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Conserved domains on  [gi|767971642|ref|XP_011518853|]
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BLOC-1-related complex subunit 5 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORCS5-like cd22789
BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related ...
 1-156 3.52e-84

BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related complex subunit 5 (BORCS5), which is also called loss of heterozygosity 12 chromosomal region 1 (LOH12CR1), myristoylated lysosomal protein, or myrlysin. BORCS5 is a component of BLOC-1 related complex (BORC), a multisubunit complex that also contains Lyspersin/C17orf59, Diaskedin/C10orf32, KxDL1, MEF2BNB, BLOS1, BLOS2, and Snapin subunits. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. LOH12CR1 may function as a tumor suppressor by inhibiting tumor growth through deregulation of the G1/S checkpoint in human colorectal carcinoma. It has been shown to bind to LKB1, a well-known tumor suppressor gene in colorectal cancer; its expression level could be used as a promising biomarker in patients. This domain has also been found in many hypothetical proteins involved in loss of heterozygosity and thus tumor suppression.


:

Pssm-ID: 439361  Cd Length: 157  Bit Score: 244.51  E-value: 3.52e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767971642   1 MDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFD 80
Cdd:cd22789    2 MDDIVVVNEGTQSSRNVSNDPDLIKLQEIPTFLPLLKGSLNLPGSPDPEVLEKLDPRPLLKLCLRYQDHLRQCAEAVAFD 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767971642  81 QNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPF 156
Cdd:cd22789   82 QNALVKRIKEVDVEIASLSNSLQERQKRYAKYAEQLQKVNELSAQLNRIQMLLDQIVPLLERLNSLLPEEERLEPF 157
 
Name Accession Description Interval E-value
BORCS5-like cd22789
BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related ...
 1-156 3.52e-84

BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related complex subunit 5 (BORCS5), which is also called loss of heterozygosity 12 chromosomal region 1 (LOH12CR1), myristoylated lysosomal protein, or myrlysin. BORCS5 is a component of BLOC-1 related complex (BORC), a multisubunit complex that also contains Lyspersin/C17orf59, Diaskedin/C10orf32, KxDL1, MEF2BNB, BLOS1, BLOS2, and Snapin subunits. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. LOH12CR1 may function as a tumor suppressor by inhibiting tumor growth through deregulation of the G1/S checkpoint in human colorectal carcinoma. It has been shown to bind to LKB1, a well-known tumor suppressor gene in colorectal cancer; its expression level could be used as a promising biomarker in patients. This domain has also been found in many hypothetical proteins involved in loss of heterozygosity and thus tumor suppression.


Pssm-ID: 439361  Cd Length: 157  Bit Score: 244.51  E-value: 3.52e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767971642   1 MDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFD 80
Cdd:cd22789    2 MDDIVVVNEGTQSSRNVSNDPDLIKLQEIPTFLPLLKGSLNLPGSPDPEVLEKLDPRPLLKLCLRYQDHLRQCAEAVAFD 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767971642  81 QNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPF 156
Cdd:cd22789   82 QNALVKRIKEVDVEIASLSNSLQERQKRYAKYAEQLQKVNELSAQLNRIQMLLDQIVPLLERLNSLLPEEERLEPF 157
LOH1CR12 pfam10158
Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved ...
 31-161 2.20e-66

Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression. The exact function of family members is not known. This region is also found in subunit 5 of the BLOC-1-related complex, which is also found in the BORC complex. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm.


Pssm-ID: 287167  Cd Length: 131  Bit Score: 198.50  E-value: 2.20e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767971642   31 TFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYA 110
Cdd:pfam10158   1 RFLPVLRGVISKRTNRTNETLEKLSSQHFINLCTRLQEHFNVCAKAVASDQNKIVARIKEVDASIITLFAETVAHQKQYA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767971642  111 KYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPD 161
Cdd:pfam10158  81 SYAEQFSKVNQISDQLCRIQIILEQNVPSMETLNNILDPDERLEPFVWKPE 131
PilN COG3166
Type IV pilus assembly protein PilN [Cell motility, Extracellular structures];
102-162 2.87e-03

