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Conserved domains on  [gi|767966252|ref|XP_011518554|]
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43 kDa receptor-associated protein of the synapse isoform X1 [Homo sapiens]

Protein Classification

TPR and TPR_12 domain-containing protein( domain architecture ID 11721580)

protein containing domains SNAP, TPR, and TPR_12

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNAP super family cl24038
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 1-80 4.49e-35

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


The actual alignment was detected with superfamily member pfam10579:

Pssm-ID: 451671 [Multi-domain]  Cd Length: 80  Bit Score: 125.90  E-value: 4.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252    1 MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDAD 80
Cdd:pfam10579   1 LGQDIAKQKIEKGLKLYEQNDQEAALRTWMKALKGTCDPEDCFQLLGCLIQAHMDMGKFKEAIEFGHAQIGIAEELDDPD 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 9-290 8.07e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 8.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252   9 QIEKGLQLYQSNQTEKALQVWTKVLEKSSDlmgrfrvlgcLVTAHSEMGRYKEMLKfavvqidtarELEDAdflLESYLN 88
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPE----------TVEAHLALGNLYRRRG----------EYDRA---IRIHQK 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  89 LARSNEKlcefhktisycktclglpgtRAGAQLG-GQVSLSMGNaflglsvFQKALESFEKALRYAHNNDDAMLEcrvcc 167
Cdd:COG2956   68 LLERDPD--------------------RAEALLElAQDYLKAGL-------LDRAEELLEKLLELDPDDAEALRL----- 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 168 sLGSFYAQVKDYEKALFFpckAAELVNNYGKgwslkyRAMSQYHMAVAYRLLGRLGSAMECCEEsmkiALQHGDRPLQAL 247
Cdd:COG2956  116 -LAEIYEQEGDWEKAIEV---LERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEK----ALKLDPDCARAL 181

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767966252 248 CLLcfADIHRSRGDLETA----------FPRYDSAMSIMTEIGNRLGQVQALL 290
Cdd:COG2956  182 LLL--AELYLEQGDYEEAiaaleraleqDPDYLPALPRLAELYEKLGDPEEAL 232
COG3899 super family cl28481
Predicted ATPase [General function prediction only];
142-463 5.08e-07

Predicted ATPase [General function prediction only];


The actual alignment was detected with superfamily member COG3899:

Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 52.55  E-value: 5.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  142 ALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKA--LFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLL 219
Cdd:COG3899   724 ALRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAeaLLERALAARALAALAALRHGNPPASARAYANLGLLLL 803

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  220 GRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVAR 299
Cdd:COG3899   804 GDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAA 883

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  300 KALDKACPPTLCFpvsKACQTALPAALAYAHLPGSGCHRESPGSGRGGGEQAEPAQAALSEREHLPQQRAAAGTAGARCE 379
Cdd:COG3899   884 AALAAAAAAAARL---LAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALAL 960

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  380 VPRVRGGDGALLRPVRRVHRREEqPAAGPTLLPHLPPQVPAEQRDPELSQLPPLIHEAWLCMTPGSRRGLPPRHSCSFST 459
Cdd:COG3899   961 AAAAAAAAAAALAAAAAAAAAAA-AAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAA 1039


                  ....
gi 767966252  460 ARQR 463
Cdd:COG3899  1040 AAAL 1043
 
Name Accession Description Interval E-value
Rapsyn_N pfam10579
Rapsyn N-terminal myristoylation and linker region; Neuromuscular junction formation relies ...
 1-80 4.49e-35

Rapsyn N-terminal myristoylation and linker region; Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction and is essential for the formation of synaptic acetylcholine receptor aggregates. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane.


Pssm-ID: 431369 [Multi-domain]  Cd Length: 80  Bit Score: 125.90  E-value: 4.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252    1 MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDAD 80
Cdd:pfam10579   1 LGQDIAKQKIEKGLKLYEQNDQEAALRTWMKALKGTCDPEDCFQLLGCLIQAHMDMGKFKEAIEFGHAQIGIAEELDDPD 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 9-290 8.07e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 8.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252   9 QIEKGLQLYQSNQTEKALQVWTKVLEKSSDlmgrfrvlgcLVTAHSEMGRYKEMLKfavvqidtarELEDAdflLESYLN 88
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPE----------TVEAHLALGNLYRRRG----------EYDRA---IRIHQK 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  89 LARSNEKlcefhktisycktclglpgtRAGAQLG-GQVSLSMGNaflglsvFQKALESFEKALRYAHNNDDAMLEcrvcc 167
Cdd:COG2956   68 LLERDPD--------------------RAEALLElAQDYLKAGL-------LDRAEELLEKLLELDPDDAEALRL----- 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 168 sLGSFYAQVKDYEKALFFpckAAELVNNYGKgwslkyRAMSQYHMAVAYRLLGRLGSAMECCEEsmkiALQHGDRPLQAL 247
Cdd:COG2956  116 -LAEIYEQEGDWEKAIEV---LERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEK----ALKLDPDCARAL 181

