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Conserved domains on  [gi|767965814|ref|XP_011518369|]
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CD82 antigen isoform X4 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 13626516)

tetraspanin family protein similar to CD37 antigen (also known as tetraspanin-26), a transmembrane (TM) protein with four TM segments which may act as a molecular facilitator in diverse processes such as in the immune system, fusion, adhesion, migration to apoptosis, and alterations of cell morphology

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 75-198 2.54e-59

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


:

Pssm-ID: 239413  Cd Length: 117  Bit Score: 182.97  E-value: 2.54e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  75 FYFNMGKLKQEMGGIVTELIRDYNSSRED-SLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCEVKGEEDN 153
Cdd:cd03160    1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENkTAEEAWDYVQFQLQCCGWTGPQDWTDNSLIKNSSEPLYPCSCCNSSATAD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767965814 154 SLSVRKGFCEAPGNRtqsgnhpeDWPVYQEGCMEKVQAWLQENLG 198
Cdd:cd03160   81 SPRPSKGFCEAPASL--------DWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
25-223 1.12e-30

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 111.64  E-value: 1.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814   25 AYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDS 104
Cdd:pfam00335  45 PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  105 ---LQDAWDYVQAQVKCCGwvsfynwtdnaelmnrpevtypcscevkgeednslsvrkgfceapgnrtqsgnhpedwpvy 181
Cdd:pfam00335 125 yscLNSALDSLQSEFGCCG------------------------------------------------------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 767965814  182 qeGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCR 223
Cdd:pfam00335 144 --GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 75-198 2.54e-59

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 182.97  E-value: 2.54e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  75 FYFNMGKLKQEMGGIVTELIRDYNSSRED-SLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCEVKGEEDN 153
Cdd:cd03160    1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENkTAEEAWDYVQFQLQCCGWTGPQDWTDNSLIKNSSEPLYPCSCCNSSATAD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767965814 154 SLSVRKGFCEAPGNRtqsgnhpeDWPVYQEGCMEKVQAWLQENLG 198
Cdd:cd03160   81 SPRPSKGFCEAPASL--------DWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
25-223 1.12e-30

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 111.64  E-value: 1.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814   25 AYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDS 104
Cdd:pfam00335  45 PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  105 ---LQDAWDYVQAQVKCCGwvsfynwtdnaelmnrpevtypcscevkgeednslsvrkgfceapgnrtqsgnhpedwpvy 181
Cdd:pfam00335 125 yscLNSALDSLQSEFGCCG------------------------------------------------------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 767965814  182 qeGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCR 223
Cdd:pfam00335 144 --GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 75-198 2.54e-59

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 182.97  E-value: 2.54e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  75 FYFNMGKLKQEMGGIVTELIRDYNSSRED-SLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCEVKGEEDN 153
Cdd:cd03160    1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENkTAEEAWDYVQFQLQCCGWTGPQDWTDNSLIKNSSEPLYPCSCCNSSATAD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767965814 154 SLSVRKGFCEAPGNRtqsgnhpeDWPVYQEGCMEKVQAWLQENLG 198
Cdd:cd03160   81 SPRPSKGFCEAPASL--------DWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
25-223 1.12e-30

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 111.64  E-value: 1.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814   25 AYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDS 104
Cdd:pfam00335  45 PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  105 ---LQDAWDYVQAQVKCCGwvsfynwtdnaelmnrpevtypcscevkgeednslsvrkgfceapgnrtqsgnhpedwpvy 181
Cdd:pfam00335 125 yscLNSALDSLQSEFGCCG------------------------------------------------------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 767965814  182 qeGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCR 223
Cdd:pfam00335 144 --GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 76-197 4.05e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 68.30  E-value: 4.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  76 YFNMGKLKQEMGGIVTELIRDYNSSreDSLQDAWDYVQAQVKCCGWVSFYNWTDNaelmnrpEVTYPCSCEVKGEEDNSL 155
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEYYVD--DDFQEAMDALQSTFECCGVNGPTDYLDL-------RLLVPSSCCKGTDGNCGL 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767965814 156 svrkgfceapgnrtqsgnhpedwPVYQEGCMEKVQAWLQENL 197
Cdd:cd03127   72 -----------------------NLYTEGCLEKLVDFLRSNL 90
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 81-197 2.25e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 55.84  E-value: 2.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  81 KLKQEMggivTELIRDYNSSREDSLQDAWDYVQAQVKCCGwVSfyNWTDNAELMNRPEVtyPCSCevkgeednslsvrkg 160
Cdd:cd03165   10 TAKDDL----KEGLELYGTRNNRGLTNAWDITQTEFRCCG-VT--NYTDWYEVLGENRV--PDSC--------------- 65

