Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 767956726  414 HLVGHMKIHTGIKPYECNICAKRF 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726   23 LNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLK----NSRRIVLPDVmNPRVFENILLSSYTGRLvMPAP 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDDV-SPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*
gi 767956726   99 EIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFL 103

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 767956726  414 HLVGHMKIHTGIKPYECNICAKRF 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  12 FPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTG 91
Cdd:cd18210    1 FPEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLKNMSSISLPGVMDPGAFESVLASAYTG 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767956726  92 RLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18210   81 KLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  15 FSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLV 94
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 767956726  95 MPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18200   81 LCMDALPSHLLVASGLQMWQVVDRCSELLK 110

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726   23 LNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLK----NSRRIVLPDVmNPRVFENILLSSYTGRLvMPAP 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDDV-SPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*
gi 767956726   99 EIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSY 89
Cdd:cd18289    7 IEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQILSFCY 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767956726  90 TGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18289   87 TGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLM 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  12 FPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTG 91
Cdd:cd18214    5 FENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSREVQISILQNSEVGRQLLLSCYTG 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767956726  92 RLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18214   85 VLEFPEMELVNYLTAASFLQMSHIVERCTQAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  16 SSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRV----------FENIL 85
Cdd:cd18228    3 SQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKCVldlhhvtvtgFAPLL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767956726  86 LSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGN 126
Cdd:cd18228   83 EYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSS 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  12 FPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNsrRIVL-PDVMNPRVFENILLSSYT 90
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDN--LINLdTDMVNPTVFRQILDFIYT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767956726  91 GRLV---MPA-PEIVSYLTAASFLQMWHVVDKCTEVLEGN 126
Cdd:cd18334   79 GKLLtsdQPGeQNFNALLTAASYLQLHDLAALCRKKLKRN 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  11 EFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFcdQVLLKNSRRIVLPDVMNPRVFENILLSSYT 90
Cdd:cd18206    1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYF--RMLFVDQKDVVHLDISNAAGLGQVLEFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 767956726  91 GRLVMPAPEIVSYLTAASFLQMWHVVDKCT 120
Cdd:cd18206   79 AKLSLSPENVDDVLAVATFLQMQDIVTACH 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSrRIVLPDVMNPRVFENILLSSY 89
Cdd:cd18208    3 INLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSVQSVQKLIDFMY 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767956726  90 TGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18208   82 SGVLRVSQSEALQILTAASILQIKTVIDECTRIV 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  17 STILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFcDQVLLKNSRRIVLP-----DVMNPRVFENILLSSYTG 91
Cdd:cd18329    6 SRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYF-KMLLSQNAKETGQPtvatfDVFSPDTFTIILDFVYSG 84

                         90       100
                 ....*....|....*....|....*...
gi 767956726  92 RLVMPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18329   85 KLSLTSQNVIEVMSAASYLQMTDVISVC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  13 PDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVlPDVMNPRVFENILLSSYTGR 92
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLD-HEMVSPGIFRLILDYIYTGR 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767956726  93 LVMPAP----EIVSYLTAASFLQMWHVVDKCTEVLEGN 126
Cdd:cd18333   81 LSEGDPgseqNLGAVLAAASYLQIPDLVALCKKKLKRN 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  13 PDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNsrRIVL-PDVMNPRVFENILLSSYTG 91
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDN--LIHLdQDMVSPTVFQQILDFIYTG 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767956726  92 RLVMPA---PEIVSYLTAASFLQMWHVVDKCTEVLEGN 126
Cdd:cd18216   79 KLLDSLfeePNLSEVLAAANYLQLPDLAALCRSKLKRG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFcdQVLLKNSRRIVLP-----DVMNPRVFENI 84
Cdd:cd18198    3 IPFPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYF--KKLFTSGAVVDQQnvyeiDFVSPEALTAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767956726  85 LLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18198   81 LEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  17 STILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFcDQVLLKNSRRIVLP-----DVMNPRVFENILLSSYTG 91
Cdd:cd18199    3 SRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYF-RMLLSHYIQDTGRPstasfDVFSSDAFSIILDFVYSG 81

                         90       100
                 ....*....|....*....|....*...
gi 767956726  92 RLVMPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18199   82 KLSLTSQNVIEVMSAASYLQMTDVINVC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYF---CDQVLLKNSRRIVLPDVMNPRVFENILL 86
Cdd:cd18323    1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFhmfYKEQLDKRDLVCINNEIVTAPAFSLLLE 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767956726  87 SSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEG 125
Cdd:cd18323   81 FMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQA 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  16 SSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYF----CDQVLLKNSRRIVLPDvMNPRVFENILLSSYTG 91
Cdd:cd18223    2 SDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFknafSSQEIWISSHVLELPD-LKAEVFAEILNFIYSS 80

                         90       100
                 ....*....|....*....|....*.
gi 767956726  92 RLVMPAPEIVSYLTAA------SFLQ 111
Cdd:cd18223   81 KVVVKRQETVTDLVAAgkklgiTFLE 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFC----DQVllkNSRRIVL--PDVMNPRVFEN 83
Cdd:cd18325    1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHlfyrDQL---DKRDIVHlnSDIVTAPAFSL 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767956726  84 ILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18325   78 LLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYF---------CDQvllknsRRIVLPDVMNPRV 80
Cdd:cd18328    3 IPFPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFkklftagtlADQ------PYVYEIDFVTPEA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767956726  81 FENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18328   77 LSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  10 VEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYF---CDQVLLKNSRRIVLPDVMNPRVFENILL 86
Cdd:cd18326    3 IPFPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFkklFTSGAVVDQQNVYEIDFVSAEALTALLD 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767956726  87 SSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18326   83 FAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726   8 FRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVL--LKNSRRIVLPDVMNPRVFENIL 85
Cdd:cd18277    3 FAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVgqADAELNITLPEEVTVKGFEPLI 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767956726  86 LSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVL 123
Cdd:cd18277   83 QFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  16 SSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFcdQVLLKNS------RRIVLPDVmNPRVFENILLSSY 89
Cdd:cd18240    1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYF--RALFTNGwnetekKVYKIPGV-SPEMMELIIEYAY 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767956726  90 TGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTV 129
Cdd:cd18240   78 TRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCP 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  16 SSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCdQVLLKNSRRIV----LPDVMNPRVFENILLSSYTG 91
Cdd:cd18332    3 SSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFY-SIFSGRVGEGVsvltLPSGLEARGFQLLLDFMYTS 81

                         90       100
                 ....*....|....*....|....*...
gi 767956726  92 RLVMPAPEIVSYLTAASFLQMWHVVDKC 119
Cdd:cd18332   82 RLPLTPRTVPAVLAAATYLQMEHVVETC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  16 SSTILQKLNQQRQQG-QLCDVSIVVQGHIFRAHKAVLAASSPYF----CDQVLLKNSRRIVLPDVMNPRVFENILLSSYT 90
Cdd:cd18207   10 SADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFesvfSAQEGDGGTPRELEMHTISSKVFGDILDFAYT 89

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767956726  91 GRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLE 124
Cdd:cd18207   90 SRIVVRLESFPELMTAAKFLLMRSVIDICQEVIK 123

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956726  32 LCDVSIVVQGHIFRAHKAVLAASSPYFCDqvLLKNSR-----RIVLPDVmNPRVFENILLSSYTGRLVMPAPEIVSYLTA 106
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAA--LLKETPpdehpVIILPDV-PYSELKALLDFIYTGEVNVSQEQLESLLKL 77

                 ....*
gi 767956726 107 ASFLQ 111
Cdd:cd18315   78 AELLQ 82