LFISGLSDQLIPPVMMKQLYELSPSrTKRLAIFPDGTH 298
Cdd:COG3458  263 LFSVGLMDPVCPPSTVFAAYNALAG-PKEILVYPFNGH 299
YpfH COG0400
Predicted esterase [General function prediction only];
115-282 5.35e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 43.36  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 115 PTIIYFHGNAGN------IGHRL---------PNALLMLvnlkvnlllvDYRGYG-----KSEGEASEEGL-----YLDs 169
Cdd:COG0400    6 PLVVLLHGYGGDeedllpLAPELalpgaavlaPRAPVPE----------GPGGRAwfdlsFLEGREDEEGLaaaaeALA- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 170 eAVLDYVMTRPDLDKTKIFLFGRSLGGAVAIHLASENSHRISAIMventflsiphmastLFS-FFPMRylPLWCYKNKFL 248
Cdd:COG0400   75 -AFIDELEARYGIDPERIVLAGFSQGAAMALSLALRRPELLAGVV--------------ALSgYLPGE--EALPAPEAAL 137
                        170       180       190
                 ....*....|....*....|....*....|....
gi 767978972 249 SYRKIsqcrmpsLFISGLSDQLIPPVMMKQLYEL 282
Cdd:COG0400  138 AGTPV-------FLAHGTQDPVIPVERAREAAEA 164
AXE1 pfam05448
Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase ...
164-300 6.87e-05

Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.


Pssm-ID: 398876 [Multi-domain]  Cd Length: 316  Bit Score: 43.93  E-value: 6.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  164 GLYLDSEAVLDYVMTRPDLDKTKIFLFGRSLGGAVAIhLASENSHRISAIMVENTFLS---------IPHMASTLFSFFP 234
Cdd:pfam05448 153 RVFLDAVRAVEIVMSFPEVDEERIVVTGGSQGGALAL-AAAALSPRIKAVVADYPFLSdfrrawemdLEHPYDELNRYFK 231
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767978972  235 -----------MRYLPLWCYKNkfLSYRkisqCRMPSLFISGLSDQLIPPVMMKQLYElSPSRTKRLAIFPDGTHND 300
Cdd:pfam05448 232 rdphhereeeaFRTLSYFDIKN--LAHR----VKGPVLMAIGLIDDVCPPSTVFAAYN-HLTTEKEIRVYPYFAHEY 301
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
149-298 1.04e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 40.51  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 149 DYRGYGKSEGE----ASEEGLYLDSEAVLDYVMTRPDLDKTKIFLFGRSLGGAVA--IHLASENSH----------RISA 212
Cdd:PLN02385 122 DYPGFGLSEGLhgyiPSFDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVAlkVHLKQPNAWdgailvapmcKIAD 201
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972 213 IMVEN-TFLSIPHMASTLF---SFFPMRYLPLWCY----KNKFLSYRKIS---QCRM----------------------P 259
Cdd:PLN02385 202 DVVPPpLVLQILILLANLLpkaKLVPQKDLAELAFrdlkKRKMAEYNVIAykdKPRLrtavellrttqeiemqleevslP 281
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767978972 260 SLFISGLSDQLIPPVMMKQLYELSPSRTKRLAIFPDGTH 298
Cdd:PLN02385 282 LLILHGEADKVTDPSVSKFLYEKASSSDKKLKLYEDAYH 320
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
111-298 6.84e-03

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 37.36  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  111 SPYSPTIIYFHG---------NAGNIGHRLPNALLMLVNLKVNLLLVDYRG--------YGKSEGEASEEGLYLDS---- 169
Cdd:pfam02230  11 DPAQATVIFLHGlgdsghgwaDAAKTEAPLPNIKFIFPHGPEIPVTLNGGMrmpawfdlVGLSPNAKEDEAGIKNSaeti 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978972  170 EAVLDYVMTRPdLDKTKIFLFGRSLGGAVAIHLASENSHRISAIMVENTFLsIPHMAstlfsfFPmrylplwcyKNKFLS 249
Cdd:pfam02230  91 EELIDAEQKKG-IPSSRIIIGGFSQGAMLALYSALTLPLPLGGIVAFSGFL-PLPTK------FP---------SHPNLV 153
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767978972  250 YRKISQCRmpslfISGLSDQLIPPVMMKQLYELSPSRTKR--LAIFPDGTH 298
Cdd:pfam02230 154 TKKTPIFL-----IHGEEDPVVPLALGKLAKEYLKTSLNKveLKIYEGLAH 199
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
182-220 8.62e-03

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 37.64  E-value: 8.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767978972 182 LDKTKIFLFGRSLGGAVAIHLASENSHRISAIMVENTFL 220
Cdd:PRK00870 112 LDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVVANTGL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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