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767966252 248 CLLcfADIHRSRGDLETA----------FPRYDSAMSIMTEIGNRLGQVQALL 290
Cdd:COG2956  182 LLL--AELYLEQGDYEEAiaaleraleqDPDYLPALPRLAELYEKLGDPEEAL 232
COG3899 COG3899
Predicted ATPase [General function prediction only];
142-463 5.08e-07

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 52.55  E-value: 5.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  142 ALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKA--LFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLL 219
Cdd:COG3899   724 ALRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAeaLLERALAARALAALAALRHGNPPASARAYANLGLLLL 803

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  220 GRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVAR 299
Cdd:COG3899   804 GDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAA 883

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  300 KALDKACPPTLCFpvsKACQTALPAALAYAHLPGSGCHRESPGSGRGGGEQAEPAQAALSEREHLPQQRAAAGTAGARCE 379
Cdd:COG3899   884 AALAAAAAAAARL---LAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALAL 960

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  380 VPRVRGGDGALLRPVRRVHRREEqPAAGPTLLPHLPPQVPAEQRDPELSQLPPLIHEAWLCMTPGSRRGLPPRHSCSFST 459
Cdd:COG3899   961 AAAAAAAAAAALAAAAAAAAAAA-AAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAA 1039


                  ....
gi 767966252  460 ARQR 463
Cdd:COG3899  1040 AAAL 1043
TPR_12 pfam13424
Tetratricopeptide repeat;
204-278 2.01e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.46  E-value: 2.01e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966252  204 YRAMSQYHMAVAYRLLGRLGSAMECCEESMKIA--LQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTE 278
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIArrLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 62-291 1.63e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252   62 MLKFAVVQIDTARELEDADFL----------LESYLNLARSNEKLCEFHKTISYCKTCLglpgtrAGAQLGGQVSLSMGN 131
Cdd:TIGR02917 536 ILALAGLYLRTGNEEEAVAWLekaaelnpqeIEPALALAQYYLGKGQLKKALAILNEAA------DAAPDSPEAWLMLGR 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  132 AFLGLSVFQKALESFEKALRYAHNNDDAMLEcrvccsLGSFYAQVKDYEKALffpckaaelvnnygkgWSLKyRAMSQY- 210
Cdd:TIGR02917 610 AQLAAGDLNKAVSSFKKLLALQPDSALALLL------LADAYAVMKNYAKAI----------------TSLK-RALELKp 666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  211 HMAVAYRLLGRLGSAMECCEESMKIALQ-HGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQAL 289
Cdd:TIGR02917 667 DNTEAQIGLAQLLLAAKRTESAKKIAKSlQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRAL 746


                  ..
gi 767966252  290 LG 291
Cdd:TIGR02917 747 LA 748
 
Name Accession Description Interval E-value
Rapsyn_N pfam10579
Rapsyn N-terminal myristoylation and linker region; Neuromuscular junction formation relies ...
 1-80 4.49e-35

Rapsyn N-terminal myristoylation and linker region; Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction and is essential for the formation of synaptic acetylcholine receptor aggregates. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane.


Pssm-ID: 431369 [Multi-domain]  Cd Length: 80  Bit Score: 125.90  E-value: 4.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252    1 MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDAD 80
Cdd:pfam10579   1 LGQDIAKQKIEKGLKLYEQNDQEAALRTWMKALKGTCDPEDCFQLLGCLIQAHMDMGKFKEAIEFGHAQIGIAEELDDPD 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 9-290 8.07e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 8.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252   9 QIEKGLQLYQSNQTEKALQVWTKVLEKSSDlmgrfrvlgcLVTAHSEMGRYKEMLKfavvqidtarELEDAdflLESYLN 88
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPE----------TVEAHLALGNLYRRRG----------EYDRA---IRIHQK 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  89 LARSNEKlcefhktisycktclglpgtRAGAQLG-GQVSLSMGNaflglsvFQKALESFEKALRYAHNNDDAMLEcrvcc 167
Cdd:COG2956   68 LLERDPD--------------------RAEALLElAQDYLKAGL-------LDRAEELLEKLLELDPDDAEALRL----- 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 168 sLGSFYAQVKDYEKALFFpckAAELVNNYGKgwslkyRAMSQYHMAVAYRLLGRLGSAMECCEEsmkiALQHGDRPLQAL 247
Cdd:COG2956  116 -LAEIYEQEGDWEKAIEV---LERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEK----ALKLDPDCARAL 181