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767965814 161 fCEapgNRTQSGNHPEDWPVYQEGCMEKVQAWLQENL 197
Cdd:cd03165   66 -CQ---EDSQDCGRNPTELWWKTGCYEKVQQWLVDNL 98
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 76-195 3.88e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 50.12  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  76 YFNMGKLKQEMGGIVTELIRDYNSSREDSLqdAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCevkgeednsl 155
Cdd:cd03163    2 YVYRAKVEDELNPSIDKVFNKYNGTNAESR--AVDYLQRQLQCCGIHNYTDWENTPWFKESKNNSVPLSC---------- 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767965814 156 svrkgfC-EAPGNRTQSGNHPEDwpVYQEGCMEKVQAWLQE 195
Cdd:cd03163   70 ------CkETFTSCTGSLTQPKD--LYQEGCEAKLVKKLQE 102
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 76-197 1.51e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 45.80  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  76 YFNMGKLKQEMGGIVTELI-RDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTY--PCSCevkgeed 152
Cdd:cd03155    1 YTYYQQLEDELKESLKRTMqENYGQSGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWINSNEANGRlvPDSC------- 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767965814 153 nslsvrkgfCEAPGNRTQS-GNHPEDWPVYQEGCMEKVQAWLQENL 197
Cdd:cd03155   74 ---------CKTVVDRCGClRDHPSNIYKVEGGCIPKLEDFLYDHL 110
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 83-197 2.92e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 44.99  E-value: 2.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  83 KQEMGGIVTELIRD--YNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDN------AELMNRPEVTYPCsCEVKGEEDns 154
Cdd:cd03158    4 SNQTIDLLEENIRKaiVHYYDDLDLQNIIDFVQKEFKCCGGDDYRDWSKNmyfncsSPNPEACGVPYSC-CIRAKDQE-- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767965814 155 lsVRKGFCeapGNRTQSGNHPE-DWPVYQEGCMEKVQAWLQENL 197
Cdd:cd03158   81 --VINTMC---GYGVQNLERLEaSKLIYTRGCIDAVVLWIEDNL 119
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 99-197 6.37e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 40.87  E-value: 6.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  99 SSREDSLQDAWDYVQAQVKCCGWVSFYNWTDNaelmNRPEVtypCSCEVKGEEDNSLSVrkgfceaPGNRtqsgnhpedw 178
Cdd:cd03154   27 GQNAKSVKKSLEKFQKELKCCGLVNGADDWGN----DIPAS---CNCTTTQSDCVVAYY-------GGSN---------- 82

                         90
                 ....*....|....*....
gi 767965814 179 pVYQEGCMEKVQAWLQENL 197
Cdd:cd03154   83 -VYKEPCISKIKDFLKKNL 100
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 91-197 9.65e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 40.42  E-value: 9.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  91 TELIRDYNSSREDSlqDAWDYVQAQVKCCGWVSFYNWTDNAELmnrPEVTYPCSCeVKGEEDNSLSVRKGFCEAPGNrtq 170
Cdd:cd03161   16 NEAVSNYNGDDERS--DAVDTVQRTLHCCGVENYTDWLNSPYF---LEKGIPLSC-CKNRSDCSPQDLKNLTKAATK--- 86

                         90       100
                 ....*....|....*....|....*..
gi 767965814 171 sgnhpedwpVYQEGCMEKVQAWLQENL 197
Cdd:cd03161   87 ---------VYQQGCFTLVTSFMEANM 104
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 82-196 3.05e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 39.44  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  82 LKQEMGGIVTELIRDYNSSREDSLQD---AWDYVQAQVKCCG------WVSFYNWTDNAELMNRPevtYPCSCEVkgeeD 152
Cdd:cd03156    5 FKKDLEDSFKNLLKNNYGNYNSTGDAitsTWNRVMIELKCCGvngptdFVDSTSFFRQKNEPNSP---YPESCCK----R 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767965814 153 NSLSVRKGFCEAPGNRTQSgnhpedwpVYQEGCMEKVQAWLQEN 196
Cdd:cd03156   78 NSNSQIVDLDCPKLGSPNS--------YNKKGCYEKLSNPIERY 113
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 76-197 4.39e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 38.61  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814  76 YFNMGKLKQEMGGIVTELIRDYNSSREdsLQDAWDYVQAQVKCCGWVSFYNWtDNAELMNRPEVtyPCSCevkgeednSL 155
Cdd:cd03166    1 YVFRDKVMSEFNDSFNQMISNYNKTND--FRKILDRMQKDLKCCGANNYTDW-ENIPSLDTDSV--PDSC--------CI 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767965814 156 SVRKGfCeapgnrtqsGNHPEDWPVYQEGCMEKVQAWLQENL 197
Cdd:cd03166   68 NVTKG-C---------GINFDEKVIHLEGCVTKIEGWLKKNI 99
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 105-194 3.94e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


Pssm-ID: 239410  Cd Length: 103  Bit Score: 36.06  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965814 105 LQDAWDYVQAQVKCCGWVSFYNWTDNAElMNRPevtyPCSCEVKgeednslsvrkgfcEAPGNRTQSgnHPEDWP-VYQE 183
Cdd:cd03157   31 LTHAWNSFQTEFKCCGVIYFTDWLEMTE-MEWP----PDSCCSN--------------QYPGCARQA--HYNDLSdLYQE 89

                         90
                 ....*....|.
gi 767965814 184 GCMEKVQAWLQ 194
Cdd:cd03157   90 GCGPKIYSFIR 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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