Type IV pilus assembly protein PilN [Cell motility, Extracellular structures];


Pssm-ID: 442399 [Multi-domain]  Cd Length: 185  Bit Score: 36.48  E-value: 2.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767971642 102 MQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDR 162
Cdd:COG3166   64 LDKQIAEIKELKKQKAELLARLQVIEQLQQSRPPWVHLLDELARLLPEGVWLTSLSQQGGT 124
 
Name Accession Description Interval E-value
BORCS5-like cd22789
BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related ...
 1-156 3.52e-84

BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related complex subunit 5 (BORCS5), which is also called loss of heterozygosity 12 chromosomal region 1 (LOH12CR1), myristoylated lysosomal protein, or myrlysin. BORCS5 is a component of BLOC-1 related complex (BORC), a multisubunit complex that also contains Lyspersin/C17orf59, Diaskedin/C10orf32, KxDL1, MEF2BNB, BLOS1, BLOS2, and Snapin subunits. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. LOH12CR1 may function as a tumor suppressor by inhibiting tumor growth through deregulation of the G1/S checkpoint in human colorectal carcinoma. It has been shown to bind to LKB1, a well-known tumor suppressor gene in colorectal cancer; its expression level could be used as a promising biomarker in patients. This domain has also been found in many hypothetical proteins involved in loss of heterozygosity and thus tumor suppression.


Pssm-ID: 439361  Cd Length: 157  Bit Score: 244.51  E-value: 3.52e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767971642   1 MDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFD 80
Cdd:cd22789    2 MDDIVVVNEGTQSSRNVSNDPDLIKLQEIPTFLPLLKGSLNLPGSPDPEVLEKLDPRPLLKLCLRYQDHLRQCAEAVAFD 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767971642  81 QNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPF 156
Cdd:cd22789   82 QNALVKRIKEVDVEIASLSNSLQERQKRYAKYAEQLQKVNELSAQLNRIQMLLDQIVPLLERLNSLLPEEERLEPF 157
LOH1CR12 pfam10158
Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved ...
 31-161 2.20e-66

Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression. The exact function of family members is not known. This region is also found in subunit 5 of the BLOC-1-related complex, which is also found in the BORC complex. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm.


Pssm-ID: 287167  Cd Length: 131  Bit Score: 198.50  E-value: 2.20e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767971642   31 TFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYA 110
Cdd:pfam10158   1 RFLPVLRGVISKRTNRTNETLEKLSSQHFINLCTRLQEHFNVCAKAVASDQNKIVARIKEVDASIITLFAETVAHQKQYA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767971642  111 KYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPD 161
Cdd:pfam10158  81 SYAEQFSKVNQISDQLCRIQIILEQNVPSMETLNNILDPDERLEPFVWKPE 131
MEKK4_N pfam19431
MEKK4 N-terminal; This domain represents the regulatory N-terminal non-catalytic region of ...
 66-115 7.01e-05

MEKK4 N-terminal; This domain represents the regulatory N-terminal non-catalytic region of Mitogen-activated protein kinase kinase kinase 4 (MEKK4) which contains a putative PH-domain. This N-terminal region acts as an autoinhibitory domain that must be dissociated from the catalytic domain to allow the activation of these kinases.


Pssm-ID: 466077  Cd Length: 974  Bit Score: 42.22  E-value: 7.01e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767971642   66 YQDHLHQcaEAVAFDQnalVKRIKEMDLSVETLFSFMQERQKRYAKYAEQ 115
Cdd:pfam19431 290 CREHLQR--QRVAFEQ---VKRVMELLEYVEALYPSLQALQKDYEKYAAK 334
PilN COG3166
Type IV pilus assembly protein PilN [Cell motility, Extracellular structures];
102-162 2.87e-03

Type IV pilus assembly protein PilN [Cell motility, Extracellular structures];


Pssm-ID: 442399 [Multi-domain]  Cd Length: 185  Bit Score: 36.48  E-value: 2.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767971642 102 MQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPFSMKPDR 162
Cdd:COG3166   64 LDKQIAEIKELKKQKAELLARLQVIEQLQQSRPPWVHLLDELARLLPEGVWLTSLSQQGGT 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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