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767966252 248 CLLcfADIHRSRGDLETA----------FPRYDSAMSIMTEIGNRLGQVQALL 290
Cdd:COG2956  182 LLL--AELYLEQGDYEEAiaaleraleqDPDYLPALPRLAELYEKLGDPEEAL 232
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
84-272 2.21e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.18  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  84 ESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGgqvslsMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLec 163
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYN------LGLAYLRLGRYEEALADYEQALELDPDDAEALN-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 164 rvccSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWslkyramsqYHMAVAYRLLGRLGSAMECCEESMKIAlqhgdrP 243
Cdd:COG0457   81 ----NLGLALQALGRYEEALEDYDKALELDPDDAEAL---------YNLGLALLELGRYDEAIEAYERALELD------P 141

                        170       180
                 ....*....|....*....|....*....
gi 767966252 244 LQALCLLCFADIHRSRGDLETAFPRYDSA 272
Cdd:COG0457  142 DDADALYNLGIALEKLGRYEEALELLEKL 170
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
52-305 5.66e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 5.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  52 AHSEMGRYKEmlkfAVVQIDTARELEDADFllESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLggqvslSMGN 131
Cdd:COG0457   17 AYRRLGRYEE----AIEDYEKALELDPDDA--EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN------NLGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 132 AFLGLSVFQKALESFEKALRYAHNNDDAMLecrvccSLGSFYAQVKDYEKALFFPCKAAELVNNYgkgwslkyrAMSQYH 211
Cdd:COG0457   85 ALQALGRYEEALEDYDKALELDPDDAEALY------NLGLALLELGRYDEAIEAYERALELDPDD---------ADALYN 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 212 MAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLG 291
Cdd:COG0457  150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229

                        250
                 ....*....|....
gi 767966252 292 VAKCWVARKALDKA 305
Cdd:COG0457  230 LLALRLAALALYQY 243
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
12-219 5.38e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 5.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  12 KGLQLYQSNQTEKALQVWTKVLEKSSDLmgrFRVLGCLVTAHSEMGRYKEmlkfAVVQIDTARELEDADFllESYLNLAR 91
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALELDPDD---AEALYNLGLAYLRLGRYEE----ALADYEQALELDPDDA--EALNNLGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  92 SNEKLCEFHKTISYCKTCLGLPGTRAGAQLggqvslSMGNAFLGLSVFQKALESFEKALRYAHNNDDAmlecrvCCSLGS 171
Cdd:COG0457   85 ALQALGRYEEALEDYDKALELDPDDAEALY------NLGLALLELGRYDEAIEAYERALELDPDDADA------LYNLGI 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767966252 172 FYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLL 219
Cdd:COG0457  153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200
COG3899 COG3899
Predicted ATPase [General function prediction only];
142-463 5.08e-07

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 52.55  E-value: 5.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  142 ALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKA--LFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLL 219
Cdd:COG3899   724 ALRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAeaLLERALAARALAALAALRHGNPPASARAYANLGLLLL 803

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  220 GRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVAR 299
Cdd:COG3899   804 GDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAA 883

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  300 KALDKACPPTLCFpvsKACQTALPAALAYAHLPGSGCHRESPGSGRGGGEQAEPAQAALSEREHLPQQRAAAGTAGARCE 379
Cdd:COG3899   884 AALAAAAAAAARL---LAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALAL 960

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  380 VPRVRGGDGALLRPVRRVHRREEqPAAGPTLLPHLPPQVPAEQRDPELSQLPPLIHEAWLCMTPGSRRGLPPRHSCSFST 459
Cdd:COG3899   961 AAAAAAAAAAALAAAAAAAAAAA-AAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAA 1039


                  ....
gi 767966252  460 ARQR 463
Cdd:COG3899  1040 AAAL 1043
TPR_12 pfam13424
Tetratricopeptide repeat;
204-278 2.01e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.46  E-value: 2.01e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966252  204 YRAMSQYHMAVAYRLLGRLGSAMECCEESMKIA--LQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTE 278
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIArrLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
139-236 6.00e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.78  E-value: 6.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 139 FQKALESFEKALRYAHNNDDAMLecrvccSLGSFYAQVKDYEKALFFPcKAAELVNNYgkgwslkyrAMSQYHMAVAYRL 218
Cdd:COG3063    8 LEEAEEYYEKALELDPDNADALN------NLGLLLLEQGRYDEAIALE-KALKLDPNN---------AEALLNLAELLLE 71

