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Conserved domains on  [gi|767958239|ref|XP_011517301|]
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zinc finger protein 189 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
87-473 5.62e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.59  E-value: 5.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239  87 RKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCN--ECGKSFSRSSFVIEHQRIHTGERPYECNYCGKT--F 162
Cdd:COG5048   24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 163 SVSSTLIRHQrIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDC------GKAFSWKSHLIE---------- 226
Cdd:COG5048  104 KASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPanslskdpss 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 227 ------HQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGK 300
Cdd:COG5048  183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 301 SFSRSSFLIEHQRIHTGER-------PYQCKECGKSFSQLCNLTRHQR--IHTG--DKPHKCEE--CGKAFSRSSGLIQH 367
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 368 QRIHT--REKTYPYNETKESFDP----NCSLVIQQEVYPKEKSYKC--DECGKTFSVSAHLVQHQRIHTGEKPYL---CT 436
Cdd:COG5048  343 ILLHTsiSPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlSNSCIRNFKRDSNLSLHIITHLSFRPYnckNP 422

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 767958239 437 VCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQL 473
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 4.45e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.45e-04
                          10        20
                  ....*....|....*....|....*
gi 767958239  504 LIQHQRIHTGEKPYKCEKCDKSFSQ 528
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-500 4.70e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 767958239  475 NLIRHQGVHTGNKPHKCDECGKAFSR 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
87-473 5.62e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.59  E-value: 5.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239  87 RKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCN--ECGKSFSRSSFVIEHQRIHTGERPYECNYCGKT--F 162
Cdd:COG5048   24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 163 SVSSTLIRHQrIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDC------GKAFSWKSHLIE---------- 226
Cdd:COG5048  104 KASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPanslskdpss 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 227 ------HQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGK 300
Cdd:COG5048  183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 301 SFSRSSFLIEHQRIHTGER-------PYQCKECGKSFSQLCNLTRHQR--IHTG--DKPHKCEE--CGKAFSRSSGLIQH 367
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 368 QRIHT--REKTYPYNETKESFDP----NCSLVIQQEVYPKEKSYKC--DECGKTFSVSAHLVQHQRIHTGEKPYL---CT 436
Cdd:COG5048  343 ILLHTsiSPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlSNSCIRNFKRDSNLSLHIITHLSFRPYnckNP 422

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 767958239 437 VCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQL 473
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 1.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 767958239  335 NLTRHQRIHTGDKPHKCEECGKAFSR 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 4.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.45e-04
                          10        20
                  ....*....|....*....|....*
gi 767958239  504 LIQHQRIHTGEKPYKCEKCDKSFSQ 528
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-500 4.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 767958239  475 NLIRHQGVHTGNKPHKCDECGKAFSR 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
87-473 5.62e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.59  E-value: 5.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239  87 RKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCN--ECGKSFSRSSFVIEHQRIHTGERPYECNYCGKT--F 162
Cdd:COG5048   24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 163 SVSSTLIRHQrIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDC------GKAFSWKSHLIE---------- 226
Cdd:COG5048  104 KASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPanslskdpss 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 227 ------HQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGK 300
Cdd:COG5048  183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 301 SFSRSSFLIEHQRIHTGER-------PYQCKECGKSFSQLCNLTRHQR--IHTG--DKPHKCEE--CGKAFSRSSGLIQH 367
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 368 QRIHT--REKTYPYNETKESFDP----NCSLVIQQEVYPKEKSYKC--DECGKTFSVSAHLVQHQRIHTGEKPYL---CT 436
Cdd:COG5048  343 ILLHTsiSPAKEKLLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlSNSCIRNFKRDSNLSLHIITHLSFRPYnckNP 422

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 767958239 437 VCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQL 473
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-571 1.18e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 179 RPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSD--CGKAFSWKSHLIEHQRTHTGEKPYhcTKCKKSFSRNSLLVEHQ 256
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 257 RIHtgerphkcgeCGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCK-------ECGKS 329
Cdd:COG5048  110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 330 FSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEVYPKEKSYKCDE 409
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 410 CGKTFSVSAHLVQHQRIHTGE-------KPYLCTVCGKSFSRSSFLIEHQR--IHTGE--RPYLCR--QCGKSFSQLCNL 476
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 477 IRHQGVHTGNKPHKC--DECGKAFSRNS-----GLIQHQRIHTGEKPYKCE--KCDKSFSQQRSLVNHQKIHAEVKTQET 547
Cdd:COG5048  340 KRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                        410       420
                 ....*....|....*....|....
gi 767958239 548 HeCDACGEAFNCRISLIQHQKLHT 571
Cdd:COG5048  420 K-NPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
123-307 6.27e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 123 KPFQCNECGKSFSRSSFVIEHQR--IHTGE--RPYEC--NYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSL 196
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 197 vkhqrihtGEKPHKCSDcgkafswKSHLIEHQRTHTGEKPyhctKCKKSFSRNSLLVEHQRIHTGERPH--KCGECGKAF 274
Cdd:COG5048  368 --------NNEPPQSLQ-------QYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSF 428

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767958239 275 RLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSF 307
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 1.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 767958239  335 NLTRHQRIHTGDKPHKCEECGKAFSR 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 429-507 3.34e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958239 429 GEKPYLCTV--CGKSFsRSSFLIEHQRIHTgerpylcrQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQ 506
Cdd:COG5189  346 DGKPYKCPVegCNKKY-KNQNGLKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 767958239 507 H 507
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 4.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.45e-04
                          10        20
                  ....*....|....*....|....*
gi 767958239  504 LIQHQRIHTGEKPYKCEKCDKSFSQ 528
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-444 6.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 767958239  419 HLVQHQRIHTGEKPYLCTVCGKSFSR 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-332 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*
gi 767958239  308 LIEHQRIHTGERPYQCKECGKSFSQ 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
195-219 1.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....*
gi 767958239  195 SLVKHQRIHTGEKPHKCSDCGKAFS 219
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-248 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 767958239  223 HLIEHQRTHTGEKPYHCTKCKKSFSR 248
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-304 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 767958239  279 YLIQHQKIHTGEKPFLCIECGKSFSR 304
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-136 2.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 767958239  111 HFIQHQRVHTGEKPFQCNECGKSFSR 136
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 321-343 4.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.04e-03
                          10        20
                  ....*....|....*....|...
gi 767958239  321 YQCKECGKSFSQLCNLTRHQRIH 343
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-500 4.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 767958239  475 NLIRHQGVHTGNKPHKCDECGKAFSR 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-472 4.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*
gi 767958239  448 LIEHQRIHTGERPYLCRQCGKSFSQ 472
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
252-274 6.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.31e-03
                          10        20
                  ....*....|....*....|...
gi 767958239  252 LVEHQRIHTGERPHKCGECGKAF 274
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 153-175 7.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|...
gi 767958239  153 YECNYCGKTFSVSSTLIRHQRIH 175
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
168-192 8.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.07e-03
                          10        20
                  ....*....|....*....|....*
gi 767958239  168 LIRHQRIHTGERPYQCNQCKQSFSQ 192
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
142-163 8.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.73e-03
                          10        20
                  ....*....|....*....|..
gi 767958239  142 EHQRIHTGERPYECNYCGKTFS 163
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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