                         90
                 ....*....|....*...
gi 767966252 219 LGRLGSAMECCEESMKIA 236
Cdd:COG3063   72 LGDYDEALAYLERALELD 89
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
169-305 6.71e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.69  E-value: 6.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 169 LGSFYAQVKDYEKALffPC--KAAELVNNYGKGWslkyramsqYHMAVAYRLLGRLGSAMECCEESMKIALQHgdrplqA 246
Cdd:COG0457   14 LGLAYRRLGRYEEAI--EDyeKALELDPDDAEAL---------YNLGLAYLRLGRYEEALADYEQALELDPDD------A 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966252 247 LCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIG---NRLGQVQALLG-VAKcwvARKALDKA 305
Cdd:COG0457   77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAealYNLGLALLELGrYDE---AIEAYERA 136
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 129-273 9.40e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 9.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 129 MGNAFLGLSVFQKALESFEKALRYAHNNDDAmlecrvCCSLGSFYAQVKDYEKALFFPCKAAELVNNYgkgwslkyrAMS 208
Cdd:COG3914  118 LGNLLLALGRLEEALAALRRALALNPDFAEA------YLNLGEALRRLGRLEEAIAALRRALELDPDN---------AEA 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767966252 209 QYHMAVAYRLLGRLGSAMECCEESMKIALQHgdrpLQALCLLCFADIHRSRGDLETAFPRYDSAM 273
Cdd:COG3914  183 LNNLGNALQDLGRLEEAIAAYRRALELDPDN----ADAHSNLLFALRQACDWEVYDRFEELLAAL 243
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 5-156 1.52e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.72  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252   5 QTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGclvTAHSEMGRYKEmlkfAVVQIDTARELEDADFllE 84
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLG---EILLQLGDLDE----AIVLLHEALELDPDEP--E 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767966252  85 SYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGgqvslsMGNAFLGLSVFQKALESFEKALRYAHNN 156
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR------LARAYRALGRPDEAIAALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 83-183 1.03e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  83 LESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGgqvslsMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLE 162
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLD------LAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                         90       100
                 ....*....|....*....|.
gi 767966252 163 crvccsLGSFYAQVKDYEKAL 183
Cdd:COG4235   91 ------LGLAAFQQGDYAEAI 105
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 52-268 1.11e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  52 AHSEMGRYKEmlkfAVVQIDTARELeDADFLlESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLggqvslSMGN 131
Cdd:COG3914   87 LLQALGRYEE----ALALYRRALAL-NPDNA-EALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYL------NLGE 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 132 AFLGLSVFQKALESFEKALRYAHNNDDAMlecrvcCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYH 211
Cdd:COG3914  155 ALRRLGRLEEAIAALRRALELDPDNAEAL------NNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQAC 228

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767966252 212 MAVAYRLLGRLGSAMECCEESMK----IALQHGDRPLQALCLLCFADIHRSRGDLETAFPR 268
Cdd:COG3914  229 DWEVYDRFEELLAALARGPSELSpfalLYLPDDDPAELLALARAWAQLVAAAAAPELPPPP 289
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 139-236 1.26e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 139 FQKALESFEKALRYAHNNDDAMLecrvccSLGSFYAQVKDYEKALFFPCKAAELVNNYgkgwslkyrAMSQYHMAVAYRL 218
Cdd:COG5010   70 FEESLALLEQALQLDPNNPELYY------NLALLYSRSGDKDEAKEYYEKALALSPDN---------PNAYSNLAALLLS 134

                         90
                 ....*....|....*...
gi 767966252 219 LGRLGSAMECCEESMKIA 236
Cdd:COG5010  135 LGQDDEAKAALQRALGTS 152
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 62-291 1.63e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252   62 MLKFAVVQIDTARELEDADFL----------LESYLNLARSNEKLCEFHKTISYCKTCLglpgtrAGAQLGGQVSLSMGN 131
Cdd:TIGR02917 536 ILALAGLYLRTGNEEEAVAWLekaaelnpqeIEPALALAQYYLGKGQLKKALAILNEAA------DAAPDSPEAWLMLGR 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  132 AFLGLSVFQKALESFEKALRYAHNNDDAMLEcrvccsLGSFYAQVKDYEKALffpckaaelvnnygkgWSLKyRAMSQY- 210
Cdd:TIGR02917 610 AQLAAGDLNKAVSSFKKLLALQPDSALALLL------LADAYAVMKNYAKAI----------------TSLK-RALELKp 666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252  211 HMAVAYRLLGRLGSAMECCEESMKIALQ-HGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQAL 289
Cdd:TIGR02917 667 DNTEAQIGLAQLLLAAKRTESAKKIAKSlQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRAL 746


                  ..
gi 767966252  290 LG 291
Cdd:TIGR02917 747 LA 748
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 124-278 2.43e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966252 124 QVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMlecrvcCSLGSFYAQVKDYEKALffpckaaelvNNYGKGWSL- 202
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAF------ALLGEILLQLGDLDEAI----------VLLHEALELd 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767966252 203 KYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDrplqALCLLcfADIHRSRGDLETAFPRYDSAMSIMTE 278
Cdd:COG4783   69 PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE----AYLRL--ARAYRALGRPDEAIAALEKALELDPD 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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